Aloe

Literaturquellen in PubMed


4.4.2002

Der aloe-vera-Wahnsinn ebbt nicht ab: Immer neue Wellen von Verkäufern branden in die Internet-Foren und verbreiten rund um die Uhr unwahre Behauptungen.

Daß dadurch Menschen zu Schaden kommen, interessiert die Verkäufer nicht. Sie haben nur "das große Geld" vor Augen. [1]

Die Wahrheit geht unter, die Kranken bleiben auf der Strecke...

Selbst Fernsehsendungen sind auf marktschreierisches und Jubel-Niveau verkommen.

Kritik an diesem menschenverachtenden Verhalten wird gelöscht. Das Gebot der christlichen Nächstenliebe, der Verantwortung für den Mitmenschen, es gilt nicht mehr.

Der Mammon regiert, wie im Himmel, so in der Sendeleitung...


Dem gilt es gegenzusteuern. Vor allem fachlich korrekte Information ist notwendig.

Aus den Datenbanken der "National Institutes of Health" (http://www.nih.gov/) sind die nun folgenden Quellen zum Stichwort "aloe" entnommen.

Es wurde absichtlich nicht "aloe vera" benutzt, weil in den Quellen die verschiedenen Schreibweisen auftreten und dadurch Texte nicht gefunden worden wären.

Die Links sind nur teilweise funktionsfähig. Sie entsprechen zwar dem aktuellen Datenbestand der NIH, aber die NIH können nicht ständig die Verfügbarkeit der verlinkten Texte kontrollieren. Wer einen Text benötigt, sollte sich diesen so schnell wie möglich besorgen, wenn er noch im Netz ist. Durch Umstellungen werden jeden Tag Texte aus dem WWW entfernt oder an andere URLs verschoben, so daß die Links nicht mehr funktionieren.

Aribert Deckers

[1] Zur Psychopathologie der Verkäufer hat der Berliner Senat ein ausgezeichnetes Buch veröffentlicht: http://www.ariplex.com/ama/amasenat.htm


Journal Citations:

Displaying items 1 - 467 of 467 found

1

The clinical effects of saline and aloe vera rinses on periodontal surgical sites.
Full author name: Rieger, Lisa; Carson, Robert E.

Rieger L, Carson RE. J Okla Dent Assoc. 2002 Winter;92(3):40-3.

[Article in English] No Abstract Available.

Department of Dental Hygiene, University of Oklahoma, College of Dentistry, USA. ISSN: 0164-9442
NLM Unique ID: 7905263
Country: United States
Entry Date: 20020327
MeSH Date: 2002/03/28 10:00
Entrez Date: 2002/03/28 10:00
Citation Subset: D
Publication Status: ppublish
J Okla Dent Assoc 2002 Winter;92(3):40-3.
PMID: 11915398 UI: 21913536 [PubMed - in process]
From PubMed


2

Mushroom tyrosinase inhibition activity of some chromones.
Full author name: Piao, Long Zhu; Park, Hyang Rae; Park, Yun Kyung; Lee, Seung Ki; Park, Jeong Hill; Park, Man Ki.

Piao LZ, Park HR, Park YK, Lee SK, Park JH, Park MK. Chem Pharm Bull (Tokyo). 2002 Mar;50(3):309-11.

[Article in English]

College of Pharmacy, Seoul National University, Korea.

Currently, aloesin is used in the cosmetic industry as a whitening agent because it inhibits tyrosinase activity. Aloesin is a C-glycosylated chromone compound isolated from aloe, and it is difficult to synthesize because of C-glycosyl moiety in the molecule. The purpose of this study is to search for a new chromone compound which is easy to synthesize and which posesses stronger tyrosinase inhibitory activity than aloesin. Fourteen chromone derivatives were synthesized and screened for their mushroom-tyrosinase inhibitory activity. 5-Methyl-7-methoxy-2-(2'-benzyl-3'-oxobutyl)chromone (15) showed the strongest activity among tested compounds. Its activity was not only stronger than aloesin, but also stronger than arbutin and kojic acid. The kinetic analysis revealed a competitive inhibition of 15 with tyrosinase for the L-tyrosine binding site. ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 20020325
MeSH Date: 2002/03/26 10:00
Entrez Date: 2002/03/26 10:00
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 2002 Mar;50(3):309-11.
PMID: 11911191 UI: 21908046 [PubMed - in process]
From PubMed


3

Herbal remedy-associated acute renal failure secondary to Cape aloes.
Full author name: Luyckx, Valerie A; Ballantine, Robert; Claeys, Magda; Cuyckens, Filip; Van den Heuvel, Hilde; Cimanga, Richard K; Vlietinck, Arnold J; De Broe, Marc E; Katz, Ivor J.

Luyckx VA, Ballantine R, Claeys M, Cuyckens F, Van den Heuvel H, Cimanga RK, Vlietinck AJ, De Broe ME, Katz IJ. Am J Kidney Dis. 2002 Mar;39(3):E13.

[Article in English]

Department of Renal Medicine, Chris Hani Baragwanath Hospital, Soweto, South Africa. vluyckx@hotmail.com

Use of traditional herbal remedies is common in Africa, and many patients who visit traditional healers do not need to resort to Western medicine. Acute renal failure is one of the most serious complications resulting from the use of traditional remedies, however, which accounts for 35% of all cases of acute renal failure in Africa. Traditional remedies rarely have been analyzed, and little is known about their nephrotoxicity. We report a case of a 47-year-old man from Soweto, South Africa, who developed acute oliguric renal failure and liver dysfunction after ingestion of an herbal remedy. The patient's renal function recovered slowly, and dialysis was discontinued after several weeks, although serum creatinine did not return to the normal range. Mass spectrometric and chromatographic analysis of the herbal remedy used by the patient revealed the presence of Cape aloes, a previously described nephrotoxin. Copyright 2002 by the National Kidney Foundation, Inc.

MeSH Terms:

Substances:

ISSN: 1523-6838
NLM Unique ID: 8110075
Country: United States
Entry Date: 20020305
Date Completed: 20020319
MeSH Date: 2002/03/20 10:01
Entrez Date: 2002/03/06 10:00
Citation Subset: IM
http://www.ajkd.org/scripts/om.dll/serve?artType=full&article=a31424
http://www.ajkd.org/scripts/om.dll/serve?action=searchDB&searchDBfor=art&artType=abs&id=a31424
Publication Status: ppublish
Am J Kidney Dis 2002 Mar;39(3):E13.
PMID: 11877593 UI: 21865999 [PubMed - indexed for MEDLINE]
From PubMed
4

Chemopreventive effects of Aloe arborescens on N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters.
Full author name: Furukawa, Fumio; Nishikawa, Akiyoshi; Chihara, Takeshi; Shimpo, Kan; Beppu, Hidehiko; Kuzuya, Hiroshi; Lee, In Seon; Hirose, Masao.

Furukawa F, Nishikawa A, Chihara T, Shimpo K, Beppu H, Kuzuya H, Lee IS, Hirose M. Cancer Lett. 2002 Apr 25;178(2):117-22.

[Article in English]

Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501, Tokyo, Japan

The modification effects of freeze-dried aloe (Aloe arborescens) whole leaf powder during the initiation phase of carcinogenesis were investigated in hamsters treated with N-nitrosobis(2-oxopropyl)amine (BOP). Female Syrian hamsters were given four weekly subcutaneous injections of BOP at a dose of 10mg/kg and then given 0, 1 or 5% aloe in their diet for 5 weeks. At week 54 of the experiment, all surviving animals were sacrificed and development of neoplastic and preneoplastic lesions was assessed histopathologically. The incidences of pancreatic adenocarcinomas, atypical hyperplasias or total atypical hyperplasias plus adenocarcinomas were significantly (P<0.05) decreased with BOP+5% aloe, and that of adenocarcinomas were also significantly (P<0.05) reduced in the BOP+1% aloe as compared to the BOP alone group. Multiplicities of pancreatic adenocarcinomas, atypical hyperplasias or total lesions were also significantly (P<0.01 or P<0.05) lower in the BOP+5% aloe group than with the BOP alone. Quantitative data for neoplastic lesions in the lung, liver, gall bladder, kidney and urinary bladder of hamsters were not significantly different among the three groups. In a satellite experiment, pretreatment with aloe significantly (P<0.01) reduced the formation of O(6)-methyldeoxyguanosine in epithelial cells of pancreatic ducts as compared to the BOP alone value. Our results thus indicate that aloe prevents BOP-induced pancreatic neoplasia in hamsters in relation to decreased DNA adduct formation in the target tissue. ISSN: 0304-3835
NLM Unique ID: 7600053
Country: Ireland
Entry Date: 20020227
MeSH Date: 2002/02/28 10:00
Entrez Date: 2002/02/28 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0304383501008400
Publication Status: ppublish
Cancer Lett 2002 Apr 25;178(2):117-22.
PMID: 11867195 UI: 21856083 [PubMed - in process]
From PubMed


5

Efficacy of crude extract of Aloe secundiflora against Salmonella gallinarum in experimentally infected free-range chickens in Tanzania.
Full author name: Waihenya, R K; Mtambo, M M A; Nkwengulila, G; Minga, U M.

Waihenya RK, Mtambo MM, Nkwengulila G, Minga UM. J Ethnopharmacol. 2002 Mar;79(3):317-23.

[Article in English]

Department of Zoology and Marine Biology, University of Dar Es Salaam, P.O. Box 35064, Dar Es Salaam, Tanzania

The ethnoveterinary use of Aloe species extract in free-range local chickens against fowl typhoid was investigated. Five-months-old local chickens, free of antibodies against fowl typhoid were used. The chickens were randomly assorted into five groups including pretreated and infected (G1, n=21), infected and untreated (G2, n=21), infected and treated (G3, n=21), untreated and uninfected (G4, n=10) and treated uninfected (G5, n=10). Groups 1, 2 and 3 were inoculated with 5.0x10(8) c.f.u/ml of Salmonella gallinarum, following which the chickens were monitored for 15 days. There was a delay on the occurrence of the clinical signs and reduced severity of the disease in the Aloe treated chickens (G1 and G3). The mortality rates were 23.8% (5/21) in G1 (pretreated and infected), 42.8% (9/21) in G2 (infected and untreated) and 14.2% (3/21) in G3 (infected and treated). Antibody levels were raised among the infected and untreated group (G2) while they remained relatively low in the Aloe treated groups (G1 and G3). However, there was a sharp increase in the levels of interleukin 6 (IL-6) in the Aloe treated groups (G1 and G3) as compared to the untreated group (G2) until day 9 post-infection. The results of this work indicate that the extract of Aloe secundiflora may be used in the control of fowl typhoid in chickens. Studies to determine the active ingredients of the plant extract are in progress. ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 20020307
MeSH Date: 2002/02/19 10:00
Entrez Date: 2002/02/19 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S037887410100397X
Publication Status: ppublish
J Ethnopharmacol 2002 Mar;79(3):317-23.
PMID: 11849835 UI: 21839127 [PubMed - in process]
From PubMed


6

Evaluation of the efficacy of the crude extract of Aloe secundiflora in chickens experimentally infected with Newcastle disease virus.
Full author name: Waihenya, R K; Mtambo, M M A; Nkwengulila, G.

Waihenya RK, Mtambo MM, Nkwengulila G. J Ethnopharmacol. 2002 Mar;79(3):299-304.

[Article in English]

Department of Zoology and Marine Biology, University of Dar es Salaam, PO Box 35064, Dar es Salaam, Tanzania

Two replicate experiments were carried out to verify the efficacy of Aloe species (Aloaceae) as used for the control of Newcastle disease (ND) in rural poultry in free-range systems among several communities in Tanzania. Four months old local chickens free of Newcastle disease antibodies were used. Following inoculation with ND virus, body weights, clinical signs, antibody levels and mortality were monitored. Results showed that there was reduced mortality rate and the severity of clinical signs during the acute phase of the infection in Aloe treated chickens compared with the non-treated ones. However, there was no significant effect of the Aloe on the antibody levels that were attributed to the recovery of the surviving chickens. The findings of this study suggest that Aloe secundiflora could be a potential candidate on the management of Newcastle disease in chickens. Further studies are in progress to identify the active ingredients of A. secundiflora against Newcastle disease virus. ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 20020218
MeSH Date: 2002/02/19 10:00
Entrez Date: 2002/02/19 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874101003701
Publication Status: ppublish
J Ethnopharmacol 2002 Mar;79(3):299-304.
PMID: 11849832 UI: 21839124 [PubMed - in process]
From PubMed


7

Evaluation of the use of complementary and alternative medicine in the largest United States-Mexico border city.
Full author name: Rivera, Jose O; Ortiz, Melchor; Lawson, Mark E; Verma, Kalpana M.

Rivera JO, Ortiz M, Lawson ME, Verma KM. Pharmacotherapy. 2002 Feb;22(2):256-64.

[Article in English]

University of Texas at El Paso-University of Texas at Austin Cooperative Pharmacy Program, 79902, USA.

STUDY OBJECTIVE: To evaluate the use of complementary and alternative medicine (CAM) in the El Paso, Texas, region. DESIGN: Prospective observational study conducted from April-October 2000. SETTING: Several hospitals and clinics. SUBJECTS: Five hundred forty-seven participants. INTERVENTION: Semi-structured interview with a bilingual questionnaire. MEASUREMENTS AND MAIN RESULTS: Complementary and alternative medicine was used in 77% of our population. The most common CAM providers were massage therapists (19.4%) and herbalists (12.4%). The most common herbal or home remedies were chamomile (13.1%) and aloe vera (8.5%). The most common nutritional or commercial products were multivitamins (16%), ginseng (3.6%), and ginkgo biloba (2.8%). We identified 599 CAM usages that could result in drug interactions, disease interactions, or adverse reactions. CONCLUSIONS: A wide range of CAM use was documented in this study. Our results indicate that Hispanics in this area use CAM at a higher rate than national trends. Many of these therapies can adversely affect a variety of disease states and drug therapies. ISSN: 0277-0008
NLM Unique ID: 8111305
Country: United States
Entry Date: 20020211
MeSH Date: 2002/02/12 10:00
Entrez Date: 2002/02/12 10:00
Citation Subset: IM
Publication Status: ppublish
Pharmacotherapy 2002 Feb;22(2):256-64.
PMID: 11837563 UI: 21824927 [PubMed - in process]
From PubMed


8

Isolation and Characterization of a Bioactive Mannose-Binding Protein from the Chinese Chive Allium tuberosum.
Full author name: Ooi, Linda S M; Yu, Hong; Chen, Chun-Mei; Sun, Samuel S M; Ooi, Vincent E C.

Ooi LS, Yu H, Chen CM, Sun SS, Ooi VE. J Agric Food Chem. 2002 Feb 13;50(4):696-700.

[Article in English]

Department of Biology, The Chinese University of Hong Kong, Shatin, Hong Kong, China, and Institute of Genetics, Fudan University, Shanghai, China.

A mannose-binding protein was isolated from two different cultivars of the Chinese chive Allium tuberosum by extraction with 0.2 M NaCl, ammonium sulfate precipitation, and affinity chromatography on mannose agarose and fetuin agarose. It exhibited hemagglutinating activity toward rabbit erythrocytes. The lectin (agglutinin) was adsorbed on the mannose-agarose column, but not on the fetuin-agarose column. This A. tuberosum lectin (ATL) is unglycosylated, and not sialic acid binding. Lectins isolated from the two cultivars exhibited the same molecular mass of 25 kDa on gel filtration (Superose 12) and 12.5 kDa on SDS-polyacrylamide gel electrophoresis, indicating that they might be a dimeric protein composed of two identical subunits. The N-terminal amino acid sequence analysis of the lectin of various cultivars of A. tuberosum revealed that they were identical and showed 50%, or more, homology to the lectins from Galanthus nivalis (family Amaryllidaceae), Narcissus tazetta (family Amaryllidaceae), and Aloe arborescenes (family Liliaceae). ISSN: 0021-8561
NLM Unique ID: 0374755
Country: United States
Entry Date: 20020206
MeSH Date: 2002/02/07 10:00
Entrez Date: 2002/02/07 10:00
Citation Subset: IM
http://dx.doi.org/10.1021/jf010878p
Publication Status: ppublish
J Agric Food Chem 2002 Feb 13;50(4):696-700.
PMID: 11829630 UI: 21818927 [PubMed - in process]
From PubMed


9

Technical note: Artificial vagina vs a vaginal collection vial for collecting semen from rams.
Full author name: Wulster-Radcliffe, M C; Williams, M A; Stellflug, J N; Lewis, G S.

Wulster-Radcliffe MC, Williams MA, Stellflug JN, Lewis GS. J Anim Sci. 2001 Dec;79(12):2964-7.

[Article in English]

USDA-ARS, U.S. Sheep Experiment Station, Dubois, ID 83423, USA.

The time required to train rams to an artificial vagina (AV) makes collecting semen from large numbers of rams difficult. To manage this problem, we developed a glass, round-bottomed, 1.9-cm i.d. x 9.8-cm long vaginal collection vial (VCV). Three experiments were conducted to determine whether the VCV affected 1) semen volume per collection, 2) percentage of motile spermatozoa, 3) forward progressive motility score before and after extension and after freezing and thawing, and 4) our ability to collect semen from untrained rams. A soft rubber cap with a hole in the center was used to cover the VCV. A VCV was inserted into the vagina of an estrual ewe, and a monofilament line attached to the VCV was clipped to the wool near the vulva. Rams were joined with unrestrained ewes in a pen until they ejaculated into the VCV. In Exp. 1, five rams trained to an AV were used in a switchback design with four collection periods. During each period (1 d), semen was collected with an AV and a VCV. Immediately after collection, semen volume and sperm motility were quantified. Semen was extended with an aloe vera gel-based diluent at a 1:4 dilution rate, motility was quantified again, and semen was frozen. At 1 h after freezing, semen was thawed and sperm motility was quantified. Ejaculate volume (mean = 0.7 mL) and all measures of motility after collection were similar (P > 0.05) for the two collection methods. In Exp. 2, 10 rams trained to an AV were used in a switchback design with five collection periods (period = 3 d). On d 1 and 3 of each period, an AV and a VCV were used to collect semen. Collection method did not affect (P > 0.05) ejaculate volume (mean = 1.0 mL), percentage of motile cells, or forward progressive motility score. In Exp. 3, 51 untrained rams were used in a switchback design with a single collection period (2 d). Semen was collected with an AV and a VCV. Ability to collect an ejaculate and time required for collection were recorded. The likelihood of collecting semen from untrained rams was greater (P < 0.01) using a VCV (mean = 31.4%) than using an AV (mean = 9.8%). Collection method did not affect (P > 0.05) ejaculate volume (mean = 0.8 mL), percentage of motile cells, or forward progressive motility score. We concluded that a VCV could be used to collect semen from rams that are not trained for semen collection without decreasing ejaculate volume or sperm motility. ISSN: 0021-8812
NLM Unique ID: 8003002
Country: United States
Entry Date: 20020128
MeSH Date: 2002/01/29 10:00
Entrez Date: 2002/01/29 10:00
Citation Subset: IM
Publication Status: ppublish
J Anim Sci 2001 Dec;79(12):2964-7.
PMID: 11811448 UI: 21669767 [PubMed - in process]
From PubMed


10

The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line.
Full author name: Wasserman, Lina; Avigad, Smadar; Beery, Einat; Nordenberg, Jardena; Fenig, Eyal.

Wasserman L, Avigad S, Beery E, Nordenberg J, Fenig E. Am J Dermatopathol. 2002 Feb;24(1):17-22.

[Article in English]

Felsenstein Medical Research Center, Sackler Faculty of Medicine, Tel Aviv University, Rabin Medical Center Beilinson Campus, Petah Tikva 49100, Israel. yardenam@clalit.org.ie

A free-floating cell line has been established from a metastatic lesion of a Merkel cell carcinoma (MCC) patient. The cell line was characterized by immunocytochemical reactions with antibodies against the epithelial and neuroendocrine antigens: cytokeratin 20, neuron-specific enolase, chromogranin A, neurofilament protein, synaptophysin, and calcitonin. Karyotype analysis of the MCC cells showed deletion in chromosomes 3 and 7, loss of chromosome 10, and several translocations in other chromosomes. No mutation was detected in the TP53 gene, after analyzing the complete coding region. Growth factors such as basic fibroblast growth factor, transforming growth factor-beta, and nerve and epidermal growth factors had no effect on the proliferation of the cells. The differentiation-inducing agents sodium butyrate and dimethyl sulfoxide, especially the former, markedly inhibited the proliferation of the MCC cells. Aloe emodin, a natural constituent of aloe vera leaves, significantly inhibited the growth of MCC cells. Aloe emodin has been reported to be nontoxic for normal cells but to possess specific toxicity for neuroectodermal tumor cells. Differentiation-inducing agents, and aloe emodin, merit further investigation as potential agents for treating MCC.

MeSH Terms:

Substances:

ISSN: 0193-1091
NLM Unique ID: 7911005
Country: United States
Entry Date: 20020122
Date Completed: 20020307
MeSH Date: 2002/03/08 10:01
Entrez Date: 2002/01/23 10:00
Citation Subset: IM
http://www.amjdermatopathology.com/article.asp?ISSN=0193-1091&VOL=24&ISS=1&PAGE=17
Publication Status: ppublish
Am J Dermatopathol 2002 Feb;24(1):17-22.
PMID: 11803275 UI: 21661396 [PubMed - indexed for MEDLINE]
From PubMed
11

Effect of aloe-emodin on expression of proliferating cell nuclear antigen of vascular smooth muscle cells in culture after arterial injury.
Full author name: Xu, C; Yin, C; Wang, S.

Xu C, Yin C, Wang S. Chin Med J (Engl). 2001 Jun;114(6):571-6.

[Article in English]

Department of Cardiology, People's Hospital, Beijing Medical University, Beijing 100044, China.

OBJECTIVE: To observe the effect of aloe-emodin on the expression of proliferating cell nuclear antigen (PCNA) in smooth muscle cells (SMCs) after arterial injury and study the molecular mechanism of inhibition of aloe-emodin on SMC proliferation. METHODS: Deendothelialization was performed at the abdominal aorta in Japanese white rabbits using a 3F Fogarty arterial embolectomy catheter. 48 hours later, the medium of abdominal aorta was isolated and primary SMCs culture was performed. Cells were synchronized to G0 by serum starvation, then aloe-emodin at a concentration of 20 micrograms/ml was added to the culture medium containing 10% [v/v] fetal calf serum. Vehicle was also added to the medium as a control. After 18 hours, the expression of PCNA at the level of mRNA and protein were examined using techniques of RT/PCR, Western blotting and inmmunocytochemistry respectively. RESULTS: Compared with the control group, the expression of PCNA mRNA and protein was prominently decreased after addition of aloe-emodin. CONCLUSION: The inhibition of aloe-emodin on SMCs proliferation may be caused by inhibiting the expression of the PCNA gene.

MeSH Terms:

Substances:

ISSN: 0366-6999
NLM Unique ID: 7513795
Country: China
Entry Date: 20020108
Date Completed: 20020213
MeSH Date: 2002/02/14 10:01
Entrez Date: 2002/01/10 10:00
Citation Subset: IM
Publication Status: ppublish
Chin Med J (Engl) 2001 Jun;114(6):571-6.
PMID: 11780429 UI: 21639653 [PubMed - indexed for MEDLINE]
From PubMed
12

Inhibition of azoxymethane-induced aberrant crypt foci formation in rat colorectum by whole leaf Aloe arborescens Miller var. natalensis Berger.
Full author name: Shimpo, K; Chihara, T; Beppu, H; Ida, C; Kaneko, T; Nagatsu, T; Kuzuya, H.

Shimpo K, Chihara T, Beppu H, Ida C, Kaneko T, Nagatsu T, Kuzuya H. Phytother Res. 2001 Dec;15(8):705-11.

[Article in English]

Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie 514-1296, Japan.

We examined the modifying effect of whole-leaf Aloe arborescens Miller var. natalensis Berger (designated as 'ALOE') on azoxymethane (AOM)-induced aberrant crypt foci (ACF), putative preneoplastic lesions, in the rat colorectum. Male F344 rats (4 weeks old) were fed the basal diet, or experimental diets containing 1% or 5% ALOE for 5 weeks. One week later, all rats except those in the vehicle-treated groups were injected s.c. with AOM (15 mg/kg, once weekly for 3 weeks). At 9 weeks of age, all the rats were killed, and the colorectum and liver were evaluated for ACF and cytosolic quinone reductase (QR; a phase 2 enzyme), respectively. In rats given AOM and ALOE (1% or 5% in diet) the numbers of ACF/colorectum, aberrant crypts/colorectum, aberrant crypts/focus and large ACF/colorectum were significantly decreased compared with those of rats given AOM alone (all p < 0.01). No ACF were found in rats treated without AOM. In addition, ALOE significantly increased cytosolic QR activity in the liver (p < 0.01). These results indicated that ALOE inhibited the development of AOM-induced ACF in the rat colorectum, with increased QR activity in the liver, and therefore suggested that ALOE might have a chemopreventive effect against colon carcinogenesis at least in the initiation stage. Copyright 2001 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20011217
Date Completed: 20020219
MeSH Date: 2002/02/20 10:01
Entrez Date: 2001/12/18 10:00
Citation Subset: IM
Publication Status: ppublish
Phytother Res 2001 Dec;15(8):705-11.
PMID: 11746864 UI: 21612622 [PubMed - indexed for MEDLINE]
From PubMed
13

Hypotensive effect of chemical constituents from Aloe barbadensis.
Full author name: Saleem, R; Faizi, S; Siddiqui, B S; Ahmed, M; Hussain, S A; Qazi, A; Dar, A; Ahmad, S I; Qazi, M H; Akhtar, S; Hasnain, S N.

Saleem R, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Dar A, Ahmad SI, Qazi MH, Akhtar S, Hasnain SN. Planta Med. 2001 Nov;67(8):757-60.

[Article in English]

Dr. H.M.I. Institute of Pharmacology and Herbal Sciences, Hamdard University, Karachi, Pakistan. rs127pk@yahoo.com

Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1). ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20011203
MeSH Date: 2001/12/04 10:00
Entrez Date: 2001/12/04 10:00
Citation Subset: IM
http://www.thieme-connect.com/DOI/DOI?10.1055/s-2001-18348
Publication Status: ppublish
Planta Med 2001 Nov;67(8):757-60.
PMID: 11731923 UI: 21588957 [PubMed - in process]
From PubMed


14

Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma.
Full author name: Lee, H Z; Hsu, S L; Liu, M C; Wu, C H.

Lee HZ, Hsu SL, Liu MC, Wu CH. Eur J Pharmacol. 2001 Nov 23;431(3):287-95.

[Article in English]

School of Pharmacy, China Medical College, 91, Hsueh-Shih Road, Taichung, 404, Taiwan. hong@mail.cmc.edu.tw

Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum. The study investigated the effects and mechanisms of aloe-emodin-induced cell death in human lung squamous cell carcinoma cell line CH27. Aloe-emodin (40 microM)-induced CH27 cell apoptosis was confirmed by DNA fragmentation (DNA ladders and sub-G(1) formation). Aloe-emodin-induced apoptosis of CH27 cells involved modulation of the expression of Bcl-2 family proteins, such as BclX(L), Bag-1, and Bak, and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions. Aloe-emodin-treated CH27 cells had an increased relative abundance of cytochrome c in the cytosolic fraction. Results demonstrated that the activation of caspase-3, caspase-8, and caspase-9 is an important determinant of apoptotic death induced by aloe-emodin. These results suggest that aloe-emodin induces CH27 cell death by the Bax and Fas death pathway.

MeSH Terms:

Substances:

ISSN: 0014-2999
NLM Unique ID: 1254354
Country: Netherlands
Entry Date: 20011203
Date Completed: 20020114
MeSH Date: 2002/01/15 10:01
Entrez Date: 2001/12/04 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0014299901014674
Publication Status: ppublish
Eur J Pharmacol 2001 Nov 23;431(3):287-95.
PMID: 11730720 UI: 21587874 [PubMed - indexed for MEDLINE]
From PubMed
15

Cytotoxic and DNA damage-inducing activities of low molecular weight phenols from rhubarb.
Full author name: Shi, Y Q; Fukai, T; Sakagami, H; Kuroda, J; Miyaoka, R; Tamura, M; Yoshida, N; Nomura, T.

Shi YQ, Fukai T, Sakagami H, Kuroda J, Miyaoka R, Tamura M, Yoshida N, Nomura T. Anticancer Res. 2001 Jul-Aug;21(4A):2847-53.

[Article in English]

School of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan.

Six new phenol (anthraquinone or stilbene) glycosides with an acyl group at 6-position of the glucopyranose moiety were isolated from rhubarb (the roots of Rheum palmatum) cultivated in Japan, together with 22 known compounds. Most of these compounds were evaluated for cytotoxic activity against tumor and normal cells and for induction of DNA damage by spore rec-assay. Among them, emodin and aloe-emodin showed higher cytotoxic activities against human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines than against normal human gingival fibroblasts (HGF). Chrysophanol 8-O-beta-(6'-acetyl)glucopyranoside, 4-(4'-hydroxyphenyl)-2-butanone 4'-O-beta-D-(2"-O-galloyl-6"-O-cinnamoyl) glucopyranoside, and 6"-O-(4'''-hydroxybenzoyl) resveratroloside exhibited relatively higher cytotoxic activities against all these cells. The other glycosides of anthraquinone or stilbene showed weaker cytotoxic activity against these tumor cell lines, but may be considered as cancer chemopreventive agents. Spore rec-assay with a recombination deficient mutant of Bacillus subtilis M45 demonstrated the DNA damage-inducing activity of emodin and aloe-emodin 15-O-beta-D-glucopyranoside among, rhubarb phenols.

MeSH Terms:

Substances:

ISSN: 0250-7005
NLM Unique ID: 8102988
Country: Greece
Entry Date: 20011128
Date Completed: 20011207
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/11/29 10:00
Citation Subset: IM
Publication Status: ppublish
Anticancer Res 2001 Jul-Aug;21(4A):2847-53.
PMID: 11724365 UI: 21580891 [PubMed - indexed for MEDLINE]
From PubMed
16

The wound-healing effect of a glycoprotein fraction isolated from aloe vera.
Full author name: Choi, S W; Son, B W; Son, Y S; Park, Y I; Lee, S K; Chung, M H.

Choi SW, Son BW, Son YS, Park YI, Lee SK, Chung MH. Br J Dermatol. 2001 Oct;145(4):535-45.

[Article in English]

Department of Pharmacology, Seoul National University College of Medicine, Seoul 110-799, Korea.

BACKGROUND: Aloe vera has been used as a family medicine for promoting wound healing, but it is not known which component of the plant is effective for this purpose. OBJECTIVES: To isolate and characterize the component effective in wound healing. METHODS: Chromatography, electrophoresis and spectroscopic methods were used. The cell-proliferation activity of each component isolated was measured by a [3H]thymidine uptake assay. The cell-proliferation activity of the effective component was tested on a three-dimensional raft culture (cell culture technique by which artificial epidermis is made from keratinocytes). The effect of the active component on cell migration and wound healing was observed on a monolayer of human keratinocytes and in hairless mice. RESULTS: A glycoprotein fraction was isolated and named G1G1M1DI2. It showed a single band on sodium dodecyl sulphate-polyacrylamide gel electrophoresis, with an apparent molecular weight of about 5.5 kDa. It exhibited significant [3H]thymidine uptake in squamous cell carcinoma cells. The effect of G1G1M1DI2 on cell migration was confirmed by accelerated wound healing on a monolayer of human keratinocytes. When this fraction was tested on a raft culture, it stimulated the formation of epidermal tissue. Furthermore, proliferation markers (epidermal growth factor receptor, fibronectin receptor, fibronectin, keratin 5/14 and keratin 1/10) were markedly expressed at the immunohistochemical level. The glycoprotein fraction enhanced wound healing in hairless mice by day 8 after injury, with significant cell proliferation. CONCLUSIONS: It is considered that this glycoprotein fraction is involved in the wound-healing effect of aloe vera via cell proliferation and migration.

MeSH Terms:

Substances:

ISSN: 0007-0963
NLM Unique ID: 0004041
Country: England
Entry Date: 20011112
Date Completed: 20011210
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/11/13 10:00
Citation Subset: IM
http://www.blackwell-synergy.com/rd.asp?abbrev=Br%20J%20Dermatol&vol=145&page=535&goto=abstract
Publication Status: ppublish
Br J Dermatol 2001 Oct;145(4):535-45.
PMID: 11703278 UI: 21560215 [PubMed - indexed for MEDLINE]
From PubMed
17

Comparative study of the assay of Artemia salina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts.
Full author name: Logarto Parra, A; Silva Yhebra, R; Guerra Sardinas, I; Iglesias Buela, L.

Logarto Parra A, Silva Yhebra R, Guerra Sardinas I, Iglesias Buela L. Phytomedicine. 2001 Sep;8(5):395-400.

[Article in English]

Drug Research and Development Center (CIDEM), Biologic Research Department, Ciudad de La Habana, Cuba. cidem@infomed.sld.cu

Artemia salina L. (Artemiidae), the brine shrimp larva, is an invertebrate used in the alternative test to determine toxicity of chemical and natural products. In this study the Medium Lethal Concentrations (LC50 value) of 20 plant extracts, Aloe vera (L.) Burm. F. (Aloeaceae), Artemisia absinthium L. (Asteraceae); Citrus aurantium L. (Rutaceae); Cymbopogon citratus (DC. Ex Nees) Stapf (Poaceae); Datura stramonium L. (Solanaceae); Justicia pectoralis Jacq. (Acanthaceae); Musa x paradisiaca L. (Musaceae); Ocimum basilicum L.; O. gratissimum L.; O. tenuiflorum L. (Lamiaceae); Pimenta dioica (L.) Merr. (Myrtaceae); Piper auritum Kunth (Piperaceae); Plantago major L. (Plantaginaceae); Plectranthus amboinicus (Lour.) Spreng. (Lamiaceae); Ruta graveolens L. (Rutaceae); Senna alata (L.) Roxb. (Fabaceae); Stachytarpheta jamaicensis (L.) Vahl (Verbenaceae); and Thuja occidentalis L. (Cupressaceae), were determined using Artemia salina L. (Artemiidae), with the objective of relating the results to the LD50 values reported in mice (tested at three concentrations: 10, 100, and 1000 microg/mL, for each extract). We found good correlation between the in vivo and the in vitro tests (r = 0.85 p < 0.05), and this method is a useful tool for predicting oral acute toxicity in plant extracts. ISSN: 0944-7113
NLM Unique ID: 9438794
Country: Germany
Entry Date: 20011106
MeSH Date: 2001/11/07 10:00
Entrez Date: 2001/11/07 10:00
Citation Subset: IM
Publication Status: ppublish
Phytomedicine 2001 Sep;8(5):395-400.
PMID: 11695884 UI: 21552300 [PubMed - in process]
From PubMed


18

Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell.
Full author name: Lee, H Z.

Lee HZ. Br J Pharmacol. 2001 Nov;134(5):1093-103.

[Article in English]

School of Pharmacy, China Medical College, 91 Hsueh-Shih Road, Taichung, 404, Taiwan. hong@mail.cmc.edu.tw

1. This study demonstrated aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell lines CH27 (human lung squamous carcinoma cell) and H460 (human lung non-small cell carcinoma cell). Aloe-emodin- and emodin-induced apoptosis was characterized by nuclear morphological changes and DNA fragmentation. 2. During apoptosis, an increase in cytochrome c of cytosolic fraction and activation of caspase-3, identified by the cleavage of its proform, were observed. 3. To elucidate whether the expression of protein kinase C (PKC) isozymes are involved in aloe-emodin- and emodin-induced apoptosis, this study examined the changes of PKC isozymes by Western blotting techniques during aloe-emodin- and emodin-induced apoptosis. 4. The expression of PKC isozymes involved in aloe-emodin- and emodin-induced apoptosis of CH27 and H460 cells. In this study, aloe-emodin and emodin induced the changes of each of PKC isozymes in CH27 and H460 cells. 5. The decrease in the expression of PKC delta and epsilon may play a critical role in aloe-emodin- and emodin-induced apoptosis in CH27 and H460 cells. 6. The present study also demonstrated that PKC stimulation occurs at a site downstream of caspase-3 in the emodin-mediated apoptotic pathway.

MeSH Terms:

Substances:

ISSN: 0007-1188
NLM Unique ID: 7502536
Country: England
Entry Date: 20011029
Date Completed: 20011207
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/10/30 10:00
Citation Subset: IM
http://www.brjpharmacol.org/cgi/pmidlookup?view=full&pmid=11682458
Full text URL: http://www.brjpharmacol.org/cgi/content/full/134/5/1093
Publication Status: ppublish
Br J Pharmacol 2001 Nov;134(5):1093-103.
PMID: 11682458 UI: 21538487 [PubMed - indexed for MEDLINE]
From PubMed
19

Roman pharmacy and the eastern drug trade.
Full author name: Scarborough, J.

Scarborough J. Pharm Hist. 1982;24(4):135-43.

[Article in English] No Abstract Available.

Publication Types:

MeSH Terms:

ISSN: 0031-7047
NLM Unique ID: 0135654
Country: United States
Entry Date: 19830104
Date Completed: 19830104
MeSH Date: 2001/10/31 10:01
Date Revised: 20011128
Entrez Date: 2001/10/20 10:00
Citation Subset: Q, QO
Publication Status: ppublish
Pharm Hist 1982;24(4):135-43.
PMID: 11611072 UI: 96637406 [PubMed - indexed for MEDLINE]
From PubMed
20

[Not Available]
Not Available

Full author name: Rohrich, H.

Rohrich H. Veroff Int Ges Gesch Pharm. 1972;38:221-9.

[Article in German] No Abstract Available.

Publication Types:

MeSH Terms:

ISSN: 0074-9729
NLM Unique ID: 7506152
Country: Germany
Vernacular Title: Zur Geschichte der "amerikanischen Aloe", Agave americana L.
Entry Date: 19760723
Date Completed: 19760723
MeSH Date: 2001/10/31 10:01
Date Revised: 20011128
Entrez Date: 2001/10/20 10:00
Citation Subset: Q, QO
Publication Status: ppublish
Veroff Int Ges Gesch Pharm 1972;38:221-9.
PMID: 11609491 UI: 96633202 [PubMed - indexed for MEDLINE]
From PubMed
21

Aloe exudate: characterization by reversed phase HPLC and headspace GC-MS.
Full author name: Saccu, D; Bogoni, P; Procida, G.

Saccu D, Bogoni P, Procida G. J Agric Food Chem. 2001 Oct;49(10):4526-30.

[Article in English]

Dipartimento di Economia e Merceologia delle Risorse Naturali e della Produzione, Via A. Valerio 6, I-34127 Trieste, Italy.

From the leaves of aloe, a succulent plant, a dried exudate commonly called aloe can be obtained, which is used as a natural drug for its cathartic effect and is widely employed as a bittering agent in alcoholic beverages. This investigation provides a tentative characterization of several commercial aloe exudates carried out both by reversed phase HPLC and by headspace GC-MS analysis. By means of HPLC the derivatives were evaluated, and by GC-MS the volatile fraction was investigated. Qualitative and quantitative differences among the constituents in various samples of different origins were found. In particular, these were evident in the HPLC profile of Kenya aloe and an Aloe barbadensis sample, which exuded a high content of isoaloeresin D and aloins, whereas GC-MS analysis showed the presence of anisole exclusively in Kenya aloe samples. Moreover, the results obtained by means of the latter technique suggested a reason for the prevailing use of Mosselbay and Port Elizabeth aloes in bitter spirits formulation.

MeSH Terms:

Substances:

ISSN: 0021-8561
NLM Unique ID: 0374755
Country: United States
Entry Date: 20011015
Date Completed: 20011205
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/10/16 10:00
Citation Subset: IM
http://dx.doi.org/10.1021/jf010179c
Publication Status: ppublish
J Agric Food Chem 2001 Oct;49(10):4526-30.
PMID: 11599983 UI: 21486305 [PubMed - indexed for MEDLINE]
From PubMed
22

[Studies on the voltammetric behaviour of barbaloin and its application]
Full author name: Li, Q L; Ren, L; Hu, J B; Feng, R Q.

Li QL, Ren L, Hu JB, Feng RQ. Yao Xue Xue Bao. 1997 Sep;32(9):691-4.

[Article in Chinese]

Department of Chemistry, Beijing Normal University, Beijing 100875.

In 0.1 mol.L-1 H2SO4 solution, a well-defined reduction wave of barbaloin was obtained by single-sweep osciflopolarography. The peak potential was shown to be -0.75 V (vs SCE). The peak current is proportional to the concentration of barbaloin over the range of 2.0 x 10(-7)-6.0 x 10(-6) mol.L-1. The detection limit is 2.0 x 10(-7) mol.L-1. The voltammetric behaviour of the system was studied by linear sweep and cyclic voltammetry. The adsorption coefficient beta was 1.91 x 10(5). The interaction factor alpha was 1.12. The system is a reversible adsorption wave.

MeSH Terms:

Substances:

ISSN: 0513-4870
NLM Unique ID: 21710340R
Country: China
Entry Date: 20011012
Date Completed: 20011231
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/10/13 10:00
Citation Subset: IM
Publication Status: ppublish
Yao Xue Xue Bao 1997 Sep;32(9):691-4.
PMID: 11596295 UI: 21480806 [PubMed - indexed for MEDLINE]
From PubMed
23

Study of silicone vehicles for Aloe vera.
Full author name: Gallardo, V; Montoya, R; Ruiz, M A.

Gallardo V, Montoya R, Ruiz MA. J Cosmet Sci. 2001 Sep-Oct;52(5):255-63.

[Article in English]

Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Granada, E-18071 Granada, Spain.

The effect of different surfactants on the synthesis of a silicone latex is studied. Distinct formulations were mixed and then tested with regard to stability as a function of time and temperature. The ones with the best characteristics for acting as a vehicle for the active cosmetic ingredient Aloe vera are indicated.

MeSH Terms:

Substances:

ISSN: 1525-7886
NLM Unique ID: 9814276
Country: United States
Entry Date: 20010921
Date Completed: 20011204
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/09/22 10:00
Citation Subset: IM
Publication Status: ppublish
J Cosmet Sci 2001 Sep-Oct;52(5):255-63.
PMID: 11567207 UI: 21450894 [PubMed - indexed for MEDLINE]
From PubMed
24

Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats.
Full author name: Maity, T K; Mandal, S C; Bhakta, T; Pal, M; Saha, B P.

Maity TK, Mandal SC, Bhakta T, Pal M, Saha BP. Phytother Res. 2001 Aug;15(5):459-60.

[Article in English]

College of Pharmaceutical Sciences, Mohuda, Berhampur, Ganjam, 760 002, Orissa, India.

Cassia tora is a well known plant of India. Aloe-emodin was isolated from the leaves of this plant and its metabolism pattern was studied. The results showed that about 15.4% of the administered aloe-emodin was excreted and the rest was probably bound or metabolized in the system. Copyright 2001 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20010816
Date Completed: 20011025
MeSH Date: 2001/10/26 10:01
Date Revised: 20011128
Entrez Date: 2001/08/17 10:00
Citation Subset: IM
Publication Status: ppublish
Phytother Res 2001 Aug;15(5):459-60.
PMID: 11507746 UI: 21398938 [PubMed - indexed for MEDLINE]
From PubMed
25

[Investigation on electrochemical behavior of emodin and its application]
Full author name: Zou, H; Yuan, Z B.

Zou H, Yuan ZB. Yao Xue Xue Bao. 1997 Apr;32(4):310-3.

[Article in Chinese]

Graduate School, USTC, Academia Sinica, Beijing 100039.

Emodin showed a second-order derivative reduction wave with peak potential of -0.75 V (SCE) by single sweep oscillopolarography using H3BO3-Na2B4O7 (pH 8.50) as base solution. The peak height of emodin is proportional to the concentration in the range of 1.42 x 10(-7)-5.7 x 10(-6) mol.L-1 and 7.1 x 10(-6)-7.1 x 10(-5) mol.L-1, respectively. The detection limit is 0.7 x 10(-7) mol.L-1. It can be employed for the determination of emodin in Rheum officinale Baill with satisfaction. The electrochemical behavior of emodin was studied and the electrode reaction mechanism was proposed. In addition, it was found that emodin, aloe-emodin, chrysophanol, rhein and physcion can scavenge superoxide anion radical produced by the autoxidation of pyrogallol. The scavenging activity is in the order: emodin > aloe-emodin > chrysophanol > rhein > physcion.

MeSH Terms:

Substances:

ISSN: 0513-4870
NLM Unique ID: 21710340R
Country: China
Entry Date: 20010813
Date Completed: 20011101
MeSH Date: 2001/11/03 10:01
Date Revised: 20011128
Entrez Date: 2001/08/14 10:00
Citation Subset: IM
Publication Status: ppublish
Yao Xue Xue Bao 1997 Apr;32(4):310-3.
PMID: 11499036 UI: 21391066 [PubMed - indexed for MEDLINE]
From PubMed
26

Adverse and beneficial effects of plant extracts on skin and skin disorders.
Full author name: Mantle, D; Gok, M A; Lennard, T W.

Mantle D, Gok MA, Lennard TW. Adverse Drug React Toxicol Rev. 2001 Jun;20(2):89-103.

[Article in English]

Department of Surgery, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE1 7RU.

Plants are of relevance to dermatology for both their adverse and beneficial effects on skin and skin disorders respectively. Virtually all cultures worldwide have relied historically, or continue to rely on medicinal plants for primary health care. Approximately one-third of all traditional medicines are for treatment of wounds or skin disorders, compared to only 1-3% of modern drugs. The use of such medicinal plant extracts for the treatment of skin disorders arguably has been based largely on historical/anecdotal evidence, since there has been relatively little data available in the scientific literature, particularly with regard to the efficacy of plant extracts in controlled clinical trials. In this article therefore, adverse and beneficial aspects of medicinal plants relating to skin and skin disorders have been reviewed, based on recently available information from the peer-reviewed scientific literature. Beneficial aspects of medicinal plants on skin include: healing of wounds and burn injuries (especially Aloe vera); antifungal, antiviral, antibacterial and acaricidal activity against skin infections such as acne, herpes and scabies (especially tea tree (Melaleuca alternifolia) oil); activity against inflammatory/immune disorders affecting skin (e.g. psoriasis); and anti-tumour promoting activity against skin cancer (identified using chemically-induced two-stage carcinogenesis in mice). Adverse effects of plants on skin reviewed include: irritant contact dermatitis caused mechanically (spines, irritant hairs) or by irritant chemicals in plant sap (especially members of the Ranunculaceae, Euphorbiaceae and Compositae plant families); phytophotodermatitis resulting from skin contamination by plants containing furocoumarins, and subsequent exposure to UV light (notably members of the Umbelliferae and Rutaceae plant families); and immediate (type I) or delayed hypersensitivity contact reactions mediated by the immune system in individuals sensitized to plants or plant products (e.g. peanut allergy, poison ivy (Toxicodendron) poisoning).

Publication Types:

MeSH Terms:

Substances:

Number of References: 68
ISSN: 0964-198X
NLM Unique ID: 9109474
Country: England
Entry Date: 20010802
Date Completed: 20020122
MeSH Date: 2002/01/23 10:01
Entrez Date: 2001/08/03 10:00
Citation Subset: IM
Publication Status: ppublish
Adverse Drug React Toxicol Rev 2001 Jun;20(2):89-103.
PMID: 11482001 UI: 21375334 [PubMed - indexed for MEDLINE]
From PubMed
27

[Effect of aloe-emodin on proliferation of vascular smooth muscle cells after arterial injury]
Full author name: Yin, C; Xu, C.

Yin C, Xu C. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1998 Jul;18(7):420-2.

[Article in Chinese]

People's Hospital, Beijing Medical University, Beijing 100044.

OBJECTIVE: To study the effect of Aloe-emodin (AE), an active ingredient of Rhubarb, on the kinetics of proliferation of smooth muscular cells (SMCs) cultured in vitro after rabbit iliac arterial injury. METHODS: Forty-eight hours after de-endothelialization (balloon endothelial denudation), the iliac arteries of the Japanese white rabbits were isolated and the smooth muscle cells were cultured primarily. AE was added to culture medium containing 10% fetal calf serum (FCS). The cultures were pulse-labeled with 3H-TdR and TdR uptake into VSMC were measured and the cell cycle of the cultures were analyzed by using flow cytometer. RESULTS: Compared with control, when the concentration gradient ranged from 10(-1) to 10(-5) g/L, the amount (cpm, count per minute) of 3H-TdR uptake into SMCs has significant differences (P < 0.05) and 10(-1) and 10(-2) g/L AE showed strong inhibitory effects on TdR uptake into VSMC and the percentage of inhibition [% inhibition = (cpm without AE - cpm with AE)/cpm without AE x 100%] was more than 90%. AE displayed concentration dependent inhibitory effects. The percentage of cells in G0/G1 phase was increased, but the percentage of cells in S phase was decreased in AE group, the transition of SMC cycle phase from G0 to S was blocked. CONCLUSIONS: AE is a strong inhibitor to the proliferation of SMCs and the pharmacological action of AE might reduce SMC proliferation in vivo and decrease intimal hyperplasia of restenosis.

MeSH Terms:

Substances:

ISSN: 1003-5370
NLM Unique ID: 9211576
Country: China
Entry Date: 20010731
Date Completed: 20011025
MeSH Date: 2001/10/26 10:01
Entrez Date: 2001/08/02 10:00
Citation Subset: IM
Publication Status: ppublish
Zhongguo Zhong Xi Yi Jie He Za Zhi 1998 Jul;18(7):420-2.
PMID: 11477819 UI: 21371120 [PubMed - indexed for MEDLINE]
From PubMed
28

Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells.
Full author name: Lee, J K; Lee, M K; Yun, Y P; Kim, Y; Kim, J S; Kim, Y S; Kim, K; Han, S S; Lee, C K.

Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, Kim K, Han SS, Lee CK. Int Immunopharmacol. 2001 Jul;1(7):1275-84.

[Article in English]

College of Pharmacy, Chungbuk National University, Cheongju 361-763, South Korea.

Acemannan, a major carbohydrate fraction of Aloe vera gel, has been known to have antiviral and antitumoral activities in vivo through activation of immune responses. The present study was set out to define the immunomodulatory activity of acemannan on dendritic cells (DCs), which are the most important accessory cells for the initiation of primary immune responses. Immature DCs were generated from mouse bone marrow (BM) cells by culturing in a medium supplemented with GM-CSF and IL-4, and then stimulated with acemannan, sulfated acemannan, and LPS, respectively. The resultant DCs were examined for phenotypic and functional properties. Phenotypic analysis for the expression of class II MHC molecules and major co-stimulatory molecules such as B7-1, B7-2, CD40 and CD54 confirmed that acemannan could induce maturation of immature DCs. Functional maturation of immature DCs was supported by increased allogeneic mixed lymphocyte reaction (MLR) and IL-12 production. The differentiation-inducing activity of acemannan was almost completely abolished by chemical sulfation. Based on these results, we propose that the adjuvant activity of acemannan is at least in part due to its capacity to promote differentiation of immature DCs.

MeSH Terms:

Substances:

ISSN: 1567-5769
NLM Unique ID: 100965259
Country: Netherlands
Entry Date: 20010719
Date Completed: 20011212
MeSH Date: 2002/01/05 10:01
Entrez Date: 2001/07/20 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S1567576901000522
Publication Status: ppublish
Int Immunopharmacol 2001 Jul;1(7):1275-84.
PMID: 11460308 UI: 21353362 [PubMed - indexed for MEDLINE]
From PubMed
29

Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity.
Full author name: Matsuda, H; Shimoda, H; Morikawa, T; Yoshikawa, M.

Matsuda H, Shimoda H, Morikawa T, Yoshikawa M. Bioorg Med Chem Lett. 2001 Jul 23;11(14):1839-42.

[Article in English]

Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, 607-8412, Kyoto, Japan.

The methanolic extract from the roots of Polygonum (P.) cuspidatum was found to enhance cell proliferation at 30 or 100 microg/mL in MCF-7, an estrogen-sensitive cell line. By bioassay-guided separation from P. cuspidatum with the most potent activity, emodin and emodin 8-O-beta-D-glucopyranoside were isolated as active principles. The methanolic extracts from Polygonum, Cassia, Aloe, and Rheum species, which were known to contain anthraquinones, also showed the MCF-7 proliferation. As a result of the evaluation of various anthraquinones from plant sources and synthetic anthraquinones, aloe-emodin, chrysophanol, chrysophanol 8-O-beta-D-glucopyranoside, and 1,8-dihydroxyanthraquinone showed weak activity. On the other hand, alizalin and 2,6-dihydroxyanthraquinone as well as emodin having the 2- and/or 6-hydroxyl groups showed potent activity. These results show that the unchelated hydroxyl group is essential for strong activity. Emodin and 2,6-dihydroxyanthraquinone also inhibited 17beta-estradiol binding to human estrogen receptors (ERs) with K(i) values of 0.77 and 0.31microM for ERalpha and 1.5 and 0.69 microM for ERbeta. These findings indicate that hydroxyanthraquinones such as emodin are phytoestrogens with an affinity to human estrogen receptors.

MeSH Terms:

Substances:

ISSN: 0960-894X
NLM Unique ID: 9107377
Country: England
Entry Date: 20010718
Date Completed: 20010927
MeSH Date: 2001/09/28 10:01
Entrez Date: 2001/07/19 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0960894X01003183
Publication Status: ppublish
Bioorg Med Chem Lett 2001 Jul 23;11(14):1839-42.
PMID: 11459643 UI: 21352581 [PubMed - indexed for MEDLINE]
From PubMed
30

Biodisposition of FITC-labeled aloemannan in mice.
Full author name: Yagi, A; Hamano, S; Tanaka, T; Kaneo, Y; Fujioka, T; Mihashi, K.

Yagi A, Hamano S, Tanaka T, Kaneo Y, Fujioka T, Mihashi K. Planta Med. 2001 Jun;67(4):297-300.

[Article in English]

Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Japan. yagi@fupharm.fukuyama-u.ac.jp

Biodisposition of FITC-labeled aloemannan (F-AM) with the homogenate from some organs in mice was demonstrated. F-AM was metabolized only by the mucosa from the large intestine into smaller molecules that were effectively absorbed in mice. The homogenate from the other tissues did not affect the metabolism of F-AM. The degraded product (1) of F-AM after incubation with 10% feces homogenate for 24 h was chromatographed on a highly porous polymer and a Sephadex LH-20 column to provide an FITC-degraded fraction (2), which was shown to have a molecular weight of 800 D on Sephadex G-25 gel permeation. Metabolite 2 was examined by physicochemical methods and shown to be a mixture of FITC-hexose and -2 hexose on FAB-MS. An FITC-degraded fraction (3) with a molecular weight of 3 KD was obtained by 6-h incubation with 10% feces homogenate on Sephadex G-25 column chromatography and was shown to be a mixture of FITC-9 and 12 x hexose on TOF-MS.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20010718
Date Completed: 20010809
MeSH Date: 2001/08/10 10:01
Date Revised: 20011128
Entrez Date: 2001/07/19 10:00
Citation Subset: IM
Publication Status: ppublish
Planta Med 2001 Jun;67(4):297-300.
PMID: 11458442 UI: 21352079 [PubMed - indexed for MEDLINE]
From PubMed
31

In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus.
Full author name: Semple, S J; Pyke, S M; Reynolds, G D; Flower, R L.

Semple SJ, Pyke SM, Reynolds GD, Flower RL. Antiviral Res. 2001 Mar;49(3):169-78.

[Article in English]

School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia. susan.semple@unisa.edu.au

Chrysophanic acid (1,8-dihydroxy-3-methylanthraquinone), isolated from the Australian Aboriginal medicinal plant Dianella longifolia, has been found to inhibit the replication of poliovirus types 2 and 3 (Picornaviridae) in vitro. The compound inhibited poliovirus-induced cytopathic effects in BGM (Buffalo green monkey) kidney cells at a 50% effective concentration of 0.21 and 0.02 microgram/ml for poliovirus types 2 and 3, respectively. The compound inhibited an early stage in the viral replication cycle, but did not have an irreversible virucidal effect on poliovirus particles. Chrysophanic acid did not have significant antiviral activity against five other viruses tested: Coxsackievirus types A21 and B4, human rhinovirus type 2 (Picornaviridae), and the enveloped viruses Ross River virus (Togaviridae) and herpes simplex virus type 1 (Herpesviridae). Four structurally-related anthraquinones--rhein, 1,8-dihydroxyanthraquinone, emodin and aloe-emodin were also tested for activity against poliovirus type 3. None of the four compounds was as active as chrysophanic acid against the virus. The results suggested that two hydrophobic positions on the chrysophanic acid molecule (C-6 and the methyl group attached to C-3) were important for the compound's activity against poliovirus.

MeSH Terms:

Substances:

ISSN: 0166-3542
NLM Unique ID: 8109699
Country: Netherlands
Entry Date: 20010628
Date Completed: 20010920
MeSH Date: 2001/09/21 10:01
Date Revised: 20011102
Entrez Date: 2001/06/29 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0166354201001255
Publication Status: ppublish
Antiviral Res 2001 Mar;49(3):169-78.
PMID: 11428243 UI: 21321889 [PubMed - indexed for MEDLINE]
From PubMed
32

Aposematic (warning) coloration associated with thorns in higher plants.
Full author name: Lev-Yadun, S.

Lev-Yadun S. J Theor Biol. 2001 Jun 7;210(3):385-8.

[Article in English]

Department of Biology, University of Haifa-Oranim, Tivon, 36006, Israel. levyadun@research.haifa.ac.il

Aposematic coloration, a well-known phenomenon in animals, has been given little attention in plants. Here I discuss two types of conspicuousness of thorns which are typical of many plant species: (1) colorful thorns, and (2) white spots, or white and colorful stripes, associated with thorns in leaves and stems. Both types of aposematic coloration predominate the spine system of taxa rich with spiny species-Cacti, the genera Agave, Aloe and Euphorbia. The phenomena have been recorded here in over a thousand species originating in several continents of both the Old and New World. I propose that this is a case of vegetal aposematic coloration analogous to such coloration of poisonous animals, and which communicates between plants and herbivores. Copyright 2001 Academic Press.

MeSH Terms:

ISSN: 0022-5193
NLM Unique ID: 0376342
Country: England
Entry Date: 20010608
Date Completed: 20010719
MeSH Date: 2001/07/20 10:01
Date Revised: 20011119
Entrez Date: 2001/06/09 10:00
Citation Subset: IM
http://www.idealibrary.com/links/citation/0022-5193/210/385
Publication Status: ppublish
J Theor Biol 2001 Jun 7;210(3):385-8.
PMID: 11397139 UI: 21291285 [PubMed - indexed for MEDLINE]
From PubMed
33

Herbal therapy: what every facial plastic surgeon must know.
Full author name: Pribitkin, E D; Boger, G.

Pribitkin ED, Boger G. Arch Facial Plast Surg. 2001 Apr-Jun;3(2):127-32.

[Article in English]

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, 925 Chestnut St, Sixth Floor, Philadelphia, PA 19107, USA. Edmund.Pribitkin@mail.tju.edu

Herbal medicine (phytomedicine) uses remedies possessing significant pharmacological activity and, consequently, potential adverse effects and drug interactions. The explosion in sales of herbal therapies has brought many products to the marketplace that do not conform to the standards of safety and efficacy that physicians and patients expect. Unfortunately, few surgeons question patients regarding their use of herbal medicines, and 70% of patients do not reveal their use of herbal medicines to their physicians and pharmacists. All surgeons should question patients about the use of the following common herbal remedies, which may increase the risk of bleeding during surgical procedures: feverfew, garlic, ginger, ginkgo, and Asian ginseng. Physicians should exercise caution in prescribing retinoids or advising skin resurfacing in patients using St John's wort, which poses a risk of photosensitivity reaction. Several herbal medicines, such as aloe vera gel, contain pharmacologically active ingredients that may aid in wound healing. Practitioners who wish to recommend herbal medicines to patients should counsel them that products labeled as supplements have not been evaluated by the US Food and Drug Administration and that no guarantee of product quality can be made.

Publication Types:

MeSH Terms:

Substances:

Number of References: 76
ISSN: 1521-2491
NLM Unique ID: 100883500
Country: United States
Entry Date: 20010522
Date Completed: 20010726
MeSH Date: 2001/07/28 10:01
Date Revised: 20011102
Entrez Date: 2001/05/23 10:00
Citation Subset: IM
http://archfaci.ama-assn.org/issues/v3n2/ffull/qoa00036.html
http://archfaci.ama-assn.org/issues/v3n2/abs/qoa00036.html
Publication Status: ppublish
Arch Facial Plast Surg 2001 Apr-Jun;3(2):127-32.
PMID: 11368667 UI: 21261387 [PubMed - indexed for MEDLINE]
From PubMed
34

Buyer beware.

[No authors listed]. Crit Path AIDS Proj. 1998 Fall;(No 33):33.

[Article in English]

Publication Types:

MeSH Terms:

ISSN: 1085-7605
NLM Unique ID: 9886098
Country: United States
Entry Date: 20000407
Date Completed: 20000407
MeSH Date: 2001/05/22 10:01
Date Revised: 20011128
Entrez Date: 2001/05/22 10:00
Citation Subset: X
Publication Status: ppublish
Crit Path AIDS Proj 1998 Fall;(No 33):33.
PMID: 11366370 UI: 20700234 [PubMed - indexed for MEDLINE]
From PubMed
35

The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy.
Full author name: Olsen, D L; Raub, W Jr; Bradley, C; Johnson, M; Macias, J L; Love, V; Markoe, A.

Olsen DL, Raub W Jr, Bradley C, Johnson M, Macias JL, Love V, Markoe A. Oncol Nurs Forum. 2001 Apr;28(3):543-7.

[Article in English]

Sylvester Comprehensive Cancer Center, University of Miami, USA.

PURPOSE/OBJECTIVES: To determine whether the use of mild soap and aloe vera gel versus mild soap alone would decrease the incidence of skin reactions in patients undergoing radiation therapy. DATA SOURCES: Prospective, randomized, blinded clinical trial. SETTING: Radiation therapy outpatient clinic in a cancer center affiliated with a major teaching medical facility. SAMPLE: The mean age of the participants was 56 years. The group consisted of Caucasians (74%) and African Americans (26%). The ethnic mix was non-Hispanic (65%) and Hispanic (35%). METHODS: Prophylactic skin care began on the first day of radiation therapy. Patients cleansed the area with mild, unscented soap. Patients randomized into the experimental arm of the trial were instructed to liberally apply aloe vera gel to the area at various intervals throughout the day. FINDINGS: At low cumulative dose levels < or = 2,700 cGy, no difference existed in the effect of adding aloe. When the cumulative dose was high (> 2,700 cGy), the median time was five weeks prior to any skin changes in the aloe/soap arm versus three weeks in the soap only arm. When the cumulative dose increases over time, there seems to be a protective effect of adding aloe to the soap regimen. IMPLICATIONS FOR NURSING PRACTICE: Skin products used to treat radiation dermatitis vary among institutions. Nurses should be aware that some patients may be predisposed to skin problems. Nurses must be aware of newly developed products and research regarding these products so that effective treatment can be instituted.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0190-535X
NLM Unique ID: 7809033
Country: United States
Entry Date: 20010507
Date Completed: 20010913
MeSH Date: 2001/09/14 10:01
Date Revised: 20011128
Entrez Date: 2001/05/08 10:00
Citation Subset: IM, N
Publication Status: ppublish
Oncol Nurs Forum 2001 Apr;28(3):543-7.
PMID: 11338761 UI: 21237435 [PubMed - indexed for MEDLINE]
From PubMed
36

A chemotaxonomic and morphological appraisal of Aloe series Purpurascentes, Aloe section Anguialoe and their hybrid, Aloe broomii.

Viljoen AM, van Wyk B. Biochem Syst Ecol. 2001 Jun;29(6):621-631.

[Article in English]

Department of Botany, Rand Afrikaans University, PO Box 524, 2006, Auckland Park, South Africa

Evidence is presented to suggest the hybrid origin of Aloe broomii, with the one putative parent belonging to Aloe series Purpurascentes and the other a member of Aloe series Anguialoe. A chemotaxonomic and morphological assessment is presented for both infrageneric groups and their hypothesised hybrid. Four of the species belonging to the series Purpurascentes display a characteristic leaf exudate profile containing the chemotaxonomic marker microstigmin. Aloe gariepensis and A. succotrina lack the diagnostic leaf exudate compounds. The distinct morphological apomorphies for Aloe section Anguialoe are supported on the chemical level reinforcing the monophyly of this group. ISSN: 0305-1978
Entry Date: 20010504
MeSH Date: 2001/05/05 10:00
Entrez Date: 2001/05/05 10:00
http://linkinghub.elsevier.com/retrieve/pii/S0305197800000958
Publication Status: ppublish
Biochem Syst Ecol 2001 Jun;29(6):621-631.
PMID: 11336811 UI: 0 [PubMed - as supplied by publisher]
From PubMed


37

The M and M's of aloe vera--is it for dentistry?
Full author name: Moore, T E.

Moore TE. J Okla Dent Assoc. 2001 Winter;91(3):30-1, 36.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0164-9442
NLM Unique ID: 7905263
Country: United States
Entry Date: 20010420
Date Completed: 20010607
MeSH Date: 2001/06/08 10:01
Date Revised: 20011128
Entrez Date: 2001/04/21 10:00
Citation Subset: D
Publication Status: ppublish
J Okla Dent Assoc 2001 Winter;91(3):30-1, 36.
PMID: 11314178 UI: 21210307 [PubMed - indexed for MEDLINE]
From PubMed
38

Isolation and identification of a phenolic antioxidant from Aloe barbadensis.
Full author name: Lee, K Y; Weintraub, S T; Yu, B P.

Lee KY, Weintraub ST, Yu BP. Free Radic Biol Med. 2000 Jan 15;28(2):261-5.

[Article in English]

Department of Food and Nutrition, Ho Seo University, Asan, Chungmam, Korea.

A potent antioxidative compound has been isolated from a methanolic extract of Aloe barbadensis Miller using a combination of column and thin-layer chromatography. The antioxidant activity of this substance was similar to that of alpha-tocopherol as assessed in vitro using rat brain homogenates. On the basis of electrospray ionization and electron-impact ionization mass spectra in combination with reversed-phase, high-performance liquid chromatographic behavior, this compound has been identified as 8-C-beta-D-[2-O-(E)-coumaroyl]glucopyranosyl-2-[2-hydroxy]-propyl-7-methox y-5-methylchromone.

MeSH Terms:

Substances:

ISSN: 0891-5849
NLM Unique ID: 8709159
Country: United States
Entry Date: 20010402
Date Completed: 20010628
MeSH Date: 2001/06/29 10:01
Date Revised: 20011128
Entrez Date: 2001/04/03 10:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S089158499900235X
Publication Status: ppublish
Free Radic Biol Med 2000 Jan 15;28(2):261-5.
PMID: 11281293 UI: 21176873 [PubMed - indexed for MEDLINE]
From PubMed
39

Herbal and alternative medicine use during pregnancy: a cross-sectional survey.

Gibson PS, Powrie R, Star J. Obstet Gynecol. 2001 Apr;97(4 Suppl 1):S44-S45.

[Article in English]

Women & Infants' Hospital of Rhode Island, Providence, RI, USA

Background: The use of herbal and alternative medical therapies has been increasing rapidly across the United States over the past 10 years. Women of reproductive age often are users of herbs. The use of herbal and alternative medical therapies among pregnant women is important but poorly studied to date.Objective: To determine the frequency of use of herbal and alternative medicine by women during pregnancy.Methods: Two hundred fifty pregnant women attending antepartum visits were prospectively enrolled in a cross-sectional survey about use of herbal and alternative medical therapies.Results: Two hundred forty-two women completed surveys (97%). Of the respondents, 9.1% reported use of herbal supplements during the current pregnancy, 7.5% using these agents at least weekly. The most commonly used herbs during pregnancy were garlic, aloe, chamomile, peppermint, ginger, echinacea, pumpkin seeds, and ginseng. Herb use during pregnancy was strongly associated with prior use of herbal supplements (25.6% versus 1.2%, P <0.001). There were trends toward greater use among white women (11.4% versus 6.1% in other racial groups) and in women with at least college-level education (10.1% versus 7.6% for high school or less). No association was found between herb use during pregnancy and age or income level. Alternative medical therapies were used by 13.3% of pregnant women. The therapies included aromatherapy, meditation/relaxation, chiropractic, yoga, acupressure, therapeutic touch, homeopathy, acupuncture, and reflexotherapy.Conclusion: Herbal and alternative medicine use is common among pregnant women. Pregnant women should be asked about their use of these therapies. Further research is needed to clarify the safety and effectiveness of these therapies during pregnancy. ISSN: 0029-7844
Journal Title Code: OC2
Entry Date: 20010328
MeSH Date: 2001/03/29 10:00
Entrez Date: 2001/03/29 10:00
http://linkinghub.elsevier.com/retrieve/pii/S0029784401012509
Publication Status: ppublish
Obstet Gynecol 2001 Apr;97(4 Suppl 1):S44-S45.
PMID: 11275149 UI: 0 [PubMed - as supplied by publisher]
From PubMed


40

Effect of Aloe vera leaves on blood glucose level in type I and type II diabetic rat models.
Full author name: Okyar, A; Can, A; Akev, N; Baktir, G; Sutlupinar, N.

Okyar A, Can A, Akev N, Baktir G, Sutlupinar N. Phytother Res. 2001 Mar;15(2):157-61.

[Article in English]

Department of Pharmacology, Faculty of Pharmacy, University of Istanbul, 34452 Universite, Istanbul, Turkey.

Aloe vera (L.) Burm. fil. (= A. barbadensis Miller) (Liliaceae) is native to North Africa and also cultivated in Turkey. Aloes have long been used all over the world for their various medicinal properties. In the past 15 years, there have been controversial reports on the hypoglycaemic activity of Aloe species, probably due to differences in the parts of the plant used or to the model of diabetes chosen. In this study, separate experiments on three main groups of rats, namely, non-diabetic (ND), type I (IDDM) and type II (NIDDM) diabetic rats were carried out. A. vera leaf pulp and gel extracts were ineffective on lowering the blood sugar level of ND rats. A. vera leaf pulp extract showed hypoglycaemic activity on IDDM and NIDDM rats, the effectiveness being enhanced for type II diabetes in comparison with glibenclamide. On the contrary, A. vera leaf gel extract showed hyperglycaemic activity on NIDDM rats. It may therefore be concluded that the pulps of Aloe vera leaves devoid of the gel could be useful in the treatment of non-insulin dependent diabetes mellitus Copyright 2001 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20010327
Date Completed: 20010719
MeSH Date: 2001/07/20 10:01
Date Revised: 20011128
Entrez Date: 2001/03/27 10:00
Citation Subset: IM
Publication Status: ppublish
Phytother Res 2001 Mar;15(2):157-61.
PMID: 11268118 UI: 21169319 [PubMed - indexed for MEDLINE]
From PubMed
41

Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity.
Full author name: Pugh, N; Ross, S A; ElSohly, M A; Pasco, D S.

Pugh N, Ross SA, ElSohly MA, Pasco DS. J Agric Food Chem. 2001 Feb;49(2):1030-4.

[Article in English]

Department of Pharmacognosy, National Center for Natural Products Research, University of Mississippi, University, Mississippi 38677, USA.

We have characterized a new immunostimulatory polysaccharide called Aloeride from commercial aloe vera (Aloe barbadensis) juice. Aloeride is between 4 and 7 million Da, and its glycosyl components include glucose (37.2%), galactose (23.9%), mannose (19.5%), and arabinose (10.3%). At 0.5 microg/mL Aloeride increased NF-kappa B directed luciferase expression in THP-1 human monocytic cells to levels 50% of those achieved by maximal concentrations (10 microg/mL) of LPS. Aloeride induced the expression of the mRNAs encoding IL-1beta and TNF-alpha to levels equal to those observed in cells maximally activated by LPS. Acemannan, the major carbohydrate component from aloe, used at 200 microg/mL in the macrophage assay resulted in negligible NF-kappa B activation. Analysis of acemannan and Aloeride using size-exclusion chromatography suggests that the low activity of acemannan is due to trace amounts of Aloeride. Although Aloeride comprises only 0.015% of the aloe juice dry weight, its potency for macrophage activation accounts fully for the activity of the crude juice.

MeSH Terms:

Substances:

ISSN: 0021-8561
NLM Unique ID: 0374755
Country: United States
Entry Date: 20010323
Date Completed: 20010524
MeSH Date: 2001/05/26 10:01
Date Revised: 20011128
Entrez Date: 2001/03/23 10:00
Citation Subset: IM
http://dx.doi.org/10.1021/jf001036d
Publication Status: ppublish
J Agric Food Chem 2001 Feb;49(2):1030-4.
PMID: 11262067 UI: 21162849 [PubMed - indexed for MEDLINE]
From PubMed
42

Determination of aloenin, barbaloin and isobarbaloin in aloe species by micellar electrokinetic chromatography.
Full author name: Kuzuya, H; Tamai, I; Beppu, H; Shimpo, K; Chihara, T.

Kuzuya H, Tamai I, Beppu H, Shimpo K, Chihara T. J Chromatogr B Biomed Sci Appl. 2001 Mar 5;752(1):91-7.

[Article in English]

Fujita Memorial Institute of Pharmacognosy, Fujita Health University, Hisai, Mie, Japan. hkuzu@fujita-hu.ac.jp

Aloenin, barbaloin and isobarbaloin in JP Aloe, Aloe barbadensis (Aloe vera) and Aloe arborescens Miller var. natalensis Berger (Aloe arborescens Miller) were determined by micellar electrokinetic chromatography (MEKC) with 50 mM sodium dodecyl sulfate. Aloenin, barbaloin and isobarbaloin were well separated by MEKC and as little as 5.5 pg/11 nl of the three compounds could be detected. The determination took around 14 min.

MeSH Terms:

Substances:

ISSN: 1387-2273
NLM Unique ID: 9714109
Country: Netherlands
Entry Date: 20010319
Date Completed: 20010607
MeSH Date: 2001/06/19 10:01
Date Revised: 20011128
Entrez Date: 2001/03/20 10:00
Citation Subset: IM
Publication Status: ppublish
J Chromatogr B Biomed Sci Appl 2001 Mar 5;752(1):91-7.
PMID: 11254203 UI: 21148851 [PubMed - indexed for MEDLINE]
From PubMed
43

[Peroxidase and soluble protein in the leaves of Aloe vera L. var. chinensis (Haw.)Berger]
Full author name: Gao, W; Xiao, P.

Gao W, Xiao P. Zhongguo Zhong Yao Za Zhi. 1997 Nov;22(11):653-4, 702.

[Article in Chinese]

Institute of Medicinal Plant, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094.

The peroxidase activity and soluble protein content in the leaves of Aloe vera var. chinensis were assayed by spectrophotometric method. The results show that the peroxidase activity in the upper most and lower parts of leaves is comparatively high. Soluble protein content decreases from top to bottom leaves. The results of electrophoresis of soluble protein show that the patterns of upper leaves have more and darker bands than those of lower leaves.

MeSH Terms:

Substances:

ISSN: 1001-5302
NLM Unique ID: 8913656
Country: China
Entry Date: 20010312
Date Completed: 20010510
MeSH Date: 2001/05/22 10:01
Entrez Date: 2001/03/13 10:00
Citation Subset: IM
Publication Status: ppublish
Zhongguo Zhong Yao Za Zhi 1997 Nov;22(11):653-4, 702.
PMID: 11243179 UI: 21133784 [PubMed - indexed for MEDLINE]
From PubMed
44

Peroxidase activity in Aloe barbadensis commercial gel: probable role in skin protection.
Full author name: Esteban, A; Zapata, J M; Casano, L; Martin, M; Sabater, B.

Esteban A, Zapata JM, Casano L, Martin M, Sabater B. Planta Med. 2000 Dec;66(8):724-7.

[Article in English]

Departamento de Biologia Vegetal, Universidad de Alcala, Alcala de Henares, Madrid, Spain.

A basic peroxidase (EC 1.11.1.7) (pl around 9.0) has been identified in commercial gel of Aloe barbadensis. In vivo, the activity is localised in the vascular system of inner aqueous leaf parenchyma. Some relevant properties of this basic peroxidase of Aloe have been investigated in leaf extract and in commercial gel where it is notably stable. The acid optimum pH (5.0) for activity and the low KM for H2O2 (0.14 mM) suggest that, when topically applied, Aloe peroxidase may scavenge H2O2 in skin surface.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20010129
Date Completed: 20010419
MeSH Date: 2001/04/21 10:01
Date Revised: 20011128
Entrez Date: 2001/02/24 12:00
Citation Subset: IM
Publication Status: ppublish
Planta Med 2000 Dec;66(8):724-7.
PMID: 11199129 UI: 21070040 [PubMed - indexed for MEDLINE]
From PubMed
45

Chemomodulatory action of Aloe vera on the profiles of enzymes associated with carcinogen metabolism and antioxidant status regulation in mice.
Full author name: Singh, R P; Dhanalakshmi, S; Rao, A R.

Singh RP, Dhanalakshmi S, Rao AR. Phytomedicine. 2000 Jun;7(3):209-19.

[Article in English]

Cancer Biology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.

The effect of two doses (30 microl and 60 microl/day/mice daily for 14 days) of the fresh leaf pulp extract of Aloe vera was examined on carcinogen-metabolizing phase-I and phase-II enzymes, antioxidant enzymes, glutathione content, lactate dehydrogenase and lipid peroxidation in the liver of mice. The modulatory effect of the pulp extract was also examined on extrahepatic organs (lung, kidney and forestomach) for the activities of glutathione S-transferase, DT-diophorase, superoxide dismutase and catalase. The positive control mice were treated with butylated hydroxyanisole (BHA). Significant increases in the levels of acid soluble sulfhydryl (-SH) content, NADPH-cytochrome P450 reductase, NADH-cytochrome b5 reductase, glutathione S-transferase (GST), DT-diaphorase (DTD), superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX) and glutathione reductase (GR) were observed in the liver. Aloe vera significantly reduced the levels of cytochrome P450 and cytochrome b5. Thus, Aloe vera is clearly an inducer of phase-II enzyme system. Treatment with both doses of Aloe caused a decrease in malondialdehyde (MDA) formation and the activity of lactate dehydrogenase in the liver, suggesting its role in protection against prooxidant-induced membrane and cellular damage. The microsomal and cytosolic protein was significantly enhanced by Aloe vera, indicating the possibility of its involvement in the induction of protein synthesis. BHA, an antioxidant compound, provided the authenticity of our assay protocol and response of animals against modulator. The pulp extract was effective in inducing GST, DTD, SOD and catalase as measured in extrahepatic organs. Thus, besides liver, other organs (lung, kidney and forestomach) were also influenced favorably by Aloe vera in order to detoxify reactive metabolites, including chemical carcinogens and drugs.

MeSH Terms:

Substances:

ISSN: 0944-7113
NLM Unique ID: 9438794
Country: Germany
Entry Date: 20010117
Date Completed: 20010322
MeSH Date: 2001/03/27 10:01
Date Revised: 20011128
Entrez Date: 2001/02/24 12:00
Citation Subset: IM
Publication Status: ppublish
Phytomedicine 2000 Jun;7(3):209-19.
PMID: 11185732 UI: 21033379 [PubMed - indexed for MEDLINE]
From PubMed
46

Screening of Yemeni medicinal plants for antibacterial and cytotoxic activities.
Full author name: Ali, N A; Julich, W D; Kusnick, C; Lindequist, U.

Ali NA, Julich WD, Kusnick C, Lindequist U. J Ethnopharmacol. 2001 Feb;74(2):173-9.

[Article in English]

Pharmacognosy Department, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.

Ethanolic extracts of 20 selected plant species used by Yemeni traditional healers to treat infectious diseases were screened for their antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as for cytotoxic activity. Fourteen of the ethanolic extracts showed variable degrees of antibacterial activity. The active ethanolic extracts were partitioned between ethyl acetate and water for a first separation. The ethyl acetate extract of Lawsonia inermis was found to be the most active one against all bacteria in the test system. Other promising results could be obtained from extracts of Aloe perryi, Indigofera oblongifolia, Meriandra benghalensis and Ziziphus spina christi. Additionally, the ethanolic extracts of the 20 plants under investigation were tested for their cytotoxic effects on FL-cells using the neutral red assay. Extracts of Calotropis procera, Chenopodium murale, Pulicaria orientalis, Tribulus terrestris and Withania somniferum displayed a remarkable activity.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 20010222
Date Completed: 20010426
MeSH Date: 2001/05/01 10:01
Entrez Date: 2001/02/13 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874100003640
Publication Status: ppublish
J Ethnopharmacol 2001 Feb;74(2):173-9.
PMID: 11167035 UI: 21104868 [PubMed - indexed for MEDLINE]
From PubMed
47

Constituents of Aloe rubroviolacea.
Full author name: Blitzke, T; Masaoud, M; Schmidt, J.

Blitzke T, Masaoud M, Schmidt J. Fitoterapia. 2001 Jan;72(1):78-9.

[Article in English]

Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle/Saale, Germany.

The isolation of three C-glycosyl chromones, four anthraquinones and a mixture of phytosterols from the leaves of Aloe rubroviolacea was reported.

MeSH Terms:

Substances:

ISSN: 0367-326X
NLM Unique ID: 16930290R
Country: Netherlands
Entry Date: 20010222
Date Completed: 20010524
MeSH Date: 2001/05/26 10:01
Date Revised: 20011128
Entrez Date: 2001/02/13 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0367326X00002392
Publication Status: ppublish
Fitoterapia 2001 Jan;72(1):78-9.
PMID: 11163949 UI: 21113321 [PubMed - indexed for MEDLINE]
From PubMed
48

A chlorinated amide and piperidine alkaloids from Aloe sabaea.
Full author name: Blitzke, T; Porzel, A; Masaoud, M; Schmidt, J.

Blitzke T, Porzel A, Masaoud M, Schmidt J. Phytochemistry. 2000 Dec;55(8):979-82.

[Article in English]

Institute of Plant Biochemistry, Halle (Saale), Germany.

Phytochemical investigations of Aloe sabaea afforded a new chlorinated amide, N-4'-chlorobutylbutyramide, and the toxic piperidine alkaloids coniine, gamma-coniceine and the quarternary N,N-dimethylconiine. This is the first report of the occurrence of a chlorinated compound in the Aloeaceae family.

MeSH Terms:

Substances:

ISSN: 0031-9422
NLM Unique ID: 0151434
Country: United States
Entry Date: 20010103
Date Completed: 20010301
MeSH Date: 2001/03/07 10:01
Date Revised: 20011128
Entrez Date: 2001/01/05 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0031942200002697
Publication Status: ppublish
Phytochemistry 2000 Dec;55(8):979-82.
PMID: 11140536 UI: 21020808 [PubMed - indexed for MEDLINE]
From PubMed
49

Chromones and anthrones from Aloe marlothii and Aloe rupestris.
Full author name: Bisrat, D; Dagne, E; van Wyk, B E; Viljoen, A.

Bisrat D, Dagne E, van Wyk BE, Viljoen A. Phytochemistry. 2000 Dec;55(8):949-52.

[Article in English]

Department of Chemistry, Addis Ababa University, Ethiopia.

A phytochemical investigation of the leaf exudate of Aloe marlothii has resulted in the isolation of a new chromone (7-O-methylaloeresin A) and a new anthrone (5-hydroxyaloin A 6'-O-acetate). Furthermore 7-O-methylaloesin was isolated as a natural product for the first time from the leaf exudate of Aloe rupestris. The structure elucidation of these compounds was based on spectral data including 2D NMR. The chemotaxonomic value of 7-O-methylaloesin in Aloe series Asperifoliae and section Pachydendron is discussed.

MeSH Terms:

Substances:

ISSN: 0031-9422
NLM Unique ID: 0151434
Country: United States
Entry Date: 20010103
Date Completed: 20010301
MeSH Date: 2001/03/07 10:01
Date Revised: 20011128
Entrez Date: 2001/01/05 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0031942200003289
Publication Status: ppublish
Phytochemistry 2000 Dec;55(8):949-52.
PMID: 11140530 UI: 21020802 [PubMed - indexed for MEDLINE]
From PubMed
50

Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride.
Full author name: Arosio, B; Gagliano, N; Fusaro, L M; Parmeggiani, L; Tagliabue, J; Galetti, P; De Castri, D; Moscheni, C; Annoni, G.

Arosio B, Gagliano N, Fusaro LM, Parmeggiani L, Tagliabue J, Galetti P, De Castri D, Moscheni C, Annoni G. Pharmacol Toxicol. 2000 Nov;87(5):229-33.

[Article in English]

Department of Internal Medicine, Milano University Study and Hospital Maggiore IRCCS, Italy.

Aloe contains several active compounds including aloin, a C-glycoside that can be hydrolyzed in the gut to form aloe-emodin anthrone which, in turn, is auto-oxidized to the quinone aloe-emodin. On the basis of the claimed hepatoprotective activity of some antraquinones, we studied aloe-emodin in a rat model of carbon tetrachloride (CCl4) intoxication, since this xenobiotic induces acute liver damage by lipid peroxidation subsequent to free radical production. Twelve rats were treated with CCl4 (3 mg/kg) intraperitoneally and six were protected with two intraperitoneally injections of aloe-emodin (50 mg/kg; CCl4+aloe-emodin); six other rats were only aloe-emodin injected (aloe-emodin) and six were untreated (control). Histological examination of the livers showed less marked lesions in the CCl4+aloe-emodin rats than in those treated with CCl4 alone, and this was confirmed by the serum levels of L-aspartate-2-oxoglutate-aminotransferase (394+/-38.6 UI/l in CCl4, 280+/-24.47 UI/l in CCl4+aloe-emodin rats; P<0.05). We also quantified changes in hepatic albumin and tumour necrosis factor-alpha mRNAs. Albumin mRNA expression was significantly lower only in the liver of CCl4 rats (P<0.05 versus control) and was only slightly reduced in the CCl4+aloe-emodin rats. In contrast tumour necrosis factor-alpha mRNA was significantly higher (P<0.05) in the CCl4 than the control rats and almost equal in the CCl4+aloe-emodin, aloe-emodin and control groups. In conclusion, aloe-emodin appears to have some protective effect not only against hepatocyte death but also on the inflammatory response subsequent to lipid peroxidation.

MeSH Terms:

Substances:

ISSN: 0901-9928
NLM Unique ID: 8702180
Country: Denmark
Entry Date: 20001220
Date Completed: 20010215
MeSH Date: 2001/03/03 10:01
Date Revised: 20011102
Entrez Date: 2000/12/29 11:00
Citation Subset: IM
Publication Status: ppublish
Pharmacol Toxicol 2000 Nov;87(5):229-33.
PMID: 11129503 UI: 21011772 [PubMed - indexed for MEDLINE]
From PubMed
51

Randomized phase III study comparing Best Supportive Care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13.
Full author name: Fisher, J; Scott, C; Stevens, R; Marconi, B; Champion, L; Freedman, G M; Asrari, F; Pilepich, M V; Gagnon, J D; Wong, G.

Fisher J, Scott C, Stevens R, Marconi B, Champion L, Freedman GM, Asrari F, Pilepich MV, Gagnon JD, Wong G. Int J Radiat Oncol Biol Phys. 2000 Dec 1;48(5):1307-10.

[Article in English]

Radiation Oncology Center, Oakwood Hospital and Medical Center, Dearborn, MI 48123, USA. fisherj@oakwood.org

PURPOSE: To determine if Biafine compared to Best Supportive Care (BSC) is effective in minimizing or preventing radiation-induced dermatitis in women undergoing breast irradiation. METHODS AND MATERIALS: Patients were randomized between Biafine (n = 83) vs. BSC (n = 89). The institutions identified preference for BSC at the time of randomization. A no-treatment arm was allowed (16% received no treatment). Patients were instructed to apply randomized product three times a day, but not within 4 h of their daily RT session. Application began following their first radiation treatment and continued 2 weeks postradiation. Skin dermatitis was scored weekly utilizing the RTOG and ONS (Oncology Nursing Society) skin toxicity scales, a weekly patient satisfaction and quality-of-life questionnaire. RESULTS: Using the RTOG toxicity scale there was no overall difference for maximum dermatitis during RT between Biafine and BSC (p = 0.77). There was no difference in maximum toxicity by arm or breast size. There was an interaction between breast size and toxicity, with large-breasted women exhibiting more toxicity. Large-breasted women receiving Biafine were more likely to have no toxicity 6 weeks post RT. CONCLUSION: There was no overall difference between BSC and Biafine in the prevention, time to, or duration of radiation-induced dermatitis.

Publication Types:

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Substances:

Grant Support:

ISSN: 0360-3016
NLM Unique ID: 7603616
Country: United States
Entry Date: 20001227
Date Completed: 20010111
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/12/21 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0360301600007823
Publication Status: ppublish
Int J Radiat Oncol Biol Phys 2000 Dec 1;48(5):1307-10.
PMID: 11121627 UI: 20573287 [PubMed - indexed for MEDLINE]
From PubMed
52

The plant kingdom as a source of anti-ulcer remedies.
Full author name: Borrelli, F; Izzo, A A.

Borrelli F, Izzo AA. Phytother Res. 2000 Dec;14(8):581-91.

[Article in English]

Department of Experimental Pharmacology, University of Naples 'Federico II', via D. Montesano 49, 80131 Naples, Italy.

Phytogenic agents have traditionally been used by herbalists and indigenous healers for the prevention and treatment of peptic ulcer. This article reviews the anti-acid/anti-peptic, gastro-protective and/or anti-ulcer properties of the most commonly employed herbal medicines and their identified active constituents. Botanical compounds with anti-ulcer activity include flavonoids (i.e. quercetin, naringin, silymarin, anthocyanosides, sophoradin derivatives) saponins (i.e. from Panax japonicus and Kochia scoparia), tannins (i.e. from Linderae umbellatae), gums and mucilages (i.e. gum guar and myrrh). Among herbal drugs, liquorice, aloe gel and capsicum (chilli) have been used extensively and their clinical efficacy documented. Also, ethnomedical systems employ several plant extracts for the treatment of peptic ulcer. Despite progress in conventional chemistry and pharmacology in producing effective drugs, the plant kingdom might provide a useful source of new anti-ulcer compounds for development as pharmaceutical entities or, alternatively, as simple dietary adjuncts to existing therapies.

Publication Types:

MeSH Terms:

Substances:

Number of References: 140
ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20010103
Date Completed: 20010329
MeSH Date: 2001/04/03 10:01
Date Revised: 20011128
Entrez Date: 2000/12/13 11:00
Citation Subset: IM
Publication Status: ppublish
Phytother Res 2000 Dec;14(8):581-91.
PMID: 11113992 UI: 20566068 [PubMed - indexed for MEDLINE]
From PubMed
53

Herbal medicines: current trends in anesthesiology practice--a hospital survey.
Full author name: Kaye, A D; Clarke, R C; Sabar, R; Vig, S; Dhawan, K P; Hofbauer, R; Kaye, A M.

Kaye AD, Clarke RC, Sabar R, Vig S, Dhawan KP, Hofbauer R, Kaye AM. J Clin Anesth. 2000 Sep;12(6):468-71.

[Article in English]

Department of Anesthesiology, Texas Tech University, Lubbock, TX 79430, USA.

STUDY OBJECTIVES: To develop a simple survey to determine the patient population actively utilizing dietary supplements and/or herbs, during the preoperative period. DESIGN: Prospective study, with survey instrument. SETTING: University medical center. PATIENTS: 1,017 patients presenting for preanesthetic evaluation prior to outpatient surgery. INTERVENTIONS: After undergoing preanesthetic evaluation, patients were asked to complete a survey listing which of the nine most popular nutraceuticals currently available on the market they were using. MEASUREMENTS AND MAIN RESULTS: A total of 1017 surveys were submitted over a period of five months, with 32% being poorly completed and thus discarded. Of the remaining 755 valid surveys, 482 patients used at least one nutraceutical agent. 90% of these patients were using vitamins, 43% garlic extracts, 32% Gingko Biloba, 30% St. John's Wort, 18% Ma Huang, 12% Ecchinaceae, 10% Aloe, 8% Cascare, 3% licorice. CONCLUSION: A significant population of patients scheduled for an elective surgical procedure are self-administering nutraceutical agents. Some of these agents have the potential to cause serious drug interactions and hemodynamic instability during surgery. Hence, it may be important to identify patients self-administering these medications, during the preoperative period.

MeSH Terms:

ISSN: 0952-8180
NLM Unique ID: 8812166
Country: United States
Entry Date: 20010103
Date Completed: 20010103
MeSH Date: 2001/02/28 10:01
Date Revised: 20011102
Entrez Date: 2000/11/25 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0952818000001951
Publication Status: ppublish
J Clin Anesth 2000 Sep;12(6):468-71.
PMID: 11090733 UI: 20544930 [PubMed - indexed for MEDLINE]
From PubMed
54

Ribosomal DNA evolution and phylogeny in Aloe (Asphodelaceae).

Adams SP, Leitch IJ, Bennett MD, Chase MW, Leitch AR. Am J Bot. 2000 Nov;87(11):1578-1583.

[Article in English]

School of Biological Sciences, Queen Mary and Westfield College, University of London, E1 4NS, UK. Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK.

All ALOE: taxa ( approximately 400 species) share a conserved bimodal karyotype with a basic genome of four large and three small submetacentric/acrocentric chromosomes. We investigated the physical organization of 18S-5.8S-26S and 5S ribosomal DNA (rDNA) using fluorescent in situ hybridization (FISH) to 13 ALOE: species. The organization was compared with a phylogenetic tree of 28 species (including the 13 used for FISH) constructed by sequence analysis of the internal transcribed spacer (ITS) of 18S-5.8S-26S rDNA. The phylogeny showed little divergence within ALOE:, although distinct, well-supported clades were found. FISH analysis of 5S rDNA distribution showed a similar interstitial location on a large chromosome in all species examined. In contrast, the distribution of 18S-5.8S-26S rDNA was variable, with differences in number, location, and size of loci found between species. Nevertheless, within well-supported clades, all species had the same organizational patterns. Thus, despite the striking stability of karyotype structure and location of 5S rDNA, the distribution of 18S-5.8S-26S rDNA is not so constrained and has clearly changed during ALOE: speciation. ISSN: 0002-9122
Journal Title Code: 3DF
Entry Date: 20001115
MeSH Date: 2000/11/18
Entrez Date: 2000/11/18
Citation Subset: IM
http://www.amjbot.org/cgi/pmidlookup?view=full&pmid=11080107
Full text URL: http://www.amjbot.org/cgi/content/full/87/11/1578
Publication Status: ppublish
Am J Bot 2000 Nov;87(11):1578-1583.
PMID: 11080107 UI: 0 [PubMed - as supplied by publisher]
From PubMed


55

Adverse effects of herbal drugs in dermatology.
Full author name: Ernst, E.

Ernst E. Br J Dermatol. 2000 Nov;143(5):923-9.

[Article in English]

Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter, 25 Victoria Park Road, Exeter EX2 4NT, UK. E.Ernst@ex.ac.uk

Herbal treatments are becoming increasingly popular, and are often used for dermatological conditions. Thus dermatologists should know about their potential to cause adverse events. This review is aimed at addressing this area in a semisystematic fashion. Some agents, particularly Chinese herbal creams, have been shown repeatedly to be adulterated with corticosteroids. Virtually all herbal remedies can cause allergic reactions and several can be responsible for photosensitization. Some herbal medicines, in particular Ayurvedic remedies, contain arsenic or mercury that can produce typical skin lesions. Other popular remedies that can cause dermatological side-effects include St John's Wort, kava, aloe vera, eucalyptus, camphor, henna and yohimbine. Finally, there are some herbal treatments used specifically for dermatological conditions, e.g. Chinese oral herbal remedies for atopic eczema, which have the potential to cause systemic adverse effects. It is concluded that adverse effects of herbal medicines are an important albeit neglected subject in dermatology, which deserves further systematic investigation.

Publication Types:

MeSH Terms:

Substances:

Number of References: 72
ISSN: 0007-0963
NLM Unique ID: 0004041
Country: England
Entry Date: 20001208
Date Completed: 20001208
MeSH Date: 2001/02/28 10:01
Date Revised: 20011102
Entrez Date: 2000/11/09 11:00
Citation Subset: IM
http://www.blackwell-synergy.com/rd.asp?abbrev=Br%20J%20Dermatol&vol=143&page=923&goto=abstract
Publication Status: ppublish
Br J Dermatol 2000 Nov;143(5):923-9.
PMID: 11069498 UI: 20521435 [PubMed - indexed for MEDLINE]
From PubMed
56

The occurrence and taxonomic distribution of the anthrones aloin, aloinoside and microdontin in Aloe.

Viljoen AM, Wyk BV, Newton LE. Biochem Syst Ecol. 2001 Jan 1;29(1):53-67.

[Article in English]

Department of Botany, Rand Afrikaans University, P.O. Box 524, 2006, Auckland Park, South Africa

A chemotaxonomic survey of 380 species of Aloe indicated the presence of the anthrone isomers aloin A and B together with the aloinoside isomers and microdontin A and B in 36 (10%) species of Aloe. This group, referred to as the microdontin chemotype, is thus characterised by a combination of exudate compounds and not merely a single phytochemical marker, implying taxonomic significance of leaf exudate compounds. The 36 representatives of the group occupy disparate taxonomic positions in the largely artificial hierarchy of the present classification system. Although many of the species have previously been considered as related (based on macromorphology only), a large number of species have not been associated with one another before. The chemical profiles and leaf exudate compositions of the species are presented, followed by a brief summary of the morphological diversity. Whilst conceding the possibility of convergent evolution, the geographical distribution of the species and thoughts on possible relationships between the taxa are discussed. ISSN: 0305-1978
Entry Date: 20001107
MeSH Date: 2000/11/09
Entrez Date: 2000/11/09
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0305197800000247
Publication Status: ppublish
Biochem Syst Ecol 2001 Jan 1;29(1):53-67.
PMID: 11068124 UI: 0 [PubMed - as supplied by publisher]
From PubMed


57

6'-O-Coumaroylaloesin from Aloe castanea--a taxonomic marker for Aloe section Anguialoe.
Full author name: van Heerden, F R; Viljoen, A M; van Wyk, B E.

van Heerden FR, Viljoen AM, van Wyk BE. Phytochemistry. 2000 Sep;55(2):117-20.

[Article in English]

Department of Chemistry and Biochemistry, Rand Afrikaans University, Auckland Park, South Africa. frvh@na.rau.ac.za

The structure of 6'-O-coumaroylaloesin [2-acetonyl-8-(6-O-coumaroyl-beta-D-glucopyranosyl)-7-hydrox y-5-methylchromone], a mono-ester chromone derivative in which only the 6-position of the glucosyl moiety is esterified, was determined by spectroscopic methods. The compound is a unique chemotaxonomic character restricted to the six species in Aloe section Anguialoe.

MeSH Terms:

Substances:

ISSN: 0031-9422
NLM Unique ID: 0151434
Country: United States
Entry Date: 20010220
Date Completed: 20010222
MeSH Date: 2001/03/03 10:01
Date Revised: 20011128
Entrez Date: 2000/11/07 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0031942200002521
Publication Status: ppublish
Phytochemistry 2000 Sep;55(2):117-20.
PMID: 11065286 UI: 20517099 [PubMed - indexed for MEDLINE]
From PubMed
58

Induction of apoptosis in human leukaemic cell lines K562, HL60 and U937 by diethylhexylphthalate isolated from Aloe vera Linne.
Full author name: Lee, K H; Hong, H S; Lee, C H; Kim, C H.

Lee KH, Hong HS, Lee CH, Kim CH. J Pharm Pharmacol. 2000 Aug;52(8):1037-41.

[Article in English]

Animal Resource Research Center, Konkuk University, Seoul, Korea.

We investigated the effect of diethylhexylphthalate (DEHP) from Aloe vera Linne on the apoptosis of human leukaemic cell lines K562, HL60 and U937 to examine its pharmacological activity. At a level of 10 microg mL(-1) DEHP a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10 microg mL(-1) DEHP for 4 h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis. These results indicate that DEHP isolated from Aloe vera Linne has a potent antileukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 20010111
Date Completed: 20010111
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/09/28 11:00
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 2000 Aug;52(8):1037-41.
PMID: 11007077 UI: 20460143 [PubMed - indexed for MEDLINE]
From PubMed
59

Optimized separation of pharmacologically active anthraquinones in Rhubarb by capillary electrochromatography.
Full author name: Li, Y; Liu, H; Ji, X; Li, J.

Li Y, Liu H, Ji X, Li J. Electrophoresis. 2000 Sep;21(15):3109-15.

[Article in English]

Department of Chemistry, Peking University, Beijing, PR China.

A capillary electrochromatography (CEC) method with diode-array detection has been developed for the separation of the therapeutically important anthraquinones from Rhubarb extract and commercial traditional Chinese drugs containing Rhubarb. The separation of four major anthraquinones (aloe-emodin, emodin, chrysophanol, and physcion) was optimized with respect to pH and concentration of buffers, addition of acetonitrile, applied voltage, and column temperature. Baseline separation was achieved for the four anthraquinones in less than 12 min using a background electrolyte consisting of 5 mM acetic acid (pH 4.5) with 80% acetonitrile. The possibility of CEC for the analysis of traditional Chinese medicines was discussed.

MeSH Terms:

Substances:

ISSN: 0173-0835
NLM Unique ID: 8204476
Country: Germany
Entry Date: 20010118
Date Completed: 20010118
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/09/23 11:00
Citation Subset: IM
http://dx.doi.org/10.1002/1522-2683(20000901)21:15<3109::AID-ELPS3109>3.0.CO;2-Q
Publication Status: ppublish
Electrophoresis 2000 Sep;21(15):3109-15.
PMID: 11001207 UI: 20454845 [PubMed - indexed for MEDLINE]
From PubMed
60

Growth, soluble carbohydrates, and aloin concentration of Aloe vera plants exposed to three irradiance levels.

Paez A, Michael Gebre G, Gonzalez ME, Tschaplinski TJ. Environ Exp Bot. 2000 Oct 1;44(2):133-139.

[Article in English]

Laboratorio de Ecofisiologia. Dept. Biologia, Facultad de Ciencias, Universidad del Zulia, Maracaibo, Venezuela

Research was conducted on Aloe vera, a traditional medicinal plant, to investigate the effects of light on growth, carbon allocation, and the concentrations of organic solutes, including soluble carbohydrates and aloin. The plants were vegetatively propagated and grown under three irradiances: full sunlight, partial (30% full sunlight), and deep shade (10% full sunlight) for 12-18 months. After 1 year of growth, five plants from each treatment were harvested to determine total above- and below ground dry mass. Four plants from the full sunlight and the partial shade treatments were harvested after 18 months to assess the soluble carbohydrate, organic acid and aloin concentrations of the clear parenchyma gel and the yellow leaf exudate, separately. Plants grown under full sunlight produced more numerous and larger axillary shoots, resulting in twice the total dry mass than those grown under partial shade. The dry mass of the plants grown under deep shade was 8.6% that of plants grown under full sunlight. Partial shade increased the number and length of leaves produced on the primary shoot, but leaf dry mass was still reduced to 66% of that in full sunlight. In contrast, partial and deep shade reduced root dry mass to 28 and 13%, respectively, of that under full sunlight, indicating that carbon allocation to roots was restricted under low light conditions. When plants were sampled 6 months later, there were only minor treatment effects on the concentration of soluble carbohydrates and aloin in the leaf exudate and gel. Soluble carbohydrate concentrations were greater in the gel than in the exudate, with glucose the most abundant soluble carbohydrate. Aloin was present only in the leaf exudate and higher irradiance did not induce a higher concentration. Limitation in light availability primarily affected total dry mass production and allocation, without substantial effects on either primary or secondary carbon metabolites. ISSN: 0098-8472
Entry Date: 20000920
MeSH Date: 2000/09/21
Entrez Date: 2000/09/21
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0098847200000629
Publication Status: ppublish
Environ Exp Bot 2000 Oct 1;44(2):133-139.
PMID: 10996366 UI: 0 [PubMed - as supplied by publisher]
From PubMed


61

The chemotaxonomic significance of the phenyl pyrone aloenin in the genus Aloe.

Viljoen AM, Van Wyk B. Biochem Syst Ecol. 2000 Dec 1;28(10):1009-1017.

[Article in English]

Department of Botany, Rand Afrikaans University, PO Box 524, 2006, Auckland Park, South Africa

The phenyl pyrone, aloenin was positively identified in 16 species in a greater chemotaxonomic study on 380 species of Aloe. A large number of species have previously been suggested to be related on the basis of their macromorphological characters. The leaf exudate composition of the 16 species are presented together with a summary of the salient morphological characters. The possible taxonomic relationships between aloenin producing species, not previously thought to be associated with one another are discussed and illustrates the need to explore additional characters of taxonomic value in this large genus of ca. 420 species where no natural classification system exists. ISSN: 0305-1978
Entry Date: 20000920
MeSH Date: 2000/09/21
Entrez Date: 2000/09/21
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0305197800000181
Publication Status: ppublish
Biochem Syst Ecol 2000 Dec 1;28(10):1009-1017.
PMID: 10996264 UI: 0 [PubMed - as supplied by publisher]
From PubMed


62

Induction of primary cutaneous melanomas in C3H mice by combined treatment with ultraviolet radiation, ethanol and aloe emodin.
Full author name: Strickland, F M; Muller, H K; Stephens, L C; Bucana, C D; Donawho, C K; Sun, Y; Pelley, R P.

Strickland FM, Muller HK, Stephens LC, Bucana CD, Donawho CK, Sun Y, Pelley RP. Photochem Photobiol. 2000 Sep;72(3):407-14.

[Article in English]

Department of Immunology, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA. fstrickl@notes.mdacc.tmc.edu

The role of ultraviolet (UV) radiation in the induction of nonmelanoma skin cancer is widely accepted, although its precise contribution to the development of primary cutaneous melanoma skin cancer requires further definition. We found that painting aloe emodin, a trihydroxyanthraquinone from Aloe barbadensis, in ethyl alcohol vehicle on the skin of mice in conjunction with exposure to UVB (280-320 nm) radiation results in the development of melanin-containing skin tumors. C3H/HeN mice were treated thrice weekly with aloe emodin in a 25% ethanol in water vehicle and exposed to 15 kJ/m2 UV radiation. Neither ethanol vehicle nor aloe emodin alone induced skin tumors in the absence of UV radiation. In two separate experiments, 20-30% of the mice treated with a combination of UV radiation and ethanol vehicle and 50-67% of the UV-irradiated animals given aloe emodin in ethanol vehicle developed primary cutaneous melanin-containing tumors. The diagnosis of melanoma was established using Fontana silver stain for melanin; these tumors were negative for vimentin and keratin. Melanin-containing melanosomes were observed by transmission electron microscopy in tumors diagnosed as melanomas. Although the mechanism of carcinogenesis in these mice is currently unknown, our findings have led to the development of the first facile murine model for the induction of primary melanoma. This model has the potential to clarify the role of UV radiation in the etiology of malignant melanoma.

MeSH Terms:

Substances:

Grant Support:

ISSN: 0031-8655
NLM Unique ID: 0376425
Country: United States
Entry Date: 20001017
Date Completed: 20001017
MeSH Date: 2000/10/21 11:01
Date Revised: 20001218
Entrez Date: 2000/09/16 11:00
Citation Subset: IM
Publication Status: ppublish
Photochem Photobiol 2000 Sep;72(3):407-14.
PMID: 10989613 UI: 20444756 [PubMed - indexed for MEDLINE]
From PubMed
63

Antifungal activity of anthraquinone derivatives from Rheum emodi.
Full author name: Agarwal, S K; Singh, S S; Verma, S; Kumar, S.

Agarwal SK, Singh SS, Verma S, Kumar S. J Ethnopharmacol. 2000 Sep;72(1-2):43-6.

[Article in English]

Central Institute of Medicinal and Aromatic Plants, P.O.-CIMAP, Lucknow 226 015, India.

Rhein, physcion, aloe-emodin and chrysophanol isolated from Rheum emodi rhizomes exhibited antifungal activity against Candida albicans, Cryptococcus neoformans, Trichophyton mentagrophytes and Aspergillus fumigatus (MIC 25-250 microg/ml).

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 20010123
Date Completed: 20010126
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/09/01 11:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874100001951
Publication Status: ppublish
J Ethnopharmacol 2000 Sep;72(1-2):43-6.
PMID: 10967452 UI: 20425162 [PubMed - indexed for MEDLINE]
From PubMed
64

Aloe L.--a second plant family without (TTTAGGG)n telomeres.
Full author name: Adams, S P; Leitch, I J; Bennett, M D; Leitch, A R.

Adams SP, Leitch IJ, Bennett MD, Leitch AR. Chromosoma. 2000 Jun;109(3):201-5.

[Article in English]

School of Biological Sciences, Queen Mary and Westfield College, University of London, UK.

The physical ends of chromosomes are protected and stabilised by telomeres. The sequence of telomeric DNA normally consists of a simple repeating unit that is conserved in many organisms. Most plants examined have been shown to possess Arabidopsis-type telomeres consisting of many repeat copies of the sequence 5'-TTTAGGG-3'. Using fluorescent in situ hybridisation, slot blotting and the asymmetric polymerase chain reaction we demonstrate an absence of Arabidopsis-type telomeres in the genus Aloe (family Asphodelaceae). The only other plant genera so far reported without such telomeres are Allium, Nothoscordum, and Tulbaghia (family Alliaceae). As these genera and Aloe are petaloid monocots in the Asparagales, it is suggested that an absence of Arabidopsis-type telomeres may be characteristic of this related group of plants.

MeSH Terms:

Substances:

ISSN: 0009-5915
NLM Unique ID: 2985138R
Country: Germany
Entry Date: 20001108
Date Completed: 20001130
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/08/10 11:00
Citation Subset: IM
http://link.springer-ny.com/link/service/journals/00412/bibs/0109003/01090201.htm
Publication Status: ppublish
Chromosoma 2000 Jun;109(3):201-5.
PMID: 10929199 UI: 20385494 [PubMed - indexed for MEDLINE]
From PubMed
65

The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens.

Gutterman Y, Chauser-Volfson E. Biochem Syst Ecol. 2000 Nov 1;28(9):825-838.

[Article in English]

Jacob Blaustein Institute for Desert Research and Dept. of Life Sciences, Ben-Gurion University of the Negev, Sede Boker Campus 84990, Israel

Aloe arborescens is a large, multi-stemmed shrub. It is used as hedge plants to protect agricultural fields or stock and as horticultural plants in gardens. In natural habitats it is one of the very common Aloe species along the Indian Ocean coast of southern Africa, from the Cape, in the south, to Zimbabwe and Malawi in the north. Secondary phenolic metabolites such as barbaloin (Rf 0.31-0.35), aloeresin (Rf 0.25-0.3) and aloenin (Rf 0.51-0.55) have been found to be distributed in the succulent leaves of Aloe arborescens in a peripheral defense strategy. The youngest leaves have the highest content. The terminal third of each leaf has the highest content and the basal third, the lowest. Along the leaf margins, on the top third and adaxial side, the content is the highest and in the base third, the lowest along the leaf center on the abaxial side. Similar relative amounts of these three secondary phenolic metabolites were found in the different leaf locations. The leaf orientation may affect the total content of these three phenols but not their relative amounts in the different parts of the leaves. It is possible that the more often the plant parts are damaged by consumption by animals such as elephants, kudu or insects, the greater the increase of their phenolic metabolites. This increase may reduce or prevent further consumption when the content of the metabolites reaches a certain level. The plants then have a chance to renew themselves. ISSN: 0305-1978
Entry Date: 20000727
MeSH Date: 2000/07/29
Entrez Date: 2000/07/29
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0305197899001295
Publication Status: ppublish
Biochem Syst Ecol 2000 Nov 1;28(9):825-838.
PMID: 10913844 UI: 0 [PubMed - as supplied by publisher]
From PubMed


66

Oxoaporphine alkaloids and quinones from Stephania dinklagei and evaluation of their antiprotozoal activities.
Full author name: Camacho, M R; Kirby, G C; Warhurst, D C; Croft, S L; Phillipson, J D.

Camacho MR, Kirby GC, Warhurst DC, Croft SL, Phillipson JD. Planta Med. 2000 Jun;66(5):478-80.

[Article in English]

Bioactivity-guided fractionation of Stephania dinklagei yielded six compounds including, two zwitterionic oxoaporphine alkaloids, N-methylliriodendronine, and 2-O,N-dimethylliriodendronine, two oxoaporphine alkaloids, liriodenine, and dicentrinone, one aporphine alkaloid, corydine, and one anthraquinone, aloe-emodin. Apart from corydine, the isolates have not been reported as constituents of S. dinklagei. N-Methylliriodendronine, and 2-O,N-dimethylliriodendronine are reported for the first time as natural products. All isolated compound were tested for antiprotozoal activity and cytotoxic activities in vitro. N-Methylliriodendronine was the most active against L. donovani amastigotes (IC50 = 36.1 microM). Liriodenine showed the highest activity against Leishmania donovani, and Plasmodium falciparum with IC50 values of 26.16 and 15 microM, respectively. Aloe-emodin was the only compound active (IC50 = 14 microM) against T. b. brucei.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20000914
Date Completed: 20000914
MeSH Date: 2000/09/19 11:01
Date Revised: 20001218
Entrez Date: 2000/07/26 11:00
Citation Subset: IM
Publication Status: ppublish
Planta Med 2000 Jun;66(5):478-80.
PMID: 10909274 UI: 20367003 [PubMed - indexed for MEDLINE]
From PubMed
67

Aloe vera: a systematic review of its clinical effectiveness.
Full author name: Vogler, B K; Ernst, E.

Vogler BK, Ernst E. Br J Gen Pract. 1999 Oct;49(447):823-8.

[Article in English]

Department of Complementary Medicine, School of Postgraduate Medicine and Health Sciences, University of Exeter.

BACKGROUND: The use of aloe vera is being promoted for a large variety of conditions. Often general practitioners seem to know less than their patients about its alleged benefits. AIM: To define the clinical effectiveness of aloe vera, a popular herbal remedy in the United Kingdom. METHOD: Four independent literature searches were conducted in MEDLINE, EMBASE, Biosis, and the Cochrane Library. Only controlled clinical trials (on any indication) were included. There were no restrictions on the language of publication. All trials were read by both authors and data were extracted in a standardized, pre-defined manner. RESULTS: Ten studies were located. They suggest that oral administration of aloe vera might be a useful adjunct for lowering blood glucose in diabetic patients as well as for reducing blood lipid levels in patients with hyperlipidaemia. Topical application of aloe vera is not an effective preventative for radiation-induced injuries. It might be effective for genital herpes and psoriasis. Whether it promotes wound healing is unclear. There are major caveats associated with all of these statements. CONCLUSION: Even though there are some promising results, clinical effectiveness of oral or topical aloe vera is not sufficiently defined at present.

Publication Types:

MeSH Terms:

Substances:

Number of References: 39
ISSN: 0960-1643
NLM Unique ID: 9005323
Country: England
Entry Date: 20000802
Date Completed: 20000802
MeSH Date: 2000/08/06 11:00
Date Revised: 20011128
Entrez Date: 2000/07/08 11:00
Citation Subset: IM
Publication Status: ppublish
Br J Gen Pract 1999 Oct;49(447):823-8.
PMID: 10885091 UI: 20343505 [PubMed - indexed for MEDLINE]
From PubMed
68

Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne.
Full author name: Lee, K H; Kim, J H; Lim, D S; Kim, C H.

Lee KH, Kim JH, Lim DS, Kim CH. J Pharm Pharmacol. 2000 May;52(5):593-8.

[Article in English]

Animal Resource Research Center, Konkuk University, Seoul, Korea.

Extracts of Aloe vera Linne have been found to exhibit cytotoxicity against human tumour cell lines. This study examines the anti-tumour effects of di(2-ethylhexyl)phthalate (DEHP) isolated from Aloe vera Linne, in human and animal cell lines. Its anti-mutagenic effects were examined using Salmonella typhimurium TA98 and TA100 strains. Growth inhibition was specifically exerted by DEHP against three leukaemic cell lines at concentrations below 100 microg mL(-1). At 100 microg mL(-1) DEHP, K562, HL60 and U937 leukaemic cell lines showed growth inhibition of 95, 97 and 95%, respectively. DEHP exhibited an inhibitory activity of 74, 83 and 81%, respectively, in K562, HL60 and U937 cell lines at a concentration of 10 microg mL(-1). At a concentration of 1 microg mL(-1), DEHP exerted an inhibitory activity of 50, 51 and 52%, respectively, in K562, HL60 and U937. In a normal cell line, MDBK, DEHP exerted 30% growth inhibition at a concentration of 100 microg mL(-1), and showed no inhibitory activity at concentrations below 50 microg mL(-1). It was found that DEHP exerted anti-mutagenic activity in the Salmonella mutation assay. The number of mutant colonies of Salmonella typhimurium strain TA98 upon exposure to AF-2 (0.2 microg/plate) decreased in a concentration-dependent manner in the presence of different DEHP concentrations (decreasing to 90.4, 83.9, 75.4, 69.6 and 46.9%, respectively, for DEHP concentrations of 100, 50, 10, 5 and 1 microg/plate). In the case of Salmonella typhimurium strain TA100, DEHP reduced AF-2-induced mutagenicity at 1, 5, 10, 50 and 100 microg/plate to 57.4, 77.5, 80.0, 89.0 and 91.5%, respectively. The isolated compound from Aloe vera Linne, DEHP, was considered to be the active principle responsible for anti-leukaemic and anti-mutagenic effects in-vitro.

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 20001103
Date Completed: 20001103
MeSH Date: 2001/02/28 10:01
Date Revised: 20011128
Entrez Date: 2000/06/23 11:00
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 2000 May;52(5):593-8.
PMID: 10864149 UI: 20320145 [PubMed - indexed for MEDLINE]
From PubMed
69

Aloe polymannose enhances anti-coxsackievirus antibody titres in mice.
Full author name: Gauntt, C J; Wood, H J; McDaniel, H R; McAnalley, B H.

Gauntt CJ, Wood HJ, McDaniel HR, McAnalley BH. Phytother Res. 2000 Jun;14(4):261-6.

[Article in English]

Department of Microbiology, University of Texas Health Science Center at San Antonio Texas, 7703 Floyd Curl Drive, San Antonio, TX 78284-7758, USA.

Aloe polymannose (AP), a high mannose biological response modifier (BRM) purified from the Aloe barbadensis Miller plant, was tested for activity in enhancing antibody titres against coxsackievirus B3 (CVB3) and CVB3-induced myocarditis in murine models of the disease. Inoculation of mice with AP over a range of three nontoxic doses and in varying schedules did not reduce virus titres in heart tissues or ameliorate virus-induced cardiopathological alterations during acute disease. However, this BRM was found to significantly enhance titres of anti-CVB3 antibodies produced during acute infection of three strains of mice with CVB3. Simultaneous intraperitoneal inoculation of AP at a dose of 0.5 mg/kg body weight per mouse with purified CVB3 significantly increased ELISA titres of anti-CVB3 antibodies and the proportion of mice with these titres, compared with similar parameters in mice inoculated only with CVB3. The data conclusively show that AP can immunopotentiate antibody production against capsid protein epitopes of a nonenveloped picornavirus and suggest this BRM (AP) might be of benefit in enhancing antibody titres against other enteroviruses during a natural infection and poliovirus vaccine strains. Copyright 2000 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20000822
Date Completed: 20000822
MeSH Date: 2000/08/29 11:01
Date Revised: 20011128
Entrez Date: 2000/06/22 10:00
Citation Subset: IM
Publication Status: ppublish
Phytother Res 2000 Jun;14(4):261-6.
PMID: 10861969 UI: 20321281 [PubMed - indexed for MEDLINE]
From PubMed
70

Use of herbal remedies by patients in a health maintenance organization.
Full author name: Bennett, J; Brown, C M.

Bennett J, Brown CM. J Am Pharm Assoc (Wash). 2000 May-Jun;40(3):353-8.

Comment in:


[Article in English]

Methodist Hospital, Omaha, Nebr., USA.

OBJECTIVE: To examine the use of and experiences with herbal remedies among a group of patients enrolled in a health maintenance organization (HMO). DESIGN: Self-administered questionnaire. SETTING: Central Texas city. PARTICIPANTS: 135 HMO patients. INTERVENTION(S): Not applicable. MAIN OUTCOME MEASURE: Patients' self-reported use of herbal remedies. RESULTS: Almost 40% of patients indicated they had used herbal remedies. The majority had used herbal remedies to treat or prevent a health condition (e.g., common cold). The remedies most frequently used were garlic, aloe gel, cranberry, and echinacea. Most respondents gathered their information on herbal remedies from the popular media, and most based their use decisions primarily on the recommendations of friends and/or relatives. Although most were unsure of the quality of the products, they felt they were safe and somewhat effective, and few had experienced any direct side effects they attributed to the herbal remedies. Most patients used the products without the knowledge of their physician or pharmacist. Herbal remedies were most often used in place of prescription or over-the-counter (OTC) medications and most frequently purchased in health food stores and mass merchandizer/grocery stores. Herbal remedies were sometimes used along with prescription or OTC medications. CONCLUSION: Given that patients are using herbal remedies for a variety of health conditions without medical supervision, pharmacists need to actively and consistently obtain information about herbal remedy use to effectively advise patients and monitor outcomes. More research is needed on herbal remedy use among patient populations and on outcomes in patients who use herbal remedies to treat primary health conditions.

MeSH Terms:

ISSN: 1086-5802
NLM Unique ID: 9601004
Country: United States
Entry Date: 20000713
Date Completed: 20000713
MeSH Date: 2000/07/15 11:00
Date Revised: 20011128
Entrez Date: 2000/06/15 09:00
Citation Subset: IM
Publication Status: ppublish
J Am Pharm Assoc (Wash) 2000 May-Jun;40(3):353-8.
PMID: 10853535 UI: 20312002 [PubMed - indexed for MEDLINE]
From PubMed
71

Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors.
Full author name: Pecere, T; Gazzola, M V; Mucignat, C; Parolin, C; Vecchia, F D; Cavaggioni, A; Basso, G; Diaspro, A; Salvato, B; Carli, M; Palu, G.

Pecere T, Gazzola MV, Mucignat C, Parolin C, Vecchia FD, Cavaggioni A, Basso G, Diaspro A, Salvato B, Carli M, Palu G. Cancer Res. 2000 Jun 1;60(11):2800-4.

[Article in English]

Department of Histology, Microbiology, and Medical Biotechnologies, Medical School, University of Padova, Italy.

Here we report that aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals. The compound does not inhibit the proliferation of normal fibroblasts nor that of hemopoietic progenitor cells. The cytotoxicity mechanism consists of the induction of apoptosis, whereas the selectivity against neuroectodermal tumor cells is founded on a specific energy-dependent pathway of drug incorporation. Taking into account its unique cytotoxicity profile and mode of action, AE might represent a conceptually new lead antitumor drug.

MeSH Terms:

Substances:

ISSN: 0008-5472
NLM Unique ID: 2984705R
Country: United States
Entry Date: 20000630
Date Completed: 20000630
MeSH Date: 2000/07/08 11:00
Date Revised: 20001218
Entrez Date: 2000/06/13 09:00
Citation Subset: IM
http://cancerres.aacrjournals.org/cgi/pmidlookup?view=full&pmid=10850417
Publication Status: ppublish
Cancer Res 2000 Jun 1;60(11):2800-4.
PMID: 10850417 UI: 20306590 [PubMed - indexed for MEDLINE]
From PubMed
72

[The effectiveness and acceptance of a medical device for the treatment of aphthous stomatitis. Clinical observation in pediatric age]
Full author name: Andriani, E; Bugli, T; Aalders, M; Castelli, S; De Luigi, G; Lazzari, N; Rolli, G P.

Andriani E, Bugli T, Aalders M, Castelli S, De Luigi G, Lazzari N, Rolli GP. Minerva Pediatr. 2000 Jan-Feb;52(1-2):15-20.

[Article in Italian]

Servizio Medicina di Base, Istituto per la Sicurezza Sociale Repubblica di S. Marino.

BACKGROUND: To evaluate the efficacy of a new bioadhesive patch, Aloe vera hydrogel, for the treatment of aphthous stomatitis. METHODS: An open, not controlled study was performed in 31 pediatric out-patients, aged 6-14 years, affected by mouth ulcers were enrolled consecutively in the 3 Gps Depts+ of San Marino Republic. For each case, data on case history and clinical profile, patterns of the lesion, presence of spontaneous or provoked pain were collected at baseline, and a bioadhesive patch ("Alovex patch") was administered on the basis of a daily regimen of < or = 3 patches for 4 days. Data on modification of the above-mentioned parameters, with patients and physicians opinion on the therapeutical efficacy, were collected during a control visit (4 days later). Moreover, by means of a daily diary, patients recorded information on the course of the symptoms during the 4 days and were also asked to compare the current treatment with other previous therapies. RESULTS: At the control visit 77% of the patients have shown a marked resolution of spontaneous pain, while in the other patients, pain was significantly decreased to a "mild" or "moderate" level. No one child declared to suffer from severe pain. Also provoked pain resulted to be significantly decreased after treatment Global efficacy was judged positively, being the therapeutical effect in more than 80% of cases "evident or of absolute improvement" both by physicians and patients opinion. A positive improvement of symptomatology started within the 2nd day of treatment in 74% of the patients. The compliance (adhesivity, acceptability and palatability) of the formulation was judged largely favourable in more than 90% of the patients. CONCLUSIONS: The results of this study underline the good efficacy and compliance of the patch for the treatment of the aphtous stomatitis; also the limit of topical available therapies, linked to the "contact time", to develop their therapeutical action, seems not to be evinced on the basis of this study, so the application of this patch seems to be more easy and beneficial.

MeSH Terms:

Substances:

ISSN: 0026-4946
NLM Unique ID: 0400740
Country: Italy
Vernacular Title: Efficacia e accettabilita di un dispositivo medico per le afte buccali. Osservazione clinica in eta pediatrica.
Entry Date: 20000713
Date Completed: 20000713
MeSH Date: 2000/07/15 11:00
Date Revised: 20011128
Entrez Date: 2000/06/01 09:00
Citation Subset: IM
Publication Status: ppublish
Minerva Pediatr 2000 Jan-Feb;52(1-2):15-20.
PMID: 10829589 UI: 20288398 [PubMed - indexed for MEDLINE]
From PubMed
73

Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats.
Full author name: Somboonwong, J; Thanamittramanee, S; Jariyapongskul, A; Patumraj, S.

Somboonwong J, Thanamittramanee S, Jariyapongskul A, Patumraj S. J Med Assoc Thai. 2000 Apr;83(4):417-25.

[Article in English]

Department of Physiology, Faculty of Medicine, Chulalongkorn University Hospital, Bangkok, Thailand.

OBJECTIVE: To demonstrate the microcirculatory and wound healing effects of Aloe vera on induced second degree burn wounds in rats. METHOD: A total of 48 male Wistar rats were equally divided into 4 groups as follows: sham controls, untreated burn-wound rats, those treated with once-daily application of normal saline (NSS) and those treated with once-daily application of lyophilized Aloe vera gel. The animals in each group were equally subdivided into 2 subgroups for the study of cutaneous microcirculation and wound healing on day 7 and 14 after burn. Dorsal skinfold chamber preparation and intravital fluorescence microscopic technique were performed to examine dermal microvascular changes, including arteriolar diameter, postcapillary venular permeability and leukocyte adhesion on postcapillary venules. RESULTS: On day 7, the vasodilation and increased postcapillary venular permeability as encountered in the untreated burn were found to be reduced significantly (p < 0.05) in both the NSS- and Aloe vera-treated groups, but to a greater extent in the latter. Leukocyte adhesion was not different among the untreated, NSS- and Aloe vera-treated groups. On day 14, vasoconstriction occurred after the wound had been left untreated. Only in the Aloe vera-treated groups, was arteriolar diameter increased up to normal condition and postcapillary venular permeability was not different from the sham controls. The amount of leukocyte adhesion was also less observed compared to the untreated and NSS- treated groups. Besides, the healing area of the Aloe vera-treated wound was better than that of the untreated and NSS- treated groups during 7 and 14 days after burn. CONCLUSION: Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound.

MeSH Terms:

ISSN: 0125-2208
NLM Unique ID: 7507216
Country: Thailand
Entry Date: 20000606
Date Completed: 20000606
MeSH Date: 2000/06/10 09:00
Date Revised: 20011128
Entrez Date: 2000/05/16 09:00
Citation Subset: IM
Publication Status: ppublish
J Med Assoc Thai 2000 Apr;83(4):417-25.
PMID: 10808702 UI: 20268747 [PubMed - indexed for MEDLINE]
From PubMed
74

Herbal anti-inflammatory agents for skin disease.
Full author name: Graf, J.

Graf J. Skin Therapy Lett. 2000;5(4):3-5.

[Article in English]

Department of Dermatology, New York University Medical Center, New York, New York, USA.

Herbs have been used in clinical medicine for thousands of years. However, it is only in recent times that we have been able to employ scientific methods to prove the efficacy of many of these herbs and to give us a better understanding of their mechanisms of action. This article will focus on the use of herbs in various dermatological conditions characterized by inflammation and pruritus. Topical preparations of many of these herbs are more commonplace in Europe. However, their availability is increasing in the US. As this is occurring we are witnessing a growing marriage between alternative and traditional medicines.

MeSH Terms:

Substances:

ISSN: 1201-5989
NLM Unique ID: 9891441
Country: Canada
Entry Date: 20000609
Date Completed: 20000609
MeSH Date: 2000/06/17 09:00
Date Revised: 20011128
Entrez Date: 2000/04/28 09:00
Citation Subset: IM
http://www.derm.ubc.ca/skintherapy/stl0504.html
Full text URL: http://www.derm.ubc.ca/skintherapy/stl0504.html
Publication Status: ppublish
Skin Therapy Lett 2000;5(4):3-5.
PMID: 10785407 UI: 20247499 [PubMed - indexed for MEDLINE]
From PubMed
75

Using a chlorine dioxide antibacterial gel for soft tissue healing.
Full author name: Babad, M S.

Babad MS. Dent Today. 1999 Jun;18(6):88-9.

[Article in English]

dadl949@aol.com

MeSH Terms:

Substances:

ISSN: 8750-2186
NLM Unique ID: 9005357
Country: United States
Entry Date: 20000425
Date Completed: 20000425
MeSH Date: 2000/04/29 09:00
Date Revised: 20011128
Entrez Date: 2000/04/15 09:00
Citation Subset: D
Publication Status: ppublish
Dent Today 1999 Jun;18(6):88-9.
PMID: 10765848 UI: 20228665 [PubMed - indexed for MEDLINE]
From PubMed
76

Distribution of verectin in Aloe vera leaves and verectin contents in clonally regenerated plants and the commercial gel powders by immunochemical screening.
Full author name: Yagi, A; Sato, Y; Shimomura, K; Akasaki, K; Tsuji, H.

Yagi A, Sato Y, Shimomura K, Akasaki K, Tsuji H. Planta Med. 2000 Mar;66(2):180-2.

[Article in English]

Verectin antiserum raised in white rabbits was immunochemically applied to examine verectin distribution in Aloe vera leaves during growth and flowering seasons, and to quantify verectin in clonally regenerated plants and commercial A. vera gel products.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20000518
Date Completed: 20000518
MeSH Date: 2000/05/20 09:00
Date Revised: 20011128
Entrez Date: 2000/04/14 09:00
Citation Subset: IM
Publication Status: ppublish
Planta Med 2000 Mar;66(2):180-2.
PMID: 10763598 UI: 20226808 [PubMed - indexed for MEDLINE]
From PubMed
77

Modified Aloe barbadensis polysaccharide with immunoregulatory activity.
Full author name: Qiu, Z; Jones, K; Wylie, M; Jia, Q; Orndorff, S.

Qiu Z, Jones K, Wylie M, Jia Q, Orndorff S. Planta Med. 2000 Mar;66(2):152-6.

[Article in English]

Department of Drug Discovery and Screening, Univera Pharmaceuticals, Inc., Broomfield, CO, USA. jqiu@upi1.com

Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbadensis gel had no effect on macrophage activation. MAP prevented ultraviolet B (UVB) irradiation-induced immune suppression as determined by contact hypersensitivity (CHS) response in C3H/HeN mice. This in vivo activity was correlated with the activity of MAP to inhibit UVB irradiation-induced tumor necrosis factor alpha (TNF-alpha) release from human epidermoid carcinoma cells (KB cells). MAP with an average molecular weight of 80,000 Dalton (Da) contained mannose, galactose, and glucose in a ratio of 40:1.4:1.0. MAP was likely a linear, highly acetylated molecule.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 20000518
Date Completed: 20000518
MeSH Date: 2000/05/20 09:00
Date Revised: 20011128
Entrez Date: 2000/04/14 09:00
Citation Subset: IM
Publication Status: ppublish
Planta Med 2000 Mar;66(2):152-6.
PMID: 10763590 UI: 20226800 [PubMed - indexed for MEDLINE]
From PubMed
78

Induction Of ovulation.
Full author name: Nandanwar, Y S; Shinde, A A; Mayadeo, N M.

Nandanwar YS, Shinde AA, Mayadeo NM. J Postgrad Med. 1999 Jul-Sep;45(3):79-80.

[Article in English]

Department of Obstetrics and Gynaecology, Seth G. S. Medical College, Parel, Mumbai, India.

Sixty-one patients with anovulation as a cause of infertility were selected for our study. Various ovulation-inducing drugs were used like clomiphene citrate, human menopausal gonadotropin (hMG), human chorionic gonadotropin (hCG), bromergocryptine and leptadene. The response of the different drugs was observed by serial sonography for ovulation. Indeed there was a good response to clomiphene citrate, but those patients who failed to respond to clomiphene citrate and were frustrated with the use of hMG and hCG due to the cost and the complications of the therapy were put on Aloe compound and leptadene - an ayurvedic drug which enhances fertility in different ways.

MeSH Terms:

Substances:

ISSN: 0022-3859
NLM Unique ID: 2985196R
Country: India
Entry Date: 20000712
Date Completed: 20000712
MeSH Date: 2000/07/15 11:00
Date Revised: 20001218
Entrez Date: 2000/03/29 09:00
Citation Subset: IM
http://www.jpgmonline.com/search_redirect.asp?fulltext=yes&id=574
Publication Status: ppublish
J Postgrad Med 1999 Jul-Sep;45(3):79-80.
PMID: 10734340 UI: 20200572 [PubMed - indexed for MEDLINE]
From PubMed
79

[Effect of biogenic stimulators--aloe extract and biotrite--on lipid peroxidation processes in saliva in inflammatory periodontal disease]
Full author name: volik, N A; Beloklitskaia, G F; Stefanov, A V.

volik NA, Beloklitskaia GF, Stefanov AV, Makarenko. Ukr Biokhim Zh. 1999 Sep-Oct;71(5):90-3.

[Article in Russian]

Odessky Scientific Research Institute of Stomatology.

The influence of biostimulators of vegetative origin, such as aloes and biotritis, on the process of lipid peroxidation in parodontium tissues, was studied. Biotritis has a more considerable parodontoprotective effect than aloes.

MeSH Terms:

Substances:

ISSN: 0201-8470
NLM Unique ID: 7804246
Country: Ukraine
Vernacular Title: Vliianie biogennykh stimuliatorov--ekstrakta aloe i biotrita--na protsessy peroksidatsii lipidov v sliune pri vospalitetl'nykh zabolevaniiakh parodonta.
Entry Date: 20000531
Date Completed: 20000531
MeSH Date: 2000/06/03 09:00
Date Revised: 20011128
Entrez Date: 2000/03/22 09:00
Citation Subset: IM
Publication Status: ppublish
Ukr Biokhim Zh 1999 Sep-Oct;71(5):90-3.
PMID: 10726317 UI: 20190516 [PubMed - indexed for MEDLINE]
From PubMed
80

Effects of stilbene constituents from rhubarb on nitric oxide production in lipopolysaccharide-activated macrophages.
Full author name: Matsuda, H; Kageura, T; Morikawa, T; Toguchida, I; Harima, S; Yoshikawa, M.

Matsuda H, Kageura T, Morikawa T, Toguchida I, Harima S, Yoshikawa M. Bioorg Med Chem Lett. 2000 Feb 21;10(4):323-7.

[Article in English]

Kyoto Pharmaceutical University, Japan.

Two new anthraquinone glucosides [chrysophanol 8-O-beta-D-(6'-galloyl)-glucopyranoside, aloe-emodin 1-O-beta-D-glucopyranoside] together with various known stilbenes and their glucosides, anthraquinone glucosides, and a naphthalene glucoside were isolated from the rhizome of Rheum undulatum L. Three stilbenes (rhapontigenin, piceatannol, resveratrol), a naphthalene glucoside (torachrysone 8-O-beta-D-glucopyranoside), and two stilbene glucoside gallates (rhaponticin 2''-O-gallate, rhaponticin 6''-O-gallate) showed inhibitory activity of NO production in lipopolysaccharide-activated macrophages, (IC50 = 11-69 microM). The oxygen functions (-OH,-OCH3) at the benzene ring were found to be essential to show the activity. Whereas, the glucoside moiety reduced the activity, while the alpha,beta-double bond did not affect the activity. Furthermore, the active stilbenes (rhapontigenin, piceatannol, resveratrol) inhibited iNOS induction.

MeSH Terms:

Substances:

ISSN: 0960-894X
NLM Unique ID: 9107377
Country: England
Entry Date: 20000515
Date Completed: 20000515
MeSH Date: 2000/05/20 09:00
Date Revised: 20011128
Entrez Date: 2000/03/14 09:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0960894X99007027
Publication Status: ppublish
Bioorg Med Chem Lett 2000 Feb 21;10(4):323-7.
PMID: 10714491 UI: 20176951 [PubMed - indexed for MEDLINE]
From PubMed
81

In vivo macrophage activation in chickens with Acemannan, a complex carbohydrate extracted from Aloe vera.
Full author name: Djeraba, A; Quere, P.

Djeraba A, Quere P. Int J Immunopharmacol. 2000 May;22(5):365-72.

[Article in English]

INRA, Virologie Aviaire et Oncologie, Station de Pathologie Aviaire et Parasitologie, 37 380, Nouzilly, France.

Acemannan (ACM 1), a beta-(1,4) -acetylated mannan isolated from Aloe vera, can be used as an effective adjuvant in vaccination against some avian viral diseases. Our results demonstrate a quick and lasting in vivo priming effect of ACM 1 on macrophage response after intramuscular inoculation in chickens (500 &mgr;g per 2-month-old bird). In response to IFN-gamma in vitro, monocytes from ACM 1-treated chickens exhibited a strong enhancement of NO production from 3 to 9 days p.i., but a weaker effect on MHC II cell surface antigen expression on day 3 p.i. A stimulating effect of ACM 1 treatment was also observed on spontaneous and inducible NO production for splenocytes only on day 3 p.i. By that time, splenocytes exhibited a strong higher capacity to proliferate in response to the T cell-mitogen PHA. At the same time, the in vivo capacity to produce NO, measured by the (NO(-)(2)+NO(-)(3)) serum level after intravenous LPS injection, increased greatly from 3 to 9 days p.i. In conclusion, ACM 1 was able efficiently and durably to increase the activation capacity of macrophages from the systemic immune compartment (in particular from the blood and spleen after an intramuscular injection) in chickens, especially for NO production. These findings provide a better understanding of the adjuvant activity of ACM 1 for viral and tumoral diseases.

MeSH Terms:

Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 20000504
Date Completed: 20000504
MeSH Date: 2000/05/08 09:00
Date Revised: 20001218
Entrez Date: 2000/03/10 09:00
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0192056199000910
Publication Status: ppublish
Int J Immunopharmacol 2000 May;22(5):365-72.
PMID: 10708884 UI: 20175494 [PubMed - indexed for MEDLINE]
From PubMed
82

Complementary and alternative medicine in wound healing.
Full author name: Salcido, R.

Salcido R. Adv Wound Care. 1999 Nov-Dec;12(9):438.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 1076-2191
NLM Unique ID: 9432971
Country: United States
Entry Date: 20000323
Date Completed: 20000323
MeSH Date: 2000/03/25 09:00
Date Revised: 20011128
Entrez Date: 2000/02/25 09:00
Citation Subset: N
Publication Status: ppublish
Adv Wound Care 1999 Nov-Dec;12(9):438.
PMID: 10687556 UI: 20152172 [PubMed - indexed for MEDLINE]
From PubMed
83

Lichen planus--report of successful treatment with aloe vera.
Full author name: Hayes, S M.

Hayes SM. Gen Dent. 1999 May-Jun;47(3):268-72.

[Article in English]

Lichen planus is a disease that involves the skin and mucous membranes. It is characterized by unique eruptions. The cause of this disease is unknown, but has been linked to emotional stress, and has also been attributed to viral infections. A case is described of a successful treatment of lichen planus.

MeSH Terms:

ISSN: 0363-6771
NLM Unique ID: 7610466
Country: United States
Entry Date: 20000301
Date Completed: 20000301
MeSH Date: 2000/03/04 09:00
Date Revised: 20011128
Entrez Date: 2000/02/25 09:00
Citation Subset: D
Publication Status: ppublish
Gen Dent 1999 May-Jun;47(3):268-72.
PMID: 10687438 UI: 20152054 [PubMed - indexed for MEDLINE]
From PubMed
84

An isozyme of the NADP-malic enzyme of a CAM plant, Aloe arborescens, with variation on conservative amino acid residues.
Full author name: Honda, H; Akagi, H; Shimada, H.

Honda H, Akagi H, Shimada H. Gene. 2000 Feb 8;243(1-2):85-92.

[Article in English]

Life Sciences Laboratory, Mitsui Chemicals, Inc., 1144 Togo, Mobara, Japan.

In Aloe arborescens, an obligate CAM plant, Western analysis detected three major isoforms of NADP-malic enzyme (NADP-ME), 72kDa with a pI of 6.0, 65kDa with a pI of 5.6 and 65kDa with a pI of 5.5. Among them, the 65kDa protein with a pI of 5.5 was leaf-specific, and the 65kDa protein with a pI of 5.6 was found only in roots, whereas the 72kDa protein was uniformly detected in both organs. Activity staining indicated enzyme activity of both 65kDa NADP-MEs but little activity of the 72kDa protein. A cDNA clone encoding a leaf-abundant NADP-ME, AME1, was isolated. Deduced amino acid sequence of AME1 showed a high degree of homology to known NADP-MEs, but it was also found that AME1 contained substitutions on five conservative amino acid residues, some of which have been predicted to be important for their enzyme activity. Transgenic rice carrying the aloe AME1 gene efficiently produced an additional 65kDa protein with a pI of 5.5 as an active NADP-ME. These results indicate that AME1 corresponds to the leaf-specific 65kDa NADP-ME, which may be involved in CAM photosynthesis. It was also shown that substitutions of these conservative amino acid residues identified in AME1 still allowed it to give enzyme activity.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 0378-1119
NLM Unique ID: 7706761
Country: Netherlands
Entry Date: 20000403
Date Completed: 20000403
MeSH Date: 2000/02/17 00:01
Date Revised: 20011128
Entrez Date: 2000/02/17
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378111999005569
Full text URL: http://www.elsevier.com:80/cgi-bin/cas/tree/store/gene/cas_sub/browse/brow se.cgi?year=2000&volume=243&issue=1-2&aid=12261
Publication Status: ppublish
Gene 2000 Feb 8;243(1-2):85-92.
PMID: 10675616 UI: 20156372 [PubMed - indexed for MEDLINE]
From PubMed
85

Aloe vera leaf gel: a review update.
Full author name: Reynolds, T; Dweck, A C.

Reynolds T, Dweck AC. J Ethnopharmacol. 1999 Dec 15;68(1-3):3-37.

[Article in English]

Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, UK.

Research since the 1986 review has largely upheld the therapeutic claims made in the earlier papers and indeed extended them into other areas. Treatment of inflammation is still the key effect for most types of healing but it is now realized that this is a complex process and that many of its constituent processes may be addressed in different ways by different gel components. A common theme running though much recent research is the immunomodulatory properties of the gel polysaccharides, especially the acetylated mannans from Aloe vera, which are now a proprietary substance covered by many patents. There have also been, however, persistent reports of active glycoprotein fractions from both Aloe vera and Aloe arborescens. There are also cautionary investigations warning of possible allergic effects on some patients. Reports also describe antidiabetic, anticancer and antibiotic activities, so we may expect to see a widening use of aloe gel. Several reputable suppliers produce a stabilized aloe gel for use as itself or in formulations and there may be moves towards isolating and eventually providing verified active ingredients in dosable quantities

Publication Types:

MeSH Terms:

Substances:

Number of References: 270
ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 20000228
Date Completed: 20000228
MeSH Date: 2000/03/04 09:00
Date Revised: 20011128
Entrez Date: 2000/01/07 09:00
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1999 Dec 15;68(1-3):3-37.
PMID: 10624859 UI: 20088197 [PubMed - indexed for MEDLINE]
From PubMed
86

Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast cells activated with specific antigen-antibody reactions.
Full author name: Ro, J Y; Lee, B C; Kim, J Y; Chung, Y J; Chung, M H; Lee, S K; Jo, T H; Kim, K H; Park, Y I.

Ro JY, Lee BC, Kim JY, Chung YJ, Chung MH, Lee SK, Jo TH, Kim KH, Park YI. J Pharmacol Exp Ther. 2000 Jan;292(1):114-21.

[Article in English]

Department of Pharmacology, Yonsei University College of Medicine, Seoul, Korea. JYRO426@yumc.yonsei.ac.kr

We previously reported that the glycoprotein extracted from aloe strongly inhibited the mediator releases caused by the activation of guinea pig lung mast cells. Therefore, this study aimed to purify a single component that has an antiallergic effect from crude aloe extract and then to assess the effects of aloe single component (alprogen) on the mechanism of mediator releases caused by the mast cell activation. We purified aloe extracts by using various columns. We also purified mast cells from guinea pig lung tissues by using enzyme digestion, rough and discontinuous density Percoll gradient. Mast cells were sensitized with IgG(1) (anti-ovalbumin) and challenged with ovalbumin. Histamine was assayed by using a fluorometric analyzer and leukotrienes by radioimmunoassay. [Ca(2+)](i) level was analyzed by using a confocal laser scanning microscope. Protein kinase activity was determined by the protein phosphorylated with [gamma-(32)P]ATP. The phospholipase D activity was assessed by the labeled phosphatidylalcohol. The amount of mass 1,2-diacylglycerol (DAG) was measured by the [(3)H]DAG produced when prelabeled with [(3)H]myristic acid. Phospholipase A(2) activity was determined by measuring the lyso-phosphatidylcholine released from the labeled phospholipids. Alprogen significantly decreased histamine and leukotriene releases and blocked completely Ca(2+) influx during mast cell activation. The protein kinase C and phospholipase D activities were decreased by alprogen in dose-dependent manner. Alprogen inhibited mass DAG formation and the phospholipase A(2) activity during mast cell activation. The data suggest that alprogen purified from aloe inhibits multiple signals as well as blocking Ca(2+) influx caused by mast cells activated with specific antigen-antibody reactions and that then the inhibition of histamine and leukotriene release follows.

MeSH Terms:

Substances:

ISSN: 0022-3565
NLM Unique ID: 0376362
Country: United States
Entry Date: 20000127
Date Completed: 20000127
MeSH Date: 1999/12/22 00:01
Date Revised: 20011128
Entrez Date: 1999/12/22
Citation Subset: IM
http://jpet.aspetjournals.org/cgi/pmidlookup?view=full&pmid=10604937
Full text URL: http://www.jpet.org/cgi/content/full/292/1/114
Publication Status: ppublish
J Pharmacol Exp Ther 2000 Jan;292(1):114-21.
PMID: 10604937 UI: 20072800 [PubMed - indexed for MEDLINE]
From PubMed
87

Aroma chemicals isolated and identified from leaves of Aloe arborescens Mill. Var. Natalensis Berger.
Full author name: Umano, K; Nakahara, K; Shoji, A; Shibamoto, T.

Umano K, Nakahara K, Shoji A, Shibamoto T. J Agric Food Chem. 1999 Sep;47(9):3702-5.

[Article in English]

Department of Environmental Toxicology, University of California, Davis, California 95616, USA.

Extracts from leaves of aloe (Aloe arborescens Mill. var. natalensis Berger) were obtained using two methods: steam distillation under reduced pressure followed by dichloromethane extraction (DRP) and simultaneous purging and extraction (SPE). A total of 123 aroma chemicals were identified in the extracts obtained by both methods using gas chromatography and gas chromatography/mass spectrometry. There were 42 alcohols, 23 terpenoids, 21 aldehydes, 9 esters, 8 ketones, 6 acids, 5 phenols, and 9 miscellaneous compounds. The major aroma constituents of this extract by DRP were (Z)-3-hexenol (29.89%), (Z)-3-hexenal (18.86%), (E)-hexenal (7.31%), 4-methyl-3-pentenol (5.66%), and butanol (4.29%). The major aroma constituents of this extract by SPE were (E)-2-hexenal (45.46%), (Z)-3-hexenal (32.12%), hexanal (9.14%), (Z)-3-hexenol (1.60%), and 3-pentanone (1.41%). Terpenoids were also found as one of the major constituents. The fresh green note of aloe leaves is due to the presence of these C(6) alcohols and aldehydes as well as terpenoids.

MeSH Terms:

Substances:

ISSN: 0021-8561
NLM Unique ID: 0374755
Country: United States
Entry Date: 20000912
Date Completed: 20000912
MeSH Date: 2000/09/19 11:01
Date Revised: 20011128
Entrez Date: 1999/12/20 09:00
Citation Subset: IM
http://dx.doi.org/10.1021/jf990116i
Full text URL: http://dx.doi.org/10.1021/jf990116i
Publication Status: ppublish
J Agric Food Chem 1999 Sep;47(9):3702-5.
PMID: 10552708 UI: 20026608 [PubMed - indexed for MEDLINE]
From PubMed
88

Screening of ten plant species for metaphase chromosome preparation in adult mosquitoes (Diptera: Culicidae) using an inoculation technique.
Full author name: Jitpakdi, A; Choochote, W; Insun, D; Tippawangkosol, P; Keha, P; Pitasawat, B.

Jitpakdi A, Choochote W, Insun D, Tippawangkosol P, Keha P, Pitasawat B. J Med Entomol. 1999 Nov;36(6):892-5.

[Article in English]

Department of Parasitology, Faculty of Medicine, Chiang Mai University, Thailand.

The screening of 10 plant species (Aloe barbadensis Mill., Asparagus officinalis L., As. plumosus Bak., As. racemosus Willd., As. sprengeri Regel, Codyline fruticosa Goppert, Dracaena loureiri Gagnep., Gloriosa superba L., Hemerocallis flava L., and Sansevieria cylindrica Bojer) for colchicine-like substance(s) using a mosquito cytogenetic assay revealed that a 1% solution of dried Gl. superba rhizome extracted in 0.85% sodium chloride solution could be used instead of a 1% colchicine in Hanks' balanced salt solution. The metaphase rates and average number of metaphase chromosomes per positive mosquito of Aedes aegypti (L.) after intrathoracic inoculation with 1% Gl. superba-extracted solution were 100% and 29.80 in females, and 90% and 25.78 in males, whereas the inoculation with 1% colchicine solution yielded 100 and 90% metaphase rates, and 20.90 and 12.22 average number of metaphase chromosomes per positive mosquito in females and males, respectively. The application of Gl. superba-extracted solution for metaphase chromosome preparation in other mosquito genera and species [e.g., Culex quinquefasciatus Say, Toxorhynchites splendens (Wiedemann), and Anopheles vagus (Doenitz)] also has yielded the satisfactory results.

MeSH Terms:

Substances:

ISSN: 0022-2585
NLM Unique ID: 0375400
Country: United States
Entry Date: 20000107
Date Completed: 20000107
MeSH Date: 1999/12/11 00:01
Date Revised: 20011128
Entrez Date: 1999/12/11
Citation Subset: IM
Publication Status: ppublish
J Med Entomol 1999 Nov;36(6):892-5.
PMID: 10593098 UI: 20060683 [PubMed - indexed for MEDLINE]
From PubMed
89

Initial characterization of the effects of Aloe vera at a crayfish neuromuscular junction.
Full author name: Friedman, R N; Si, K.

Friedman RN, Si K. Phytother Res. 1999 Nov;13(7):580-3.

[Article in English]

Section of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana 46202-5112, USA. rfriedma@iupui.edu

This study examines the effects of Aloe vera on neurotransmission processes in a well-established invertebrate neuromuscular junction preparation. We studied concentration-response relationships of an Aloe vera extract on excitatory junctional potentials (EJPs) at the opener muscle of the dactyl in the first and second walking limbs of crayfish (Procambarus clarkii and simulans). We observed concentration-dependent depolarizations of the muscle fibre membrane resting potential, depression of EJP amplitudes and an increase in latency to onset of the EJP following electrical stimulation of the isolated excitatory axon in the meropodite. These effects occurred with Aloe concentrations within the 1%-10% (wt-vol) range. Effects of lower concentrations, ranging to a minimum of 0.01% were equivocal. The effects of Aloe were at least partially, and in a majority of cases totally, reversible. EJPs reduced by Aloe could be restored by increasing the nerve stimulation amplitude. This, along with the latency increase, suggests a depression of action potential generation and conduction. The results provide a preliminary characterization of the effects of Aloe vera on the neurotransmission process and suggest that these effects may at least partially account for Aloe's analgesic and antiinflammatory effects. This study shows that the crayfish NMJ preparation should be useful for further elucidating the location(s) and mechanism(s) of action of Aloe on the nervous system. Copyright 1999 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 20000104
Date Completed: 20000104
MeSH Date: 1999/11/05 00:01
Date Revised: 20011128
Entrez Date: 1999/11/05
Citation Subset: IM
Publication Status: ppublish
Phytother Res 1999 Nov;13(7):580-3.
PMID: 10548750 UI: 20018455 [PubMed - indexed for MEDLINE]
From PubMed
90

Preparative isolation and purification of hydroxyanthraquinones from Rheum officinale Baill by high-speed counter-current chromatography using pH-modulated stepwise elution.
Full author name: Yang, F; Zhang, T; Tian, G; Cao, H; Liu, Q; Ito, Y.

Yang F, Zhang T, Tian G, Cao H, Liu Q, Ito Y. J Chromatogr A. 1999 Oct 8;858(1):103-7.

[Article in English]

Beijing Institute of New Technology Application, China.

Analytical and preparative high-speed counter-current chromatography was successfully used for the isolation and purification of hydroxyanthraquinones from Rheum officinale Baill (Dahuang) using pH-modulated stepwise elution. Four major components including chrysophanol, emodin, physcion and aloe-emodin were isolated each at over 98% purity.

MeSH Terms:

Substances:

NLM Unique ID: 9318488
Country: Netherlands
Entry Date: 19991116
Date Completed: 19991116
MeSH Date: 1999/11/02 00:01
Date Revised: 20011128
Entrez Date: 1999/11/02
Citation Subset: IM
Publication Status: ppublish
J Chromatogr A 1999 Oct 8;858(1):103-7.
PMID: 10544895 UI: 20010979 [PubMed - indexed for MEDLINE]
From PubMed
91

Separation and some properties of Aloe vera L. leaf pulp lectins.
Full author name: Akev, N; Can, A.

Akev N, Can A. Phytother Res. 1999 Sep;13(6):489-93.

[Article in English]

Department of Biochemistry, Faculty of Pharmacy, University of Istanbul, 34452 Universite, Istanbul, Turkey.

The separation and partial purification of two lectins from the leaf pulp of Aloe vera L. (=barbadensis Miller) is presented. The fraction showing haemagglutinating activity was precipitated at 50% ammonium sulphate concentration from the crude leaf pulp extract. The precipitate thus obtained, after dialysis, was applied to a hydroxylapatite column. Stepwise elution resulted in two peaks showing haemagglutinating activity eluted with 5 mM (Aloctin I) and 20 mM (Aloctin II) phosphate buffers. Haemagglutinating activity was estimated visually by adding a 4% rabbit erythrocyte suspension to serial two-fold dilutions of the lectins in microtitration plates. None of the 20 sugars tested inhibited haemag--glutinating activity of Aloctin I up a concentration of 500 mM. Aloctin II was inhibited by N-acetyl-D--galactosamine at 250 mM concentration. Of 10 metal ions tested, only Al(3+) salts were found to activate Aloctin I and II. On the other hand, it was shown that neither lectin possessed any alpha- and beta- galactosidase or alpha- and beta- glucosidase activity. The lectins were of glycoprotein structure containing approximately 5% neutral sugar. The specificity of the lectins towards human and rat erythrocytes was investigated. Copyright 1999 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 19991119
Date Completed: 19991119
MeSH Date: 1999/09/10 00:01
Date Revised: 20011128
Entrez Date: 1999/09/10
Citation Subset: IM
Publication Status: ppublish
Phytother Res 1999 Sep;13(6):489-93.
PMID: 10479759 UI: 99410711 [PubMed - indexed for MEDLINE]
From PubMed
92

Phenolic constituents of Cassia seeds and antibacterial effect of some naphthalenes and anthraquinones on methicillin-resistant Staphylococcus aureus.
Full author name: Hatano, T; Uebayashi, H; Ito, H; Shiota, S; Tsuchiya, T; Yoshida, T.

Hatano T, Uebayashi H, Ito H, Shiota S, Tsuchiya T, Yoshida T. Chem Pharm Bull (Tokyo). 1999 Aug;47(8):1121-7.

[Article in English]

Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Okayama University, Japan.

Thirteen phenolic glycosides including six new compounds were isolated from seeds of Cassia tora (Leguminosae). The structures of the new compounds, rubrofusarin triglucoside (7), nor-rubrofusarin gentiobioside (9), demethylflavasperone gentiobioside (10), torachrysone gentiobioside (11), torachrysone tetraglucoside (12) and torachrysone apioglucoside (13), were elucidated on the basis of spectroscopic and chemical evidence. The effects of the phenolic glycosides, their aglycones and several other compounds structurally related to them on Escherichia coli K12, Pseudomonas aeruginosa PAO1 and some strains of Staphylococcus aureus were then examined. Among them, torachrysone (15), toralactone (16), aloe-emodin (18), rhein (19) and emodin (20) showed noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-64 micrograms/ml. On the other hand, the phenolic compounds tested did not show strong antibacterial effects on E. coli and P. aeruginosa.

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19991022
Date Completed: 19991022
MeSH Date: 1999/09/09 00:01
Date Revised: 20011128
Entrez Date: 1999/09/09
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1999 Aug;47(8):1121-7.
PMID: 10478467 UI: 99407905 [PubMed - indexed for MEDLINE]
From PubMed
93

Antifungal effects of different plant extracts and their major components of selected aloe species.
Full author name: Ali, M I; Shalaby, N M; Elgamal, M H; Mousa, A S.

Ali MI, Shalaby NM, Elgamal MH, Mousa AS. Phytother Res. 1999 Aug;13(5):401-7.

[Article in English]

Botany Department, Faculty of Science, Cairo University, Giza 12613, Egypt.

Different extracts of both fresh and dry leaves of Aloe eru A. Berger, A. vera L. Webb & Berth and A. arborescens Mill. were screened for their antifungal activity against Aspergillus niger, Cladosporium herbarum and Fusarium moniliforme. The toxicity of the isolated pure components were evaluated on the tested fungi. A comparative chromatographic study was performed to differentiate between natural components existing in various fractions and extracts of Aloe species and specific spray reagents were used for the detection of anthraquinones in the isolated components. Copyright 1999 John Wiley & Sons, Ltd.

MeSH Terms:

Substances:

ISSN: 0951-418X
NLM Unique ID: 8904486
Country: England
Entry Date: 19991007
Date Completed: 19991007
MeSH Date: 1999/08/12 00:01
Date Revised: 20011128
Entrez Date: 1999/08/12
Citation Subset: IM
Publication Status: ppublish
Phytother Res 1999 Aug;13(5):401-7.
PMID: 10441780 UI: 99373519 [PubMed - indexed for MEDLINE]
From PubMed
94

Characterization of the genotoxicity of anthraquinones in mammalian cells.
Full author name: Mueller, S O; Stopper, H.

Mueller SO, Stopper H. Biochim Biophys Acta. 1999 Aug 5;1428(2-3):406-14.

[Article in English]

Department of Toxicology, University of Wurzburg, 97078, Wurzburg, Germany. mueller1@niehs.nih.gov

Naturally occurring 1,8-dihydroxyanthraquinones are under consideration as possible carcinogens. Here we wanted to elucidate a possible mechanism of their genotoxicity. All three tested anthraquinones, emodin, aloe-emodin, and danthron, showed capabilities to inhibit the non-covalent binding of bisbenzimide Hoechst 33342 to isolated DNA and in mouse lymphoma L5178Y cells comparable to the topoisomerase II inhibitor and intercalator m-amsacrine. In a cell-free decatenation assay, emodin exerted a stronger, danthron a similar and aloe-emodin a weaker inhibition of topoisomerase II activity than m-amsacrine. Analysis of the chromosomal extent of DNA damage induced by these anthraquinones was performed in mouse lymphoma L5178Y cells. Anthraquinone-induced mutant cell clones showed similar chromosomal lesions when compared to the topoisomerase II inhibitors etoposide and m-amsacrine, but were different from mutants induced by the DNA alkylator ethyl methanesulfonate. These data support the idea that inhibition of the catalytic activity of topoisomerase II contributes to anthraquinone-induced genotoxicity and mutagenicity.

MeSH Terms:

Substances:

ISSN: 0006-3002
NLM Unique ID: 0217513
Country: Netherlands
Entry Date: 19990927
Date Completed: 19990927
MeSH Date: 1999/08/06 00:01
Date Revised: 20011128
Entrez Date: 1999/08/06
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0304416599000641
Full text URL: http://www.elsevier.com:80/cgi-bin/cas/tree/store/bbagen/cas_sub/browse/br owse.cgi?year=1999&volume=1428&issue=2-3&aid=24822
Publication Status: ppublish
Biochim Biophys Acta 1999 Aug 5;1428(2-3):406-14.
PMID: 10434060 UI: 99365032 [PubMed - indexed for MEDLINE]
From PubMed
95

In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor).
Full author name: Kim, H S; Kacew, S; Lee, B M.

Kim HS, Kacew S, Lee BM. Carcinogenesis. 1999 Aug;20(8):1637-40.

[Article in English]

Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Changan-ku, Chunchun-dong, Kyunggi-do, Suwon 440-746, Korea.

A plant polysaccharide, Aloe gel extract, was reported to have an inhibitory effect on benzo[a]pyrene (B[a]P)-DNA adduct formation in vitro and in vivo. Hence, chemopreventive effects of plant polysaccharides [Aloe barbadensis Miller (APS), Lentinus edodes (LPS), Ganoderma lucidum (GPS) and Coriolus versicolor (CPS)] were compared using in vitro short-term screening methods associated with both initiation and promotion processes in carcinogenesis. In B[a]P-DNA adduct formation, APS (180 micrograms/ml) was the most effective in inhibition of B[a]P binding to DNA in mouse liver cells. Oxidative DNA damage (by 8-hydroxydeoxyguanosine) was significantly decreased by APS (180 micrograms/ml) and CPS (180 micrograms/ml). In induction of glutathione S-transferase activity, GPS was found to be the most effective among plant polysaccharides. In screening anti-tumor promoting effects, APS (180 micrograms/ml) significantly inhibited phorbol myristic acetate (PMA)-induced ornithine decarboxylase activity in Balb/3T3 cells. In addition, APS significantly inhibited PMA-induced tyrosine kinase activity in human leukemic cells. APS and CPS significantly inhibited superoxide anion formation. These results suggest that some plant polysaccharides produced both anti-genotoxic and anti-tumor promoting activities in in vitro models and, therefore, might be considered as potential agents for cancer chemoprevention.

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ISSN: 0143-3334
NLM Unique ID: 8008055
Country: England
Entry Date: 19990923
Date Completed: 19990923
MeSH Date: 1999/07/30 00:01
Date Revised: 20011128
Entrez Date: 1999/07/30
Citation Subset: IM
http://carcin.oupjournals.org/cgi/pmidlookup?view=full&pmid=10426820
Full text URL: http://carcin.oupjournals.org/cgi/content/full/20/8/1637
Publication Status: ppublish
Carcinogenesis 1999 Aug;20(8):1637-40.
PMID: 10426820 UI: 99355758 [PubMed - indexed for MEDLINE]
From PubMed
96

In vivo metabolism of aloemannan.
Full author name: Yagi, A; Nakamori, J; Yamada, T; Iwase, H; Tanaka, T; Kaneo, Y; Qiu, J; Orndorff, S.

Yagi A, Nakamori J, Yamada T, Iwase H, Tanaka T, Kaneo Y, Qiu J, Orndorff S. Planta Med. 1999 Jun;65(5):417-20.

[Article in English]

Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Japan. yagi@fupharm.fukuyama-u.ac.jp

The metabolism of fluoresceinyl isothiocyanate labeled aloemannan (FITC-AM) was examined by p.o. and i.v. administration in mice at a dose of 120 mg/kg. Analysis of FITC-AM in urine and feces showed that FITC-AM (MW 500 KD) was metabolized into smaller molecules that mainly accumulated in the kidneys. AM was catabolized by the human intestinal microflora to catabolites 1 and 2 with molecular weights of 30 and 10 KD, respectively. Hydrolysis of AM showed hexosamine peaks on HPAE. The findings suggest that the immunomodulation of AM may come from not only neutral polysaccharides but also contaminated hexosamine in AM.

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ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19990819
Date Completed: 19990819
MeSH Date: 1999/07/27 00:01
Date Revised: 20011128
Entrez Date: 1999/07/27
Citation Subset: IM
Publication Status: ppublish
Planta Med 1999 Jun;65(5):417-20.
PMID: 10418327 UI: 99346881 [PubMed - indexed for MEDLINE]
From PubMed
97

Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components.
Full author name: Lee, C K; Han, S S; Shin, Y K; Chung, M H; Park, Y I; Lee, S K; Kim, Y S.

Lee CK, Han SS, Shin YK, Chung MH, Park YI, Lee SK, Kim YS. Int J Immunopharmacol. 1999 May;21(5):303-10.

[Article in English]

College of Pharmacy, Chungbuk National University, Cheongju, South Korea. cklee@cbucc.chungbuk.ac.kr

We have recently reported that Aloe vera gel contains small molecular weight immunomodulators, G1C2F1, that restore ultraviolet B (UVB)-suppressed accessory cell function of epidermal Langerhans cells (LC) in vitro. In the present study we evaluated the UVB-protective activity of G1C2F1 in vivo. Exposure of the shaved abdominal skin of mice to 2.4 KJ/m2 of UVB radiation resulted in suppression of contact sensitization through the skin to 41.1%, compared to normal unirradiated skin. Topical application of G1C2F1 immediately after irradiation reduced this suppression significantly. The percentage recovery of UVB-suppressed contact hypersensitivity (CHS) response was 52.3, 77.3, and 86.6% when the irradiated skin was treated once with 0.1, 0.5, and 2.5 mg/ml of G1C2F1-containing cream, respectively. G1C2F1 did not show nonspecific stimulatory activity on CHS response. The present study, together with the previous observation, show that Aloe vera gel contains small molecular weight immunomodulators that prevent UVB-induced immune suppression in the skin by restoration of UVB-induced damages on epidermal LC.

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ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19990914
Date Completed: 19990914
MeSH Date: 1999/07/17 00:01
Date Revised: 20011128
Entrez Date: 1999/07/17
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0192056199000120
Publication Status: ppublish
Int J Immunopharmacol 1999 May;21(5):303-10.
PMID: 10408627 UI: 99335112 [PubMed - indexed for MEDLINE]
From PubMed
98

Medicinal herbs: a primer for primary care.
Full author name: Hadley, S K; Petry, J J.

Hadley SK, Petry JJ. Hosp Pract (Off Ed). 1999 Jun 15;34(6):105-6, 109-12, 115-6 passim.

Comment in:


[Article in English]

Department of Family and Community Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, Vt., USA.

Used for centuries as folk remedies, herbs are enjoying a surge of public interest. Some empiric findings have been supported by formal research results. In order to advise patients about such preparations, physicians need to be aware of the indications, contraindications, drug interactions, and potential side effects. Eight popular herbs are reviewed.

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Number of References: 12
ISSN: 8750-2836
NLM Unique ID: 8404149
Country: United States
Entry Date: 19990712
Date Completed: 19990712
MeSH Date: 1999/07/01 00:01
Date Revised: 20011128
Entrez Date: 1999/07/01
Citation Subset: AIM, IM
Publication Status: ppublish
Hosp Pract (Off Ed) 1999 Jun 15;34(6):105-6, 109-12, 115-6 passim.
PMID: 10386114 UI: 99313892 [PubMed - indexed for MEDLINE]
From PubMed
99

Antiinflammatory activity of Muktashukti bhasma.
Full author name: Chauhan, O; Godhwani, J L; Khanna, N K; Pendse, V K.

Chauhan O, Godhwani JL, Khanna NK, Pendse VK. Indian J Exp Biol. 1998 Oct;36(10):985-9.

[Article in English]

Department of Pharmacology and Experimental Therapeutics, Dr. Sampurnanand Medical College, Jodhpur, India.

Muktashukti bhasma (MSB), an Ayurvedic compound, consisting of pearl, Aloe vera and vinegar, inhibited acute and subacute inflammation in albino rats as induced by subplanter injection of carrageenan, histamine, 5-HT, nystatin and subcutaneous implant of cotton pellets. In all the test procedures the antiinflammatory response of 1000 mg/kg MSB was comparable to the response observed with 300 mg/kg acetylsalicylic acid (ASA). Oral premedication with MSB delayed castor oil-induced diarrhoea in rats, indicating its prostaglandin inhibitory activity. The antiinflammatory activity of the compound is attributed to its ability to cause inhibition of prostaglandins, histamine and 5-HT and also by stabilization of the lysosomal membranes. The antiinflammatory activity of MSB seems one third to half as potent as ASA.

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ISSN: 0019-5189
NLM Unique ID: 0233411
Country: India
Entry Date: 19990707
Date Completed: 19990707
MeSH Date: 1999/06/05 00:01
Date Revised: 20011128
Entrez Date: 1999/06/05
Citation Subset: IM
Publication Status: ppublish
Indian J Exp Biol 1998 Oct;36(10):985-9.
PMID: 10356960 UI: 99285448 [PubMed - indexed for MEDLINE]
From PubMed
100

[Phytotherapy in chronic dermatoses and wounds: what is the evidence?]
Full author name: Grimme, H; Augustin, M.

Grimme H, Augustin M. Forsch Komplementarmed. 1999 Apr;6 Suppl 2:5-8.

[Article in German]

Universitas-Hautklinik Freiburg. grimme@haut.ukl.uni-freiburg.de

Phytotherapeutic preparations and synthetic derivatives of plant origin have been used in conventional dermatology for a long time. A further spectrum of phytotherapeutic agents for the treatment of dermatological diseases and wounds is known from alternative medical treatment. To the efficacy of these phytotherapeutic agents only few data from studies are available. Own studies and studies published in the specialist literature, especially on chamomile, arnica, calendula, hamamelis, Aloe vera, cardiospermum, Mahonia aquifolium, oak bark, bittersweet stalk, and capsaicin indicate that these plants may be of value in selected dermatological indications. Other controlled clinical efficacy studies and pharmacological studies are needed to prove the assumed effects, to record the spectrum of side effects, and to clarify the mechanisms of action.

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Number of References: 36
ISSN: 1021-7096
NLM Unique ID: 9440428
Country: Switzerland
Vernacular Title: Phytotherapie bei chronischen Dermatosen und Wunden: Was ist gesichert?
Entry Date: 19990628
Date Completed: 19990628
MeSH Date: 2000/10/06 11:01
Date Revised: 20011102
Entrez Date: 1999/06/03 10:00
Citation Subset: IM
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=FKM&action=render&rendertype=fulltext&uid=FKM.fkm6b005
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=FKM&action=render&rendertype=pdf&uid=FKM.fkm6b005
Publication Status: ppublish
Forsch Komplementarmed 1999 Apr;6 Suppl 2:5-8.
PMID: 10352374 UI: 99286405 [PubMed - indexed for MEDLINE]
From PubMed
101

Wild Aloe harvesting in South Africa.
Full author name: Sachedina, H; Bodeker, G.

Sachedina H, Bodeker G. J Altern Complement Med. 1999 Apr;5(2):121-3.

[Article in English]

Selous Game Reserve, Tanzania.

MeSH Terms:

ISSN: 1075-5535
NLM Unique ID: 9508124
Country: United States
Entry Date: 19990915
Date Completed: 19990915
MeSH Date: 1999/05/18 00:01
Date Revised: 20011128
Entrez Date: 1999/05/18
Citation Subset: IM
Publication Status: ppublish
J Altern Complement Med 1999 Apr;5(2):121-3.
PMID: 10328633 UI: 99259185 [PubMed - indexed for MEDLINE]
From PubMed
102

Acemannan hydrogel dressing versus saline dressing for pressure ulcers. A randomized, controlled trial.
Full author name: Thomas, D R; Goode, P S; LaMaster, K; Tennyson, T.

Thomas DR, Goode PS, LaMaster K, Tennyson T. Adv Wound Care. 1998 Oct;11(6):273-6.

[Article in English]

Department of Internal Medicine, St. Louis University, MO, USA.

Aloe vera has been used for centuries as a topical treatment for various conditions and as a cathartic. An amorphous hydrogel dressing derived from the aloe plant (Carrasyn Gel Wound Dressing, Carrington Laboratories, Inc., Irving, TX) is approved by the Food and Drug Administration for the management of Stages I through IV pressure ulcers. To evaluate effectiveness of this treatment, 30 patients were randomized to receive either daily topical application of the hydrogel study dressing (acemannan hydrogel wound dressing) or a moist saline gauze dressing. Complete healing of the study ulcer occurred in 19 of 30 subjects (63%) during the 10-week observation period. No difference was observed in complete healing between the experimental and the control groups (odds ratio 0.93, 95% CI 0.16, 5.2). This study indicates that the acemannan hydrogel dressing is as effective as, but is not superior to, a moist saline gauze wound dressing for the management of pressure ulcers.

Publication Types:

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Substances:

ISSN: 1076-2191
NLM Unique ID: 9432971
Country: United States
Entry Date: 19990520
Date Completed: 19990520
MeSH Date: 1999/05/18 00:01
Date Revised: 20001218
Entrez Date: 1999/05/18
Citation Subset: N
Publication Status: ppublish
Adv Wound Care 1998 Oct;11(6):273-6.
PMID: 10326343 UI: 99258202 [PubMed - indexed for MEDLINE]
From PubMed
103

Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice.
Full author name: Yagi, T; Yamauchi, K.

Yagi T, Yamauchi K. J Pharm Pharmacol. 1999 Jan;51(1):93-5.

[Article in English]

Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.

This study was performed to determine whether intracaecally administered rhein anthrone and anthraquinones such as aloe-emodin, chrysophanol, emodin or rhein synergistically enhance the purgative action as has been observed for rhein anthrone and aloe-emodin anthrone. These anthraquinones were less potent than rhein anthrone. An equimolar mixture of aloe-emodin and rhein anthrone had synergistic potentiating effects because the ED50 value (50% purgative dose) of the combination was smaller than that calculated additively from the ED50 values of aloe-emodin and rhein anthrone. An equimolar mixture of other anthraquinones and rhein anthrone tended to potentiate the purgative action. These results confirmed that rhein anthrone and aloe-emodin synergistically exert a purgative action as has been observed for rhein anthrone and aloe-emodin anthrone.

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ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 19990709
Date Completed: 19990709
MeSH Date: 1999/04/10 00:01
Date Revised: 20001218
Entrez Date: 1999/04/10
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 1999 Jan;51(1):93-5.
PMID: 10197424 UI: 99211281 [PubMed - indexed for MEDLINE]
From PubMed
104

Isolation and characterization of a mannose-binding lectin from leaves of the Chinese daffodil Narcissus tazetta.
Full author name: Ooi, L S; Wang, H; Ng, T B; Ooi, V E.

Ooi LS, Wang H, Ng TB, Ooi VE. Biochem Cell Biol. 1998;76(4):601-8.

[Article in English]

Department of Biochemistry, Chinese University of Hong Kong, Shatin, New Territories, China. vincent-ooi@cuhk.edu.hk

A mannose-binding lectin was isolated from leaves of the Chinese daffodil Narcissus tazetta (family Amaryllidaceae) using a procedure that comprised extraction with aqueous buffer, ammonium sulfate precipitation, ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel Blue gel and mannose-agarose, and FPLC-gel filtration on Superose 12. The lectin was adsorbed on mannose-agarose and unadsorbed on DEAE-cellulose and Affi-gel Blue gel. It was an unglycosylated homodimer with a molecular mass of 26 kDa. Analysis of the N-terminal sequence of the N. tazetta lectin revealed considerable homology to lectins from the daffodil Narcissus pseudonarcissus, the snowdrop Galanthus nivalis (family Amaryllidaceae), the tulip Tulipa, and Kidachi aloe Aloe arborescens (family Liliaceae), and the orchid lectins (family Orchidaceae). The most striking likeness exists among the Amaryllidaceae lectins. The N. tazetta lectin exhibits hemagglutinating activity toward rabbit erythrocytes.

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ISSN: 0829-8211
NLM Unique ID: 8606068
Country: Canada
Entry Date: 19990615
Date Completed: 19990615
MeSH Date: 1999/04/01 00:01
Date Revised: 20020117
Entrez Date: 1999/04/01
Citation Subset: IM
Publication Status: ppublish
Biochem Cell Biol 1998;76(4):601-8.
PMID: 10099780 UI: 99199553 [PubMed - indexed for MEDLINE]
From PubMed
105

The role of nitric oxide in aloe-induced diarrhoea in the rat.
Full author name: Izzo, A A; Sautebin, L; Borrelli, F; Longo, R; Capasso, F.

Izzo AA, Sautebin L, Borrelli F, Longo R, Capasso F. Eur J Pharmacol. 1999 Feb 26;368(1):43-8.

[Article in English]

Department of Experimental Pharmacology, University of Naples Federico II, Italy.

The role of nitric oxide (NO) on aloe-induced diarrhoea was studied in the rat. Nine hours after oral administration, aloe produced diarrhoea at doses of 5 g kg(-1)(20% rats with diarrhoea) and 20 g kg(-1) (100% of rats with diarrhoea). Lower doses of aloe (0.1 and 1 g kg(-1) did not produce a diarrhoeal response. Pre-treatment (i.p.) of rats with the NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME 2.5-25 mg kg(-1) reduced the diarrhoea induced by aloe (20 g kg(-1) 9 h after its oral administration. L-NAME (25 mg kg(-1)) also reduced the increase in faecal water excretion produced by aloe (20 g kg(-1). L-arginine (1500 mg kg(-1), i.p.), administered to rats pre-treated with L-NAME (25 mg kg(-1), drastically reduced the effect of L-NAME on diarrhoea and increase in faecal water excretion induced by aloe (20 g kg(-1). Given alone, L-arginine did not modify aloe-induced diarrhoea. Basal Ca2+ -dependent NO synthase activity in the rat colon was dose-dependently inhibited by aloe (0.1-20 g kg(-1)) and by aloin (0.1-1 g kg(-1)), the active ingredient of aloe. These results suggest that endogenous NO modulates the diarrhoeal effect of aloe.

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Substances:

ISSN: 0014-2999
NLM Unique ID: 1254354
Country: Netherlands
Entry Date: 19990513
Date Completed: 19990513
MeSH Date: 1999/03/30 00:01
Date Revised: 20011128
Entrez Date: 1999/03/30
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0014299999000072
Publication Status: ppublish
Eur J Pharmacol 1999 Feb 26;368(1):43-8.
PMID: 10096768 UI: 99194432 [PubMed - indexed for MEDLINE]
From PubMed
106

The therapeutic potential of Aloe Vera in tumor-bearing rats.
Full author name: Corsi, M M; Bertelli, A A; Gaja, G; Fulgenzi, A; Ferrero, M E.

Corsi MM, Bertelli AA, Gaja G, Fulgenzi A, Ferrero ME. Int J Tissue React. 1998;20(4):115-8.

[Article in English]

Institute of General Pathology, Medical Faculty, University of Milan, Italy.

Aloe Vera has been claimed to contain several important therapeutic properties, including anticancer effects. The effect of Aloe Vera administration was studied on a pleural tumor in rat. Growth of Yoshida AH-130 ascite hepatoma cells injected (2 x 10(5) in 0.1 ml) into pleura of male inbred Fisher rats was evaluated at different times (7th and 14th days). Data show that the use of Aloe Vera proved a therapeutic method, and that the present experimental model could be useful in the study of other therapeutics treatments in vivo.

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Substances:

ISSN: 0250-0868
NLM Unique ID: 8302116
Country: Switzerland
Entry Date: 19990520
Date Completed: 19990520
MeSH Date: 1999/03/27 00:01
Date Revised: 20011128
Entrez Date: 1999/03/27
Citation Subset: IM
Publication Status: ppublish
Int J Tissue React 1998;20(4):115-8.
PMID: 10093794 UI: 99193754 [PubMed - indexed for MEDLINE]
From PubMed
107

Inhibition of UV-induced immune suppression and interleukin-10 production by plant oligosaccharides and polysaccharides.
Full author name: Strickland, F M; Darvill, A; Albersheim, P; Eberhard, S; Pauly, M; Pelley, R P.

Strickland FM, Darvill A, Albersheim P, Eberhard S, Pauly M, Pelley RP. Photochem Photobiol. 1999 Feb;69(2):141-7.

[Article in English]

Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. fstrickl@notes.mdacc.tmc.edu

Application of Aloe barbadensis poly/oligosaccharides to UV-irradiated skin prevents photosuppression of delayed-type hypersensitivity (DTH) responses in mice. We tested the hypothesis that these carbohydrates belong to a family of biologically active, plant-derived polysaccharides that can regulate responses to injury in animal tissues. C3H mice were exposed to 5 kJ/m2 UVB from unfiltered FS40 sunlamps and treated with between 1 pg and 10 micrograms tamarind xyloglucans or control polysaccharides methylcellulose or dextran in saline. The mice were sensitized 3 days later with Candida albicans. Tamarind xyloglucans and purified Aloe poly/oligosaccharides prevented suppression of DTH responses in vivo and reduced the amount of interleukin (IL)-10 observed in UV-irradiated murine epidermis. Tamarind xyloglucans were immunoprotective at low picogram doses. In contrast, the control polysaccharides methylcellulose and dextran had no effect on immune suppression or cutaneous IL-10 at any dose. Tamarind xyloglucans and Aloe poly/oligosaccharides also prevented suppression of immune responses to alloantigen in mice exposed to 30 kJ/m2 UVB radiation. To assess the effect of the carbohydrates on keratinocytes, murine Pam212 cells were exposed to 300 J/m2 UVB radiation and treated for 1 h with tamarind xyloglucans or Aloe poly/oligosaccharides. Treatment of keratinocytes with immunoprotective carbohydrates reduced IL-10 production by approximately 50% compared with the cells treated with UV radiation alone and completely blocked suppressive activity of the culture supernatants in vivo. The tamarind xyloglucans also blocked UV-activated phosphorylation of SAPK/JNK protein but had no effect on p38 phosphorylation. These results indicate that animals, like plants, may use carbohydrates to regulate responses to environmental stimuli.

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Grant Support:

ISSN: 0031-8655
NLM Unique ID: 0376425
Country: United States
Entry Date: 19990323
Date Completed: 19990323
MeSH Date: 1999/02/27 00:01
Date Revised: 20011128
Entrez Date: 1999/02/27
Citation Subset: IM
Publication Status: ppublish
Photochem Photobiol 1999 Feb;69(2):141-7.
PMID: 10048309 UI: 99157869 [PubMed - indexed for MEDLINE]
From PubMed
108

Effects of an aqueous extract of Aloe buettneri, Justicia insularis, Hibiscus macranthus, Dicliptera verticillata on some physiological and biochemical parameters of reproduction in immature female rats.
Full author name: Telefo, P B; Moundipa, P F; Tchana, A N; Tchouanguep Dzickotze, C; Mbiapo, F T.

Telefo PB, Moundipa PF, Tchana AN, Tchouanguep Dzickotze C, Mbiapo FT. J Ethnopharmacol. 1998 Dec;63(3):193-200.

[Article in English]

Department of Biochemistry, Faculty of Science, University of Yaounde I, Cameroon.

Different doses of aqueous extracts from the leaves of Aloe buettneri, Justicia insularis, Hibiscus macranthus and Dicliptera verticillata, locally used to regulate the menstrual cycle and to treat dysmenorrhea or infertility in women, were given daily to 22 day old rats for 5, 10, 15, 20 and 25 days by gastric intubation. At the end of each experimental period, the weights of ovaries and uteri, levels of uterine and ovarian proteins, ovarian cholesterol and serum oestradiol were evaluated. The results showed a decrease in growth rate of animals treated with 94 mg/kg per day at the end of the experimental period. The ovarian and uterine weights were high in all treated groups especially within the pubertal period (36-41 days old) when compared to the respective controls. During the same period, the parameters analysed showed significant differences in treated rats when compared to the controls. This was seen with ovarian and uterine protein levels, as well as with serum oestradiol whose level was especially high in the groups given 49 or 94 mg/kg per day of the plant extracts (52 and 42%, respectively when compared with the respective controls). A concomitant decrease in ovarian cholesterol was observed in the same treated groups. These results suggested a possible presence of oestrogenic compounds in the plant extracts.

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Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 19990604
Date Completed: 19990604
MeSH Date: 1999/02/25 00:01
Date Revised: 20001218
Entrez Date: 1999/02/25
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874198000622
Publication Status: ppublish
J Ethnopharmacol 1998 Dec;63(3):193-200.
PMID: 10030723 UI: 99153794 [PubMed - indexed for MEDLINE]
From PubMed
109

Medical therapy of inflammatory bowel disease for the 21st century.
Full author name: Robinson, M.

Robinson M. Eur J Surg Suppl. 1998;(582):90-8.

[Article in English]

University of Oklahoma College of Medicine, Oklahoma Foundation for Digestive Research, Oklahoma City 73104, USA. malcolm-robinson@ouhsc.edu

Inflammatory bowel disease therapy can be considered in several subcategories, and this review is designed to provide selective updates for some of the most important therapeutic entities currently marketed or soon to be available for the medical management of IBD. Although conventional corticosteroids have been a major component of acute inflammatory bowel disease management, steroids have many serious disadvantages; and toxicity is heightened with chronic steroid therapy. Newer corticosteroids, particularly budesonide, may be less toxic than older agents such as prednisone. Budesonide may be used as an enema in active distal ulcerative colitis (UC) or as delayed release tablets in Crohn's disease (CD). However, budesonide is not completely free from steroid side effects, and may share in some of the toxicity of older corticosteroids, particularly when high dose budesonide is administered. Topical and oral aminosalicylates are widely utilized for the treatment of mild to moderate active UC and mild active CD, and they also are efficacious for maintenance of IBD remission. Recent data continue to support the concept that higher doses and prolonged use of mesalamine-based drugs are therapeutically superior to lower doses and short term treatment. In addition, the combination of oral and rectal aminosalicylate formulations often succeeds in patients refractory to either used alone. The immunomodulatory drugs azathioprine and 6-mercaptopurine are particularly effective in treating both CD and UC, and methotrexate has also shown some promise in CD therapy. Immunosuppressive therapy for inflammatory bowel disease initially met with strong physician resistance. However, views have shifted in response to positive data on the utility of immunosuppressive agents in many cases of IBD. Although cyclosporine may be used as a 'rescue' medication in some severe IBD cases, it has been associated with severe toxic reactions. Possible candidates for cyclosporine treatment should be offered such therapy only in academic centers highly experienced with the nuances of this modality. Clinical trials of the newer entities IL-10, IL-11, tacrolimus, and anti-TNFalpha, have demonstrated variable efficacy in refractory IBD patients. Anti-TNFalpha has been very impressive, particularly in the presence of fistulizing Crohn's disease. Many physicians have utilized various antibiotics empirically as part of their 'general' management of IBD. Only metronidazole has been adequately studied in controlled CD trials, but other antibiotic studies are pending. Further exploration of antimicrobial treatment for IBD is clearly warranted. Many other investigational agents in disparate pharmaceutical categories have been employed in IBD therapy; and some of these also show varying degrees of promise, including the aloe vera derivative acemannan, several formulations of heparin, and both transdermal and intra-rectal nicotine. Despite the growing list of medications and formulations promoted for the treatment of IBD, no single drug or recognized combination has yet been confirmed as dependably clinically effective. Many additional investigations of IBD medical therapy are needed, including permutations of conventional medications, along with newer agents that may be more precisely targeted to specific aspects of IBD pathophysiology. All physicians who care for UC and CD patients enthusiastically await more optimal regimens for these challenging disorders.

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MeSH Terms:

Number of References: 64
NLM Unique ID: 9114489
Country: Norway
Entry Date: 19990421
Date Completed: 19990421
MeSH Date: 1999/02/24 00:01
Date Revised: 20001218
Entrez Date: 1999/02/24
Citation Subset: IM
Publication Status: ppublish
Eur J Surg Suppl 1998;(582):90-8.
PMID: 10029372 UI: 99151830 [PubMed - indexed for MEDLINE]
From PubMed
110

The development of a new method to detect the adulteration of commercial aloe gel powders.
Full author name: Kim, K H; Lee, J G; Kim, D G; Kim, M K; Park, J H; Shin, Y G; Lee, S K; Jo, T H; Oh, S T.

Kim KH, Lee JG, Kim DG, Kim MK, Park JH, Shin YG, Lee SK, Jo TH, Oh ST. Arch Pharm Res. 1998 Oct;21(5):514-20.

[Article in English]

College of Pharmacy, Kangwon National University, Chunchon, Korea.

Simple and accurate methods to detect the adulteration of commercial aloe gel powder were developed. Crude polysaccharide in aloe gel powder was isolated by precipitating with excess ethyl alcohol and total hexose in isolated polysaccharide was determined by Dubois assay. After hydrolysis of non-dialysable polysaccharides, resultant free sugar was determined by gas chromatography for sugar recognition and ash contents was considered simultaneously. In some products, the content of ash was very low while the content of total hexose was very high. And polysaccharides of these products revealed typical dextran pattern, therefore, these products could be identified that adulterated with commercial maltodextrin. The content of maltodextrin in adulterated product was determined by HPLC and TLC analysis which could be adopted as a part of a certification process.

MeSH Terms:

Substances:

ISSN: 0253-6269
NLM Unique ID: 8000036
Country: Korea
Entry Date: 19990208
Date Completed: 19990208
MeSH Date: 1999/01/06 00:01
Date Revised: 20011128
Entrez Date: 1999/01/06
Citation Subset: IM
Publication Status: ppublish
Arch Pharm Res 1998 Oct;21(5):514-20.
PMID: 9875487 UI: 99092646 [PubMed - indexed for MEDLINE]
From PubMed
111

In vitro angiogenic activity of Aloe vera gel on calf pulmonary artery endothelial (CPAE) cells.
Full author name: Lee, M J; Lee, O H; Yoon, S H; Lee, S K; Chung, M H; Park, Y I; Sung, C K; Choi, J S; Kim, K W.

Lee MJ, Lee OH, Yoon SH, Lee SK, Chung MH, Park YI, Sung CK, Choi JS, Kim KW. Arch Pharm Res. 1998 Jun;21(3):260-5.

[Article in English]

Institute of Biotechnology, Yeungnam University, Taegu, Korea.

Angiogenic activity of Aloe vera gel was investigated by in vitro assay. We obtained the most active fraction from dichloromethane extract of Aloe vera gel by partitioning between hexane and 90% aqueous methanol. The most active fraction (F3) increased the proliferation of calf pulmonary artery endothelial (CPAE) cells. In addition, F3 fraction induced CPAE cells to invade type 1 collagen gel and form capillary-like tube through in vitro angiogenesis assay, and increased the invasion of CPAE cells into matrigel through in vitro invasion assay. Furthermore, the effect on the mRNA expression of proteolytic enzymes which are key participants in the regulation of extracellular matrix degradation was investigated by northern blot analysis. F3 fraction enhanced mRNA expression of urokinase-type plasminogen activator (u-PA), matrix metalloproteinase-2 (MMP-2), and membrane-type MMP (MT-MMP) in CPAE cells whereas the expression of plasminogen activator inhibitor-1 (PAI-1) mRNA was not changed.

MeSH Terms:

Substances:

ISSN: 0253-6269
NLM Unique ID: 8000036
Country: Korea
Entry Date: 19990209
Date Completed: 19990209
MeSH Date: 1999/01/06 00:01
Date Revised: 20011128
Entrez Date: 1999/01/06
Citation Subset: IM
Publication Status: ppublish
Arch Pharm Res 1998 Jun;21(3):260-5.
PMID: 9875441 UI: 99092600 [PubMed - indexed for MEDLINE]
From PubMed
112

Influence of Aloe vera on collagen turnover in healing of dermal wounds in rats.
Full author name: Chithra, P; Sajithlal, G B; Chandrakasan, G.

Chithra P, Sajithlal GB, Chandrakasan G. Indian J Exp Biol. 1998 Sep;36(9):896-901.

[Article in English]

Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India.

Treatment of full-thickness wounds with A. vera, on rats resulted in increased biosynthesis of collagen and its degradation. A corresponding increase in the urinary excretion of hydroxyproline was also observed. Elevated levels of lysyl oxidase also indicated increased crosslinking of newly synthesised collagen. The results suggest that A. vera influences the wound healing process by enhancing collagen turnover in the wound tissue.

MeSH Terms:

Substances:

ISSN: 0019-5189
NLM Unique ID: 0233411
Country: India
Entry Date: 19990204
Date Completed: 19990204
MeSH Date: 1998/12/17 00:01
Date Revised: 20011128
Entrez Date: 1998/12/17
Citation Subset: IM
Publication Status: ppublish
Indian J Exp Biol 1998 Sep;36(9):896-901.
PMID: 9854430 UI: 99071594 [PubMed - indexed for MEDLINE]
From PubMed
113

Studies of aloe. VI. Cathartic effect of isobarbaloin.
Full author name: Ishii, Y; Takino, Y; Toyo'oka, T; Tanizawa, H.

Ishii Y, Takino Y, Toyo'oka T, Tanizawa H. Biol Pharm Bull. 1998 Nov;21(11):1226-7.

[Article in English]

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

The cathartic effect of isobarbaloin, a stereoisomer of barbaloin (compound principally responsible for the cathartic activity of Aloe), was examined in male rats by oral administration. Individual differences in sensitivity in the laxative activity of isobarbaloin and barbaloin was not found. The cathartic activity (ED50) of isobarbaloin in barbaloin positive rats was 19.2 mg/kg, nearly equal to that of barbaloin (19.5 mg/kg). Also, isobarbaloin administered orally was demonstrated to decompose to aloe-emodin-9-anthrone (active metabolite of barbaloin) as well as to barbaloin. Therefore, it is considered that the mechanism underlying the cathartic effect of isobarbaloin is the same as that of barbaloin.

MeSH Terms:

Substances:

ISSN: 0918-6158
NLM Unique ID: 9311984
Country: Japan
Entry Date: 19990226
Date Completed: 19990226
MeSH Date: 1998/12/16 00:01
Date Revised: 20011128
Entrez Date: 1998/12/16
Citation Subset: IM
Publication Status: ppublish
Biol Pharm Bull 1998 Nov;21(11):1226-7.
PMID: 9853419 UI: 99068308 [PubMed - indexed for MEDLINE]
From PubMed
114

Effect of anthraquinone-laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells.
Full author name: Schorkhuber, M; Richter, M; Dutter, A; Sontag, G; Marian, B.

Schorkhuber M, Richter M, Dutter A, Sontag G, Marian B. Eur J Cancer. 1998 Jun;34(7):1091-8.

[Article in English]

Institute of Tumour Biology--Cancer Research, University of Vienna, Austria.

Even though 1,8-dihydroxyanthraquinone (DHA)-laxatives have been implicated in colon carcinogenesis, the available information is still inconclusive. The aim of this study was to demonstrate the effect of the DHA-laxatives, danthrone, rhein, aloe-emodin and sennidine, on colorectal tumour cells. In SW480 carcinoma cultures, dose-dependent induction of urokinase secretion into the medium was the predominant effect. Simultaneously, cell numbers were decreased by DHA-aglycones, but not by sennoside or the biphenylic laxative bisacodyl. DNA synthesis was not similarly reduced: 0.4-4 microM danthrone and sennidine even stimulated 5-bromo-2'-desoxyuridine (BrdU) uptake into DNA. When uptake was normalised to cell number, danthrone and sennidine doubled BrdU uptake/10(6) cells, 18 microM rhein and 0.7 microM aloe-emodin induced increases of 37 and 50%, respectively. This may at least partially be due to selective resistance of S-phase cells to DHA-caused cell loss. In VACO235 adenoma cells, sennidine and aloe-emodin did not affect urokinase secretion, but stimulated growth. Both cell numbers and DNA synthesis were increased. In contrast to SW480 carcinoma cells, VACO235 cells were also sensitive to sennoside and bisacodyl. No effects of DHA were observed in normal colorectal epithelial cells. The biological effects were preceeded by specific phosphorylation of cellular proteins with molecular weights of 110, 78, 63, 57 kDa, indicating the specific induction of a cellular signalling cascade by the laxatives.

MeSH Terms:

Substances:

ISSN: 0959-8049
NLM Unique ID: 9005373
Country: England
Entry Date: 19981215
Date Completed: 19981215
MeSH Date: 1998/12/16 00:01
Date Revised: 20001218
Entrez Date: 1998/12/16
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0959804998000379
Publication Status: ppublish
Eur J Cancer 1998 Jun;34(7):1091-8.
PMID: 9849460 UI: 99066322 [PubMed - indexed for MEDLINE]
From PubMed
115

Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat.
Full author name: Shamaan, N A; Kadir, K A; Rahmat, A; Ngah, W Z.

Shamaan NA, Kadir KA, Rahmat A, Ngah WZ. Nutrition. 1998 Nov-Dec;14(11-12):846-52.

[Article in English]

Department of Biochemistry and Microbiology, Universiti Putra Malaysia, Selangor, Malaysia.

The effects of vitamin C and aloe vera gel extract supplementation on induced hepatocarcinogenesis in male Sprague-Dawley rats (120-150 g) by diethylnitrosamine (DEN) and 2-acetylaminofluorene (AAF) was investigated. The severity of the carcinogenesis process was determined by measuring gamma-glutamyl transpeptidase (GGT) and the placental form of glutathione S-transferase (GSTP) histochemically in situ and in plasma and liver fractions. In addition, plasma alkaline phosphatase (ALP) and liver microsomal uridine diphosphate glucuronyl transferase (UDPGT) activity were also determined. Administration of DEN/AAF caused an increase in the surface area and number of enzyme-positive foci (both GGT and GSTP) compared with control. Supplementation of vitamin C or aloe vera gel extract to the cancer-induced rats suppressed this increase significantly (P < 0.05; P < 0.001). Increases in liver UDPGT, GGT, and GSTP activities were also observed with cancer induction that were again suppressed with either vitamin C or aloe vera gel supplementation. Plasma GGT in the DEN/AAF rats were determined monthly for the duration of the experiment and found to be reduced as early as 1 mo with aloe vera gel supplementation and 2 mo with vitamin C supplementation. In conclusion, vitamin C and aloe vera gel extract supplementation were found to be able to reduce the severity of chemical hepatocarcinogenesis.

MeSH Terms:

Substances:

ISSN: 0899-9007
NLM Unique ID: 8802712
Country: United States
Entry Date: 19990309
Date Completed: 19990309
MeSH Date: 1998/12/03 00:01
Date Revised: 20011128
Entrez Date: 1998/12/03
Citation Subset: IM
Publication Status: ppublish
Nutrition 1998 Nov-Dec;14(11-12):846-52.
PMID: 9834927 UI: 99051992 [PubMed - indexed for MEDLINE]
From PubMed
116

Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis.
Full author name: Garnick, J J; Singh, B; Winkley, G.

Garnick JJ, Singh B, Winkley G. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 Nov;86(5):550-6.

[Article in English]

Department of Periodontics, School of Dentistry, Medical College of Georgia, Augusta, USA.

This research protocol was designed to test the effectiveness of a gel containing silicon dioxide, aloe vera, and allantoin in the healing of recurrent aphthous ulcers. The subjects were patients with histories of developing multiple ulcers on the oral mucosa during a 3-to-4-month period. The parameters used to evaluate healing were number of lesions during a 3-to-4-month period, length of the interval between ulcers, size of ulcers, and pain from ulcers. An approach was used in which data were accumulated from diaries maintained by the subjects throughout the study intervals. Because 3 active substances were present in the gel, a preliminary study (study I) was performed to indicate the effect of each active substance and each combination. In this phase, different combinations of the substances were compared with the use of the 2(3) factorial experimental design. The results of this study demonstrated that statistical differences in the durations of lesions (P = .017) were present when all 3 substances were included in the gel. In the next study (study II), which was initiated to test the results of study I, additional subjects were divided into 2 groups; one used a control gel with silicon dioxide, and the other a gel with all 3 active substances. Study II found no statistical differences in the parameters when the 2 groups were compared. In study III, a modified crossover design was used with the subjects of study II, and a significant difference was found in lesion-free intervals (P = have been caused by the differences in study length. Alteration in the occurrence of aphthous ulcers was demonstrated by the reduction in numbers of lesions in study I and by the increase in length of intervals between lesions in study III. However, a consistent pattern was not present; this indicated a lack of effect of the gel on aphthous ulcers.

Publication Types:

MeSH Terms:

Substances:

ISSN: 1079-2104
NLM Unique ID: 9508562
Country: United States
Entry Date: 19990113
Date Completed: 19990113
MeSH Date: 1998/11/27 00:01
Date Revised: 20011128
Entrez Date: 1998/11/27
Citation Subset: D, IM
Publication Status: ppublish
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998 Nov;86(5):550-6.
PMID: 9830646 UI: 99048338 [PubMed - indexed for MEDLINE]
From PubMed
117

[The action of an aqueous extract of Aloe barbadensis Miller in an in-vitro culture of Trichomonas vaginalis]
Full author name: Rojas, L; Matamoros, M; Garrido, N; Finlay, C.

Rojas L, Matamoros M, Garrido N, Finlay C. Rev Cubana Med Trop. 1995;47(3):181-4.

[Article in Spanish]

Instituto de Medicina Tropical Pedro Kouri.

The antiparasitic action of an aqueous extract of Aloe barbadensis Miller against and in vitro culture of Trichomonas vaginalis was studied for the first time. Three strains of this parasite were used for the study. Taking an initial concentration of 400 mg/mL of the extract, double serial dilutions were performed, and final concentrations based on the dried weight of the extract were 10.4, 20.8, 41, 83, and 160 mg/mL. Within 24 hours, percentages of inhibition greater than 50% were obtained from concentrations of 20.8 micrograms/mL. Similar results were obtained at 48, and 72 hours, with a lower concentration, the inhibition of growth was greater than 50%.

MeSH Terms:

Substances:

ISSN: 0375-0760
NLM Unique ID: 0074364
Country: Cuba
Vernacular Title: Acciion del extracto acuoso de aloe barbadensis Miller en el cultivo in vitro de Trichomonas vaginalis.
Entry Date: 19981125
Date Completed: 19981125
MeSH Date: 1998/11/14 00:01
Date Revised: 20011128
Entrez Date: 1998/11/14
Citation Subset: IM
Publication Status: ppublish
Rev Cubana Med Trop 1995;47(3):181-4.
PMID: 9813472 UI: 99030968 [PubMed - indexed for MEDLINE]
From PubMed
118

In vitro evaluation of complex carbohydrate denture adhesive formulations.
Full author name: Tello, C G; Ford, P; Iacopino, A M.

Tello CG, Ford P, Iacopino AM. Quintessence Int. 1998 Sep;29(9):585-93.

[Article in English]

Department of Restorative Dentistry, Baylor College of Dentistry, Dallas, Texas 75266-0677, USA.

OBJECTIVE: Acemannan, a complex mannose carbohydrate derived from the aloe vera plant, has an inherent stickiness/viscosity. Prototype Acemannan denture adhesive formulations were evaluated for pH changes, cytotoxicity to human gingival fibroblasts and adhesive strength in both dry and wet conditions. METHOD AND MATERIALS: The denture adhesive formulations consisted of five combinations of Acemannan with varying concentrations of preservatives and two other formulations without preservatives. The pH of each formulation was measured over 24 hours. Assessment of cytotoxicity was accomplished using the in vitro, tetrazolium-based colorimetric assay on cultures of human gingival fibroblasts after exposure to the adhesive formulations for up to 24 hours. The adhesive strength was evaluated with a universal testing machine under initial dry conditions and after immersion in a constant-temperature water bath for up to 20 minutes. RESULTS: Formulations 1 and 2 achieved and maintained pH values above 6.0 (the critical pH for hydroxyapatite dissolution) approximately 6 hours into the study. None of the prototypes demonstrated an initial pH above the critical pH. Formulations 1, 2, 3, and 5 exhibited significant cytotoxicity to human gingival fibroblasts over 24 hours. Formulations 4, 20:1, and 150:1 demonstrated minimal cytotoxicity. Formulation 1 exhibited the poorest adhesive strength, while the most viscous formulation (prototype 150:1) was by far the best performer. Generally, adhesive bond strengths for all prototypes were quite high and relatively stable over time in a wet environment. CONCLUSION: To achieve the ideal adhesive in terms of strength, pH, and cytotoxicity, Acemannan formulation 150:1 should be adjusted to contain the preservative concentration of formulation 4 and have an initial pH value of 6.0 or higher.

MeSH Terms:

Substances:

ISSN: 0033-6572
NLM Unique ID: 0342677
Country: England
Entry Date: 19981110
Date Completed: 19981110
MeSH Date: 1998/11/10 00:01
Date Revised: 20001218
Entrez Date: 1998/11/10
Citation Subset: D
Publication Status: ppublish
Quintessence Int 1998 Sep;29(9):585-93.
PMID: 9807143 UI: 99024275 [PubMed - indexed for MEDLINE]
From PubMed
119

Biotherapy with the pineal immunomodulating hormone melatonin versus melatonin plus aloe vera in untreatable advanced solid neoplasms.
Full author name: Lissoni, P; Giani, L; Zerbini, S; Trabattoni, P; Rovelli, F.

Lissoni P, Giani L, Zerbini S, Trabattoni P, Rovelli F. Nat Immun. 1998;16(1):27-33.

[Article in English]

Division of Radiation Oncology, San Gerardo Hospital, Monza, Milan, Italy.

The possibility of natural cancer therapy has been recently suggested by advances in the knowledge of tumor immunobiology. Either cytokines such as IL-2, or neurohormones, such as the pineal indole melatonin (MLT), may activate anticancer immunity. In addition, immunomodulating substances have also been isolated from plants, particularly from Aloe vera. Preliminary clinical studies had already shown that MLT may induce some benefits in untreatable metastatic solid tumor patients, whereas, for the time being, no clinical trial has been performed with aloe products. We have carried out a clinical study to evaluate whether the concomitant administration of aloe may enhance the therapeutic results of MLT in patients with advanced solid tumors for whom no effective standard anticancer therapies are available. The study included 50 patients suffering from lung cancer, gastrointestinal tract tumors, breast cancer or brain glioblastoma, who were treated with MLT alone (20 mg/day orally in the dark period) or MLT plus A. vera tincture (1 ml twice/day). A partial response (PR) was achieved in 2/24 patients treated with MLT plus aloe and in none of the patients treated with MLT alone. Stable disease (SD) was achieved in 12/24 and in 7/26 patients treated with MLT plus aloe or MLT alone, respectively. Therefore, the percentage of nonprogressing patients (PR + SD) was significantly higher in the group treated with MLT plus aloe than in the MLT gorup (14/24 vs. 7/26, p < 0.05). The percent 1-year survival was significantly higher in patients treated with MLT plus aloe (9/24 vs. 4/26, p < 0.05). Both treatments were well tolerated. This preliminary study would suggest that natural cancer therapy with MLT plus A. vera extracts may produce some therapeutic benefits, at least in terms of stabilization of disease and survival, in patients with advanced solid tumors, for whom no other standard effective therapy is available.

Publication Types:

MeSH Terms:

Substances:

ISSN: 1018-8916
NLM Unique ID: 9206126
Country: Switzerland
Entry Date: 19981223
Date Completed: 19981223
MeSH Date: 2000/08/16 11:00
Date Revised: 20011128
Entrez Date: 1998/10/28 03:02
Citation Subset: IM
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=NAM&action=render&rendertype=fulltext&uid=NAM.nam16027
http://www.online.karger.com/library/karger/renderer/dataset.exe?jcode=NAM&action=render&rendertype=pdf&uid=NAM.nam16027
Publication Status: ppublish
Nat Immun 1998;16(1):27-33.
PMID: 9789122 UI: 99007155 [PubMed - indexed for MEDLINE]
From PubMed
120

Aloe vera: magic or medicine?
Full author name: Atherton, P.

Atherton P. Nurs Stand. 1998 Jul 1-7;12(41):49-52, 54.

[Article in English]

Green College, University of Oxford.

Some recent studies appear to show topical and orally administered aloe vera preparations in patients with chronic venous leg ulcers may aid healing. Despite encouraging results, in the absence of larger research studies, the author cautions against generalisation of this complementary treatment.

Publication Types:

MeSH Terms:

Number of References: 18
ISSN: 0029-6570
NLM Unique ID: 9012906
Country: England
Entry Date: 19981022
Date Completed: 19981022
MeSH Date: 1998/10/20 00:01
Date Revised: 20011128
Entrez Date: 1998/10/20
Citation Subset: N
Publication Status: ppublish
Nurs Stand 1998 Jul 1-7;12(41):49-52, 54.
PMID: 9776900 UI: 98450063 [PubMed - indexed for MEDLINE]
From PubMed
121

Saprophytic and cycloheximide resistant fungi isolated from golden hamster.
Full author name: Bagy, M M; el-Shanawany, A A; Abdel-Mallek, A Y.

Bagy MM, el-Shanawany AA, Abdel-Mallek AY. Acta Microbiol Immunol Hung. 1998;45(2):195-207.

[Article in English]

Department of Botany, Faculty of Science, Assiut University, Egypt.

Healthy hair samples from golden hamsters were examined for the presence of dermatophytes and non-dermatophytes using baiting technique and direct inoculation. Thirty-four species and 2 varieties attributed to 17 genera were recovered. Paecilomyces variotii (isolated from 84.4% of the examined hair) and Aspergillus niger (81.3%) were the more frequent isolates on Sabouraud's dextrose agar (SDA) without cycloheximide. Our results have clearly demonstrated that the hair of hamster was free from true dermatophytes. Using the dilution plate method many fungal species were isolated from cage material (7 genera and 10 species + 1 variety); from faeces (10 genera and 17 species); from standard chow (3 genera and 6 species) of hamster. P. variotii which was the most frequent fungus in the preceding 3 substrates was completely absent in the presence of cycloheximide in SDA. The present study has demonstrated for the first time the isolation of Trichophyton rubrum from hamster faeces. Also, several saprophytic and cycloheximide resistant fungi were isolated. In the air of hamster cage Cladosporium cladosporioides, Penicillium chrysogenum, Alternaria alternata and Scopulariopsis brevicaulis were the most dominant species on SDA with or without cycloheximide. Using the agar diffusion method, Aloe sap, onion oil, garlic bulb extract and aqueous leaf extracts of Andropogon citratus, Euphorbia sp. and Ruta graveolens were tested for their antifungal activity on 10 fungal species. It was observed that onion oil exhibited a high inhibitory effect against most of the tested fungi.

MeSH Terms:

Substances:

ISSN: 1217-8950
NLM Unique ID: 9434021
Country: Hungary
Entry Date: 19981217
Date Completed: 19981217
MeSH Date: 1998/10/13 00:01
Date Revised: 20001218
Entrez Date: 1998/10/13
Citation Subset: IM
Publication Status: ppublish
Acta Microbiol Immunol Hung 1998;45(2):195-207.
PMID: 9768288 UI: 98441402 [PubMed - indexed for MEDLINE]
From PubMed
122

The efficacy of a new topical treatment for psoriasis: Mirak.
Full author name: Seyger, M M; van de Kerkhof, P C; van Vlijmen-Willems, I M; de Bakker, E S; Zwiers, F; de Jong, E M.

Seyger MM, van de Kerkhof PC, van Vlijmen-Willems IM, de Bakker ES, Zwiers F, de Jong EM. J Eur Acad Dermatol Venereol. 1998 Jul;11(1):13-8.

[Article in English]

Department of Dermatology, University Hospital Nijmegen, The Netherlands. m.seijger@derma.azn.nl

BACKGROUND: A new natural product for the treatment of psoriasis has recently become available in many European countries: Mirak. The Mirak Home Care Packs consist of natural spring water, volcanic earth and vitamin E cream. Recently, the efficacy of Mirak has come into question. As this treatment is used by many psoriasis patients in Europe, it is important for dermatologists to be informed about the clinical effects of the therapy. AIM: To evaluate the efficacy and side effects of the Mirak Home Care Packs. METHODS: By means of a placebo-controlled left/right comparison, both clinical and histological parameters were evaluated during 6 weeks of treatment. RESULTS: The reduction in induration was significantly greater in the Mirak-treated lesions than in the lesions treated with a placebo. A reduction in desquamation was found in both treatments; the difference between the treatments was not statistically significant. A decrease in number of proliferative cells in the Mirak-treated lesions was seen, but the difference with placebo-treated lesions was not significant. The other investigated parameters did not change during treatment. No side effects were seen. CONCLUSIONS: The Mirak Home Care Pack induces a modest therapeutic effect compared to placebo treatment, without significant side effects. Treatment with the Mirak Home Care Packs alone will probably not be able to compete with the already existing treatments for psoriasis.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0926-9959
NLM Unique ID: 9216037
Country: Netherlands
Entry Date: 19981112
Date Completed: 19981112
MeSH Date: 1998/09/10 00:01
Date Revised: 20011128
Entrez Date: 1998/09/10
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0926995998000075
Publication Status: ppublish
J Eur Acad Dermatol Venereol 1998 Jul;11(1):13-8.
PMID: 9731960 UI: 98400709 [PubMed - indexed for MEDLINE]
From PubMed
123

Observations on ethnoveterinary medicines in Trinidad and Tobago.
Full author name: Lans, C; Brown, G.

Lans C, Brown G. Prev Vet Med. 1998 May 1;35(2):125-42.

[Article in English]

School of Veterinary Medicine, University of the West Indies, St. Augustine, Trinidad and Tobago.

In 1995 research was conducted in Trinidad and Tobago with the aim of collecting knowledge on ethnoveterinary medicines in order to lay a foundation for further scientific study and validation. This paper describes only the ethnoveterinary practices used in the poultry sub-sector. A four stage process was used to conduct the research and document these ethnoveterinary practices. 28 ethnoveterinary respondents were identified using a modified Rapid Rural Appraisal (RRA) technique, the student essay method. Semi-structured interviews were conducted with these respondents as well as with 30 veterinarians, 27 extension officers and 19 animal health assistants/agricultural officers, and the 7 key respondents that they identified. 5 participatory workshops were then held with 55 of the respondents interviewed to discuss the data generated from the interviews and to determine dosages for some of the plants mentioned. 12 plant species were used to treat 4 categories of health problems common to poultry production. Aloe vera, Bryophyllum pinnatum, Citrus sp. and Momordica charantia were the main medicinal plants being used.

MeSH Terms:

ISSN: 0167-5877
NLM Unique ID: 8217463
Country: Netherlands
Entry Date: 19980910
Date Completed: 19980910
MeSH Date: 1998/07/01 00:01
Date Revised: 20001218
Entrez Date: 1998/07/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S016758779700055X
Publication Status: ppublish
Prev Vet Med 1998 May 1;35(2):125-42.
PMID: 9646336 UI: 98310304 [PubMed - indexed for MEDLINE]
From PubMed
124

Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites.
Full author name: Mueller, S O; Stopper, H; Dekant, W.

Mueller SO, Stopper H, Dekant W. Drug Metab Dispos. 1998 Jun;26(6):540-6.

[Article in English]

Department of Toxicology, University of Wurzburg, Versbacherstr. 9, 97078 Wurzburg, Germany.

The studies presented here were designed to elucidate the enzymes involved in the biotransformation of naturally occurring 1, 8-dihydroxyanthraquinones and to investigate whether biotransformation of 1,8-dihydroxyanthraquinones may represent a bioactivation pathway. We first studied the metabolism of emodin (1, 3,8-trihydroxy-6-methylanthraquinone), a compound present in pharmaceutical preparations. With rat liver microsomes, the formation of two emodin metabolites, omega-hydroxyemodin and 2-hydroxyemodin, was observed. The rates of formation of omega-hydroxyemodin were not different with microsomes from rats that had been pretreated with inducers for different cytochrome P450 enzymes. Thus, the formation of omega-hydroxyemodin seems to be catalyzed by several cytochrome P450 enzymes at low rates. The formation of 2-hydroxyemodin was increased in liver microsomes from 3-methylcholanthrene-pretreated rats and was inhibited by alpha-naphthoflavone, by an anti-rat cytochrome P450 1A1/2 antibody, and, to a lesser degree, by an anti-rat cytochrome P450 1A1 antibody. These data suggest the involvement of cytochrome P450 1A2 in the formation of this metabolite. However, other cytochrome P450 enzymes also seem to catalyze this reaction. The anthraquinone chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is transformed, in a cytochrome P450-dependent oxidation, to aloe-emodin (1, 8-dihydroxy-3-hydroxymethylanthraquinone) as the major product formed. The mutagenicity of the parent dihydroxyanthraquinones and their metabolites was compared in the in vitro micronucleus test in mouse lymphoma L5178Y cells. 2-Hydroxyemodin induced much higher micronucleus frequencies, compared with emodin. omega-Hydroxyemodin induced lower micronucleus frequencies, compared with emodin. Aloe-emodin induced significantly higher micronucleus frequencies than did chrysophanol. These data indicate that the cytochrome P450-dependent biotransformation of emodin and chrysophanol may represent bioactivation pathways for these compounds.

MeSH Terms:

Substances:

ISSN: 0090-9556
NLM Unique ID: 9421550
Country: United States
Entry Date: 19980701
Date Completed: 19980701
MeSH Date: 1998/06/17 00:01
Date Revised: 20001218
Entrez Date: 1998/06/17
Citation Subset: IM
http://dmd.aspetjournals.org/cgi/pmidlookup?view=full&pmid=9616189
Publication Status: ppublish
Drug Metab Dispos 1998 Jun;26(6):540-6.
PMID: 9616189 UI: 98282253 [PubMed - indexed for MEDLINE]
From PubMed
125

The effects of nutritional supplements on the symptoms of fibromyalgia and chronic fatigue syndrome.
Full author name: Dykman, K D; Tone, C; Ford, C; Dykman, R A.

Dykman KD, Tone C, Ford C, Dykman RA. Integr Physiol Behav Sci. 1998 Jan-Mar;33(1):61-71.

[Article in English]

Mannatech Inc., Coppell Texas 75019, USA.

This article reports the results of a within-subject design. Fifty subjects with a physician diagnosis of fibromyalgia (FM) and/or chronic fatigue syndrome (CFS) were interviewed using a structured interview from. Each subject was interviewed initially, and again nine months later (follow-up). Subjects had, on their own, consumed nutritional supplements including freeze-dried aloe vera gel extract; a combination of freeze-dried aloe vera gel extract and additional plant-derived saccharides; freeze-dried fruits and vegetables in combination with the saccharides; and a formulation of dioscorea complex containing the saccharides and a vitamin/mineral complex. With medical treatments, approximately 25 percent of FM patients improve, but the beneficial effects of medical treatment rarely persist more than a few months. All subjects in this study had received some form of medical treatment prior to taking the nutritional supplements, but none with enduring success. Nutritional supplements resulted in a remarkable reduction in initial symptom severity, with continued improvement in the period between initial assessment and the follow-up. Further research is needed to verify these results, specifically crossover designs in well-defined populations.

Publication Types:

MeSH Terms:

ISSN: 1053-881X
NLM Unique ID: 9105843
Country: United States
Entry Date: 19980714
Date Completed: 19980714
MeSH Date: 1998/05/22 00:01
Date Revised: 20001218
Entrez Date: 1998/05/22
Citation Subset: IM
Publication Status: ppublish
Integr Physiol Behav Sci 1998 Jan-Mar;33(1):61-71.
PMID: 9594356 UI: 98256712 [PubMed - indexed for MEDLINE]
From PubMed
126

Immunochemical distinction of Aloe vera, A. arborescens, and A. chinensis gels.
Full author name: Yagi, A; Tsunoda, M; Egusa, T; Akasaki, K; Tsuji, H.

Yagi A, Tsunoda M, Egusa T, Akasaki K, Tsuji H. Planta Med. 1998 Apr;64(3):277-8.

[Article in English]

Verectin antiserum raised in white rabbits was immunoprecipitated with the Aloe vera nondialysable fraction. Analysis of the immunoprecipitation revealed that verectin accounted for about 1.25% of the total proteins in the nondialysable fraction of Aloe vera gel. The verectin antibody showed differential immunoreactivities against nondialysable fractions of A. arborescens, A. chinensis, and A. vera: 1) an immunopreciptin line was formed against the fraction of A. vera, but not against those of A. arborescens and A. chinensis gel in an Ouchterlony double immunodiffusion test and 2) an immunopositive band was detected in the A. vera and A. chinensis nondialysable fractions but not in that of A. arborescens in immunoblotting. These findings indicate that the verectin antibody can be used to distinguish Aloe materials.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19980618
Date Completed: 19980618
MeSH Date: 1998/05/15 00:01
Date Revised: 20001218
Entrez Date: 1998/05/15
Citation Subset: IM
Publication Status: ppublish
Planta Med 1998 Apr;64(3):277-8.
PMID: 9581527 UI: 98242628 [PubMed - indexed for MEDLINE]
From PubMed
127

Aloe barbadensis extracts reduce the production of interleukin-10 after exposure to ultraviolet radiation.
Full author name: Byeon, S W; Pelley, R P; Ullrich, S E; Waller, T A; Bucana, C D; Strickland, F M.

Byeon SW, Pelley RP, Ullrich SE, Waller TA, Bucana CD, Strickland FM. J Invest Dermatol. 1998 May;110(5):811-7.

[Article in English]

Department of Immunology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.

Cutaneous exposure to ultraviolet radiation suppresses the induction of T cell mediated responses such as contact and delayed type hypersensitivity (DTH) by altering the function of immune cells in the skin and causing the release of immunoregulatory cytokines. Extracts of crude Aloe barbadensis gel prevent this photosuppression. Because the regulation of contact hypersensitivity and DTH responses differ, we investigated whether protection was afforded by a single or multiple agents in Aloe and the mechanism by which this material prevents suppression of DTH immunity. The ability of Aloe gel to prevent suppression of contact hypersensitivity responses to hapten decayed rapidly after manufacture. In contrast, agents that protected against systemic suppression of DTH responses to Candida albicans were stable over time. Oligosaccharides prepared from purified Aloe polysaccharide prevented suppression of DTH responses in vivo and reduced the amount of IL-10 observed in ultraviolet irradiated murine epidermis. To assess the effect of Aloe extracts on keratinocytes, Pam 212 cells were exposed in vitro to ultraviolet radiation and treated for 1 h with Aloe oligosaccharides. Culture supernatants were collected 24 h later and injected into mice. Supernatants from ultraviolet irradiated keratinocytes suppressed the induction of DTH responses, whereas Aloe oligosaccharide treatment reduced IL-10 and blocked the suppressive activity of the supernatants. These results indicate that Aloe contains multiple immunoprotective factors and that Aloe oligosaccharides may prevent ultraviolet induced suppression of DTH by reducing keratinocyte derived immunosuppressive cytokines.

MeSH Terms:

Substances:

Grant Support:

ISSN: 0022-202X
NLM Unique ID: 0426720
Country: United States
Entry Date: 19980601
Date Completed: 19980601
MeSH Date: 1998/05/14 00:01
Date Revised: 20011128
Entrez Date: 1998/05/14
Citation Subset: IM
http://www.blackwell-synergy.com/rd.asp?abbrev=J%20Invest%20Dermatol&vol=110&page=811&goto=abstract
Publication Status: ppublish
J Invest Dermatol 1998 May;110(5):811-7.
PMID: 9579551 UI: 98239154 [PubMed - indexed for MEDLINE]
From PubMed
128

Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats.
Full author name: Chithra, P; Sajithlal, G B; Chandrakasan, G.

Chithra P, Sajithlal GB, Chandrakasan G. Mol Cell Biochem. 1998 Apr;181(1-2):71-6.

[Article in English]

Department of Biochemistry, Central Leather Research Institute, Adyar, Madras, India.

Wound healing is a fundamental response to tissue injury that results in restoration of tissue integrity. This end is achieved mainly by the synthesis of the connective tissue matrix. Collagen is the major protein of the extracellular matrix, and is the component which ultimately contributes to wound strength. In this work, we report the influence of Aloe vera on the collagen content and its characteristics in a healing wound. It was observed that Aloe vera increased the collagen content of the granulation tissue as well as its degree of crosslinking as seen by increased aldehyde content and decreased acid solubility. The type I/type III collagen ratio of treated groups were lower than that of the untreated controls, indicating enhanced levels of type III collagen. Wounds were treated either by topical application or oral administration of Aloe vera to rats and both treatments were found to result in similar effects.

MeSH Terms:

Substances:

ISSN: 0300-8177
NLM Unique ID: 0364456
Country: Netherlands
Entry Date: 19980529
Date Completed: 19980529
MeSH Date: 1998/04/30 00:01
Date Revised: 20011128
Entrez Date: 1998/04/30
Citation Subset: IM
Publication Status: ppublish
Mol Cell Biochem 1998 Apr;181(1-2):71-6.
PMID: 9562243 UI: 98220712 [PubMed - indexed for MEDLINE]
From PubMed
129

10-Hydroxyaloin B 6'-O-Acetate, an Oxanthrone from Aloe claviflora

Dagne E, Bisrat D, Van Wyk BE, Viljoen A. J Nat Prod. 1998 Feb 27;61(2):256-7.

[Article in English]

Department of Chemistry, Addis Ababa University, P.O. Box 30270, Addis Ababa, Ethiopia, and Department of Botany, Rand Afrikaans University, P.O. Box 524, Auckland Park, Johannesburg, 2006, South Africa.

Analysis of the leaf exudate of Aloe claviflora resulted in the isolation of a new oxanthrone, 10-hydroxyaloin B 6'-O-acetate (1), whose structure was determined on the basis of spectral evidence as well as by conversion to the known compound 10-hydroxyaloin B (2). ISSN: 0163-3864
Journal Title Code: JA4
Entry Date: 19980420
MeSH Date: 1998/04/21
Entrez Date: 1998/04/21
Citation Subset: IM
http://dx.doi.org/10.1021/np970368i
Publication Status: ppublish
J Nat Prod 1998 Feb 27;61(2):256-7.
PMID: 9548856 UI: 0 [PubMed - as supplied by publisher]
From PubMed


130

Aloe-emodin effects on arylamine N-acetyltransferase activity in the bacterium Helicobacter pylori.
Full author name: Wang, H H; Chung, J G; Ho, C C; Wu, L T; Chang, S H.

Wang HH, Chung JG, Ho CC, Wu LT, Chang SH. Planta Med. 1998 Mar;64(2):176-8.

[Article in English]

Arylamine N-acetyltransferase (NAT) activities with p-aminobenzoic acid (PABA) and 2-aminofluorene (AF) were determined in H. pylori collected from peptic ulcer patients. Cytosols or suspensions of H. pylori with or without different concentrations of aloe-emodin co-treatment showed different percentages of AF and PABA acetylation. The data indicate that there was decreased NAT activity associated with increased aloe-emodin in H. pylori cytosols. Inhibition of growth study from H. pylori demonstrated that aloe-emodin elicited dose-dependent growth inhibition in H. pylori cultures. The report is the first finding of aloe-emodin inhibition of arylamine NAT activity in a strain of H. pylori.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19980423
Date Completed: 19980423
MeSH Date: 1998/04/03 00:01
Date Revised: 20001218
Entrez Date: 1998/04/03
Citation Subset: IM
Publication Status: ppublish
Planta Med 1998 Mar;64(2):176-8.
PMID: 9525111 UI: 98185824 [PubMed - indexed for MEDLINE]
From PubMed
131

Influence of aloe vera on the healing of dermal wounds in diabetic rats.
Full author name: Chithra, P; Sajithlal, G B; Chandrakasan, G.

Chithra P, Sajithlal GB, Chandrakasan G. J Ethnopharmacol. 1998 Jan;59(3):195-201.

[Article in English]

Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai, India.

The positive influence of Aloe vera, a tropical cactus, on the healing of full-thickness wounds in diabetic rats is reported. Full-thickness excision/incision wounds were created on the back of rats, and treated either by topical application on the wound surface or by oral administration of the Aloe vera gel to the rat. Wound granulation tissues were removed on various days and the collagen, hexosamine, total protein and DNA contents were determined, in addition to the rates of wound contraction and period of epithelialization. Measurements of tensile strength were made on treated/untreated incision wounds. The results indicated that Aloe vera treatment of wounds in diabetic rats may enhance the process of wound healing by influencing phases such as inflammation, fibroplasia, collagen synthesis and maturation, and wound contraction. These effects may be due to the reported hypoglycemic effects of the aloe gel.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 19980415
Date Completed: 19980415
MeSH Date: 1998/03/21 00:01
Date Revised: 20011128
Entrez Date: 1998/03/21
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874197001244
Publication Status: ppublish
J Ethnopharmacol 1998 Jan;59(3):195-201.
PMID: 9507904 UI: 98167322 [PubMed - indexed for MEDLINE]
From PubMed
132

Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats.
Full author name: Chithra, P; Sajithlal, G B; Chandrakasan, G.

Chithra P, Sajithlal GB, Chandrakasan G. J Ethnopharmacol. 1998 Jan;59(3):179-86.

[Article in English]

Department of Biochemistry, Central Leather Research Institute, Madras, India.

The influence of Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein GAG conjugates. In the present work, we have studied the influence of Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 19980415
Date Completed: 19980415
MeSH Date: 1998/03/21 00:01
Date Revised: 20011128
Entrez Date: 1998/03/21
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874197001128
Publication Status: ppublish
J Ethnopharmacol 1998 Jan;59(3):179-86.
PMID: 9507902 UI: 98167320 [PubMed - indexed for MEDLINE]
From PubMed
133

Isolation of cDNA for an NADP-malic enzyme from Aloe arborescens.
Full author name: Honda, H; Shimada, H; Akagi, H.

Honda H, Shimada H, Akagi H. DNA Res. 1997 Dec 31;4(6):397-400.

[Article in English]

Life Science Institute, Mitsui Chemicals, Inc., Mobara, Japan.

NADP-malic enzyme catalyzes the reaction of decarboxylation from malate. In CAM plants, functions of this enzyme diverged to include both photosynthetic and non-photosynthetic roles. A full length cDNA for an NADP-malic enzyme was isolated from an 'obligate' CAM plant aloe (Aloe arborescens). The cDNA contains an ORF encoding 592 amino acid residues, whose sequence is highly homologous to the known plant NADP-malic enzymes. This gene is constitutively expressed in all organs in a low level. The amount of the transcript exhibited no diurnal variation, suggesting that this gene is not involved in photosynthetic functions.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 1340-2838
NLM Unique ID: 9423827
Country: Japan
Entry Date: 19980428
Date Completed: 19980428
MeSH Date: 1998/03/21 00:01
Date Revised: 20011128
Entrez Date: 1998/03/21
Citation Subset: IM
Publication Status: ppublish
DNA Res 1997 Dec 31;4(6):397-400.
PMID: 9501996 UI: 98162727 [PubMed - indexed for MEDLINE]
From PubMed
134

Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae), and phorbol esters in Jatropha curcas (Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania, Biomphalaria and Bulinus.
Full author name: Liu, S Y; Sporer, F; Wink, M; Jourdane, J; Henning, R; Li, Y L; Ruppel, A.

Liu SY, Sporer F, Wink M, Jourdane J, Henning R, Li YL, Ruppel A. Trop Med Int Health. 1997 Feb;2(2):179-88.

[Article in English]

Institute of Tropical Hygiene and Public Health, University, Heidelburg, Germany.

Hot water extracts of Rheum plamatum and Rheum dentatus (from China) showed molluscicidal activity against the snails Oncomelania hupensis, Biomphalaria glabrata and Bulinus globosus, which are vectors of Schistosoma japonicum, S. mansoni and S. haematobium, respectively. Activity was correlated with antraquinones which were identified by HPLC: rhein and chrysophanol-anthron were most active (> 50% dead snails after 2 days in a 0.03% solution). Molluscicidal activity was intermediate with Rheum-emodin and physcion and was not detectable with cinnamic acid or Aloe-emodin. The snail O. hupensis tended to be more sensitive for several compounds than B. glabrata. Extracts of Jatropha curcas seeds (from Mali) showed molluscicidal activity against both B. glabrata and O. hupensis, the latter being the more sensitive snail. The activity was associated with phorbol esters extracted from Jatropha oil. Of the pure phorbol esters tested, 4 beta-phorbol-13-decanoate killed both snail species at a concentration of 0.001% (10 p.p.m). As Jatropha is locally grown in Mali for other purposes, it might potentially be exploited for schistosomiasis control.

MeSH Terms:

Substances:

ISSN: 1360-2276
NLM Unique ID: 9610576
Country: England
Entry Date: 19980324
Date Completed: 19980324
MeSH Date: 1998/02/24 00:01
Date Revised: 20011128
Entrez Date: 1998/02/24
Citation Subset: IM
Publication Status: ppublish
Trop Med Int Health 1997 Feb;2(2):179-88.
PMID: 9472303 UI: 98132888 [PubMed - indexed for MEDLINE]
From PubMed
135

Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel.
Full author name: Avila, H; Rivero, J; Herrera, F; Fraile, G.

Avila H, Rivero J, Herrera F, Fraile G. Toxicon. 1997 Sep;35(9):1423-30.

[Article in English]

Centro de Investigaciones Biomedicas (BIOMED), Facultad de Ciencias de la Salud, Universidad de Carabobo, Maracay, Venezuela.

The cytotoxicity of a low mol. wt fraction (LMWF) obtained from Aloe vera gel was determined by two different assays. Firstly, exposure of monolayers of chicken fibroblasts to LMWF induced disruption of intercellular junctions and detachment of individual cells from the bottom of the flask, with formation of cell-free gaps in the monolayer. Secondly, LMWF inhibited the production of reactive oxygen species by human polymorphonuclear leukocytes stimulated by zymosan, as followed by luminol-dependent chemiluminescence. The toxic activity of LMWF was compared to that of sodium dodecyl sulfate (a well-known toxic substance), aloe-emodin and aloin (an anthraquinone and its precursor present in Aloe vera cortex) using the chemilumescence assay, and was found to be of similar potency to these toxic substances on a weight-to-weight basis. These results confirm that Aloe vera gel contains toxic low mol. wt compounds, and every effort must be made to limit the amount of these toxins in the commercially prepared Aloe vera gel products.

MeSH Terms:

Substances:

ISSN: 0041-0101
NLM Unique ID: 1307333
Country: England
Entry Date: 19971231
Date Completed: 19971231
MeSH Date: 1997/12/24 00:01
Date Revised: 20011128
Entrez Date: 1997/12/24
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0041010197000202
Publication Status: ppublish
Toxicon 1997 Sep;35(9):1423-30.
PMID: 9403965 UI: 98067751 [PubMed - indexed for MEDLINE]
From PubMed
136

Prevention of ultraviolet radiation-induced suppression of accessory cell function of Langerhans cells by Aloe vera gel components.
Full author name: Lee, C K; Han, S S; Mo, Y K; Kim, R S; Chung, M H; Park, Y I; Lee, S K; Kim, Y S.

Lee CK, Han SS, Mo YK, Kim RS, Chung MH, Park YI, Lee SK, Kim YS. Immunopharmacology. 1997 Oct;37(2-3):153-62.

[Article in English]

College of Pharmacy, Chungbuk National University, Cheongju, South Korea.

The active components of Aloe vera gel that can prevent ultraviolet B (UVB)-induced suppression of accessory cell function of Langerhans cells (LC) were purified by activity-guided sequential fractionation followed by in vitro functional assay. The functional assay was based on the fact that exposure of freshly isolated murine epidermal cells (EC) to UVB radiation resulted in impairment of accessory cell function of LC, as measured by their ability to support anti-CD3 monoclonal antibody (mAb)-primed T-cell mitogenesis. This UVB-suppressed LC accessory cell function was prevented by addition of partially purified Aloe gel components to cultures of UVB-irradiated EC. The Aloe gel components appeared to prevent events occurring within the first 24 h after UVB irradiation that lead to the impairment of accessory cell function. The Aloe gel components did not cause proliferation of anti-CD3 mAb-primed T-cells, nor did induce proliferation of normal EC. The activity-guided final purification of Aloe gel components resulted in the isolation of two components. Both of the components were small molecular weight (MW) substances with an apparent MW of less than 1,000 Da but different from each other in net charge characteristics at pH 7.4. These results suggest that Aloe vera gel contains at least two small molecular weight immunomodulators that may prevent UVB-induced immune suppression in the skin.

MeSH Terms:

Substances:

ISSN: 0162-3109
NLM Unique ID: 7902474
Country: Netherlands
Entry Date: 19980202
Date Completed: 19980202
MeSH Date: 1997/12/24 00:01
Date Revised: 20011128
Entrez Date: 1997/12/24
Citation Subset: IM
Publication Status: ppublish
Immunopharmacology 1997 Oct;37(2-3):153-62.
PMID: 9403333 UI: 98067037 [PubMed - indexed for MEDLINE]
From PubMed
137

Effect of the combination of Aloe vera, nitroglycerin, and L-NAME on wound healing in the rat excisional model.
Full author name: Heggers, J P; Elzaim, H; Garfield, R; Goodheart, R; Listengarten, D; Zhao, J; Phillips, L G.

Heggers JP, Elzaim H, Garfield R, Goodheart R, Listengarten D, Zhao J, Phillips LG. J Altern Complement Med. 1997 Summer;3(2):149-53.

[Article in English]

University of Texas Medical Branch, Galveston, USA.

PURPOSE: Many systemic and topical therapeutic agents such as growth hormone, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), epidermal growth factor (EGF), and insulin-like growth factor (IGF) have been used as vulnerary agents. However, the role of nitric oxide (NO) as a wound-healing stimulant has been received with mixed reviews. NO is a potent vasodilator that is thought to be an endothelium-dependent relaxing factor, and a regulator of blood pressure and regional blood flow. It affects vascular smooth muscle proliferation and inhibits platelet aggregation and leukocyte adhesion. Therefore we compared the effects of several topical substances that have similar or reverse properties. METHODS: Using the excisional rat wound model, we evaluated the topical effects of Dermaide Aloe (D-Aloe, Dermaide Research Corp, Palos Heights, IL), nitroglycerin, Aquaphor (Beuersdorf, Inc., Norwalk, CT) alone, with D-Aloe with nitroglycerin, 2%, and L-NAME (NO inhibitor) with Aquaphor, and L-NAME with Aquaphor and D-Aloe for a 21-day period. All wounds were measured by planimetry at 1, 7, 10, 13, 16, 18, and 21 days. RESULTS: At day 1, all wounds had an average wound size of 2.27 cm2 (SD +/- 0.372) with no significant difference in wound size among the groups. Topically applied D-Aloe appeared to promote wound healing faster than the remaining other topicals (p < .05, Student-Newman-Keuls and Dunn's Method) over the study period. However, topicals combined with D-Aloe, the vehicle Aquaphor, and L-NAME improved the wound healing process when compared with nitroglycerin alone (p < .05). CONCLUSIONS: D-Aloe appears to have a wound-healing advancement factor that can reverse the effects of petrolatum- and nitroglycerin-based products as observed in the remaining groups when compared with nitroglycerin alone. It appears that D-Aloe's effect of preventing dermal ischemia by reversing the effects of thromboxane synthetase (TxA2) may act synergistically with NO or could be an oxygen radical scavenger.

MeSH Terms:

Substances:

ISSN: 1075-5535
NLM Unique ID: 9508124
Country: United States
Entry Date: 19980107
Date Completed: 19980107
MeSH Date: 1997/12/13 00:01
Date Revised: 20011128
Entrez Date: 1997/12/13
Citation Subset: IM
Publication Status: ppublish
J Altern Complement Med 1997 Summer;3(2):149-53.
PMID: 9395704 UI: 98051887 [PubMed - indexed for MEDLINE]
From PubMed
138

Beneficial effect of Aloe on wound healing in an excisional wound model.
Full author name: Heggers, J P; Kucukcelebi, A; Listengarten, D; Stabenau, J; Ko, F; Broemeling, L D; Robson, M C; Winters, W D.

Heggers JP, Kucukcelebi A, Listengarten D, Stabenau J, Ko F, Broemeling LD, Robson MC, Winters WD. J Altern Complement Med. 1996 Summer;2(2):271-7.

[Article in English]

University of Texas Medical Branch, Galveston, USA.

Recent evidence from in vitro and in vivo experiments suggests that topical antimicrobials may be toxic to fibroblasts and keratinocytes and retard wound healing. The purpose of this study was to determine the effects of Aloe, a potential wound-healing agent, on wound contraction in excisional wounds treated with topical antimicrobials. Sprague-Dawley rats were prepared with four 1.5 cm2 dorsal defects through the skin and panniculus. The animals were divided into five groups (n = 10 per group): (1) Aloe, (2) NaOCl solution (0.025%), (3) mafenide acetate, (4) mafenide acetate + Aloe, and (5) control. Wounds were treated topically for 14 days 3 times a day. Serial standard photographs and serial wound planimetry were performed weekly. Following healing, the breaking strength of each resultant scar was determined using an Instron tensiometer. Kruskal-Wallis, ANOVA, and multiple comparison methods were used for data analysis. Aloe and NaOCl solution significantly accelerated wound contraction (p < 0.05). In the mafenide acetate + Aloe group, contraction was similar to the control, whereas the mafenide acetate alone retarded wound healing. The addition of Aloe in combination and alone in wounds increased the breaking energy when compared to controls (p < 0.05). Aloe appears to expedite wound contraction and neutralize the wound retardant effect seen with the topical mafenide acetate alone. This effect appears to be due to an increased collagen activity, which is enhanced by a lectin, consequently improving the collagen matrix and enhancing the breaking strength.

MeSH Terms:

Substances:

ISSN: 1075-5535
NLM Unique ID: 9508124
Country: United States
Entry Date: 19971223
Date Completed: 19971223
MeSH Date: 1997/12/13 00:01
Date Revised: 20011128
Entrez Date: 1997/12/13
Citation Subset: IM
Publication Status: ppublish
J Altern Complement Med 1996 Summer;2(2):271-7.
PMID: 9395659 UI: 98051842 [PubMed - indexed for MEDLINE]
From PubMed
139

An overview of the topical management of wounds.
Full author name: Liptak, J M.

Liptak JM. Aust Vet J. 1997 Jun;75(6):408-13.

[Article in English]

Department of Companion Animal Medicine and Surgery, University of Queensland.

Wounds in animals are a common and frequent reason for seeking veterinary attention. The way in which wounds are managed affect the rate of healing, the time to return to normal function, the final cosmetic appearance, and hence the satisfaction of customers. The management of wounds depends on the stage of wound healing and can include irrigation, mechanical and chemical debridement, the use of antiseptics and antimicrobials, adherent and nonadherent dressings, and miscellaneous topical applications such as aloe vera, honey and live yeast cell derivative. The advantages, disadvantages and indications for initial wound management, topical applicants and dressings are discussed.

Publication Types:

MeSH Terms:

Substances:

Number of References: 29
ISSN: 0005-0423
NLM Unique ID: 0370616
Country: Australia
Entry Date: 19971124
Date Completed: 19971124
MeSH Date: 1997/06/01 00:01
Date Revised: 20001218
Entrez Date: 1997/06/01
Citation Subset: IM
Publication Status: ppublish
Aust Vet J 1997 Jun;75(6):408-13.
PMID: 9247688 UI: 97390853 [PubMed - indexed for MEDLINE]
From PubMed
140

Necrotizing fasciitis: case study of a nursing dilemma.
Full author name: Ardire, L.

Ardire L. Ostomy Wound Manage. 1997 Jun;43(5):30-4, 36, 38-40; passim.

[Article in English]

Shore Memorial Hospital, Somers Point, NJ, USA.

Necrotizing fasciitis usually manifests as a low grade cellulitis that quickly deteriorates to a limb and life threatening soft tissue infection. Immediate surgical debridement is essential, after which wound management becomes the nurse's primary concern. Case #1 reports on a 72 year old female who, upon presenting to the ER with a "sore bottom," subsequently had these diagnoses: (1) anal-rectal abscess, (2) Fournier's gangrene, (3) ulcerative enterocolitis, (4) chronic blood loss/anemia, and (5) protein caloric malnutrition. After debridement, her anal-rectal wound extended from labia to left buttocks. Care was multidisciplinary and included applying a water based aloe gel and saline soaked gauze twice a day. After 45 days, the wound exhibited a pink base with granulation tissue and contraction of the wound edges. Case #2 reports on a 48 year old male with seroma of the left leg secondary to a crush injury. Within three days he developed deep vein thrombosis in that leg as well as two large seroma cavities on either side of the thigh. Care included packing with the aloe gel and saline soaked sponges. Two weeks after admission, the anterior wound was covered with a split thickness skin graft while partial closure of the lateral cavity was attempted unsuccessfully with retention sutures. After five weeks, healing was complete for the anterior wound and 95 percent complete for the posterior wound.

MeSH Terms:

ISSN: 0889-5899
NLM Unique ID: 8912029
Country: United States
Entry Date: 19970801
Date Completed: 19970801
MeSH Date: 1997/06/01 00:01
Date Revised: 20001218
Entrez Date: 1997/06/01
Citation Subset: N
Publication Status: ppublish
Ostomy Wound Manage 1997 Jun;43(5):30-4, 36, 38-40; passim.
PMID: 9233237 UI: 97377580 [PubMed - indexed for MEDLINE]
From PubMed
141

Inhibition of benzo[a]pyrene-DNA adduct formation by Aloe barbadensis Miller.
Full author name: Kim, H S; Lee, B M.

Kim HS, Lee BM. Carcinogenesis. 1997 Apr;18(4):771-6.

[Article in English]

Division of Toxicology, College of Pharmacy, Sung Kyun Kwan University, Suwon City, Kyunggi-Do, South Korea.

The antigenotoxic and chemopreventive effect of Aloe barbadensis Miller (polysaccharide fraction) on benzo[a]pyrene (B[a]P)-DNA adducts was investigated in vitro and in vivo. Aloe showed a time-course and dose-dependent inhibition of [3H]B[a]P-DNA adduct formation in primary rat hepatocytes (1x10(6) cells/ml) treated with [3H]B[a]P (4 nmol/ml). At concentrations of 0.4-250 microg/ml aloe, the binding of [3H]B[a]P metabolites to rat hepatocyte DNA was inhibited by 9.1-47.9%. Also, in rat hepatocytes cultured for 3-48 h with aloe (250 microg/ml) and [3H]B[a]P (4 nmol/ml), [3H]B[a]P-DNA adducts were significantly reduced by 36% compared with [3H]B[a]P alone. Aloe also inhibited cellular uptake of [3H]B[a]P in a dose-dependent manner at a concentration of 0.4-250 microg/ml by 6.3-34.1%. After a single oral administration of B[a]P to male ICR mice (10 mg/mouse), benzo[a]pyrene diol epoxide I (BPDE-I)-DNA adduct formation and persistence for 16 days following daily treatment with aloe (50 mg/mouse) were quantitated by enzyme-linked immunosorbent assay using monoclonal antibody 8E11. In this animal model, BPDE-I-DNA adduct formation was significantly inhibited in various organs (liver, kidney, forestomach and lung) (P < 0.001). When mice were pretreated with aloe for 16 days before B[a]P treatment, inhibition of BPDE-I-DNA adduct formation and persistence was enhanced. Glutathione S-transferase activity was slightly increased in the liver but cytochrome P450 content was not affected by aloe. These results suggest that the inhibitory effect of aloe on BPDE-I-DNA adduct formation might have a chemopreventive effect by inhibition of B[a]P absorption.

MeSH Terms:

Substances:

ISSN: 0143-3334
NLM Unique ID: 8008055
Country: England
Entry Date: 19970509
Date Completed: 19970509
MeSH Date: 1997/04/01 00:01
Date Revised: 20011128
Entrez Date: 1997/04/01
Citation Subset: IM
Publication Status: ppublish
Carcinogenesis 1997 Apr;18(4):771-6.
PMID: 9111213 UI: 97265276 [PubMed - indexed for MEDLINE]
From PubMed
142

The use of genomic in situ hybridization (GISH) to show transmission of recombinant chromosomes by a partially fertile bigeneric hybrid, Gasteria lutzii x Aloe aristata (Aloaceae), to its progeny.
Full author name: Takahashi, C; Leitch, I J; Ryan, A; Bennett, M D; Brandham, P E.

Takahashi C, Leitch IJ, Ryan A, Bennett MD, Brandham PE. Chromosoma. 1997 Apr;105(6):342-8.

[Article in English]

Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey TW9 3DS, UK.

Genomic in situ hybridization (GISH) was used to study somatic chromosomes of parental and progeny plants (all 2n=2x=14) of the bigeneric hybrid between Gasteria lutzii and Aloe aristata (Aloaceae), which is partially fertile, a rare occurrence in plants. GISH successfully distinguished between the two parental genomes in the F1 hybrid and revealed numerous genomic recombinations in chromosomes transmitted by the F1 to the back-cross progeny. The results indicate high levels of meiotic compatibility between the parental genomes, even though they differ in size by 20%. Recombination occurred at a frequency that was higher than that expected from the analysis of orcein-stained meiosis in the F1. The discrepancy suggests that terminalization may occur prior to or during metaphase I, reducing the apparent chiasma frequency, or possibly reveals an under-estimation caused by difficulties in resolving closely grouped chiasmata by eye.

MeSH Terms:

Substances:

ISSN: 0009-5915
NLM Unique ID: 2985138R
Country: Germany
Entry Date: 19970616
Date Completed: 19970616
MeSH Date: 1997/04/01 00:01
Date Revised: 20011128
Entrez Date: 1997/04/01
Citation Subset: IM
http://link.springer-ny.com/link/service/journals/00412/bibs/7105006/71050342.htm
Publication Status: ppublish
Chromosoma 1997 Apr;105(6):342-8.
PMID: 9087376 UI: 97244572 [PubMed - indexed for MEDLINE]
From PubMed
143

Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan.
Full author name: Stuart, R W; Lefkowitz, D L; Lincoln, J A; Howard, K; Gelderman, M P; Lefkowitz, S S.

Stuart RW, Lefkowitz DL, Lincoln JA, Howard K, Gelderman MP, Lefkowitz SS. Int J Immunopharmacol. 1997 Feb;19(2):75-82.

[Article in English]

Department of Biological Sciences, Texas Tech University, Lubbock 79409, U.S.A.

Previous studies by these investigators have shown that mannosylated bovine serum albumin (m-BSA) enhances the respiratory burst (RB), phagocytosis, and killing of Candida albicans by resident murine peritoneal macrophages (MO). Upregulation of the above MO functions was associated with binding of m-BSA to the MO-mannose receptor. The present study was done to determine if the immunostimulant, acemannan prepared from aloe vera, could stimulate MO in a similar manner. Resident peritoneal MO collected from C57BL/6 mice were exposed to acemannan for 10 min. The RB was measured using chemiluminescence and demonstrated approximately a two-fold increase above the media controls. In studies involving phagocytosis, MO were exposed to acemannan, washed and exposed to Candida at a ratio of 1:5. The percent phagocytosis and Candida killing were determined using fluorescence microscopy. There was a marked increase in phagocytosis in the treated cultures (45%) compared to controls (25%). Macrophages exposed to acemannan for 10 min resulted in ca 38% killing of Candida albicans compared with 0-5% killing in controls. If MO were incubated with acemannan for 60 min, 98% of the yeast were killed compared to 0-5% in the controls. The results of the present study indicate that short term exposure of MO to acemannan upregulates the RB, phagocytosis and candidicidal activity. Further studies are needed to clarify the potential use of this immunostimulant as an anti-fungal agent.

MeSH Terms:

Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19971023
Date Completed: 19971023
MeSH Date: 1997/02/01 00:01
Date Revised: 20011102
Entrez Date: 1997/02/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0192056197000106
Publication Status: ppublish
Int J Immunopharmacol 1997 Feb;19(2):75-82.
PMID: 9278177 UI: 97422409 [PubMed - indexed for MEDLINE]
From PubMed
144

Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells.
Full author name: Lee, K Y; Park, J H; Chung, M H; Park, Y I; Kim, K W; Lee, Y J; Lee, S K.

Lee KY, Park JH, Chung MH, Park YI, Kim KW, Lee YJ, Lee SK. Biochem Mol Biol Int. 1997 Feb;41(2):285-92.

[Article in English]

College of Pharmacy, Seoul National University, Korea.

In the present study, we show that aloesin, which is a low molecular weight ingredients present in Aloe vera, stimulates the proliferation of cultured human hepatoma SK-HEP-1 cells. The incorporation of [3H] thymidine into DNA in the cell cultures was significantly increased at a dose of 10 microM aloesin. The aloesin-induced DNA synthesis appears to require newly synthesized proteins because cycloheximide treatment blocked the DNA synthesis evoked by this compound. We then examined whether this compound increases the intracellular levels of cell cycle regulators by immunoblotting. The data showed that aloesin increased the levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells. In addition, immuno-complex kinase assays showed that aloesin up-regulated the enzyme activity of cyclin E/CDK2 kinase in a dose-dependent manner. Collectively, these results suggest that aloesin stimulates the proliferation of SK-HEP-1 cells by inducing the intracellular levels of cyclin E/CDK2 kinase complex and CDC25A, which, together, result in the up-regulation of cyclin E-dependent kinase activity.

MeSH Terms:

Substances:

ISSN: 1039-9712
NLM Unique ID: 9306673
Country: Australia
Entry Date: 19970611
Date Completed: 19970611
MeSH Date: 1997/02/01 00:01
Date Revised: 20011102
Entrez Date: 1997/02/01
Citation Subset: IM
Publication Status: ppublish
Biochem Mol Biol Int 1997 Feb;41(2):285-92.
PMID: 9063568 UI: 97217597 [PubMed - indexed for MEDLINE]
From PubMed
145

Isolation and characterization of the glycoprotein fraction with a proliferation-promoting activity on human and hamster cells in vitro from Aloe vera gel.
Full author name: Yagi, A; Egusa, T; Arase, M; Tanabe, M; Tsuji, H.

Yagi A, Egusa T, Arase M, Tanabe M, Tsuji H. Planta Med. 1997 Feb;63(1):18-21.

[Article in English]

Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan.

Fractions of leaf gel from Aloe barbadensis Mill. were prepared by gel permeation using DEAE Sephadex A-25, Sepharose 6B, and Sephadex G-50 columns. These were then tested by in vitro assays for proliferation of human normal dermal and baby hamster kidney cells. The glycoprotein fraction promoted cell growth, while the neutral polysaccharide fraction did not show any growth stimulation. Moreover, the polar-colored glycoprotein fraction strongly inhibited the in vitro assays. An active glycoprotein fraction (protein 82%, carbohydrate 11%) examined on polyacrylamide gel electrophoresis (PAGE) and SDS-PAGE showed a single band. Its molecular weight was 29 kD on a Sephadex G-50 column and its isoelectric point was pH 6.8. Immunoblotting after SDS-PAGE showed that the glycoprotein was composed of two subunits (14 kD). Deglycosylation of glycoprotein (Pg21-2b fraction) by trifluoromethanesulphonic acid provided a protein band with a molecular weight of 13 kD on SDS-PAGE. The colored glycoprotein fraction was shown on SDS-PAGE to be a mixture with a molecular weight of 18 kD-15 kD. It was later hydrolyzed with 10% H2SO4 to produce phenolic substances.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19970409
Date Completed: 19970409
MeSH Date: 1997/02/01 00:01
Date Revised: 20011128
Entrez Date: 1997/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1997 Feb;63(1):18-21.
PMID: 9063091 UI: 97217070 [PubMed - indexed for MEDLINE]
From PubMed
146

The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion.
Full author name: Yagi, T; Yamauchi, K; Kuwano, S.

Yagi T, Yamauchi K, Kuwano S. J Pharm Pharmacol. 1997 Jan;49(1):22-5.

[Article in English]

Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan.

This study aimed to explore the mechanism involved in the synergistic purgative action of aloe-emodin anthrone and rhein anthrone, the active metabolites of sennoside C. Aloe-emodin anthrone and rhein anthrone, and their equimolar mixture, induced excretion of an approximately equal number of faeces by intracaecal administration at a dose of 23.2 mumol kg-1 in mice (= 1.0 standard dose). The number of wet faeces induced by aloe-emodin anthrone was less than those of rhein anthrone and the mixture. At the same dose, rhein anthrone and the mixture significantly stimulated large intestinal propulsion, though aloe-emodin anthrone had little stimulatory effect. Aloe-emodin anthrone and rhein anthrone decreased net water absorption but could not reverse it to the net secretion at 1/2 dose. The mixture significantly decreased net water absorption and reversed it to the net secretion at this dose. These anthrones did not stimulate mucus secretion in the colon at 1/2 dose. We concluded that the synergistic purgative effect of aloe-emodin anthrone and rhein anthrone in mice results from synergistic stimulation of large intestinal transit and large intestinal water secretion.

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 19970424
Date Completed: 19970424
MeSH Date: 1997/01/01 00:01
Date Revised: 20001218
Entrez Date: 1997/01/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 1997 Jan;49(1):22-5.
PMID: 9120764 UI: 97176171 [PubMed - indexed for MEDLINE]
From PubMed
147

Assessment of the genotoxic risk from laxative senna products.
Full author name: Brusick, D; Mengs, U.

Brusick D, Mengs U. Environ Mol Mutagen. 1997;29(1):1-9.

[Article in English]

Corning Hazleton Inc., Vienna, Virginia 22182, USA.

Laxative senna products and several of their specific components have been submitted to a large number of genetic tests. While most studies gave negative responses, results from some of the studies suggest that components of senna products, particularly emodin and aloe-emodin, have genotoxic activity. Assessment of the genotoxicity profile of these substances, in light of other data from animal and human metabolism or kinetic studies, human clinical trials and rodent carcinogenicity studies do not support concerns that senna laxatives pose a genotoxic risk to humans when consumed under prescribed use conditions.

Publication Types:

MeSH Terms:

Substances:

Number of References: 33
ISSN: 0893-6692
NLM Unique ID: 8800109
Country: United States
Entry Date: 19970307
Date Completed: 19970307
MeSH Date: 2000/06/20 09:00
Date Revised: 20011128
Entrez Date: 1997/01/01
Citation Subset: IM
http://dx.doi.org/10.1002/(SICI)1098-2280(1997)29:1<1::AID-EM1>3.0.CO;2-J
Publication Status: ppublish
Environ Mol Mutagen 1997;29(1):1-9.
PMID: 9020301 UI: 97172217 [PubMed - indexed for MEDLINE]
From PubMed
148

Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated?
Full author name: Muller, S O; Eckert, I; Lutz, W K; Stopper, H.

Muller SO, Eckert I, Lutz WK, Stopper H. Mutat Res. 1996 Dec 20;371(3-4):165-73.

[Article in English]

Department of Toxicology, University of Wurzburg, Germany.

1,8-Dihydroxyanthraquinones are under debate as plant-derived carcinogens that are found in laxatives, food colors, and possibly vegetables. Published genotoxicity data are controversial, and so three of them (emodin, danthron and aloe-emodin) were tested in a number of in vitro assay systems. All three compounds induced tk-mutations in mouse lymphoma L5178Y cells. Induction of micronuclei also occurred in the same cell line, and was dose-dependent, with the potency ranking being danthron > aloe-emodin > emodin. In a DNA decatenation assay with a network of mitochondrial DNA of C. fasciulata, all three test compounds inhibited the topoisomerase II-mediated decatenation. Danthron and aloe-emodin, but not emodin, increased the fraction of DNA moving into comet tails when tested at concentrations around 50 microM in single-cell gel-electrophoresis assays (SCGE; comet assay). Comet assays were also used in modified form to determine whether pretreatment of the cells with the test compounds would reduce the effects of etoposide, a potent topoisomerase II inhibitor. All three test chemicals were effective in this pretreatment protocol, with danthron again being the most potent. Given clearcut evidence of their genotoxic activity, further research on the human cancer risk of these compounds may be warranted.

MeSH Terms:

Substances:

ISSN: 0027-5107
NLM Unique ID: 0400763
Country: Netherlands
Entry Date: 19970219
Date Completed: 19970219
MeSH Date: 1996/12/20 00:01
Date Revised: 20011128
Entrez Date: 1996/12/20
Citation Subset: IM
Publication Status: ppublish
Mutat Res 1996 Dec 20;371(3-4):165-73.
PMID: 9008718 UI: 97161463 [PubMed - indexed for MEDLINE]
From PubMed
149

Antiinflammatory activity of extracts from Aloe vera gel.
Full author name: Vazquez, B; Avila, G; Segura, D; Escalante, B.

Vazquez B, Avila G, Segura D, Escalante B. J Ethnopharmacol. 1996 Dec;55(1):69-75.

[Article in English]

Laboratory of Pharmacology, Escuela Nacional de Estudios Profesionales Iztacala (E.N.E.P-I), Universidad Nacional Autonoma de Mexico, Tlalnepantla, Mexico.

We studied the effects of aqueous, chloroform, and ethanol extracts of Aloe vera gel on carrageenan-induced edema in the rat paw, and neutrophil migration into the peritoneal cavity stimulated by carrageenan. We also studied the capacity of the aqueous extract to inhibit cyclooxygenase activity. The aqueous and chloroform extracts decreased the edema induced in the hind-paw and the number of neutrophils migrating into the peritoneal cavity, whereas the ethanol extract only decreased the number of neutrophils. The antiinflammatory agents indomethacin and dexamethasone also decreased carrageenan-induced edema and neutrophil migration. The aqueous extract inhibited prostaglandin E2 production from [14C]arachidonic acid. The chemical tests performed in the aqueous extract for anthraglycosides, reductor sugars and cardiotonic glycosides were positive. In the ethanol extract, the chemical tests performed for saponins, carbohydrates naftoquinones, sterols, triterpenoids and anthraquinones were also positive. In the chloroform extract, the chemical tests performed for sterols type delta 5, and anthraquinones were positive. These results demonstrated that the extracts of Aloe vera gel have antiinflammatory activity and suggested its inhibitory action on the arachidonic acid pathway via cyclooxygenase.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 19970424
Date Completed: 19970424
MeSH Date: 1996/12/01 00:01
Date Revised: 20011128
Entrez Date: 1996/12/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0378874196014766
Publication Status: ppublish
J Ethnopharmacol 1996 Dec;55(1):69-75.
PMID: 9121170 UI: 97184847 [PubMed - indexed for MEDLINE]
From PubMed
150

Hematopoietic augmentation by a beta-(1,4)-linked mannan.
Full author name: Egger, S F; Brown, G S; Kelsey, L S; Yates, K M; Rosenberg, L J; Talmadge, J E.

Egger SF, Brown GS, Kelsey LS, Yates KM, Rosenberg LJ, Talmadge JE. Cancer Immunol Immunother. 1996 Dec;43(4):195-205.

[Article in English]

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA.

CARN 750 (injectable acemannan) is a polydispersed beta-(1,4)-linked acetylated mannan isolated from the Aloe barbadensis plant. It has multiple therapeutic properties including activity in wound repair and as a biological agent for the treatment of neoplasia in animals as well as the ability to activate macrophages. We report herein that CARN 750 directly or indirectly has significant hematoaugmenting properties. We observed that the subcutaneous administration of CARN 750 significantly increases splenic and peripheral blood cellularity, as well as hematopoietic progenitors in the spleen and bone marrow as determined by the interleukin-3-responsive colony-forming unit culture assay and the high-proliferative-potential colony-forming-cell (HPP-CFC) assay (a measure of primitive hematopoietic precursors) in myelosuppressed (7 Gy) C57BL/6 mice. The greatest hematopoietic effect was observed following sublethal irradiation in mice receiving 1 mg CARN 750/ animal, with less activity observed at higher or lower doses. Further, CARN 750, following daily injection, has activity equal to or greater than the injection of an optimal dose of granulocyte-colony-stimulating factor (G-CSF) in myelosuppressed mice. In this comparison, significantly greater activity was observed in the splenic and peripheral blood cellularity, and in the frequency and absolute number of splenic HPP-CFC as compared to the mice receiving G-CSF at 3 micrograms/animal. CARN 750, when administered to myelosuppressed animals, decreased the frequency of lymphocytes with a concomitant significant increase in the frequency of polymorphonuclear leukocytes (PMN). However, owing to the increased cellularity, a significant increase in the absolute number of PMN, lymphocytes, monocytes and platelets was observed, suggesting activity on multiple cell lineages. The latter is the primary difference in activity as compared to G-CSF which has activity predominantly on PMN.

MeSH Terms:

Substances:

ISSN: 0340-7004
NLM Unique ID: 8605732
Country: Germany
Entry Date: 19970219
Date Completed: 19970219
MeSH Date: 1996/12/01 00:01
Date Revised: 20011102
Entrez Date: 1996/12/01
Citation Subset: IM
http://link.springer-ny.com/link/service/journals/00262/bibs/6043004/60430195.htm
Publication Status: ppublish
Cancer Immunol Immunother 1996 Dec;43(4):195-205.
PMID: 9003464 UI: 97157083 [PubMed - indexed for MEDLINE]
From PubMed
151

Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe.
Full author name: Chung, J H; Cheong, J C; Lee, J Y; Roh, H K; Cha, Y N.

Chung JH, Cheong JC, Lee JY, Roh HK, Cha YN. Biochem Pharmacol. 1996 Nov 8;52(9):1461-8.

[Article in English]

College of Pharmacy, Seoul National University, Korea.

Aloe contains abundant aloin, a C-glycoside derivative of anthraquinone. Based on recent reports indicating that the water extract of Aloe enhances the ethanol oxidation rate and also that quinones, in general, have a functional role in elevating the alcohol oxidation rate in vivo, we have attempted to identify the quinone derivative contained in Aloe that could increase the alcohol oxidation rate. Upon oral administration of aloin (300 mg/kg) given 12 hr prior to the administration of alcohol (3.0 g/kg), the blood alcohol area under the curve (AUC) was found to be decreased significantly (by 40%). This was supported by increases in the rates of blood alcohol elimination and the disappearance of alcohol from the body by 45 and 50%, respectively. Analysis of hepatic triglyceride (TG) levels revealed that both the ethanol and the aloin treatment alone significantly increased the TG levels in a comparable manner; however, the level obtained by the combined treatment of aloin and ethanol was not statistically different from that produced by either treatment alone. The levels of serum L-aspartate:2-oxoglutarate aminotransferase (AST) and L-alanine:2-oxoglutarate aminotransferase (ALT) activities were not increased by acute alcohol intoxication, aloin alone, or by the combined treatment of alcohol and aloin. Pretreatments with aloe-emodin, the anthraquinone aglycone of aloin, resulted in a significantly decreased blood alcohol AUC and an increase in the rate of ethanol disappearance. These results suggested that when the aloin localized primarily in the skin of Aloe is ingested, aloe-emodin (the quinone aglycone) may be released, and the released quinone may produce acceleration of the ethanol metabolism rate in vivo.

MeSH Terms:

Substances:

ISSN: 0006-2952
NLM Unique ID: 0101032
Country: England
Entry Date: 19961231
Date Completed: 19961231
MeSH Date: 1996/11/08 00:01
Date Revised: 20011128
Entrez Date: 1996/11/08
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S000629529600514X
Publication Status: ppublish
Biochem Pharmacol 1996 Nov 8;52(9):1461-8.
PMID: 8937458 UI: 97091792 [PubMed - indexed for MEDLINE]
From PubMed
152

Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel.
Full author name: Zhang, L; Tizard, I R.

Zhang L, Tizard IR. Immunopharmacology. 1996 Nov;35(2):119-28.

[Article in English]

Department of Veterinary Pathobiology, Texas A & M University College Station 77843, USA.

Acemannan is the name given to the major carbohydrate fraction obtained from the gel of the Aloe vera leaf. It has been claimed to have several important therapeutic properties including acceleration of wound healing, immune stimulation, anti-cancer and anti-viral effects. However, the biological mechanisms of these activities are unclear. Because of this wide diversity of effects, it is believed that they may be exerted through pluripotent effector cells such as macrophages. The effects of acemannan on the mouse macrophage cell line, RAW 264.7 cells were therefore investigated. It was found that acemannan could stimulate macrophage cytokine production, nitric oxide release, surface molecule expression, and cell morphologic changes. The production of the cytokines IL-6 and TNF-alpha were dependent on the dose of acemannan provided. Nitric oxide production, cell morphologic changes and surface antigen expression were increased in response to stimulation by a mixture of acemannan and IFN-gamma. These results suggest that acemannan may function, at least in part, through macrophage activation.

MeSH Terms:

Substances:

ISSN: 0162-3109
NLM Unique ID: 7902474
Country: Netherlands
Entry Date: 19970310
Date Completed: 19970310
MeSH Date: 1996/11/01 00:01
Date Revised: 20011128
Entrez Date: 1996/11/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S016231099600135X
Publication Status: ppublish
Immunopharmacology 1996 Nov;35(2):119-28.
PMID: 8956975 UI: 97115605 [PubMed - indexed for MEDLINE]
From PubMed
153

Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity.
Full author name: Williams, M S; Burk, M; Loprinzi, C L; Hill, M; Schomberg, P J; Nearhood, K; O'Fallon, J R; Laurie, J A; Shanahan, T G; Moore, R L; Urias, R E; Kuske, R R; Engel, R E; Eggleston, W D.

Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, O'Fallon JR, Laurie JA, Shanahan TG, Moore RL, Urias RE, Kuske RR, Engel RE, Eggleston WD. Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):345-9.

[Article in English]

Toledo Community Clinical Oncology Program, OH, USA.

PURPOSE: Considerable pilot data and clinical experience suggested that an aloe vera gel might help to prevent radiation therapy-induced dermatitis. METHODS AND MATERIALS: Two Phase III randomized trials were conducted. The first one was double blinded, utilized a placebo gel, and involved 194 women receiving breast or chest wall irradiation. The second trial randomized 108 such patients to aloe vera gel vs. no treatment. Skin dermatitis was scored weekly during both trials both by patients and by health care providers. RESULTS: Skin dermatitis scores were virtually identical on both treatment arms during both of the trials. The only toxicity from the gel was rare contact dermatitis. CONCLUSIONS: This dose and schedule of an aloe vera gel does not protect against radiation therapy-induced dermatitis.

Publication Types:

MeSH Terms:

Substances:

Grant Support:

ISSN: 0360-3016
NLM Unique ID: 7603616
Country: United States
Entry Date: 19961120
Date Completed: 19961120
MeSH Date: 1996/09/01 00:01
Date Revised: 20011128
Entrez Date: 1996/09/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/S0360301696003203
Publication Status: ppublish
Int J Radiat Oncol Biol Phys 1996 Sep 1;36(2):345-9.
PMID: 8892458 UI: 97047538 [PubMed - indexed for MEDLINE]
From PubMed
154

Isolation of a cDNA for a phosphoenolpyruvate carboxylase from a monocot CAM-plant, Aloe arborescens: structure and its gene expression.
Full author name: Honda, H; Okamoto, T; Shimada, H.

Honda H, Okamoto T, Shimada H. Plant Cell Physiol. 1996 Sep;37(6):881-8.

[Article in English]

Life Science Institute, Mitsui Toatsu Chemicals, Inc., Mobara, Japan.

A phosphoenolpyruvate carboxylase (PEPCase) cDNA was isolated from Aloe arborescens, a monocot CAM plant. Northern analysis of the PEPCase transcript indicated that it is specifically expressed in green leaves, strongly suggesting its involvement in CAM photosynthesis. No diurnal change in expression level was evident. Western blot analysis also showed no alteration of the amount of the PEPCase protein. These results suggest that circadian rhythm in PEPCase activity may be regulated post-translationally. The representative cDNA clone contained an ORF encoding 964 amino acid residues. Deduced amino acid sequence of the aloe PEPCase is highly conserved as compared with other PEPCases. The phosphorylation site which may be modified by PEPC-kinase was conserved. An evolutional map with known PEPCases suggested that CAM-type PEPCases were located between C4 and housekeeping PEPCases.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 0032-0781
NLM Unique ID: 9430925
Country: Japan
Entry Date: 19970513
Date Completed: 19970513
MeSH Date: 1996/09/01 00:01
Date Revised: 20011128
Entrez Date: 1996/09/01
Citation Subset: IM
Publication Status: ppublish
Plant Cell Physiol 1996 Sep;37(6):881-8.
PMID: 8888625 UI: 97043427 [PubMed - indexed for MEDLINE]
From PubMed
155

Management of psoriasis with Aloe vera extract in a hydrophilic cream: a placebo-controlled, double-blind study.
Full author name: Syed, T A; Ahmad, S A; Holt, A H; Ahmad, S H; Afzal, M.

Syed TA, Ahmad SA, Holt AH, Ahmad SA, Ahmad SH, Afzal M. Trop Med Int Health. 1996 Aug;1(4):505-9.

[Article in English]

Department of Clinical Physiology, Malmo University Hospital, Sweden.

The purpose of this double-blind, placebo-controlled study was to evaluate the clinical efficacy and tolerability of topical Aloe vera extract 0.5% in a hydrophilic cream to cure patients with psoriasis vulgaris. Sixty patients (36M/24F) aged 18-50 years (mean 25.6) with slight to moderate chronic plaque-type psoriasis and PASI (Psoriasis Area and Severity Index) scores between 4.8 and 16.7 (mean 9.3) were enrolled and randomized to two parallel groups. The mean duration of the disease prior to enrollment was 8.5 years (range 1-21). Patients were provided with a precoded 100g tube, placebo or active (with 0.5% Aloe vera extract), and they self-administered trial medication topically (without occlusion) at home 3 times daily for 5 consecutive days per week (maximum 4 weeks active treatment). Patients were examined on a weekly basis and those showing a progressive reduction of lesions, desquamation followed by decreased erythema, infiltration and lowered PASI score were considered healed. The study was scheduled for 16 weeks with 12 months of follow-up on a monthly basis. The treatment was well tolerated by all the patients, with no adverse drug-related symptoms and no dropouts. By the end of the study, the Aloe vera extract cream had cured 25/30 patients (83.3%) compared to the placebo cure rate of 2/30 (6.6%) (P < 0.001) resulting in significant clearing of the psoriatic plaques (328/396 (82.8%) vs placebo 28/366 (7.7%), P < 0.001) and a decreased PASI score to a mean of 2.2. The findings of this study suggest that topically applied Aloe vera extract 0.5% in a hydrophilic cream is more effective than placebo, and has not shown toxic or any other objective side-effects. Therefore, the regimen can be considered a safe and alternative treatment to cure patients suffering from psoriasis.

Publication Types:

MeSH Terms:

Substances:

ISSN: 1360-2276
NLM Unique ID: 9610576
Country: England
Entry Date: 19960913
Date Completed: 19960913
MeSH Date: 1996/08/01 00:01
Date Revised: 20011128
Entrez Date: 1996/08/01
Citation Subset: IM
Publication Status: ppublish
Trop Med Int Health 1996 Aug;1(4):505-9.
PMID: 8765459 UI: 96343964 [PubMed - indexed for MEDLINE]
From PubMed
156

Hypoallergenic products.
Full author name: Gale, A E.

Gale AE. Med J Aust. 1996 Jul 1;165(1):62.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0025-729X
NLM Unique ID: 0400714
Country: Australia
Entry Date: 19960815
Date Completed: 19960815
MeSH Date: 1996/07/01 00:01
Date Revised: 20011128
Entrez Date: 1996/07/01
Citation Subset: IM
Publication Status: ppublish
Med J Aust 1996 Jul 1;165(1):62.
PMID: 8676787 UI: 96292152 [PubMed - indexed for MEDLINE]
From PubMed
157

Non-conventional topical therapies for wound care.
Full author name: Rund, C R.

Rund CR. Ostomy Wound Manage. 1996 Jun;42(5):18-20, 22-4, 26.

[Article in English]

There seems to be a resurgence of interest among healthcare professionals in treating wounds with various topical agents. There are practitioners who are recommending and/or using topical therapies for wounds without having an understanding of why or how they affect a wound. Many of these products are used based upon here-say or clinical observations, since there is a lack of researched-based practice regarding the use of such topicals in wound healing. This article reviews such non-conventional topical therapies as aloe vera, antacids, benzoyl peroxide, collagen, dilantin, gentian violet, impregnated gauzes, insulin, mercurochrome, oxygen therapy, sugar, and vinegar. Each agent is described, its mode of action is discussed, and clinical studies regarding the use of these topicals to promote wound healing are examined, if any. The reader should review this article along with other existing literature regarding topical therapies before making a decision about using such in the care of wounds. When caring for wounds, one should ask, what is the goal of wound care at this particular time? And then ask, based upon available research, what, if any, of these agents can help achieve this goal? The following information should assist one in answering these questions.

Publication Types:

MeSH Terms:

Number of References: 32
ISSN: 0889-5899
NLM Unique ID: 8912029
Country: United States
Entry Date: 19960919
Date Completed: 19960919
MeSH Date: 1996/06/01 00:01
Date Revised: 20001218
Entrez Date: 1996/06/01
Citation Subset: N
Publication Status: ppublish
Ostomy Wound Manage 1996 Jun;42(5):18-20, 22-4, 26.
PMID: 8717010 UI: 96359011 [PubMed - indexed for MEDLINE]
From PubMed
158

Antiinflammatory C-glucosyl chromone from Aloe barbadensis.
Full author name: Hutter, J A; Salman, M; Stavinoha, W B; Satsangi, N; Williams, R F; Streeper, R T; Weintraub, S T.

Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, Weintraub ST. J Nat Prod. 1996 May;59(5):541-3.

[Article in English]

Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.

A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.

MeSH Terms:

Substances:

ISSN: 0163-3864
NLM Unique ID: 7906882
Country: United States
Entry Date: 19960917
Date Completed: 19960917
MeSH Date: 1996/05/01 00:01
Date Revised: 20011128
Entrez Date: 1996/05/01
Citation Subset: IM
http://dx.doi.org/10.1021/np9601519
Publication Status: ppublish
J Nat Prod 1996 May;59(5):541-3.
PMID: 8778246 UI: 96366693 [PubMed - indexed for MEDLINE]
From PubMed
159

Zinc acetate and lyophilized aloe barbadensis as vaginal contraceptive.
Full author name: Fahim, M S; Wang, M.

Fahim MS, Wang M. Contraception. 1996 Apr;53(4):231-6.

[Article in English]

Center of Reproductive Science and Technology, School of Medicine, University of Missouri, Columbia 65212, USA.

Twenty samples of fresh ejaculate, donated by healthy volunteers ranging in age from 20-30 years, were obtained from the Center for Fertility & Cryobiology, University of Missouri, Columbia, Missouri. Average semen volume was 2.49 ml; average sperm motility was 71.32%; and average sperm density was 113.71 x 10(6) /ml. Testing for spermicidal effectiveness of a 1% concentration of zinc acetate, zinc sulfate, zinc chloride, and zinc gluconate proved that only zinc acetate was spermicidal. It appears this is due to the acetate in zinc acetate which may decrease oxygen utilization by sperm. Zinc acetate in vitro was antiviral while lyophilized aloe barbadensis was not. Lyophilized aloe barbadensis at concentrations of 7.5% and 10% proved to be spermicidal due to the multiple micro elements (boron, barium, calcium, chromium, copper, iron, potassium, magnesium, manganese, phosphorus, and zinc) which were toxic to the tail causing instant immobilization. The two compounds did not irritate or cause ulceration of rabbit vaginal epithelium. These results suggest the possibility of using zinc acetate and lyophilized aloe barbadensis as a new, effective and safe vaginal contraceptive.

MeSH Terms:

Substances:

ISSN: 0010-7824
NLM Unique ID: 0234361
Country: United States
Entry Date: 19960912
Date Completed: 19960912
MeSH Date: 1996/04/01 00:01
Date Revised: 20011128
Entrez Date: 1996/04/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/001078249600042X
Publication Status: ppublish
Contraception 1996 Apr;53(4):231-6.
PMID: 8706441 UI: 96276558 [PubMed - indexed for MEDLINE]
From PubMed
160

Decreased levels of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts in rats treated with beta-carotene, alpha-tocopherol and freeze-dried aloe.
Full author name: Uehara, N; Iwahori, Y; Asamoto, M; Baba-Toriyama, H; Iigo, M; Ochiai, M; Nagao, M; Nakayama, M; Degawa, M; Matsumoto, K; Hirono, I; Beppu, H; Fujita, K; Tsuda, H.

Uehara N, Iwahori Y, Asamoto M, Baba-Toriyama H, Iigo M, Ochiai M, Nagao M, Nakayama M, Degawa M, Matsumoto K, Hirono I, Beppu H, Fujita K, Tsuda H. Jpn J Cancer Res. 1996 Apr;87(4):342-8.

[Article in English]

Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.

To assess mechanisms of chemoprevention of hepatocarcinogenesis by trans-beta-carotene (beta-C), DL-alpha-tocopherol (alpha-T), and freeze-dried whole leaves of Kidachi aloe (Aloe), formation of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA adducts was measured by 32P-post-labeling analysis, and CYP1A1 and CYP1A2 protein levels were analyzed by ELISA. Group 1 rats were fed diet containing 0.02% beta-C, 1.5% alpha-T or 30% Aloe over an 8-day period, while group 2 was given basal diet alone. On day 7, all animals were subjected to two-thirds partial hepatectomy (PH). Twelve hours after PH, they received a single dose of the carcinogenic food pyrolysate IQ (100 mg/kg) intragastrically, to initiate hepatocarcinogenesis. Rats were killed 6, 12, 24 and 48 h after IQ administration. The levels of adducts, expressed as relative adduct labeling values in rats treated with beta-C, alpha-T and Aloe, were decreased as compared with the control group at hour 24 (36 h after PH), with a significant difference in the case of the beta-C group (46.4% of the control value). Similarly, all showed a tendency for decrease at hour 48. Furthermore, the levels of CYP1A2, known to be responsible for activation of IQ, showed a significant reduction at hour 24. It is concluded that beta-C, and possibly also alpha-T and Aloe, have the potential to reduce IQ-DNA adduct formation, presumably as a result of decreased formation of active metabolites. The results may explain, at least in part, the previously observed inhibitory effects of these compounds on induction of preneoplastic hepatocellular lesions.

MeSH Terms:

Substances:

ISSN: 0910-5050
NLM Unique ID: 8509412
Country: Japan
Entry Date: 19960717
Date Completed: 19960717
MeSH Date: 1996/04/01 00:01
Date Revised: 20011128
Entrez Date: 1996/04/01
Citation Subset: IM
Publication Status: ppublish
Jpn J Cancer Res 1996 Apr;87(4):342-8.
PMID: 8641964 UI: 96217790 [PubMed - indexed for MEDLINE]
From PubMed
161

The preventive and therapeutic potential of the squalene-containing compound, Roidex, on tumor promotion and regression.
Full author name: Desai, K N; Wei, H; Lamartiniere, C A.

Desai KN, Wei H, Lamartiniere CA. Cancer Lett. 1996 Mar 19;101(1):93-6.

[Article in English]

Department of Pharmacology and Toxicology, University of Alabama at Birmingham, 35294, USA.

Recent scientific evidence has shown free radicals or reactive oxygen species (ROS) to play an important role in the initiation and progression of cancer. Many radical scavengers have also been found to help reduce the attacks by these ROS. Interestingly, the ROS scavengers that have been investigated are naturally occurring compounds such as vitamins C and E. Roidex is a formulation of squalene, vitamin e, and aloe vera. It was our goal to investigate whether Roidex was able to prevent the development of chemically induced cancer and to cause regression of any tumors already formed in a mouse skin model. In the prevention study, skin tumors were initiated in 50 female CD-1 mice with 7,12-dimethylbenz[a]-anthracene (DMBA) and promoted with 12-O-tetradecanoylphorbol-13-acetate (TPA). The mice were treated with either mineral oil, 5% squalene, or Roidex. At the end of the prevention study, there was a 33.34% incidence to tumors (multiplicity of 1.40) in the mineral oil-treatment group, 26.67% (multiplicity of 0.467) in the 5% squalene and Roidex groups, respectively. The tumor regression study involved the selection of mice with tumors and possible regression of these tumors with Roidex treatment. There was a regression of 33.34% of the tumors in the Roidex-treated group (39 tumors to 26 tumors) compared to the non-treated group whose tumors regressed only 3.44% (29 tumors to 28 tumors).

MeSH Terms:

Substances:

ISSN: 0304-3835
NLM Unique ID: 7600053
Country: Ireland
Entry Date: 19960621
Date Completed: 19960621
MeSH Date: 1996/03/19 00:01
Date Revised: 20011128
Entrez Date: 1996/03/19
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/0304383596041225
Publication Status: ppublish
Cancer Lett 1996 Mar 19;101(1):93-6.
PMID: 8625289 UI: 96202642 [PubMed - indexed for MEDLINE]
From PubMed
162

Studies on optimal dose and administration schedule of a hematopoietic stimulatory beta-(1,4)-linked mannan.
Full author name: Egger, S F; Brown, G S; Kelsey, L S; Yates, K M; Rosenberg, L J; Talmadge, J E.

Egger SF, Brown GS, Kelsey LS, Yates KM, Rosenberg LJ, Talmadge JE. Int J Immunopharmacol. 1996 Feb;18(2):113-26.

[Article in English]

Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5660, USA.

Several complex carbohydrates have been found to significantly stimulate hematopoiesis. CARN 750, a polydispersed beta-(1,4)-linked acetylated mannan isolated from the Aloe vera plant, has been shown to have activity in wound repair, to function as a antineoplastic, and to activate macrophages. We report, herein, the hematoaugmenting properties of CARN 750 and its optimal dose and timing of administration in an animal model of irradiation-induced myelosuppression. We observed that subcutaneous injections of 1 mg/animal of CARN 750 had equal or greater stimulatory activity for white blood cell (WBC) counts and spleen cellularity as well as on the absolute numbers of neutrophils, lymphocytes, monocytes and platelets than did higher or lower doses of CARN 750 or an optimal dose of granulocyte-colony stimulating factor (G-CSF). Hematopoietic progenitors, measured as interleukin-3-supported colony forming units-culture (CFU-C) and high proliferative potential colony-forming cells (HPP-CFC) assays, were similarly increased by CARN 750 in the spleen but not in the bone marrow. The frequency of splenic HPP-CFCs and absolute number of splenic HPP-CFCs and CFU-Cs were optimally increased by 1 mg/animal of CARN 750. In contrast, bone marrow cellularity, frequency and absolute number of HPP-CFCs and CFU-Cs had as a dosage optimum 2 mg/animal of CARN 750. These parameters were similarly increased by G-CSF. In studies to determine the optimal protocol for the administration of CARN 750 we found that the hematopoietic activity of CARN 750 increased with the frequency of administration. The greatest activity in myelosuppressed mice was observed for all hematopoietic parameters except the platelet number in mice receiving daily administration of 1 mg/animal of CARN 750 with activity equal to or greater than G-CSF.

MeSH Terms:

Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19961107
Date Completed: 19961107
MeSH Date: 1996/02/01 00:01
Date Revised: 20001218
Entrez Date: 1996/02/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/0192056195001123
Publication Status: ppublish
Int J Immunopharmacol 1996 Feb;18(2):113-26.
PMID: 8799361 UI: 96392573 [PubMed - indexed for MEDLINE]
From PubMed
163

Isozymes of superoxide dismutase from Aloe vera.
Full author name: Sabeh, F; Wright, T; Norton, S J.

Sabeh F, Wright T, Norton SJ. Enzyme Protein. 1996;49(4):212-21.

[Article in English]

Department of Biological Sciences, University of North Texas, Denton 76203, USA.

Extracts from the parenchymatous leaf gel and the rind of the Aloe vera plant (Aloe barbadensis Miller) were shown to contain seven electrophoretically-identifiable superoxide dismutases (SODs). The chromatographic elution profiles and the migration of these bands on native polyacrylamide gel electrophoresis (PAGE), for both the gel and rind, are quite similar. Two of these seven activities are insensitive to cyanide treatment, suggesting that they are mangano-SODs. The other five activities are sensitive to cyanide treatment, but insensitive to azide treatment and are presumed to be cupro-zinc SODs. All of the seven proteins appear to be homodimers with apparent native molecular masses centered at approximately 32 and 42 kD as indicated by SDS-PAGE and gel-filtration (FPLC) chromatography. The specific activities of SODs in the A. vera rind and gel are comparable to those of spinach leaves and of rabbit liver.

MeSH Terms:

Substances:

ISSN: 1019-6773
NLM Unique ID: 9422761
Country: Switzerland
Entry Date: 19970414
Date Completed: 19970414
MeSH Date: 1996/01/01 00:01
Date Revised: 20011128
Entrez Date: 1996/01/01
Citation Subset: IM
Publication Status: ppublish
Enzyme Protein 1996;49(4):212-21.
PMID: 9030888 UI: 97182749 [PubMed - indexed for MEDLINE]
From PubMed
164

Use of plant-derived therapies in a rural, biracial population in Mississippi.
Full author name: Frate, D A; Croom, E M Jr; Frate, J B; Juergens, J P; Meydrech, E F.

Frate DA, Croom EM Jr, Frate JB, Juergens JP, Meydrech EF. J Miss State Med Assoc. 1996 Jan;37(1):427-9.

[Article in English]

Research Institute of Pharmaceutical Sciences, University of Mississippi, University, USA.

Exploring the use of plant-derived medicines has recently received much attention in both scientific and popular journals. A study conducted in central Mississippi on medicinal plants investigated the frequency of use, types of plants used, and symptoms treated. A randomly selected probability sample of 223 households found that over 70 percent of the adults used at least one plant-derived medicine during the past year. The most frequently used plants included lemon, aloe, castor, turpentine, tobacco, and garlic. Frequency of use varied by race with a higher proportion of African-Americans than Caucasians reporting use of a plant-derived medicine. Due to the possible presence of toxic compounds or potential drug interactions, it is recommended that health care professionals investigate the use of plant-derived therapies as part of the patient's medical history.

MeSH Terms:

ISSN: 0026-6396
NLM Unique ID: 7505622
Country: United States
Entry Date: 19961028
Date Completed: 19961028
MeSH Date: 2001/03/28 10:01
Date Revised: 20011102
Entrez Date: 1996/01/01
Citation Subset: IM
Publication Status: ppublish
J Miss State Med Assoc 1996 Jan;37(1):427-9.
PMID: 8821719 UI: 96418934 [PubMed - indexed for MEDLINE]
From PubMed
165

A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone.
Full author name: Akao, T; Che, Q M; Kobashi, K; Hattori, M; Namba, T.

Akao T, Che QM, Kobashi K, Hattori M, Namba T. Biol Pharm Bull. 1996 Jan;19(1):136-8.

[Article in English]

Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

Orally administered barbaloin (100 mg/kg) did not induce any diarrhea in male Wistar rats, in spite of severe diarrhea with sennoside B (40 mg/kg). Also, in gnotobiote rats mono-associated with Peptostreptococcus intermedius, a human intestinal anaerobe capable of reducing sennidins to rhein anthrone, barbaloin did not induce diarrhea; the faecal water content (71.9%) 8 h after the administration of barbaloin was not increased, compared with that (73.9%) just before the treatment. However, severe diarrhea was induced with barbaloin in gnotobiote rats mono-associated with Eubacterium sp. strain BAR, another human intestinal anaerobe capable of transforming barbaloin to aloe-emodin anthrone; the faecal water content was significantly increased to 85.5% 8 h after the administration, from 73.2% before the treatment. At this time, barbaloin was transformed to aloe-emodin anthrone in the feces from the gnotobiote rats mono-associated with the strain BAR, but not in feces from the conventional rats or the gnotobiote rats mono-associated with P. intermedius. These facts indicate that barbaloin is inactive as a laxative itself but is activated to aloe-emodin anthrone, a genuine purgative component, by Eubacterium sp. strain BAR.

MeSH Terms:

Substances:

ISSN: 0918-6158
NLM Unique ID: 9311984
Country: Japan
Entry Date: 19961115
Date Completed: 19961115
MeSH Date: 1996/01/01 00:01
Date Revised: 20001218
Entrez Date: 1996/01/01
Citation Subset: IM
Publication Status: ppublish
Biol Pharm Bull 1996 Jan;19(1):136-8.
PMID: 8820926 UI: 96418141 [PubMed - indexed for MEDLINE]
From PubMed
166

A 35 kDa mannose-binding lectin with hemagglutinating and mitogenic activities from "Kidachi Aloe" (Aloe arborescens Miller var. natalensis Berger).
Full author name: Koike, T; Beppu, H; Kuzuya, H; Maruta, K; Shimpo, K; Suzuki, M; Titani, K; Fujita, K.

Koike T, Beppu H, Kuzuya H, Maruta K, Shimpo K, Suzuki M, Titani K, Fujita K. J Biochem (Tokyo). 1995 Dec;118(6):1205-10.

[Article in English]

Institute of Pharmacognosy, Fujita Health University, Mie.

A novel lectin was isolated from the leaf skin of "Kidachi Aloe" (Aloe arborescens Miller var. natalensis Berger) by sequential chromatographies on Sephadex G-25 gel filtration, DEAE ion exchange, and Superdex 75 gel filtration columns. The native lectin exhibited a molecular mass of about 35 kDa on both gel filtration on a Superdex 75 column and native-PAGE under nonreducing conditions. SDS-PAGE in the presence or absence of beta-mercaptoethanol revealed two distinct peptides with molecular masses of about 5.5 and 2.3 kDa, respectively, in addition to a major 9.2 kDa subunit, indicating the presence of a partially processed subunit. The N-terminal amino acid sequence of the intact subunit showed homology with that of snowdrop lectin. The native lectin showed hemagglutinating activity toward rabbit but not human and sheep erythrocytes, and specifically bound to mannose like snowdrop lectin did, indicating that the Aloe and snowdrop lectins are structurally and functionally similar proteins. In addition, the native lectin showed strong mitogenic activity toward mouse lymphocytes.

MeSH Terms:

Substances:

ISSN: 0021-924X
NLM Unique ID: 0376600
Country: Japan
Entry Date: 19961010
Date Completed: 19961010
MeSH Date: 1995/12/01 00:01
Date Revised: 20011128
Entrez Date: 1995/12/01
Citation Subset: IM
Publication Status: ppublish
J Biochem (Tokyo) 1995 Dec;118(6):1205-10.
PMID: 8720136 UI: 96362159 [PubMed - indexed for MEDLINE]
From PubMed
167

High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances.
Full author name: Zonta, F; Bogoni, P; Masotti, P; Micali, G.

Zonta F, Bogoni P, Masotti P, Micali G. J Chromatogr A. 1995 Dec 1;718(1):99-106.

[Article in English]

Istituto di Statistica e Ricerca Operativa, Universita di Trento, Italy.

Characteristic HPLC profiles of fresh and aged aloe solutions, detected at 360 and 220 nm, are presented and compared. Several aloe constituents (aloesin, aloeresin A, hydroxyaloin, aloin A and B and aloinoside A and B) were simultaneously separated and identified. The determination of aloin is described (detection limit 0.15 ppm) and discussed. In aloe-based alcoholic beverages, the aloins could not be detected, owing to their instability and degradation in solution; this is discussed in relation to the EEC Council Directive 88/388, which fixed the values of maximum allowable concentrations for aloin in food and beverages. Instead of aloin, other aloe compounds (e.g., aloeresin A or aloesin) should perhaps be used as an index of the presence of aloe in alcoholic beverages.

MeSH Terms:

Substances:

NLM Unique ID: 9318488
Country: Netherlands
Entry Date: 19960228
Date Completed: 19960228
MeSH Date: 1995/12/01 00:01
Date Revised: 20011128
Entrez Date: 1995/12/01
Citation Subset: IM
Publication Status: ppublish
J Chromatogr A 1995 Dec 1;718(1):99-106.
PMID: 8556168 UI: 96129767 [PubMed - indexed for MEDLINE]
From PubMed
168

The complete amino acid sequence of a mannose-binding lectin from "Kidachi Aloe" (Aloe arborescens Miller var. natalensis Berger).
Full author name: Koike, T; Titani, K; Suzuki, M; Beppu, H; Kuzuya, H; Maruta, K; Shimpo, K; Fujita, K.

Koike T, Titani K, Suzuki M, Beppu H, Kuzuya H, Maruta K, Shimpo K, Fujita K. Biochem Biophys Res Commun. 1995 Sep 5;214(1):163-70.

[Article in English]

Institute of Pharmacognosy, Fujita Health University, Mie, Japan.

The complete amino acid sequence of a mannose-binding lectin purified from the leaf skin of "Kidachi Aloe" (Aloe arborescens Miller var. natalensis Berger) is presented. The 109-residue sequence of the subunit was determined by analysis of peptides of the intact or S-pyridylethylated protein generated by digestion with cyanogen bromide, BNPS-skatole, Achromobacter protease I, or trypsin. The subunit contains an intrachain disulfide bridge. The sequence is highly homologous to that of a mannose-binding lectin from snowdrop bulb.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 0006-291X
NLM Unique ID: 0372516
Country: United States
Entry Date: 19951012
Date Completed: 19951012
MeSH Date: 1995/09/05 00:01
Date Revised: 20011128
Entrez Date: 1995/09/05
Citation Subset: IM
Publication Status: ppublish
Biochem Biophys Res Commun 1995 Sep 5;214(1):163-70.
PMID: 7669035 UI: 95398630 [PubMed - indexed for MEDLINE]
From PubMed
169

Effect of aloe vera gel to healing of burn wound a clinical and histologic study.
Full author name: Visuthikosol, V; Chowchuen, B; Sukwanarat, Y; Sriurairatana, S; Boonpucknavig, V.

Visuthikosol V, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V. J Med Assoc Thai. 1995 Aug;78(8):403-9.

[Article in English]

Department of Surgery, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

In a study of twenty-seven patients with partial thickness burn wound, they were treated with aloe vera gel compared with vaseline gauze. It revealed the aloe vera gel treated lesion healed faster than the vaseline gauze area. The average time of healing in the aloe gel area was 11.89 days and 18.19 days for the vaseline gauze treated wound. Statistical analysis by using t-test and the value of P < 0.002 was statistically significant. In histologic study, it showed early epithelialization in the treated aloe vera gel area. Only some minor adverse effects, such as discomfort and pain were encountered in the 27 cases. This study showed the effectiveness of aloe vera gel on a partial thickness burn wound, and it might be beneficial to do further trials on burn wounds.

MeSH Terms:

Substances:

ISSN: 0125-2208
NLM Unique ID: 7507216
Country: Thailand
Entry Date: 19951122
Date Completed: 19951122
MeSH Date: 1995/08/01 00:01
Date Revised: 20011128
Entrez Date: 1995/08/01
Citation Subset: IM
Publication Status: ppublish
J Med Assoc Thai 1995 Aug;78(8):403-9.
PMID: 7561562 UI: 96033500 [PubMed - indexed for MEDLINE]
From PubMed
170

Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in C3H mice.
Full author name: Roberts, D B; Travis, E L.

Roberts DB, Travis EL. Int J Radiat Oncol Biol Phys. 1995 Jul 15;32(4):1047-52.

[Article in English]

Department of Experimental Radiotherapy, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.

PURPOSE: To determine (a) whether a wound dressing gel that contains acemannan extracted from aloe leaves affects the severity of radiation-induced acute skin reactions in C3H mice; (b) if so, whether other commercially available gels such as a personal lubricating jelly and a healing ointment have similar effects; and (c) when the wound dressing gel should be applied for maximum effect. METHODS AND MATERIALS: Male C3H mice received graded single doses of gamma radiation ranging from 30 to 47.5 Gy to the right leg. In most experiments, the gel was applied daily beginning immediately after irradiation. To determine timing of application for best effect, gel was applied beginning on day -7, 0, or +7 relative to the day of irradiation (day 0) and continuing for 1, 2, 3, 4, or 5 weeks. The right inner thigh of each mouse was scored on a scale of 0 to 3.5 for severity of radiation reaction from the seventh to the 35th day after irradiation. Dose-response curves were obtained by plotting the percentage of mice that reached or exceeded a given peak skin reaction as a function of dose. Curves were fitted by logit analysis and ED50 values, and 95% confidence limits were obtained. RESULTS: The average peak skin reactions of the wound dressing gel-treated mice were lower than those of the untreated mice at all radiation doses tested. The ED50 values for skin reactions of 2.0-2.75 were approximately 7 Gy higher in the wound dressing gel-treated mice. The average peak skin reactions and the ED50 values for mice treated with personal lubricating jelly or healing ointment were similar to irradiated control values. Reduction in the percentage of mice with skin reactions of 2.5 or more was greatest in the groups that received wound dressing gel for at least 2 weeks beginning immediately after irradiation. There was no effect if gel was applied only before irradiation or beginning 1 week after irradiation. CONCLUSION: Wound dressing gel, but not personal lubricating jelly or healing ointment, reduces acute radiation-induced skin reactions in C3H mice if applied daily for at least 2 weeks beginning immediately after irradiation.

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Substances:

Grant Support:

ISSN: 0360-3016
NLM Unique ID: 7603616
Country: United States
Entry Date: 19950817
Date Completed: 19950817
MeSH Date: 1995/07/15 00:01
Date Revised: 20011128
Entrez Date: 1995/07/15
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/036030169400467Y
Publication Status: ppublish
Int J Radiat Oncol Biol Phys 1995 Jul 15;32(4):1047-52.
PMID: 7607925 UI: 95332055 [PubMed - indexed for MEDLINE]
From PubMed
171

Treatment of experimental frostbite with pentoxifylline and aloe vera cream.
Full author name: Miller, M B; Koltai, P J.

Miller MB, Koltai PJ. Arch Otolaryngol Head Neck Surg. 1995 Jun;121(6):678-80.

[Article in English]

Division of Otolaryngology, Albany (NY) Medical College, USA.

OBJECTIVE: To compare the therapeutic effects of systemic pentoxifylline and topical aloe vera cream in the treatment of frostbite. DESIGN: The frostbitten ears of 10 New Zealand white rabbits were assigned to one of four treatment groups: untreated controls, those treated with aloe vera cream, those treated with pentoxifylline, and those treated with aloe vera cream and pentoxifylline. MAIN OUTCOME MEASURES: Tissue survival was calculated as the percent of total frostbite area that remained after 2 weeks. RESULTS: The control group had a 6% tissue survival. Tissue survival was notably improved with pentoxifylline (20%), better with aloe vera cream (24%), and the best with the combination therapy (30%). CONCLUSION: Pentoxifylline is as effective as aloe vera cream in improving tissue survival after frostbite injury.

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Substances:

ISSN: 0886-4470
NLM Unique ID: 8603209
Country: United States
Entry Date: 19950707
Date Completed: 19950707
MeSH Date: 1995/06/01 00:01
Date Revised: 20011128
Entrez Date: 1995/06/01
Citation Subset: AIM, IM
Publication Status: ppublish
Arch Otolaryngol Head Neck Surg 1995 Jun;121(6):678-80.
PMID: 7772322 UI: 95290168 [PubMed - indexed for MEDLINE]
From PubMed
172

Geographical variation in the major compounds of Aloe ferox leaf exudate.
Full author name: van Wyk, B E; van Rheede van Oudtshoorn, M C; Smith, G F.

van Wyk BE, van Rheede van Oudtshoorn MC, Smith GF. Planta Med. 1995 Jun;61(3):250-3.

[Article in English]

Department of Botany, Rand Afrikaans University, Johannesburg, South Africa.

Geographical variation in fresh Aloe ferox leaf exudate of which the dried product is commercially known as Cape Aloes, was investigated throughout the natural distribution range of the species. The composition of the major compounds is remarkably invariable, with aloeresin A, aloesin, and aloin (both epimers A and B) contributing between 70% and 97% of total dry weight, in a ratio of approximately 4:3:2, respectively. Minor compounds are less evenly distributed, with aloinoside A and aloinoside B more frequent in the western parts of the distribution area and aloeresin C and 5-hydroxyaloin A generally present in small quantities throughout the distribution area. The aloin content of the exudate is clearly related to provenance but there are no distinct geographical discontinuities. The selection of high-yielding provenances, with total aloin levels above 25%, is recommended for commercial cultivation.

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Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19950824
Date Completed: 19950824
MeSH Date: 1995/06/01 00:01
Date Revised: 20011128
Entrez Date: 1995/06/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1995 Jun;61(3):250-3.
PMID: 7617769 UI: 95343017 [PubMed - indexed for MEDLINE]
From PubMed
173

Age and laxative use in hospitalized patients. A report of the "Gruppo Italiano di Farmacovigilanza nell'Anziano--GIFA".
Full author name: Pahor, M; Mugelli, A; Guralnik, J M; Manto, A; Carosella, L; Sgadari, A; Carbonin, P U.

Pahor M, Mugelli A, Guralnik JM, Manto A, Carosella L, Sgadari A, Carbonin PU. Aging (Milano). 1995 Apr;7(2):128-35.

[Article in English]

Istituto di Medicina Interna e Geriatria, Univesita Cattolica del Sacro Cuore, Roma, Italy.

Laxatives are frequently taken especially by older persons, who have multiple diseases and are disabled. Major differences exist among countries in the type of laxatives taken, and knowledge of the intake patterns is important because of the potential adverse effects associated with particular ingredients. Laxatives and factors related to their use are described in a sample of 3257 patients admitted to 58 hospitals of the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA) in 1991. The mean age was 68.2 years, median 73 years, more than 30% were age > or = 80 years, and 48.7% were men. The overall prevalence rates of laxative use during hospital stay and prior to admission were 11.5% and 11.3%, respectively. Increasing age was independently associated with laxative use after adjusting for gender, activities of daily living, cognitive function, number of active medical problems, medications taken, Italian region and length of stay. After excluding the prescriptions for hyperammoniemia, lactulose was the most frequently taken laxative (prevalence: 6.7% during hospital stay and 4.3% prior to hospital admission), followed by anthranoid laxatives such as senna, cascara, rhein and aloe (1.9% in-hospital and 3.3% pre-hospital). Other less frequently taken laxatives were picosulfate, phenolphthalein, lactitol, glycerol, bisacodyl and docusate. These patterns differ substantially from those reported by surveys conducted in other countries. Further studies are needed to assess the risks and benefits related to the intake of specific laxative ingredients.

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Substances:

ISSN: 0394-9532
NLM Unique ID: 9102503
Country: Italy
Entry Date: 19951113
Date Completed: 19951113
MeSH Date: 1995/04/01 00:01
Date Revised: 20001218
Entrez Date: 1995/04/01
Citation Subset: IM
Publication Status: ppublish
Aging (Milano) 1995 Apr;7(2):128-35.
PMID: 7548263 UI: 96044906 [PubMed - indexed for MEDLINE]
From PubMed
174

Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera.
Full author name: Karaca, K; Sharma, J M; Nordgren, R.

Karaca K, Sharma JM, Nordgren R. Int J Immunopharmacol. 1995 Mar;17(3):183-8.

[Article in English]

University of Minnesota, College of Veterinary Medicine, Department of Pathobiology, St Paul 55108, USA.

Cultures of normal chicken spleen cells and HD11 line cells produce nitric oxide (NO) in response to Acemannan, a complex carbohydrate derived from the Aloe vera plant. Neither cell type produced detectable amounts of NO in response to similar concentrations of yeast mannan, another complex carbohydrate. Nitric oxide production was dose dependent and inhibitable by the nitric oxide synthase inhibitor NG-methyl-L-arginine. In addition, the production of NO was inhibited by preincubation of ACM with concanavalin A in a dose-dependent manner. These results suggest that ACM-induced NO synthesis may be mediated through macrophage mannose receptors, and macrophage activation may be accountable for some of the immunomodulatory effects of ACM in chickens.

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Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19951120
Date Completed: 19951120
MeSH Date: 1995/03/01 00:01
Date Revised: 20001218
Entrez Date: 1995/03/01
Citation Subset: IM
http://linkinghub.elsevier.com/retrieve/pii/019205619400102T
Publication Status: ppublish
Int J Immunopharmacol 1995 Mar;17(3):183-8.
PMID: 7558512 UI: 96053455 [PubMed - indexed for MEDLINE]
From PubMed
175

Bioactive anthraquinone glycosides from Picramnia antidesma spp. fessonia.
Full author name: Solis, P N; Ravelo, A G; Gonzalez, A G; Gupta, M P; Phillipson, J D.

Solis PN, Ravelo AG, Gonzalez AG, Gupta MP, Phillipson JD. Phytochemistry. 1995 Jan;38(2):477-80.

[Article in English]

Department of Pharamacognosy, School of Pharmacy, London, U.K.

A bioactivity guided fractionation, using KB cells and brine shrimp assays, of the methanolic extract from the leaves of Picramnia antidesma yielded two known anthraquinones, aloe-emodin and aloe-emodin anthrone, and three new aloe-emodin C-glycosides, named picramnioside A, picramnioside B and picramnioside C. Structures were established by spectroscopic methods (UV, IR, mass spectrometry, 1H and 13C and 2D NMR including COSY 45, HMQC, HMBC and ROESY). CD was used to establish the absolute configuration of the picramniosides.

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Substances:

ISSN: 0031-9422
NLM Unique ID: 0151434
Country: United States
Entry Date: 19950710
Date Completed: 19950710
MeSH Date: 1995/01/01 00:01
Date Revised: 20001218
Entrez Date: 1995/01/01
Citation Subset: B
http://linkinghub.elsevier.com/retrieve/pii/003194229400598N
Publication Status: ppublish
Phytochemistry 1995 Jan;38(2):477-80.
PMID: 7772307 UI: 95290152 [PubMed - indexed for MEDLINE]
From PubMed
176

[Studies on chemical radioprotectors against X-irradiation used by soft X-ray accelerator]
Full author name: Shinoda, M.

Shinoda M. Yakugaku Zasshi. 1995 Jan;115(1):24-41.

[Article in Japanese]

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

This review describes the modes of mice radiation injuries induced by soft X-irradiation under various conditions and the protective effects of several kinds of substances on these injuries. The models of radiation injuries in this study were bone marrow death after lethal irradiation, skin damage induced by irradiation with long length soft X-ray and leukocytopenia in the peripheral blood after sublethal irradiation. Two bioassay methods were established for the survival effect on the lethal irradiation and protective potency on the skin damage induced by soft X-irradiation. The protective potencies of various sulfur compounds, related compounds of ferulic acid, nucleic acid constitutional compounds, crude drugs and chinese traditional medicines were determined and then many effective drugs were recognized. Effective components in the methanol extracts of Cnidii Rhizoma and Aloe arborescens recognized as radioprotectable were fractionated. As a result of these studies, it was observed that the active principles in Cnidii Rhizoma were identified as ferulic acid and adenosine. The scavenge action of active oxygens, a protective effect on the damages of deoxyribonucleic acid and superoxide dismutase by in vitro soft X-irradiation were evaluated as radiation protective mechanisms.

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Substances:

Number of References: 47
ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19950502
Date Completed: 19950502
MeSH Date: 1995/01/01 00:01
Date Revised: 20001218
Entrez Date: 1995/01/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1995 Jan;115(1):24-41.
PMID: 7699579 UI: 95213939 [PubMed - indexed for MEDLINE]
From PubMed
177

Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation.
Full author name: Davis, R H; DiDonato, J J; Johnson, R W; Stewart, C B.

Davis RH, DiDonato JJ, Johnson RW, Stewart CB. J Am Podiatr Med Assoc. 1994 Dec;84(12):614-21.

[Article in English]

Pennsylvania College of Podiatric Medicine, Philadelphia.

Aloe vera at doses of 100 and 300 mg/kg daily for 4 days blocked the wound healing suppression of hydrocortisone acetate up to 100% using the wound tensile strength assay. This response was because of the growth factors present in A. vera masking the wound healing inhibitors such as sterols and certain amino acids. The sterols showed good anti-inflammatory activity (-36%) in reducing the croton oil-induced ear swelling. This activity displayed a dose-response relationship.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19950313
Date Completed: 19950313
MeSH Date: 1994/12/01 00:01
Date Revised: 20011128
Entrez Date: 1994/12/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1994 Dec;84(12):614-21.
PMID: 7853156 UI: 95156229 [PubMed - indexed for MEDLINE]
From PubMed
178

Oral ulcers remedy gets FDA clearance.

[No authors listed]. J Am Dent Assoc. 1994 Oct;125(10):1308, 1310.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0002-8177
NLM Unique ID: 7503060
Country: United States
Entry Date: 19950309
Date Completed: 19950309
MeSH Date: 1994/10/01 00:01
Date Revised: 20011128
Entrez Date: 1994/10/01
Citation Subset: D, IM
Publication Status: ppublish
J Am Dent Assoc 1994 Oct;125(10):1308, 1310.
PMID: 7844295 UI: 95146704 [PubMed - indexed for MEDLINE]
From PubMed
179

Studies of aloe. V. Mechanism of cathartic effect. (4).
Full author name: Ishii, Y; Tanizawa, H; Takino, Y.

Ishii Y, Tanizawa H, Takino Y. Biol Pharm Bull. 1994 May;17(5):651-3.

[Article in English]

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

Aloe-emodin-9-anthrone(AE-anthrone), produced from barbaloin in the rat large intestine, caused not only an increase in the intestinal water content but also stimulated mucus secretion. This might play an important role in the occurrence of diarrhea. It was demonstrated that the amount of AE-anthrone produced in the rat large intestine(maximal amount: 568 micrograms/rat at 4 h after injection) was enough to cause both of these effects, which were observed following intracecal administration of barbaloin (31.1 mg/kg). These results together with our previous data, which showed a relationship between increase in the intestinal water content and the stimulation of peristalsis, confirm that AE-anthrone is the principal agent responsible for the cathartic effect of barbaloin. We also propose that the increase in water content is a more important factor than stimulation of peristalsis in the induction of diarrhea by barbaloin.

MeSH Terms:

Substances:

ISSN: 0918-6158
NLM Unique ID: 9311984
Country: Japan
Entry Date: 19941025
Date Completed: 19941025
MeSH Date: 1994/05/01 00:01
Date Revised: 20011128
Entrez Date: 1994/05/01
Citation Subset: IM
Publication Status: ppublish
Biol Pharm Bull 1994 May;17(5):651-3.
PMID: 7920425 UI: 95004237 [PubMed - indexed for MEDLINE]
From PubMed
180

Studies of aloe. IV. Mechanism of cathartic effect. (3).
Full author name: Ishii, Y; Tanizawa, H; Takino, Y.

Ishii Y, Tanizawa H, Takino Y. Biol Pharm Bull. 1994 Apr;17(4):495-7.

[Article in English]

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

Charcoal transport, as an indicator of the degree of peristalsis, and water content in the large intestine after the intracaecal administration of barbaloin, were measured simultaneously in the same rat. Charcoal transport was significantly accelerated at both 3.5 and 6.5 h after the administration of barbaloin. At 6.5 h, diarrhea instead of normal faeces was observed. Moreover, at 1 h before the acceleration of charcoal transport, a marked increase in the relative water content of the large intestine was observed. It appears that the increase in water content of the large intestine induced by barbaloin precedes the stimulation of peristalsis, attended by diarrhea. Therefore, it is suggested that the increase in water content is a more important factor than the stimulation of peristalsis in the diarrhea induced by barbaloin.

MeSH Terms:

Substances:

ISSN: 0918-6158
NLM Unique ID: 9311984
Country: Japan
Entry Date: 19940926
Date Completed: 19940926
MeSH Date: 1994/04/01 00:01
Date Revised: 20011128
Entrez Date: 1994/04/01
Citation Subset: IM
Publication Status: ppublish
Biol Pharm Bull 1994 Apr;17(4):495-7.
PMID: 8069255 UI: 94348457 [PubMed - indexed for MEDLINE]
From PubMed
181

Anti-inflammatory and wound healing activity of a growth substance in Aloe vera.
Full author name: Davis, R H; Donato, J J; Hartman, G M; Haas, R C.

Davis RH, Donato JJ, Hartman GM, Haas RC. J Am Podiatr Med Assoc. 1994 Feb;84(2):77-81.

[Article in English]

Department of Biomedical Sciences, Pennsylvania College of Podiatric Medicine, Philadelphia.

Aloe vera improves wound healing and inhibits inflammation. Since mannose-6-phosphate is the major sugar in the Aloe gel, the authors examined the possibility of its being an active growth substance. Mice receiving 300 mg/kg of mannose-6-phosphate had improved wound healing over saline controls. This dose also had anti-inflammatory activity. The function of mannose-6-phosphate in A. vera is discussed.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19940601
Date Completed: 19940601
MeSH Date: 1994/02/01 00:01
Date Revised: 20011128
Entrez Date: 1994/02/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1994 Feb;84(2):77-81.
PMID: 8169808 UI: 94223512 [PubMed - indexed for MEDLINE]
From PubMed
182

Prevention of ultraviolet radiation-induced suppression of contact and delayed hypersensitivity by Aloe barbadensis gel extract.
Full author name: Strickland, F M; Pelley, R P; Kripke, M L.

Strickland FM, Pelley RP, Kripke ML. J Invest Dermatol. 1994 Feb;102(2):197-204.

[Article in English]

Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

We investigated the ability of Aloe barbadensis gel extract to prevent suppression of contact hypersensitivity (CHS) and delayed-type hypersensitivity (DTH) responses in mice by ultraviolet (UV) irradiation. Local immune suppression was induced in C3H mice by exposure to four daily doses of 400 J/m2 UV-B (280-320 nm) radiation from FS40 sunlamps, followed by sensitization with 0.5% fluorescein isothiocyanate (FITC) through the irradiated skin. Topical application of 0.167-1.67% Aloe gel after each irradiation significantly reduced this suppression. Aloe treatment partially preserved the number and morphology of Langerhans and Thy-1+ dendritic epidermal cells in skin, compared to those in the skin of mice given only UVR or UVR plus the vehicle. Experiments using a single (2 kJ/m2) dose of UVR followed by Aloe treatment showed that the effect of Aloe was not due to screening of the UVR. Systemic suppression of DTH to Candida albicans or CHS to FITC was induced in C3H mice exposed to 5 or 10 kJ/m2 UV-B radiation, respectively, on shaved dorsal skin and sensitized 3 d later with a subcutaneous injection of formalin-fixed Candida or FITC painted on unirradiated, ventral skin. Treatment of the UV-irradiated skin with Aloe immediately after irradiation prevented suppression of both DTH to Candida and CHS to FITC. Aloe treatment did not prevent the formation of cyclobutyl pyrimidine dimers in the DNA of UV-irradiated skin or accelerate the repair of these lesions. These studies demonstrate that topical application of Aloe barbadensis gel extract to the skin of UV-irradiated mice ameliorates UV-induced immune suppression by a mechanism that does not involve DNA damage or repair.

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Substances:

Grant Support:

ISSN: 0022-202X
NLM Unique ID: 0426720
Country: United States
Entry Date: 19940322
Date Completed: 19940322
MeSH Date: 1994/02/01 00:01
Date Revised: 20011128
Entrez Date: 1994/02/01
Citation Subset: IM
Publication Status: ppublish
J Invest Dermatol 1994 Feb;102(2):197-204.
PMID: 7906286 UI: 94149291 [PubMed - indexed for MEDLINE]
From PubMed
183

Analytics of senna drugs with regard to the toxicological discussion of anthranoids.
Full author name: Grimminger, W; Witthohn, K.

Grimminger W, Witthohn K. Pharmacology. 1993 Oct;47 Suppl 1:98-109.

[Article in English]

Chemical Research Department, Madaus AG, Koln, FRG.

Toxicological studies indicate that two hydroxyanthraquinones (HAs), aloe-emodin and emodin, present as minor components in senna, might represent a genotoxic or cancerogenetic risk for man. Since aloe-emodin and emodin occur in senna in the free form as well as their glucosides and dianthrone glucosides, a HPLC method was established to allow the quantification of all free and glycosidic 1,8-dihydroxy anthranoids. The sum of the free HAs and their calculated content in each of their prodrug forms is defined as the potential HA content. For the comparison of different senna drugs in respect to the genotoxic risk arising from their potential aloe-emodin or emodin contents, a risk index has been established.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011102
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:98-109.
PMID: 8234448 UI: 94052328 [PubMed - indexed for MEDLINE]
From PubMed
184

Antioxidant and radical scavenging effects of anthraquinones and anthrones.
Full author name: Malterud, K E; Farbrot, T L; Huse, A E; Sund, R B.

Malterud KE, Farbrot TL, Huse AE, Sund RB. Pharmacology. 1993 Oct;47 Suppl 1:77-85.

[Article in English]

Department of Pharmacognosy, University of Oslo, Norway.

The activity of seven anthraquinones and four anthrones against nonenzymatic and enzymatic lipid peroxidation in vitro and their ability to scavenge free radicals have been studied. In nonenzymatic peroxidation in rat hepatocytes induced by t-butyl hydroperoxide, dithranol and anthrone were the strongest antioxidants, having IC50 values of 8 +/- 1 and 24 +/- 5 mumol/l, respectively. Rhein (IC50 64 +/- 2 mumol/l) and aloe-emodin (IC50 65 +/- 3 mumol/l) showed the highest inhibitory activity against peroxidation of linoleic acid catalyzed by soybean 15-lipoxygenase. Anthrone (IC50 62 +/- 2 mumol/l), dithranol (IC50 72 +/- 1 mumol/l) and rhein anthrone (IC50 76 +/- 6 mumol/l) were the most effective radical scavengers of the diphenylpicrylhydrazyl radical. The antioxidant activities in hepatocytes and the radical scavenging activities were correlated, whereas the inhibition of enzymatic lipid peroxidation showed no correlation with the two other effects.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20001218
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:77-85.
PMID: 8234446 UI: 94052326 [PubMed - indexed for MEDLINE]
From PubMed
185

Sennosides and aloin do not promote dimethylhydrazine-induced colorectal tumors in mice.
Full author name: Siegers, C P; Siemers, J; Baretton, G.

Siegers CP, Siemers J, Baretton G. Pharmacology. 1993 Oct;47 Suppl 1:205-8.

[Article in English]

Institutes of Toxicology, Medical University of Lubeck, FRG.

In a model of dimethylhydrazine-induced colorectal tumors in male mice aloin- or sennoside-enriched diets (0.03%) did not promote incidence and growth of adenomas and carcinomas after 20 weeks. Furthermore, in anthranoid-fed mice no significant changes in serum electrolytes as well as parameters of hepato- and nephrotoxicity were observed.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011128
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:205-8.
PMID: 8234430 UI: 94052309 [PubMed - indexed for MEDLINE]
From PubMed
186

The senna drug and its chemistry.
Full author name: Franz, G.

Franz G. Pharmacology. 1993 Oct;47 Suppl 1:2-6.

[Article in English]

Department of Pharmacy, University of Regensburg, FRG.

Senna consists of the dried leaflets or fruits of Cassia senna (C. acutifolia) known in commerce as Alexandrian senna and of Cassia angustifolia commonly known as Tinnevelly senna. The senna plants are small shrubs of Leguminosae cultivated either in Somalia, the Arabian peninsula and near the Nile river. Tinnevelly senna is obtained from cultivated plants mainly in South India and Pakistan. Owing to the careful way in which the plant is harvested, the leaflets of the drug are usually little broken. Damaged leaves and lower quality products are often used for making galenicals. The senna pods (fruits) are collected during the same period as the leaves, then dried and separated into various qualities. The active principle of Senna was first isolated and characterized by Stoll in 1941. The first two glycosides were identified and attributed to the anthraquinone family. These were found to be dimeric products of aloe emodin and/or rhein which were named sennoside A and sennoside B. They both hydrolyze to give the aglycones sennidin A and B and two molecules of glucose. Later work confirmed these findings and further demonstrated the presence of sennosides C and D. Small quantities of monomeric glycosides and free anthraquinones seem to be present as well. The active constituents of the pods are similar to those of the leaves but present in larger quantities. Two naphthalene glycosides isolated from senna leaves and pods are 6-hydroxymusicin glucoside and tinnevellin glucoside.Both compounds can be utilized to distinguish between the Alexandrian senna and the India senna, since tinnevellin glucoside is only found in the latter and the first only in the C. senna.(ABSTRACT TRUNCATED AT 250 WORDS)

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Substances:

Number of References: 8
ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011128
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:2-6.
PMID: 8234429 UI: 94052308 [PubMed - indexed for MEDLINE]
From PubMed
187

The genotoxicity status of senna.
Full author name: Heidemann, A; Miltenburger, H G; Mengs, U.

Heidemann A, Miltenburger HG, Mengs U. Pharmacology. 1993 Oct;47 Suppl 1:178-86.

[Article in English]

CCR Cytotest Cell Research, Rossdorf, FRG.

Genotoxicity tests were performed by several laboratories with the drug fructus sennae, senna extract, sennosides, rhein and aloe-emodin. The drug fructus sennae, the sennosides and rhein did not increase mutation frequencies in the following test systems: bacterial systems (Salmonella reverse mutation test and/or Escherichia coli forward mutation test); mammalian cell cultures [hypoxanthine guanine phosphoribosyl transferase (HGPRT) test; mouse lymphoma test; chromosome aberration test with Chinese hamster ovary cells]; bone marrow (micronucleus test; chromosome aberration test); melanoblast cells (mouse spot test) of rodents. With aloe-emodin mutagenic effects were observed only in vitro in the chromosome aberration test with CHO cells and in the Salmonella reverse mutation test (frameshift mutations in strains TA 1537, TA 1538 and TA 98). In the in vitro gene mutation test with V79 cells (HGPRT test) no mutagenic potential of aloe-emodin was observed. In in vivo studies [micronucleus test with bone marrow cells of NMRI mice, chromosome aberration test with bone marrow cells of Wistar rats, mouse spot test (crossing DBA/2J x NMRI) no indication for a mutagenic activity of aloe-emodin was found. The relevance of the absence of a mutagenic potential in in vivo test systems was strengthened by the fact that aloe-emodin could be found in the blood serum after oral administration. Additional information on the interaction of aloe-emodin with DNA was obtained from an ex vivo unscheduled DNA synthesis test performed with hepatocytes of male Wistar rats: aloe-emodin did not induce unscheduled DNA synthesis as expression of DNA damage.(ABSTRACT TRUNCATED AT 250 WORDS)

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011102
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:178-86.
PMID: 8234427 UI: 94052305 [PubMed - indexed for MEDLINE]
From PubMed
188

Cleavages of the O- and C-glucosyl bonds of anthrone and 10,10'-bianthrone derivatives by human intestinal bacteria.
Full author name: Hattori, M; Akao, T; Kobashi, K; Namba, T.

Hattori M, Akao T, Kobashi K, Namba T. Pharmacology. 1993 Oct;47 Suppl 1:125-33.

[Article in English]

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University.

A strictly anaerobic bacterium, Bifidobacterium sp. SEN, capable of hydrolyzing the O-glucosyl of sennosides was isolated from human feces. The bacterium stepwisely hydrolyzed sennoside B to sennidin B through sennidin-8-monoglucoside in PYF medium but not in GAM broth. Addition of D-glucose to PYF medium resulted in loss of the hydrolyzing activity in culture but addition of D-fructose did not affect the activity. Coculture of this bacterium with Peptostreptococcus intermedius led to rapid accumulation of rhein anthrone in the medium. Similarly, a bacterium, Eubacterium sp. BAR, capable of cleaving the C-glucosyl of barbaloin was isolated from human feces. This bacterium grew in PYF medium containing barbaloin and produced enzyme(s) that cleave(s) the C-glucosyl. The induction of the enzymes was completely inhibited in the presence of D-glucose. Nojirimycin inhibited the enzyme activity induced by barbaloin but it did not inhibit the bacterial growth in the presence of D-glucose.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011128
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:125-33.
PMID: 8234419 UI: 94052297 [PubMed - indexed for MEDLINE]
From PubMed
189

Rhein and aloe-emodin kinetics from senna laxatives in man.
Full author name: Krumbiegel, G; Schulz, H U.

Krumbiegel G, Schulz HU. Pharmacology. 1993 Oct;47 Suppl 1:120-4.

[Article in English]

Department of Pharmacokinetics, Madaus AG, Koln, FRG.

Therapeutic doses of two laxatives (Agiolax and Sennatin) were repeatedly administered to 10 healthy volunteers in a two-way change-over design. Blood samples were collected up to 96 h after the first dose, and plasma levels of total aloe-emodin and rhein were determined simultaneously with a sensitive (lower limit of quantification: 0.5 ng aloe-emodin and 2.5 ng rhein per millilitre plasma) and specific fluorometric HPLC method. Aloe-emodin was not detectable in any plasma sample of any subject. Rhein concentration time courses showed highest levels of 150-160 ng/ml and peak maxima at 3-5 h and 10-11 h after dosing probably according to absorption of free rhein and rhein released from prodrugs (e.g. sennosides) by bacterial metabolism, respectively.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20011128
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:120-4.
PMID: 8234418 UI: 94052296 [PubMed - indexed for MEDLINE]
From PubMed
190

Pharmacokinetic-metabolic studies with 14C-aloe emodin after oral administration to male and female rats.
Full author name: Lang, W.

Lang W. Pharmacology. 1993 Oct;47 Suppl 1:110-9.

[Article in English]

Department of Radiobiochemistry, Madaus AG, Koln, FRG.

After oral administration of 4.5 mg/kg 14C-aloe emodin (AE) to rats 20-30% of the dose was excreted in urine and the rest in feces. AE was quickly metabolized to rhein, to an unknown metabolite and to conjugates of all three. In the plasma about 10% of 14C-activity was identified as free AE. Maximum plasma values were reached 1.5-3 h p.a. with 248 (male) and 441 (female) ng equivalents AE/ml. Maximum concentrations in plasma were about 3 times higher than those in ovaries and 10 times higher than those in testes. Only liver, kidney and intestinal tract showed higher concentrations than plasma. Terminal half-life (for radioactivity) in blood was about 50 h.

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19931220
Date Completed: 19931220
MeSH Date: 1993/10/01 00:01
Date Revised: 20001218
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1993 Oct;47 Suppl 1:110-9.
PMID: 8234417 UI: 94052295 [PubMed - indexed for MEDLINE]
From PubMed
191

[The molecular structure of iso-aloesin isolated from the leaves of Aloe vera L. var. chinensis (Haw.) Berge]
Full author name: Yuan, A X.

Yuan AX. Zhongguo Zhong Yao Za Zhi. 1993 Oct;18(10):609-11, 639.

[Article in Chinese]

Guanxi Institute of Traditional Chinese Medical and Pharmaceutical Sciences, Nanning.

A new constituent iso-aloesin was isolated from the leaves of Aloe vera var. chinensis found in the Province of Guangxi. The molecular formula of iso-aloesin is C19H22O9, which is 2-acetonyl-6-C-beta-D-glucopyranosyl-7-hydroxy-5-methyl-chromone.

MeSH Terms:

Substances:

ISSN: 1001-5302
NLM Unique ID: 8913656
Country: China
Entry Date: 19940718
Date Completed: 19940718
MeSH Date: 1993/10/01 00:01
Date Revised: 20011128
Entrez Date: 1993/10/01
Citation Subset: IM
Publication Status: ppublish
Zhongguo Zhong Yao Za Zhi 1993 Oct;18(10):609-11, 639.
PMID: 8003214 UI: 94271443 [PubMed - indexed for MEDLINE]
From PubMed
192

Anthranoid laxative abuse--a risk for colorectal cancer?
Full author name: Siegers, C P; von Hertzberg-Lottin, E; Otte, M; Schneider, B.

Siegers CP, von Hertzberg-Lottin E, Otte M, Schneider B. Gut. 1993 Aug;34(8):1099-101.

[Article in English]

Institute of Toxicology, Medical University of Lubeck, Germany.

Anthranoid-containing laxatives--aloe, cascara, frangula, and rheum--may play a role in colorectal cancer. This risk is particularly important in view of the wide abuse of self administered laxatives for chronic constipation. There are data on the genotoxic potential of anthranoids and there is evidence of a tumourigenic potential in rodents. A case report and clinical-epidemiological studies have evaluated the cancer risk in patients who have abused anthranoid laxatives over a long period. Pseudomelanosis coli is a reliable parameter of chronic laxative abuse (> 9-12 months) and is specific for anthranoid drugs. In a retrospective study of 3049 patients who underwent diagnostic colorectal endoscopy the incidence of pseudomelanosis coli was 3.13% in patients without pathological changes. In those with colorectal adenomas, the incidence increased to 8.64% (p < 0.01), and in those with colorectal carcinomas it was 3.29%. This lower rate was probably caused by incomplete documentation of pseudomelanosis coli in those with carcinoma. In a prospective study of 1095 patients, the incidence of pseudomelanosis coli was 6.9% for patients with no abnormality seen on endoscopy, 9.8% (p = 0.068) for patients with adenomas, and 18.6% for patients with colorectal carcinomas. From these data a relative risk of 3.04 (1.18, 4.90; 95% confidence interval) can be calculated for colorectal cancer as a result of anthranoid laxative abuse.

MeSH Terms:

Substances:

ISSN: 0017-5749
NLM Unique ID: 2985108R
Country: England
Entry Date: 19940607
Date Completed: 19940607
MeSH Date: 1993/08/01 00:01
Date Revised: 20001218
Entrez Date: 1993/08/01
Citation Subset: AIM, IM
Publication Status: ppublish
Gut 1993 Aug;34(8):1099-101.
PMID: 8174962 UI: 94229551 [PubMed - indexed for MEDLINE]
From PubMed
193

Components of the gel of Aloe vera (L.) burm. f.
Full author name: Yamaguchi, I; Mega, N; Sanada, H.

Yamaguchi I, Mega N, Sanada H. Biosci Biotechnol Biochem. 1993 Aug;57(8):1350-2.

[Article in English]

Department of Nutrition, Faculty of Home Economics, Tokyo Kasei University, Japan.

MeSH Terms:

Substances:

ISSN: 0916-8451
NLM Unique ID: 9205717
Country: Japan
Entry Date: 19931014
Date Completed: 19931014
MeSH Date: 1993/08/01 00:01
Date Revised: 20011128
Entrez Date: 1993/08/01
Citation Subset: B
Publication Status: ppublish
Biosci Biotechnol Biochem 1993 Aug;57(8):1350-2.
PMID: 7764018 UI: 93379359 [PubMed - indexed for MEDLINE]
From PubMed
194

Determination of the position of the O-acetyl group in a beta-(1-->4)-mannan (acemannan) from Aloe barbardensis Miller.
Full author name: Manna, S; McAnalley, B H.

Manna S, McAnalley BH. Carbohydr Res. 1993 Mar 17;241:317-9.

[Article in English]

Synthetic Organic Division, Carrington Laboratories, Inc., Dallas, TX 75356-9500.

MeSH Terms:

Substances:

ISSN: 0008-6215
NLM Unique ID: 0043535
Country: Netherlands
Entry Date: 19930517
Date Completed: 19930517
MeSH Date: 1993/03/17 00:01
Date Revised: 20011128
Entrez Date: 1993/03/17
Citation Subset: IM
Publication Status: ppublish
Carbohydr Res 1993 Mar 17;241:317-9.
PMID: 8472257 UI: 93230529 [PubMed - indexed for MEDLINE]
From PubMed
195

[The therapeutic properties of aloe]
Full author name: Iena, Ia M.

Iena IaM. Lik Sprava. 1993 Feb-Mar;(2-3):142-5.

[Article in Ukrainian]

Data are reported on the use of aloes in research and folk medicine. Aloes is used in the form of dry juice of aloe leaves, fluid extract, juice, ointments. The author discusses indications and contraindications to the use of aloe. Recipes are given of mixtures with aloe which may be used in domestic conditions for increasing the defensive forces of the body during radiation lesions.

Publication Types:

MeSH Terms:

Substances:

Number of References: 9
ISSN: 1019-5297
NLM Unique ID: 9601540
Country: Ukraine
Vernacular Title: Likuval'ni vlastyvosti aloe.
Entry Date: 19940623
Date Completed: 19940623
MeSH Date: 1993/02/01 00:01
Date Revised: 20011128
Entrez Date: 1993/02/01
Citation Subset: IM
Publication Status: ppublish
Lik Sprava 1993 Feb-Mar;(2-3):142-5.
PMID: 8191716 UI: 94249208 [PubMed - indexed for MEDLINE]
From PubMed
196

Identification of natural antimutagens with modulating effects on DNA repair.
Full author name: Vukovic-Gacic, B; Simic, D.

Vukovic-Gacic B, Simic D. Basic Life Sci. 1993;61:269-77.

[Article in English]

Botanical Institute and Garden, University of Belgrade, Yugoslavia.

The results of a study of bioantimutagenesis, with emphasis on natural antimutagens from plant extracts with modulating effects on DNA repair in Escherichia coli bacteria are presented in this chapter. Comparative screening for spontaneous or induced mutagenesis, as well as expression of the SOS gene, sfiA was accomplished. Antimutagenic capacity was obtained with nontoxic concentrations of the plant extracts; the same plant extract may decrease or increase the mutation rate, or even be ineffective, depending on the bacterial strain used and the concentration of the extract applied. Since antimutagenic effects may be the consequence of either stimulation of error-free repair, inhibition of error-prone repair, or involvement of multiple mechanisms, the effects of several plant extracts on the level of UV-induced beta-galactosidase were screened (to monitor SOS induction in cells). Reduction of the enzyme activity induced by UV was observed following addition of St. John's wort extract, while there was not reduction after thyme, aloe, camomile, or lime-tree and the level of UV-induced enzyme was even higher with sage extract. Our results indicate that the antimutagenic effect of St. John's wort is probably due to suppression of error-prone repair. Moreover, we assume that an antimutagenic effect obtained with thyme, mint, and sage under certain conditions may be due to enhanced error-free repair.

MeSH Terms:

Substances:

ISSN: 0090-5542
NLM Unique ID: 0360077
Country: United States
Entry Date: 19940307
Date Completed: 19940307
MeSH Date: 1993/01/01 00:01
Date Revised: 20001218
Entrez Date: 1993/01/01
Citation Subset: IM
Gene Symbol: argE, mutH, mutL, mutS, uvrD
Publication Status: ppublish
Basic Life Sci 1993;61:269-77.
PMID: 8304938 UI: 94137240 [PubMed - indexed for MEDLINE]
From PubMed
197

Purification and characterization of a glutathione peroxidase from the Aloe vera plant.
Full author name: Sabeh, F; Wright, T; Norton, S J.

Sabeh F, Wright T, Norton SJ. Enzyme Protein. 1993;47(2):92-8.

[Article in English]

Department of Biological Sciences, University of North Texas, Denton 76201.

Extracts from the parenchymous leaf-gel of the Aloe vera plant (Aloe barbadensis Miller) were shown to contain glutathione peroxidase (GSHPx) activity. The activity was purified to homogeneity by ion exchange and gel filtration (FPLC) chromatography in the presence of 0.5 mM glutathione. The native enzyme has an apparent molecular weight of 62 kD as determined by gel filtration. In the presence of sodium dodecylsulfate (SDS), the molecular weight was estimated to be about 16 kD as determined by polyacrylamide-gel electrophoresis (SDS-PAGE). The native enzyme is proposed to be constituted of four identical subunits; it also contains one atom of selenium per subunit, as found with most glutathione peroxidases from animal sources. The Km values were determined to be 3.2 mM for glutathione and 0.26 mM for the hydroperoxide substrate, cumene hydroperoxide. The enzyme is competitively inhibited by N, S, bis-FMOC glutathione (Ki = 0.32 mM), a potent inhibitor of glyoxalase II. Inhibitors of glyoxalase I (e.g. S-octylglutathione) have no effect on the peroxidase activity.

MeSH Terms:

Substances:

ISSN: 1019-6773
NLM Unique ID: 9422761
Country: Switzerland
Entry Date: 19940628
Date Completed: 19940628
MeSH Date: 1993/01/01 00:01
Date Revised: 20011128
Entrez Date: 1993/01/01
Citation Subset: IM
Publication Status: ppublish
Enzyme Protein 1993;47(2):92-8.
PMID: 8193675 UI: 94251296 [PubMed - indexed for MEDLINE]
From PubMed
198

Metabolic activation of sennoside C in mice: synergistic action of anthrones.
Full author name: Yamauchi, K; Shinano, K; Nakajima, K; Yagi, T; Kuwano, S.

Yamauchi K, Shinano K, Nakajima K, Yagi T, Kuwano S. J Pharm Pharmacol. 1992 Dec;44(12):973-6.

[Article in English]

Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Hyogo, Japan.

Sennosides A and C directly injected into the caecum of mice showed equal purgative activity. Intracaecal administration reduced time to onset of diarrhoea induced by sennoside C from about 3 h after oral administration to about 24 min. At 2.3 h after oral administration of sennoside C, nearly equimolar amounts of aloe-emodin anthrone and rhein anthrone were detected in the large intestine of mice. The purgative effect of oral sennoside C could be reduced by pretreating mice with chloramphenicol. This was observed as a decreased formation of total anthrones in the large intestine. Both anthrones and an equimolar mixture of both anthrones directly injected into the caecum exerted a purgative effect, although the activity was lower for aloe-emodin anthrone. The intracaecal ED50 values were 54.5 (24.1-89.6), 11.4 (5.0-15.7) and 11.2 (6.1-14.6) mumol kg-1 for aloe-emodin anthrone, rhein anthrone and an equimolar mixture of both anthrones, respectively. We concluded that aloe-emodin anthrone and rhein anthrone, formed mainly by intraluminal bacterial action, are the true active metabolites of sennoside C in mice and that both anthrones synergistically exert their purgative effects on mice.

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 19930125
Date Completed: 19930125
MeSH Date: 1992/12/01 00:01
Date Revised: 20001218
Entrez Date: 1992/12/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 1992 Dec;44(12):973-6.
PMID: 1361561 UI: 93108236 [PubMed - indexed for MEDLINE]
From PubMed
199

Some pharmacological actions of aloe extracts and Cassia abbreviata on rats and mice.
Full author name: Parry, O; Matambo, C.

Parry O, Matambo C. Cent Afr J Med. 1992 Oct;38(10):409-14.

[Article in English]

Department of Physiology, University of Zimbabwe, Harare.

The effects of crude extracts (500 mg/kg IP and 500-1000 mg/kg PO) of three species of aloes and Cassia abbreviata in rats and mice were studied, particularly as regards their abortifacient actions. The LD50 values were as follows: A. globuligemma < 250 mg/kg IP; A.chabaudii 250-500 mg/kg IP; A. cryptopoda > 1500 mg/kg IP and C.abbreviata 500-750 mg/kg IP. Thus the most toxic was A.globuligemma. Their most visibly striking toxic effects in rats were CNS depression, and post mortem investigations showed widespread haemorrhagic lesions. Administration of the aloes and A.abbreviata to pregnant mice and rats did not cause expulsion or resorption of the foetuses. Several rats died within 36 hours of injection of A.chabaudii and A.globuligemma, but even in these rats there was no expulsion or resorption of the foetuses. Rats which survived the treatment delivered normal sized, healthy litters at term. It is suggested that neither the aloe species test nor C.abbreviata possess abortifacient activity at doses which are not toxic to the animals.

MeSH Terms:

Substances:

ISSN: 0008-9176
NLM Unique ID: 0372566
Country: Zimbabwe
Entry Date: 19931008
Date Completed: 19931008
MeSH Date: 1992/10/01 00:01
Date Revised: 20011128
Entrez Date: 1992/10/01
Citation Subset: IM
Publication Status: ppublish
Cent Afr J Med 1992 Oct;38(10):409-14.
PMID: 1308715 UI: 93380002 [PubMed - indexed for MEDLINE]
From PubMed
200

Toxicologic evaluation of injectable acemannan in the mouse, rat and dog.
Full author name: Fogleman, R W; Chapdelaine, J M; Carpenter, R H; McAnalley, B H.

Fogleman RW, Chapdelaine JM, Carpenter RH, McAnalley BH. Vet Hum Toxicol. 1992 Jun;34(3):201-5.

[Article in English]

Pharmakon Research International, Waverly, PA 18471.

Acemannan, the USAN-accepted name for long-chain polydispersed beta-(1,4)-acetylated polymannose with interspersed 0-acetyl groups with a mannose monomer/acetyl ratio of approximately 1:1 and extracted from Aloe vera (barbadensis Miller), was administered as a 1.0 mg/ml solution to mice, rats and dogs, either as single dose or repeated at 4-d intervals for 8 doses by iv or ip routes. No significant signs of intoxication and no deaths occurred in animals treated with the single injection of acemannan at dosages of 80 mg/kg iv or 200 mg/kg ip in mice, 15 mg/kg iv or 50 mg/kg ip in rats, and 10 mg/kg iv or 50 mg/kg ip in dogs. On repeated injections systemic toxicity was limited to obvious transient discomfort that appeared dose related. There was accumulation of macrophages and monocytes without subsequent inflammatory reaction in lungs of the iv-treated animals, and in liver and spleen and on peritoneal surfaces of ip-treated animals. The effects were not considered adverse, but were consistent with the known immune stimulating activity of acemannan. A few deaths occurred in mice and rats that were suggestive of resulting from improper injection or sequella of necrosis of the injection site. The NOAELs for acemannan determined from these repeated injection studies were 20 mg/kg iv or ip in the mouse, 4.0 mg/kg iv and 50 mg/kg ip in the rat, and 1.0 mg/kg iv in dogs; 5.0 mg acemannan/kg ip in the dog was considered to be LOAEL, based on the emesis and abdominal discomfort induced.

MeSH Terms:

Substances:

ISSN: 0145-6296
NLM Unique ID: 7704194
Country: United States
Entry Date: 19920717
Date Completed: 19920717
MeSH Date: 1992/06/01 00:01
Date Revised: 20001218
Entrez Date: 1992/06/01
Citation Subset: IM
Publication Status: ppublish
Vet Hum Toxicol 1992 Jun;34(3):201-5.
PMID: 1609484 UI: 92303099 [PubMed - indexed for MEDLINE]
From PubMed
201

Photodermatitis to aloe vera.
Full author name: Dominguez-Soto, L.

Dominguez-Soto L. Int J Dermatol. 1992 May;31(5):372.

Comment on:


[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0011-9059
NLM Unique ID: 0243704
Country: United States
Entry Date: 19920623
Date Completed: 19920623
MeSH Date: 1992/05/01 00:01
Date Revised: 20011128
Entrez Date: 1992/05/01
Citation Subset: IM
Publication Status: ppublish
Int J Dermatol 1992 May;31(5):372.
PMID: 1587675 UI: 92267774 [PubMed - indexed for MEDLINE]
From PubMed
202

Subchronic oral administration of acemannan in the rat and dog.
Full author name: Fogleman, R W; Shellenberger, T E; Balmer, M F; Carpenter, R H; McAnalley, B H.

Fogleman RW, Shellenberger TE, Balmer MF, Carpenter RH, McAnalley BH. Vet Hum Toxicol. 1992 Apr;34(2):144-7.

[Article in English]

Carrington Laboratories, Dallas, TX 75356.

Acemannan is the USAN-accepted name for long-chain polydispersed beta-(1,4)-acetylated polymannose with interspersed O-acetyl groups, with a mannose monomer/acetyl ratio of approximately 1:1. This complex polysaccharide is extracted from Aloe vera (barbadensis Miller); the technical material contains approximately 78% acemannan. Technical grade acemannan was administered po to rats for 14 d at 5% of the diet and for 6 mo at up to 2,000 mg/kg/d, and to beagle dogs for 90 d at up to 1,500 mg/kg/d without significant effect on any parameter measured in either species.

MeSH Terms:

Substances:

ISSN: 0145-6296
NLM Unique ID: 7704194
Country: United States
Entry Date: 19920918
Date Completed: 19920918
MeSH Date: 1992/04/01 00:01
Date Revised: 20001218
Entrez Date: 1992/04/01
Citation Subset: IM
Publication Status: ppublish
Vet Hum Toxicol 1992 Apr;34(2):144-7.
PMID: 1509675 UI: 92377179 [PubMed - indexed for MEDLINE]
From PubMed
203

Aloe vera and the inflamed synovial pouch model.
Full author name: Davis, R H; Stewart, G J; Bregman, P J.

Davis RH, Stewart GJ, Bregman PJ. J Am Podiatr Med Assoc. 1992 Mar;82(3):140-8.

[Article in English]

Pennsylvania College of Podiatric Medicine, Philadelphia.

Administration of air under the skin produced a pouch wall that closely resembled a synovium in that the inner lining was made up of macrophages and fibroblasts. Administration of 1% carrageenan directly into the 7-day-old air pouch produced an inflammation characterized by an increased number of mast cells in pouch fluid as well as an increase in wall vascularity. A punch biopsy weight of the pouch wall did not reveal an increase in 1% carrageenan-treated animals. However, a 10% Aloe vera treatment of carrageenan-inflamed synovial pouches reduced the vascularity 50% and the number of mast cells in synovial fluid 48%. The pouch wall punch biopsy weight was increased by A. vera, which was verified by histologic examination of the inner synovial lining. Aloe vera stimulated the synovial-like membrane, as evidenced by an increased number of fibroblasts, suggesting that A. vera stimulated fibroblasts for growth and repair of the synovial model. The synovial air pouch can be used to study simultaneously the acute anti-inflammatory and fibroblast stimulating activities of A. vera.

MeSH Terms:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19920611
Date Completed: 19920611
MeSH Date: 1992/03/01 00:01
Date Revised: 20011128
Entrez Date: 1992/03/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1992 Mar;82(3):140-8.
PMID: 1578350 UI: 92251606 [PubMed - indexed for MEDLINE]
From PubMed
204

The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats.
Full author name: al-Awadi, F; Fatania, H; Shamte, U.

al-Awadi F, Fatania H, Shamte U. Diabetes Res. 1991 Dec;18(4):163-8.

[Article in English]

Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat.

We have previously reported on plant mixture extract comprising of Nigella sativa, Myrrh, Gum Olibanum, Gum Asafoetida and Aloe to have a blood glucose lowering effect. The present study with streptozotocin diabetic rats is focussed on the mechanism of action, specifically on a) hepatic gluconeogenesis b) activity of key gluconeogenic enzymes, pyruvate carboxylase (PC) and phosphoenol-pyruvate carboxykinase (PEPCK). Similar studies using a biguanide, phenformin, have been conducted to compare the mode of action of these two compounds. The blood glucose levels (mean +/- SEM) before and after treatment with the plants extract were (16.7 +/- 1.7 mmol/L and 8.5 +/- 1.3 mmol/L) and with phenformin (15.1 +/- 1.3 mmol/L and 10.7 +/- 1.5 mmol/L). The rate of gluconeogenesis in isolated hepatocytes as well as activity of PC and PEPCK in liver homogenates is significantly lowered following treatment with the plants extract. Although phenformin also lowers blood glucose, it does not affect hepatic gluconeogenesis under stated experimental conditions. It is concluded that the anti-diabetic action of the plants extract may, at least partly, be mediated through decreased hepatic gluconeogenesis. The extract may prove to be a useful therapeutic agent in the treatment of non-insulin dependent diabetes mellitus (NIDDM).

MeSH Terms:

Substances:

ISSN: 0265-5985
NLM Unique ID: 8502339
Country: Scotland
Entry Date: 19930125
Date Completed: 19930125
MeSH Date: 1991/12/01 00:01
Date Revised: 20001218
Entrez Date: 1991/12/01
Citation Subset: IM
Publication Status: ppublish
Diabetes Res 1991 Dec;18(4):163-8.
PMID: 1842751 UI: 93105582 [PubMed - indexed for MEDLINE]
From PubMed
205

Inactivation of enveloped viruses by anthraquinones extracted from plants.
Full author name: Sydiskis, R J; Owen, D G; Lohr, J L; Rosler, K H; Blomster, R N.

Sydiskis RJ, Owen DG, Lohr JL, Rosler KH, Blomster RN. Antimicrob Agents Chemother. 1991 Dec;35(12):2463-6.

[Article in English]

Department of Microbiology, University of Maryland, Baltimore 21201.

To determine the extent of antiviral activity present in a number of plant extracts, hot glycerin extracts were prepared from Rheum officinale, Aloe barbadensis, Rhamnus frangula, Rhamnus purshianus, and Cassia angustifolia and their virucidal effects were tested against herpes simplex virus type 1. All the plant extracts inactivated the virus. The active components in these plants were separated by thin-layer chromatography and identified as anthraquinones. A purified sample of aloe emodin was prepared from aloin, and its effects on the infectivity of herpes simplex virus type 1 and type 2, varicella-zoster virus, pseudorabies virus, influenza virus, adenovirus, and rhinovirus were tested by mixing virus with dilutions of aloe emodin for 15 min at 37 degrees C, immediately diluting the sample, and assaying the amount of infectious virus remaining in the sample. The results showed that aloe emodin inactivated all of the viruses tested except adenovirus and rhinovirus. Electron microscopic examination of anthraquinone-treated herpes simplex virus demonstrated that the envelopes were partially disrupted. These results show that anthraquinones extracted from a variety of plants are directly virucidal to enveloped viruses.

MeSH Terms:

Substances:

ISSN: 0066-4804
NLM Unique ID: 0315061
Country: United States
Entry Date: 19920528
Date Completed: 19920528
MeSH Date: 1991/12/01 00:01
Date Revised: 20011128
Entrez Date: 1991/12/01
Citation Subset: IM
Publication Status: ppublish
Antimicrob Agents Chemother 1991 Dec;35(12):2463-6.
PMID: 1810179 UI: 92238665 [PubMed - indexed for MEDLINE]
From PubMed
206

[Mechanochemical solid state reactions of natural products for medicinal use containing hydroxyanthraquinone derivatives]
Full author name: Kuzuya, M; Sakata, H; Kondo, S; Noguchi, A.

Kuzuya M, Sakata H, Kondo S, Noguchi A. Yakugaku Zasshi. 1991 Nov;111(11):665-71.

[Article in Japanese]

Gifu Pharmaceutical University, Japan.

In commercial powdered natural products for medicinal use containing various combined forms of hydroxyanthraquinone derivatives such as Sennae Folium, Cassiae Semen, Rhei Rhizoma and Aloe a considerable amount of stable free radicals (ca. 10(17)-10(18) spin/g) was found to be contained by use of electron spin resonance (ESR) spectral measurements. It was also found that the vibratory milling of such powders in a metallic vessel enhanced the ESR spectral intensities, demonstrating the occurrence of mechanoradical formation. Separate experiments also demonstrated that the vibratory milling of various kinds of powdered hydroxyanthraquinone derivatives mixed with calcium oxalate has produced the mechanoradicals effectively, but they decayed gradually on standing at room temperature. It was suggested, therefore, that the mechanoradicals formed in the above natural products are metal complexes of the corresponding semiquinone anion radicals induced by solid state one electron transfer mechanism from the active metal surface, part of which is further immobilized in polymeric fibers or the like in the plant tissues.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19920317
Date Completed: 19920317
MeSH Date: 1991/11/01 00:01
Date Revised: 20001218
Entrez Date: 1991/11/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1991 Nov;111(11):665-71.
PMID: 1664462 UI: 92148655 [PubMed - indexed for MEDLINE]
From PubMed
207

The use of botanicals for health purposes by members of a prepaid health plan.
Full author name: Brown, J S; Marcy, S A.

Brown JS, Marcy SA. Res Nurs Health. 1991 Oct;14(5):339-50.

[Article in English]

School of Nursing, Oregon Health Sciences University, Portland 97201.

Interviews were conducted with 100 adults (27 men, 73 women) enrolled in a prepaid medical health plan to investigate their use of botanical remedies. They were asked which of 50 listed herbs they or members of their families had used for health purposes and with what effect; which of 60 listed health problems they had treated with home remedies; and what additional home remedies or alternative health care resources they had used. Over 100 different home remedies were identified, with most considered effective. Individual respondents used from 0 to 33 herbal and plant remedies (Md = 7), some of which have toxic properties. A remedy was reported for almost every health problem listed. Substances most frequently used were aloe vera, honey, peppermint, garlic, eucalyptus, and rose hips; health problems most frequently treated were burns, colds, indigestion, insect bites, insomnia, rashes. Persons who were married, from larger households, of higher socioeconomic status, who had consulted alternative healers, or who had patronized health food stores tended to use home remedies more than their counterparts. Implications for further evaluation of self-care practices are discussed.

MeSH Terms:

Substances:

ISSN: 0160-6891
NLM Unique ID: 7806136
Country: United States
Entry Date: 19911016
Date Completed: 19911016
MeSH Date: 1991/10/01 00:01
Date Revised: 20011102
Entrez Date: 1991/10/01
Citation Subset: IM, N
Publication Status: ppublish
Res Nurs Health 1991 Oct;14(5):339-50.
PMID: 1891620 UI: 91368053 [PubMed - indexed for MEDLINE]
From PubMed
208

Aloe vera. Its chemical and therapeutic properties.
Full author name: Shelton, R M.

Shelton RM. Int J Dermatol. 1991 Oct;30(10):679-83.

Comment in:


[Article in English]

Department of Dermatology, Brooke Army Medical Center, Fort Sam Houston, San Antonio, Texas.

Publication Types:

MeSH Terms:

Number of References: 61
ISSN: 0011-9059
NLM Unique ID: 0243704
Country: United States
Entry Date: 19920102
Date Completed: 19920102
MeSH Date: 1991/10/01 00:01
Date Revised: 20011128
Entrez Date: 1991/10/01
Citation Subset: IM
Publication Status: ppublish
Int J Dermatol 1991 Oct;30(10):679-83.
PMID: 1823544 UI: 92064333 [PubMed - indexed for MEDLINE]
From PubMed
209

Isolation of a stimulatory system in an Aloe extract.
Full author name: Davis, R H; Parker, W L; Samson, R T; Murdoch, D P.

Davis RH, Parker WL, Samson RT, Murdoch DP. J Am Podiatr Med Assoc. 1991 Sep;81(9):473-8.

[Article in English]

Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

The authors' previous work on a 50% ethanol extract of Aloe vera was done to evaluate anti-inflammatory activity using the croton oil-induced ear swelling assay. The anti-inflammatory activity was found in the supernatant fraction. The supernatant fraction decreased inflammation, when applied topically, by 29.2%, and the precipitate decreased inflammation by 12.1%. However, in the present work, the precipitate fraction decreased the wound diameter by an average of 47.1% (stimulatory system). Little or no wound healing activity was found in the supernatant. Aloe vera appears to act as a modulatory system toward wounds and inflammation and is a potentially valuable tool for managing lower extremity conditions.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19920122
Date Completed: 19920122
MeSH Date: 1991/09/01 00:01
Date Revised: 20011128
Entrez Date: 1991/09/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1991 Sep;81(9):473-8.
PMID: 1748962 UI: 92085227 [PubMed - indexed for MEDLINE]
From PubMed
210

In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives.
Full author name: Andersen, D O; Weber, N D; Wood, S G; Hughes, B G; Murray, B K; North, J A.

Andersen DO, Weber ND, Wood SG, Hughes BG, Murray BK, North JA. Antiviral Res. 1991 Sep;16(2):185-96.

[Article in English]

Department of Microbiology, Brigham Young University, Provo, Utah 84602.

Anthraquinones and anthraquinone derivatives were characterized for their antiviral and virucidal activities against viruses representing several taxonomic groups. One of these compounds, hypericin, had activity against vesicular stomatitis virus, herpes simplex virus types 1 and 2, parainfluenza virus, and vaccinia virus (from 0.5 to 3.8 log10 reductions in infectivity) at concentrations of less than 1 microgram/ml as determined by a direct pre-infection incubation assay. Human rhinovirus was not sensitive to hypericin at concentrations up to 10 micrograms/ml. Addition of small amounts of Tween-80 to solutions containing hypericin enhanced, by up to 2.6 log10, hypericin's virucidal activity. Anthraquinones and anthraquinone derivatives with the hydroxyl and alkyl substitution pattern of emodin (i.e. emodin, emodin anthrone, emodin bianthrone and hypericin) were active against the enveloped viruses tested. The following general pattern of activity was found: hypericin greater than emodin bianthrone greater than emodin anthrone greater than emodin. Chrysophanic acid, aloe-emodin, and sennosides A and B did not possess activity against any of the viruses tested.

MeSH Terms:

Substances:

ISSN: 0166-3542
NLM Unique ID: 8109699
Country: Netherlands
Entry Date: 19920413
Date Completed: 19920413
MeSH Date: 1991/09/01 00:01
Date Revised: 20011102
Entrez Date: 1991/09/01
Citation Subset: IM
Publication Status: ppublish
Antiviral Res 1991 Sep;16(2):185-96.
PMID: 1665961 UI: 92189336 [PubMed - indexed for MEDLINE]
From PubMed
211

Aloe vera dermal wound gel is associated with a delay in wound healing.
Full author name: Schmidt, J M; Greenspoon, J S.

Schmidt JM, Greenspoon JS. Obstet Gynecol. 1991 Jul;78(1):115-7.

[Article in English]

Department of Nursing, Women's Hospital, Los Angeles County-University of Southern California Medical Center.

We evaluated the time interval required for wound healing using a standard wound management protocol with and without aloe vera gel. Twenty-one women were studied who had wound complications requiring healing by second intention after cesarean delivery or laparotomy for gynecologic surgery. Wounds treated with standard management healed in a mean (+/- SD) time interval of 53 +/- 24 days, whereas those treated with aloe vera gel required 83 +/- 28 days (P = associated with a significant delay in wound healing compared with treatment with an otherwise identical regimen that did not include aloe vera.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0029-7844
NLM Unique ID: 0401101
Country: United States
Entry Date: 19910716
Date Completed: 19910716
MeSH Date: 1991/07/01 00:01
Date Revised: 20011128
Entrez Date: 1991/07/01
Citation Subset: AIM, IM
Publication Status: ppublish
Obstet Gynecol 1991 Jul;78(1):115-7.
PMID: 2047051 UI: 91261319 [PubMed - indexed for MEDLINE]
From PubMed
212

Decreased mortality of Norman murine sarcoma in mice treated with the immunomodulator, Acemannan.
Full author name: Peng, S Y; Norman, J; Curtin, G; Corrier, D; McDaniel, H R; Busbee, D.

Peng SY, Norman J, Curtin G, Corrier D, McDaniel HR, Busbee D. Mol Biother. 1991 Jun;3(2):79-87.

[Article in English]

Department of Anatomy, College of Veterinary Medicine, Texas A & M University, College Station 77843.

An extract from the parenchyma of Aloe barbadensis Miller shown to contain long chain polydispersed beta (1,4)-linked mannan polymers with random O-acetyl groups (acemannan, Carrisyn) was found to initiate the phagocyte production of monokines that supported antibody dependent cellular cytotoxicity and stimulated blastogenesis in thymocytes. Acemannan, in both enriched and highly purified forms, was administered intraperitoneally to female CFW mice into which murine sarcoma cells had been subcutaneously implanted. The rapidly growing, highly malignant and invasive sarcoma grew in 100% of implanted control animals, resulting in mortality in 20 to 46 days, dependent on the number of cells implanted. Approximately 40% of animals treated with acemannan at the time of tumor cell implantation (1.5 x 10(6) cells) survived. Tumors in acemannan-treated animals exhibited vascular congestion, edema, polymorphonuclear leukocyte infiltration, and central necrosing foci with hemorrhage and peripheral fibrosis. The data indicate that in vivo treatment of peritoneal macrophages stimulates the macrophage production of monokines, including interleukin-1 and tumor necrosis factor. The data further indicate that sarcomas in animals treated i.p. with acemannan at the time of tumor cell implantation were infiltrated by immune system cells, became necrotic, and regressed. The combined data suggest that acemannan-stimulated synthesis of monokines resulted in the initiation of immune attack, necrosis, and regression of implanted sarcomas in mice.

MeSH Terms:

Substances:

ISSN: 0952-8172
NLM Unique ID: 8904897
Country: United States
Entry Date: 19911101
Date Completed: 19911101
MeSH Date: 1991/06/01 00:01
Date Revised: 20011128
Entrez Date: 1991/06/01
Citation Subset: IM
Publication Status: ppublish
Mol Biother 1991 Jun;3(2):79-87.
PMID: 1910624 UI: 92000401 [PubMed - indexed for MEDLINE]
From PubMed
213

The isolation of an active inhibitory system from an extract of aloe vera.
Full author name: Davis, R H; Parker, W L; Samson, R T; Murdoch, D P.

Davis RH, Parker WL, Samson RT, Murdoch DP. J Am Podiatr Med Assoc. 1991 May;81(5):258-61.

[Article in English]

Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

An Aloe vera extract was prepared with 50% ethanol. The resultant supernatant and precipitate were tested for anti-inflammatory activity using the croton oil-induced ear-swelling assay. The supernatant fraction decreased inflammation, when applied topically, by 29.2%, and the precipitate decreased inflammation by 12.1%. The authors have shown that the anti-inflammatory activity (inhibitory system) resides in the supernatant of a 50% ethanol extract.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19910808
Date Completed: 19910808
MeSH Date: 1991/05/01 00:01
Date Revised: 20011128
Entrez Date: 1991/05/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1991 May;81(5):258-61.
PMID: 2061823 UI: 91286962 [PubMed - indexed for MEDLINE]
From PubMed
214

[Isolation and identification of aloesin from the leaves of Aloe vera L. var, chinensis (Haw.) Berger]
Full author name: Yuan, A; Kang, S; Qin, L; Ruan, B; Fan, Y.

Yuan A, Kang S, Qin L, Ruan B, Fan Y. Zhongguo Zhong Yao Za Zhi. 1991 May;16(5):292-3, 319.

[Article in Chinese]

Guangxi Institute of Traditional Chinese Medical and Pharmaceutical Sciences, Nanning.

MeSH Terms:

Substances:

ISSN: 1001-5302
NLM Unique ID: 8913656
Country: China
Entry Date: 19920313
Date Completed: 19920313
MeSH Date: 1991/05/01 00:01
Date Revised: 20001218
Entrez Date: 1991/05/01
Citation Subset: IM
Publication Status: ppublish
Zhongguo Zhong Yao Za Zhi 1991 May;16(5):292-3, 319.
PMID: 1781897 UI: 92143949 [PubMed - indexed for MEDLINE]
From PubMed
215

Barbaloin stimulates growth of Eubacterium sp. strain BAR, a barbaloin-metabolizing bacterium from human feces.
Full author name: Che, Q M; Akao, T; Hattori, M; Tsuda, Y; Namba, T; Kobashi, K.

Che QM, Akao T, Hattori M, Tsuda Y, Namba T, Kobashi K. Chem Pharm Bull (Tokyo). 1991 Mar;39(3):757-60.

[Article in English]

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

Eubacterium sp. strain BAR, isolated from human feces, transformed barbaloin to aloe-emodin anthrone in a basal medium lacking carbohydrate. Barbaloin remarkably stimulated the growth of strain BAR in the basal medium, the stimulative extent of the growth depending on the amount of barbaloin added. The addition of D-glucose, D-galactose, maltose, cellobiose, sucrose or D-amygdalin to the basal medium containing barbaloin caused a decrease of the growth stimulated by barbaloin to the growth level with each sugar, resulting in a complete inhibition of the barbaloin transformation. On the other hand, the addition of D-fructose, which itself stimulated the growth of strain BAR, further increased the growth in the presence of barbaloin and little inhibited barbaloin transformation. Nojirimycin bisulfite, a specific inhibitor of glucosidases, potently inhibited the growth with barbaloin, but did not affect the growth with glucose or cellobiose. Also, nojirimycin bisulfite completely inhibited the transformation of barbaloin to aloe-emodin anthrone. These results indicate that a unique enzyme capable of cleaving the C-glycosyl bond is induced in strain BAR by barbaloin and, consequently, strain BAR grows by utilizing as a nutrient the carbohydrate liberated from barbaloin. It is further suggested that the barbaloin-cleaving enzyme is inhibited by nojirimycin bisulfite and that the induction of the enzyme is repressed with D-glucose and D-galactose.

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19910821
Date Completed: 19910821
MeSH Date: 1991/03/01 00:01
Date Revised: 20001218
Entrez Date: 1991/03/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1991 Mar;39(3):757-60.
PMID: 2070461 UI: 91300606 [PubMed - indexed for MEDLINE]
From PubMed
216

Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel.
Full author name: Hunter, D; Frumkin, A.

Hunter D, Frumkin A. Cutis. 1991 Mar;47(3):193-6.

[Article in English]

College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City.

Three women and one man aged forty-one to sixty-five years experienced a severe burning sensation following the application of aloe vera or vitamin E preparations to a skin area that had been subjected to a chemical peel or dermabrasion. Subsequently, a severe dermatitis occurred that required hospitalization of one patient and intravenous administration of steroids. The dermatitis abated very slowly in all patients: full recovery took three months or more. One patient resumed the use of vitamin E creams two years after the episode of dermatitis and experienced no adverse effect. Patients undergoing dermabrasion or chemical peel procedures should be cautioned specifically against the use of aloe vera or vitamin E topically in the first weeks after surgery.

MeSH Terms:

Substances:

ISSN: 0011-4162
NLM Unique ID: 0006440
Country: United States
Entry Date: 19910606
Date Completed: 19910606
MeSH Date: 1991/03/01 00:01
Date Revised: 20011128
Entrez Date: 1991/03/01
Citation Subset: IM
Publication Status: ppublish
Cutis 1991 Mar;47(3):193-6.
PMID: 2022130 UI: 91215945 [PubMed - indexed for MEDLINE]
From PubMed
217

Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone.
Full author name: Che, Q M; Akao, T; Hattori, M; Kobashi, K; Namba, T.

Che QM, Akao T, Hattori M, Kobashi K, Namba T. Planta Med. 1991 Feb;57(1):15-9.

[Article in English]

Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, Japan.

A strictly anaerobic bacterium, Eubacterium sp. BAR, was isolated from human feces as one of the intestinal bacteria capable of metabolizing barbaloin. The bacterium grew in PYF broth containing barbaloin and converted barbaloin to aloe-emodin anthrone. On the other hand, the bacterium had little metabolic activity in GAM broth.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: Germany
Entry Date: 19910807
Date Completed: 19910807
MeSH Date: 1991/02/01 00:01
Date Revised: 20011128
Entrez Date: 1991/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1991 Feb;57(1):15-9.
PMID: 2062951 UI: 91288685 [PubMed - indexed for MEDLINE]
From PubMed
218

Topical use of aloe vera derived allantoin gel in otolaryngology.
Full author name: Thompson, J E.

Thompson JE. Ear Nose Throat J. 1991 Feb;70(2):119.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0145-5613
NLM Unique ID: 7701817
Country: United States
Entry Date: 19910718
Date Completed: 19910718
MeSH Date: 1991/02/01 00:01
Date Revised: 20011128
Entrez Date: 1991/02/01
Citation Subset: IM
Publication Status: ppublish
Ear Nose Throat J 1991 Feb;70(2):119.
PMID: 2044477 UI: 91256902 [PubMed - indexed for MEDLINE]
From PubMed
219

Topical use of aloe vera derived allantoin gel in otolaryngology.
Full author name: Thompson, J E.

Thompson JE. Ear Nose Throat J. 1991 Jan;70(1):56.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0145-5613
NLM Unique ID: 7701817
Country: United States
Entry Date: 19910809
Date Completed: 19910809
MeSH Date: 1991/01/01 00:01
Date Revised: 20001218
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Ear Nose Throat J 1991 Jan;70(1):56.
PMID: 2065624 UI: 91293013 [PubMed - indexed for MEDLINE]
From PubMed
220

Aloe vera as a biologically active vehicle for hydrocortisone acetate.
Full author name: Davis, R H; Parker, W L; Murdoch, D P.

Davis RH, Parker WL, Murdoch DP. J Am Podiatr Med Assoc. 1991 Jan;81(1):1-9.

[Article in English]

Pennsylvania College of Podiatric Medicine, Philadelphia 19107.

Aloe vera, as a biological vehicle for hydrocortisone 21-acetate, was tested topically and systemically against acute inflammation. Systemically, the combination of A. vera and hydrocortisone produced a maximum 88.1% inhibition of edema. Polymorphonuclear leukocyte infiltration was reduced 91.1%. The topical inhibition of edema peaked at 97%. The possibility that A. vera has significant potential as a biologically active vehicle for steroids is discussed.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19910319
Date Completed: 19910319
MeSH Date: 1991/01/01 00:01
Date Revised: 20011128
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1991 Jan;81(1):1-9.
PMID: 1993971 UI: 91132421 [PubMed - indexed for MEDLINE]
From PubMed
221

[Studies on chemical protectors against radiation. XXXIII. Protective mechanisms of various compounds against skin injury induced by radiation]
Full author name: Sato, Y; Kumazawa, N; Suzuki, M; Wang, C M; Ohta, S; Shinoda, M.

Sato Y, Kumazawa N, Suzuki M, Wang CM, Ohta S, Shinoda M. Yakugaku Zasshi. 1991 Jan;111(1):51-8.

[Article in Japanese]

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

The radiation protective mechanisms on skin injury induced by soft X-irradiation were investigated by use of various radiation protective agents such as sulfur compounds (MEA, MEG, thiourea), nucleic acid constitutional compounds (adenosine, inosine), antioxidative compounds (sesamol, ferulic acid, ascorbic acid), crude drugs (Rosae Fructus, Anemarrhenae Rhizoma, Trapae Fructus, Forsythiae Fructus, Aloe arborescens). Scavenge action of activated oxygen, inhibitory effect of lipid peroxidation, induction of antioxidative protein and protective effect against damage of deoxyribonucleic acid and superoxide dismutase by X-irradiation were evaluated as the radiation protective mechanisms, and relationship between these results and protective effect of skin injury induced by radiation was studied.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19910731
Date Completed: 19910731
MeSH Date: 1991/01/01 00:01
Date Revised: 20001218
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1991 Jan;111(1):51-8.
PMID: 1905349 UI: 91277966 [PubMed - indexed for MEDLINE]
From PubMed
222

Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids.
Full author name: Schumacher, J M; Short, M P; Hyman, B T; Breakefield, X O; Isacson, O.

Schumacher JM, Short MP, Hyman BT, Breakefield XO, Isacson O. Neuroscience. 1991;45(3):561-70.

[Article in English]

Neuroregeneration Laboratory, Harvard Medical School, Belmont, MA.

With the exception of L-DOPA pharmacological treatment in Parkinson's disease, the neurodegenerative diseases lack effective treatment. Previous studies of neurodegenerative diseases suggest that symptoms arise secondary to defects in local neuronal circuitry and cannot be treated effectively with systemic drug delivery. Therefore, a promising treatment is the application of fetal or genetically engineering cells which protect or replace neurons in deficient regions. Engineered cells can be derived from cell lines or grown from recipient host fibroblasts or other cells, then modified to produce and secrete substances at a specific area of the brain. A previous study using parallel intracerebral infusions of nerve growth factor and an excitotoxic amino acid into the rat striatum demonstrated a protective effect of nerve growth factor on neurons [Aloe L. (1987) Biotechnology 5, 1085-1086]. In order to further test this paradigm, we have utilized a biological delivery system of nerve growth factor by implanting fibroblasts into the rat striatum which secrete high levels of nerve growth factor, prior to infusing the neurotoxins quinolinate or quisqualate. Animals in this group had smaller lesions than did a group implanted with a similar non-nerve growth factor-producing graft. In addition, marked neuronal sparing was noted within areas of lesions in those animals containing a nerve growth factor-producing graft. These results indicate that implantation of genetically engineered nerve growth factor-secreting cells can be used to protect neurons at a specific target from excitotoxin-induced lesions.

MeSH Terms:

Substances:

Grant Support:

ISSN: 0306-4522
NLM Unique ID: 7605074
Country: England
Entry Date: 19920304
Date Completed: 19920304
MeSH Date: 1991/01/01 00:01
Date Revised: 20001218
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Neuroscience 1991;45(3):561-70.
PMID: 1837849 UI: 92131247 [PubMed - indexed for MEDLINE]
From PubMed
223

Experimental study of the hypoglycemic effect of some antidiabetic plants.
Full author name: Roman-Ramos, R; Flores-Saenz, J L; Partida-Hernandez, G; Lara-Lemus, A; Alarcon-Aguilar, F.

Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, Lara-Lemus A, Alarcon-Aguilar F. Arch Invest Med (Mex). 1991 Jan-Mar;22(1):87-93.

[Article in English]

Health Sciences Department, Metropolitan Autonomous University, Iztapalapa Campus, Mexico, D.F.

The purpose of this work is to look for the hypoglycemic effect of 12 plants most used in Mexico for controlling diabetes mellitus. The studies were realized in 27 rabbits submitted weekly to glucose tolerance tests after gastric administration of water, tolbutamide or a preparation of the plant. The results showed that tolbutamide and studied plants (except Aloe barbadensis) decreased significantly (p less than 0.05) the area under glucose tolerance curve, in relation with the water control. The strongest effect was yielded by Psacalium peltatum (27.9%), followed by Curcubita ficifolia (26.4%), Lepechinia caulescens (26.0%), Opuntia streptacantha (21.4%), Slanum verbascifolum (21.1%), Teucrium cubense (19.4%), Cecropia obtusifolia (18.9%), Phaseolus vulgaris (18.5%), Tecoma stans (17.5%), Eriobotrya japonica (17.2%), Salpianthus macrodonthus (15.0%), tolbutamide (14.3%), and Aloe barbadensis (1.4%). Our results point out that the majority of the plants most used by the Mexican population to control diabetes mellitus have an evident hypoglycemic action.

MeSH Terms:

Substances:

ISSN: 0066-6769
NLM Unique ID: 0262036
Country: Mexico
Entry Date: 19920730
Date Completed: 19920730
MeSH Date: 1991/01/01 00:01
Date Revised: 20001218
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Invest Med (Mex) 1991 Jan-Mar;22(1):87-93.
PMID: 1819981 UI: 92313168 [PubMed - indexed for MEDLINE]
From PubMed
224

A double-blind trial of a celandin, aloevera and psyllium laxative preparation in adult patients with constipation.
Full author name: Odes, H S; Madar, Z.

Odes HS, Madar Z. Digestion. 1991;49(2):65-71.

[Article in English]

Intestinal Diseases Unit, Soroka Medical Center, Beer Sheva, Israel.

The aim of this study was to evaluate the effect of a novel laxative preparation, composed of celandin, aloevera and psyllium in patients with chronic constipation. Thirty-five men and women were randomized to receive capsules containing celandin-aloevera-psyllium, or placebo, in a double-blind trial lasting 28 days. Symptoms in the last 2 weeks of the treatment period were compared to those in the 14-day pre-trial basal period. In the celandin, aloevera and psyllium group, bowel movements became more frequent, the stools were softer and laxative dependence was reduced. In the placebo group, all these parameters were unchanged. Abdominal pain was not reduced in either group. The results of this study show that the preparation is an effective laxative in the treatment of constipation.

Publication Types:

MeSH Terms:

Substances:

ISSN: 0012-2823
NLM Unique ID: 0150472
Country: Switzerland
Entry Date: 19920421
Date Completed: 19920421
MeSH Date: 1991/01/01 00:01
Date Revised: 20011128
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Digestion 1991;49(2):65-71.
PMID: 1800188 UI: 92192352 [PubMed - indexed for MEDLINE]
From PubMed
225

[Immunomodulation in patients with cavernous kidney tuberculosis using piperazine adipinate and amniocene]
Full author name: Kozin, Iu I; Cherniavskii, V I.

Kozin IuI, Cherniavskii VI. Probl Tuberk. 1991;(6):29-32.

[Article in Russian]

Findings of a complex immunologic examination of 138 patients with active cavernous tuberculosis of the kidneys concurrent with secondary immunodeficiency are presented. Biostimulators and immunomodulating drugs were administered as conservative treatment in this case. Changes in cellular and humoral immunity indices as well as those of the mononuclear-phagocyte system before and after treatment were traced in the groups of patients receiving biogenic stimulators (such, as aloe extract, vitreous body, plasmol, Fibs) and immunoregulating drugs (like piperazine adipinate and injected amniocene). It was found that the biogenic stimulators fail to have a pronounced effect on the immunologic indices. The inclusion of piperazine adipinate and injected amniocene into a complex of antibiotic and chemotherapy brings about a significant improvement of the cellular immunity indices and the mononuclear-phagocyte system function which are inhibited to a greater extent in patients with active destructive nephrophthisis. A recommended use of piperazine adipinate and amniocene as adjuncts to a complex treatment has been proved in patients of this category by means of clinicoimmunologic correlations.

MeSH Terms:

Substances:

ISSN: 0032-9533
NLM Unique ID: 0414141
Country: ussr
Vernacular Title: Immunokorrektsiia u bol'nykh kavernoznym tuberkulezom pochek piperazina adipinatom i amniotsenom.
Entry Date: 19920309
Date Completed: 19920309
MeSH Date: 1991/01/01 00:01
Date Revised: 20011119
Entrez Date: 1991/01/01
Citation Subset: IM
Publication Status: ppublish
Probl Tuberk 1991;(6):29-32.
PMID: 1780305 UI: 92141160 [PubMed - indexed for MEDLINE]
From PubMed
226

Frostbite. Methods to minimize tissue loss.
Full author name: McCauley, R L; Heggers, J P; Robson, M C.

McCauley RL, Heggers JP, Robson MC. Postgrad Med. 1990 Dec;88(8):67-8, 73-7.

[Article in English]

Department of Surgery, University of Texas Medical School, Galveston.

If frostbite is to be treated successfully, direct and indirect effects of injury must be understood. Rapid rewarming helps to preserve tissue by limiting the amount of direct cellular injury. Selective management of blisters helps protect the subdermal plexus, and application of Aloe vera cream (eg, Dermaide Aloe Cream) combats the local vasoconstrictive effects of thromboxane. Oral administration of ibuprofen decreases systemic levels of thromboxane.

MeSH Terms:

Substances:

ISSN: 0032-5481
NLM Unique ID: 0401147
Country: United States
Entry Date: 19910103
Date Completed: 19910103
MeSH Date: 1990/12/01 00:01
Date Revised: 20011128
Entrez Date: 1990/12/01
Citation Subset: AIM, IM
Publication Status: ppublish
Postgrad Med 1990 Dec;88(8):67-8, 73-7.
PMID: 2243830 UI: 91057195 [PubMed - indexed for MEDLINE]
From PubMed
227

A drug for all seasons. Medical and pharmacological history of aloe.
Full author name: Haller, J S Jr.

Haller JS Jr. Bull N Y Acad Med. 1990 Nov-Dec;66(6):647-59.

[Article in English]

Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver.

Publication Types:

MeSH Terms:

ISSN: 0028-7091
NLM Unique ID: 7505398
Country: United States
Entry Date: 19910315
Date Completed: 19910315
MeSH Date: 2001/03/28 10:01
Date Revised: 20011128
Entrez Date: 1990/11/01
Citation Subset: IM, Q
Publication Status: ppublish
Bull N Y Acad Med 1990 Nov-Dec;66(6):647-59.
PMID: 2282445 UI: 91129451 [PubMed - indexed for MEDLINE]
From PubMed
228

[Studies on chemical protectors against radiation. XXXI. Protection effects of Aloe arborescens on skin injury induced by X-irradiation]
Full author name: Sato, Y; Ohta, S; Shinoda, M.

Sato Y, Ohta S, Shinoda M. Yakugaku Zasshi. 1990 Nov;110(11):876-84.

[Article in Japanese]

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

Protective effects of Aloe arborescens (AA) on mouse skin injury induced by soft X-irradiation were examined. The mechanisms on radiation protection by measuring scavenge activity of activated oxygen, protective effects of nucleic acid, induction of antioxidative protein and so on were further investigated. Consequently a significant protective effect of skin injury was observed in AA S6-3-b. As the mechanisms of radiation protection in AA, the following matters were found. AA S6-3-b showed scavenge activity of hydroxyl radicals generated by Haber-Weiss reaction. AA S6-3-b suppressed the changes of activity in superoxide dismutase and glutathione peroxidase at 7d after soft X-irradiation. Metallothionein was induced in the skin and liver against normal mice at 24 h after administration of AA S6-3-b.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19910507
Date Completed: 19910507
MeSH Date: 1990/11/01 00:01
Date Revised: 20011128
Entrez Date: 1990/11/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1990 Nov;110(11):876-84.
PMID: 2082014 UI: 91186347 [PubMed - indexed for MEDLINE]
From PubMed
229

Glyoxalase I and glyoxalase II from Aloe vera: purification, characterization and comparison with animal glyoxalases.
Full author name: Norton, S J; Talesa, V; Yuan, W J; Principato, G B.

Norton SJ, Talesa V, Yuan WJ, Principato GB. Biochem Int. 1990 Nov;22(3):411-8.

[Article in English]

Department of Biochemistry, University of North Texas, Denton.

Glyoxalase I and glyoxalase II from the outer green rind of Aloe vera leaves were purified by (matrix) affinity ligand-enzyme binding methods. The purified enzymes exhibited single protein bands on SDS-PAGE electrophoresis, with MW values of approximately 44,000 and 27,000 for glyoxalase I and glyoxalase II, respectively. The glyoxalase I is a basic protein (pI 7.8), while the glyoxalase II (3 protein bands) is acidic (pI 4.7, 4.8 [prevalent form], and 5.0). The kinetic constants, Km and Vmax, and Ki values for certain inhibitors are reported for both glyoxalase I and glyoxalase II. The glyoxalase enzymes from Aloe vera were compared with reported animal and plant glyoxalases.

MeSH Terms:

Substances:

ISSN: 0158-5231
NLM Unique ID: 8100311
Country: Australia
Entry Date: 19910418
Date Completed: 19910418
MeSH Date: 1990/11/01 00:01
Date Revised: 20011128
Entrez Date: 1990/11/01
Citation Subset: IM
Publication Status: ppublish
Biochem Int 1990 Nov;22(3):411-8.
PMID: 2076100 UI: 91166568 [PubMed - indexed for MEDLINE]
From PubMed
230

Hydroxyanthraquinones as tumor promoters: enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes.
Full author name: Wolfle, D; Schmutte, C; Westendorf, J; Marquardt, H.

Wolfle D, Schmutte C, Westendorf J, Marquardt H. Cancer Res. 1990 Oct 15;50(20):6540-4.

[Article in English]

Department of Toxicology, University of Hamburg Medical School, Federal Republic of Germany.

Because danthron, though carcinogenic, does not seem to be genotoxic, it and 8 other hydroxyanthraquinones were comparatively investigated for activities associated with tumor promotion, such as stimulation of cell proliferation and enhancement of malignant transformation. The in vivo treatment of primary rat hepatocytes with danthron, aloe-emodin, chrysophanol, and rhein resulted in a 2-3-fold increase of DNA synthesis, lucidin and purpurin were less active, and emodin, purpuroxanthin, and alizarin were essentially inactive. In addition, danthron, rhein, and chrysophanol (preliminary data), but not alizarin, enhanced transformation of C3H/M2 mouse fibroblasts initiated by N-methyl-N'-nitro-N-nitrosoguanidine or 3-methylcholanthrene. The results of these in vitro studies suggest that hydroxyanthraquinones, possessing 2 hydroxy groups in the 1,8-positions, e.g., danthron, rhein, and chrysophanol, may have tumor-promoting activities. This conclusion is in accordance with the hypothesis that the in vivo carcinogenic activity of danthron may be associated with tumor promotion.

MeSH Terms:

Substances:

ISSN: 0008-5472
NLM Unique ID: 2984705R
Country: United States
Entry Date: 19901121
Date Completed: 19901121
MeSH Date: 1990/10/15 00:01
Date Revised: 20001218
Entrez Date: 1990/10/15
Citation Subset: IM
Publication Status: ppublish
Cancer Res 1990 Oct 15;50(20):6540-4.
PMID: 2208114 UI: 91003999 [PubMed - indexed for MEDLINE]
From PubMed
231

Gas chromatographic and mass spectral determination of aloenin in skin-care cosmetics.
Full author name: Nakamura, H; Okuyama, T.

Nakamura H, Okuyama T. J Chromatogr. 1990 Jun 22;509(2):377-82.

[Article in English]

Tokyo Metropolitan Research Laboratory of Public Health, Japan.

MeSH Terms:

Substances:

ISSN: 0021-9673
NLM Unique ID: 0427043
Country: Netherlands
Entry Date: 19901115
Date Completed: 19901115
MeSH Date: 1990/06/22 00:01
Date Revised: 20011128
Entrez Date: 1990/06/22
Citation Subset: IM
Publication Status: ppublish
J Chromatogr 1990 Jun 22;509(2):377-82.
PMID: 2211901 UI: 91009659 [PubMed - indexed for MEDLINE]
From PubMed
232

The stimulation of postdermabrasion wound healing with stabilized aloe vera gel-polyethylene oxide dressing.
Full author name: Fulton, J E Jr.

Fulton JE Jr. J Dermatol Surg Oncol. 1990 May;16(5):460-7.

[Article in English]

Acne Research Institute, Newport Beach, CA 92663.

Full-face dermabrasion provided an ideal opportunity to document the effects of dressings on wound healing management. Following the procedure, the abraded face was divided in half. One side was treated with the standard polyethylene oxide gel wound dressings. The other side was treated with a polyethylene oxide gel dressing saturated with stabilized aloe vera. The polyethylene oxide dressing provided an excellent matrix for the release of aloe vera gel during the initial 5 days of wound healing. By 24-48 hours there was dramatic vasoconstriction and accompanying reduction in edema on the aloe-treated side. By the third to fourth day there was less exudate and crusting at the aloe site, and by the fifth to sixth day the reepithelialization at the aloe site was complete. Overall, wound healing was approximately 72 hours faster at the aloe site. This acceleration in wound healing is important to reduce bacterial contamination, subsequent keloid formation, and/or pigmentary changes. The exact mechanism of acceleration of wound healing by aloe vera is unknown.

MeSH Terms:

Substances:

ISSN: 0148-0812
NLM Unique ID: 7707501
Country: United States
Entry Date: 19900625
Date Completed: 19900625
MeSH Date: 2001/03/28 10:01
Date Revised: 20011128
Entrez Date: 1990/05/01
Citation Subset: IM
Publication Status: ppublish
J Dermatol Surg Oncol 1990 May;16(5):460-7.
PMID: 2341661 UI: 90257209 [PubMed - indexed for MEDLINE]
From PubMed
233

[Aloe vera--the real truth]
Full author name: Shelkovitz-Shilo, I; Kaplan, B; Yorav, S.

Shelkovitz-Shilo I, Kaplan B, Yorav S. Harefuah. 1990 Feb 15;118(4):228-9.

[Article in Hebrew]

Publication Types:

MeSH Terms:

Substances:

Number of References: 16
ISSN: 0017-7768
NLM Unique ID: 0034351
Country: Israel
Entry Date: 19900711
Date Completed: 19900711
MeSH Date: 1990/02/15 00:01
Date Revised: 20011128
Entrez Date: 1990/02/15
Citation Subset: IM
Publication Status: ppublish
Harefuah 1990 Feb 15;118(4):228-9.
PMID: 2189803 UI: 90269681 [PubMed - indexed for MEDLINE]
From PubMed
234

Effect of aloes on blood glucose levels in normal and alloxan diabetic mice.
Full author name: Ajabnoor, M A.

Ajabnoor MA. J Ethnopharmacol. 1990 Feb;28(2):215-20.

[Article in English]

Department of Clinical Biochemistry, College of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

The acute and chronic effects of the exudate of Aloe barbadensis leaves and its bitter principle were studied on plasma glucose levels of alloxan-diabetic mice. Aloes was administered orally, 500 mg/kg, and the bitter principle was administered intraperitoneally, 5 mg/kg. The hypoglycemic effect of a single oral dose of aloes on serum glucose level was insignificant whereas that of the bitter principle was very highly significant and extended over a period of 24 h with maximum hypoglycemia observed at +8 h. In chronic studies, aloes was administered twice daily and the bitter principle was administered once a day for 4 days. The maximum reduction in plasma glucose level was observed at the 5th day in both cases. The hypoglycemic effect of aloes and its bitter principle may be mediated through stimulating synthesis and/or release of insulin from the beta-cells of Langerhans.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Switzerland
Entry Date: 19900529
Date Completed: 19900529
MeSH Date: 1990/02/01 00:01
Date Revised: 20011128
Entrez Date: 1990/02/01
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1990 Feb;28(2):215-20.
PMID: 2109811 UI: 90230754 [PubMed - indexed for MEDLINE]
From PubMed
235

[Extra-weak chemiluminescence of drugs. X. Extra-weak chemiluminescence quenching component of rhubarb]
Full author name: Sato, H; Kurosaki, Y; Hirayama, H; Mizugaki, M.

Sato H, Kurosaki Y, Hirayama H, Mizugaki M. Yakugaku Zasshi. 1990 Jan;110(1):55-8.

[Article in Japanese]

Department of Pharmaceutical Sciences, Tohoku University Hospital, Aoba-ku Sendai, Japan.

Active components contained in rhubarb (Rhei Rhizoma) that show a quenching effect of extra-week chemiluminescence (CL) arising from Maillard reaction, had been studied. As the result of fractionation and purification of rhubarb, CL quenching activity was found to exist mainly in the fraction of quinone derivatives as emodin, aloe-emodin or rhein. The authentic samples of these quinones showed high CL quenching activities.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19900725
Date Completed: 19900725
MeSH Date: 1990/01/01 00:01
Date Revised: 20011128
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1990 Jan;110(1):55-8.
PMID: 2355309 UI: 90285819 [PubMed - indexed for MEDLINE]
From PubMed
236

[Effect of chemotherapy combined with the use of tissue preparations on nonspecific immunity in patients with pulmonary tuberculosis]
Full author name: Nersesian, O N; Bogatyreva, E V.

Nersesian ON, Bogatyreva EV. Probl Tuberk. 1990;(1):28-31.

[Article in Russian]

General and local nonspecific immunity was studied in 143 new cases of pulmonary tuberculosis (71 and 72 persons, respectively). The results showed that combination of chemotherapy using desensitizing agents and tissue preparations according to V. P. Filatov (a suspension of placenta tissue and aloe) had an immunomodulating effect. The efficacy of the combined chemotherapy amounted to 87 per cent with an account of the general immunity status.

MeSH Terms:

Substances:

ISSN: 0032-9533
NLM Unique ID: 0414141
Country: ussr
Vernacular Title: Vliianie khimioterapii v komplekse s tkanevymi preparatami na nespetsificheskii immunitet u bol'nykh tuberkulezom legkikh.
Entry Date: 19900613
Date Completed: 19900613
MeSH Date: 1990/01/01 00:01
Date Revised: 20011128
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Probl Tuberk 1990;(1):28-31.
PMID: 2336432 UI: 90245813 [PubMed - indexed for MEDLINE]
From PubMed
237

Genotoxicity of naturally occurring hydroxyanthraquinones.
Full author name: Westendorf, J; Marquardt, H; Poginsky, B; Dominiak, M; Schmidt, J.

Westendorf J, Marquardt H, Poginsky B, Dominiak M, Schmidt J, Marquardt H. Mutat Res. 1990 Jan;240(1):1-12.

[Article in English]

Department of Toxicology, University of Hamburg Medical School, F.R.G.

A variety of structurally related hydroxyanthraquinones (HA) were investigated in a test battery for the evaluation of mutagenicity and cell-transforming activity. The tests were: (1) the Salmonella typhimurium mutagenicity assay, (2) the V79-HGPRT mutagenicity assay, (3) the DNA-repair induction assay in primary rat hepatocytes and (4) the in vitro transformation of C3H/M2 mouse fibroblasts. In Salmonella, most of the tested compounds were mutagenic in strain TA1537, but only a few were active in other strains. Among these were HA with a hydroxymethyl group, such as lucidin and aloe-emodin. In V79 cells, only HA with 2 hydroxy groups in the 1,3 positions (1,3-DHA, purpurin, emodin) or with a hydroxymethyl sidechain (lucidin and aloe-emodin) were mutagenic. The compounds found to be active in V79 cells were also active in the DNA-repair assay and in the C3H/M2 transformation assay. Thus, it appears that the genotoxicity of HA is dependent on certain structural requirements.

MeSH Terms:

Substances:

ISSN: 0027-5107
NLM Unique ID: 0400763
Country: Netherlands
Entry Date: 19900129
Date Completed: 19900129
MeSH Date: 1990/01/01 00:01
Date Revised: 20001218
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Mutat Res 1990 Jan;240(1):1-12.
PMID: 2294411 UI: 90097979 [PubMed - indexed for MEDLINE]
From PubMed
238

Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils.
Full author name: 't Hart, L A; Nibbering, P H; van den Barselaar, M T; van Dijk, H; van den Berg, A J; Labadie, R P.

't Hart LA, Nibbering PH, van den Barselaar MT, van Dijk H, van den Berg AJ, Labadie RP. Int J Immunopharmacol. 1990;12(4):427-34.

[Article in English]

Department of Pharmacognosy, Faculty of Pharmacy, University of Utrecht, The Netherlands.

In traditional South-East Asian medicine the therapeutic value of the parenchymous leaf-gel of Aloe vera for inflammatory-based diseases is well-reputed. The aim of this study is to investigate at which level gel-constituents exert their activity. We show here that low -Mr constituents of an aqueous gel-extract inhibit the release of reactive oxygen species (ROS) by PMA-stimulated human PMN. The compounds inhibit the ROS-dependent extracellular effects of PMN such as lysis of red blood cells. The capacity of the PMN to phagocytose and kill micro-organisms at the intracellular level is not affected. The inhibitory activity of the low-Mr compounds is most pronounced in the PMA-induced ROS production, but is significantly antagonized by the Ca-ionophore A23187. It is shown that the inhibitory effect of the low-Mr compounds is the indirect result of the diminished availability of intracellular free Ca-ions.

MeSH Terms:

Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19901002
Date Completed: 19901002
MeSH Date: 1990/01/01 00:01
Date Revised: 20011128
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Int J Immunopharmacol 1990;12(4):427-34.
PMID: 2167880 UI: 90361441 [PubMed - indexed for MEDLINE]
From PubMed
239

Studies of aloe. III. Mechanism of cathartic effect. (2).
Full author name: Ishii, Y; Tanizawa, H; Takino, Y.

Ishii Y, Tanizawa H, Takino Y. Chem Pharm Bull (Tokyo). 1990 Jan;38(1):197-200.

[Article in English]

School of Pharmaceutical Sciences, University of Shizuoka, Japan.

The mechanism of action of aloe-emodin-9-anthrone, a decomposition product of barbaloin, in causing a significant increase in the water content of the rat large intestine, was investigated. Aloe-emodin-9-anthrone inhibited rat colonic Na+, K(+)-adenosine triphosphatase (ATPase) in vitro, and increased the paracellular permeability across the rat colonic mucosa in vivo. Therefore, it seemed that the increase in water content of the rat large intestine produced by aloe-emodin-9-anthrone was due to both inhibition of absorption and stimulation of secretion without stimulation of peristalsis. Furthermore, pretreatment with loperamide, an antidiarrheal agent, completely prevented the increase of paracellular permeability induced by aloe-emodin-9-anthrone but did not completely reduce the concomitant increase in residual fluid volume. These findings suggest that aloe-emodin-9-anthrone has multiple mechanisms of action involved in the increase of water content in the rat large intestine.

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19900615
Date Completed: 19900615
MeSH Date: 1990/01/01 00:01
Date Revised: 20011128
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1990 Jan;38(1):197-200.
PMID: 2159853 UI: 90249072 [PubMed - indexed for MEDLINE]
From PubMed
240

[The effect of tissue preparations on the development of anaphylaxis]
Full author name: Degtiarenko, T V.

Degtiarenko TV. Oftalmol Zh. 1990;(7):428-32.

[Article in Russian]

The paper analyses results of experimental studies conducted in 60 guinea pigs with the purpose to determine the influence of preparations of a group of distillate (torfot, FiBS) and protein preparations of vegetable (aloe extract) and animal (extract of placenta) origin on the development of a reaction of hypersensitivity of a delayed type. It was found that tissue preparations both in doses adequate to those used in clinic (0.03 ml) and in doses biologically active in pharmacologic tests (0.3 ml) don't stimulate the development of anaphylactic shock and the usage of FiBS leads to a remarkable reduction of its manifestations in experimental animals. The results obtained speak about the difference between immunomodulating influence of the preparation of a group of distillates and protein preparations on the development of anaphylaxis and allow to show, for the first time, a desensitizing action of a bioregulator of medicinal peloids (FiBS).

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Vliianie tkanevykh preparatov na razvitie anafilaksii.
Entry Date: 19910612
Date Completed: 19910612
MeSH Date: 1990/01/01 00:01
Date Revised: 20001218
Entrez Date: 1990/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1990;(7):428-32.
PMID: 2092265 UI: 91226929 [PubMed - indexed for MEDLINE]
From PubMed
241

[Protective effect of extracts from Aloe vera L. var. chinensis (Haw.) Berg. on experimental hepatic lesions and a primary clinical study on the injection of in patients with hepatitis]
Full author name: Fan, Y J; Li, M; Yang, W L; Qin, L; Zou, J.

Fan YJ, Li M, Yang WL, Qin L, Zou J. Zhongguo Zhong Yao Za Zhi. 1989 Dec;14(12):746-8.

[Article in Chinese]

The injection(10-15 ml/kg/d, ip x 4), total glycoside (125-225 mg/kg/d, ip x (3-4); 600 mg/kg/d, ig x 3) and crystal III (120 mg/kg/d, ip x 4) of Aloe vera var. chinensis were found to be effective in lowering the elevated sGPT induced by CCl4, thioacetamide and D-aminogalactose in mice or rats. It was also observed that these agents could protect hepatic cells from the CCl4-induced injury. When dogs were given in with Aloe injection of 0.1 ml/kg/d x 180, no toxicity was noted. The total effective sGPT-lowering rate of Aloe injection on 38 patients of chronic hepatitis with positive HBsAg was 86.8%.

MeSH Terms:

Substances:

ISSN: 1001-5302
NLM Unique ID: 8913656
Country: China
Entry Date: 19900615
Date Completed: 19900615
MeSH Date: 1989/12/01 00:01
Date Revised: 20001218
Entrez Date: 1989/12/01
Citation Subset: IM
Publication Status: ppublish
Zhongguo Zhong Yao Za Zhi 1989 Dec;14(12):746-8.
PMID: 2635602 UI: 90248098 [PubMed - indexed for MEDLINE]
From PubMed
242

An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera.
Full author name: t'Hart, L A; van den Berg, A J; Kuis, L; van Dijk, H; Labadie, R P.

t'Hart LA, van den Berg AJ, Kuis L, van Dijk H, Labadie RP. Planta Med. 1989 Dec;55(6):509-12.

[Article in English]

The aim of the study is to develop new substances with immunomodulatory activity. To this end, extracts from plants used in traditional medicine are used as starting material. This study deals with the mucilagenous leaf-gel of Aloe vera which is well reputed for its therapeutical effect on inflammatory-based disorders. The purification of an aqueous gel-extract guided by inhibition of complement activity in HPS is described. Using anion-exchange and gel permeation chromatography a highly active polysaccharide fraction was isolated, that is present in the gel in various chain lengths. The polysaccharides consist of several monosaccharides of which mannose is dominant. The inhibition is based on alternative pathway activation, resulting in consumption of C3. With respect to their biological activity the polysaccharides inhibit the opsonization of zymosan in HPS and display adjuvant activity on specific antibody production and the induction of delayed type hypersensitivity in mice.

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19900301
Date Completed: 19900301
MeSH Date: 1989/12/01 00:01
Date Revised: 20011128
Entrez Date: 1989/12/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1989 Dec;55(6):509-12.
PMID: 2616669 UI: 90139301 [PubMed - indexed for MEDLINE]
From PubMed
243

Wound healing. Oral and topical activity of Aloe vera.
Full author name: Davis, R H; Leitner, M G; Russo, J M; Byrne, M E.

Davis RH, Leitner MG, Russo JM, Byrne ME. J Am Podiatr Med Assoc. 1989 Nov;79(11):559-62.

[Article in English]

The influence of Aloe vera, orally and topically, on wound healing was studied. Wounds were induced on both sides of the vertebral column of ICR mice using a biopsy punch. For the oral study, experimental animals received A. vera in their drinking water for 2 months, whereas the control animals received only water. In the topical study, experimental animals were given 25% A. vera in Eucerin cream topically. The control animals received cream only. A 62.5% reduction in wound diameter was noted in mice receiving 100 mg/kg/day oral A. vera and a 50.8% reduction was recorded in animals receiving topical 25% A. vera. These data suggest that A. vera is effective by both oral and topical routes of administration.

MeSH Terms:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19900214
Date Completed: 19900214
MeSH Date: 1989/11/01 00:01
Date Revised: 20011128
Entrez Date: 1989/11/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1989 Nov;79(11):559-62.
PMID: 2607423 UI: 90112031 [PubMed - indexed for MEDLINE]
From PubMed
244

The role of topical agents in the healing of full-thickness wounds.
Full author name: Watcher, M A; Wheeland, R G.

Watcher MA, Wheeland RG. J Dermatol Surg Oncol. 1989 Nov;15(11):1188-95.

[Article in English]

Department of Dermatology, University of California, Sacramento 95816.

Eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. The following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. The rate of reepithelialization was significantly enhanced by treatment with capsaicin, bacitracin, silver sulfadiazine, and scarlet red, and was markedly retarded by treatment with tretinoin. Wound contraction was significantly retarded by mupirocin, bacitracin, and silver sulfadizine. Knowledge of the effects of topical agents on various aspects of healing allows the clinician to choose the most appropriate material to use in a given clinical situation to optimize the healing process and produce the best final result.

MeSH Terms:

Substances:

ISSN: 0148-0812
NLM Unique ID: 7707501
Country: United States
Entry Date: 19891215
Date Completed: 19891215
MeSH Date: 1989/11/01 00:01
Date Revised: 20011128
Entrez Date: 1989/11/01
Citation Subset: IM
Publication Status: ppublish
J Dermatol Surg Oncol 1989 Nov;15(11):1188-95.
PMID: 2509527 UI: 90037909 [PubMed - indexed for MEDLINE]
From PubMed
245

Aloe vera does not affect cutaneous erythema and blood flow following ultraviolet B exposure.
Full author name: Crowell, J; Hilsenbeck, S; Penneys, N.

Crowell J, Hilsenbeck S, Penneys N. Photodermatol. 1989 Oct;6(5):237-9.

[Article in English]

Department of Dermatology, University of Miami School of Medicine, Florida.

MeSH Terms:

Substances:

ISSN: 0108-9684
NLM Unique ID: 8407997
Country: Denmark
Entry Date: 19900315
Date Completed: 19900315
MeSH Date: 1989/10/01 00:01
Date Revised: 20011128
Entrez Date: 1989/10/01
Citation Subset: IM
Publication Status: ppublish
Photodermatol 1989 Oct;6(5):237-9.
PMID: 2616366 UI: 90138468 [PubMed - indexed for MEDLINE]
From PubMed
246

Processed Aloe vera administered topically inhibits inflammation.
Full author name: Davis, R H; Rosenthal, K Y; Cesario, L R; Rouw, G A.

Davis RH, Rosenthal KY, Cesario LR, Rouw GA. J Am Podiatr Med Assoc. 1989 Aug;79(8):395-7.

[Article in English]

Aloe vera preparations were evaluated for topical anti-inflammatory activity using the croton oil-induced edema assay. The results show that small amounts of A. vera given topically will inhibit inflammation induced by a moderate amount of irritant. In general, the decolorized Aloe was more effective than the colorized Aloe (with anthraquinone). A 47.1% inhibition of inflammation was obtained by 5% decolorized irradiated Aloe. These results may be used as a baseline to assess the biologic activity of A. vera in the treatment of inflammation by podiatric physicians.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19891130
Date Completed: 19891130
MeSH Date: 1989/08/01 00:01
Date Revised: 20011128
Entrez Date: 1989/08/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1989 Aug;79(8):395-7.
PMID: 2810076 UI: 90040137 [PubMed - indexed for MEDLINE]
From PubMed
247

[Effect of drug preparations in vitro on the morphofunctional status of spermatozoa]
Full author name: Israilov, S R.

Israilov SR. Vrach Delo. 1989 Aug;(8):52-4.

[Article in Russian]

The effect was studied of different drugs (aloe extract, penicillin, vitreous body and lidase) in 20 specimens of the ejaculate with established normozoospermia and in 20 specimens with oligozoospermia, asthenozoospermia and hypozoospermia. Experiments were carried out at +4 degrees C to -38 degrees C, every 2 hours for 72 hours. It was established that depending on the time, temperature and drugs there was an essential difference between the percent of mobility and ultrastructure of spermatozoa. The most favourable effect on spermatozoa was produced by temperature ranges from 11 to 18 degrees C, lidase and penicillin.

MeSH Terms:

ISSN: 0049-6804
NLM Unique ID: 0413607
Country: ussr
Vernacular Title: Vliianie nekotorykh lekarstvennykh preparatov in vitro na morfofunktsional'noe sostoianie spermatozoonov.
Entry Date: 19900109
Date Completed: 19900109
MeSH Date: 1989/08/01 00:01
Date Revised: 20001218
Entrez Date: 1989/08/01
Citation Subset: IM
Publication Status: ppublish
Vrach Delo 1989 Aug;(8):52-4.
PMID: 2588530 UI: 90070580 [PubMed - indexed for MEDLINE]
From PubMed
248

[Rehabilitation of patients with ulcers under hospital conditions]
Full author name: Kovalenko, M F; Dergachev, B P.

Kovalenko MF, Dergachev BP. Voen Med Zh. 1989 Jun;(6):29-30.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0026-9050
NLM Unique ID: 2984871R
Country: ussr
Vernacular Title: Reabilitatsiia bol'nykh iazvennoi bolezn'iu v statsionarnykh usloviiakh.
Entry Date: 19891121
Date Completed: 19891121
MeSH Date: 1989/06/01 00:01
Date Revised: 20011128
Entrez Date: 1989/06/01
Citation Subset: IM
Publication Status: ppublish
Voen Med Zh 1989 Jun;(6):29-30.
PMID: 2800396 UI: 90021263 [PubMed - indexed for MEDLINE]
From PubMed
249

Anti-inflammatory activity of Aloe vera against a spectrum of irritants.
Full author name: Davis, R H; Leitner, M G; Russo, J M; Byrne, M E.

Davis RH, Leitner MG, Russo JM, Byrne ME. J Am Podiatr Med Assoc. 1989 Jun;79(6):263-76.

[Article in English]

The authors have evaluated the spectrum of anti-inflammatory activity of A. vera in a number of models of inflammation in the hind paw of the experimental rat induced by kaolin, carrageenan, albumin, dextran, gelatin, and mustard. Croton oil was used in a topical model of inflammation to determine the oral activity and time-dependent dosing of A. vera. The authors found that A. vera was active in all models of inflammation. Of the various irritants tested, A. vera was especially active against gelatin-induced and kaolin-induced edema and, in contrast, had minimal activity when tested against dextran-induced edema. Oral activity of A. vera was demonstrated to be dependent on the presence of anthraquinones. The various irritant-induced edema models provided a broad spectrum of anti-inflammatory activity for A. vera.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19890817
Date Completed: 19890817
MeSH Date: 1989/06/01 00:01
Date Revised: 20011128
Entrez Date: 1989/06/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1989 Jun;79(6):263-76.
PMID: 2746485 UI: 89311023 [PubMed - indexed for MEDLINE]
From PubMed
250

Aloe vera and burn wound healing.
Full author name: Kaufman, T; Newman, A R; Wexler, M R.

Kaufman T, Newman AR, Wexler MR. Plast Reconstr Surg. 1989 Jun;83(6):1075-6.

[Article in English]

Publication Types:

MeSH Terms:

ISSN: 0032-1052
NLM Unique ID: 1306050
Country: United States
Entry Date: 19890712
Date Completed: 19890712
MeSH Date: 1989/06/01 00:01
Date Revised: 20011128
Entrez Date: 1989/06/01
Citation Subset: AIM, IM
Publication Status: ppublish
Plast Reconstr Surg 1989 Jun;83(6):1075-6.
PMID: 2727155 UI: 89265229 [PubMed - indexed for MEDLINE]
From PubMed
251

Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet.
Full author name: Sakai, R.

Sakai R. Jpn J Cancer Res. 1989 Jun;80(6):513-20.

[Article in English]

Department of Epidemiology, School of Health Sciences, Ryukyu University, Okinawa.

This case-control study of lung cancer was based on a cross-sectional questionnaire survey of inpatients at 5 general hospitals in Okinawa, Japan, from 1982 to 1987. The purpose of the study was to clarify the relations of lung cancer to cigarette smoking and plant diet. Ingestion frequencies of 17 major dietary plants and/or herbs were obtained by means of a questionnaire interview. As eligible subjects for a case-control analysis, there were 673 respondents aged over 30 years with clear smoking history, age, sex and diagnosis. Psychiatric patients were excluded. Odds ratios of newly diagnosed lung cancer were calculated by the Mantel-Haenszel procedure. A pair consisted of a case and two controls which were selected randomly by using multivariate caliper matching. Sixty-four pairs matched for age (+/- 5) and sex showed a significantly high odds ratio of 2.9 (P less than 0.0005). However, three male groups who were categorized by the number of cigarettes smoked did not exhibit dose-dependency of lung cancer on smoking. Lung cancer was more prevalent in ex-smokers than in current smokers. Case-control analyses by male generations revealed that lung cancer incidence was age-dependent, and there was a clear dose-response relationship between smoking and lung cancer in males in their sixties. A case-control analysis of each of 17 edible plants based on 44 pairs who were matched for age (+/- 5), sex and smoking history demonstrated that the odds ratio of aloe (Aloe arborescens Mill var. natalensis Berger) was 0.5 (P less than 0.1), suggesting that the aloe may prevent human carcinogenesis at various sites.

MeSH Terms:

ISSN: 0910-5050
NLM Unique ID: 8509412
Country: Japan
Entry Date: 19890908
Date Completed: 19890908
MeSH Date: 1989/06/01 00:01
Date Revised: 20001218
Entrez Date: 1989/06/01
Citation Subset: IM
Publication Status: ppublish
Jpn J Cancer Res 1989 Jun;80(6):513-20.
PMID: 2503472 UI: 89340133 [PubMed - indexed for MEDLINE]
From PubMed
252

[Effects of aloe extracts, aloctin A, on gastric secretion and on experimental gastric lesions in rats]
Full author name: Saito, H; Imanishi, K; Okabe, S.

Saito H, Imanishi K, Okabe S. Yakugaku Zasshi. 1989 May;109(5):335-9.

[Article in Japanese]

Effect of aloctin A, glycoprotein isolated from leaves of Aloe arborescens MILL, on gastric secretion and on acute gastric lesions in rats were examined. Aloctin A given intravenously dose-dependently inhibited the volume of gastric juice, acid and pepsin output in pylorus-ligated rats. Aloctin A given intravenously significantly inhibited the development of Shay ulcers and indomethacin-induced gastric lesions in rats. It also inhibited water-immersion stress lesions induced in pylorus-ligated rats.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19900410
Date Completed: 19900410
MeSH Date: 1989/05/01 00:01
Date Revised: 20001218
Entrez Date: 1989/05/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1989 May;109(5):335-9.
PMID: 2625663 UI: 90172180 [PubMed - indexed for MEDLINE]
From PubMed
253

[Experience using antihypoxic drugs in the treatment of acute neurosensory hearing loss in children with meningitis]
Full author name: Ryndina, A M; Lin'kov, V I; Dadiomova, M A; Buriakova, A V.

Ryndina AM, Lin'kov VI, Dadiomova MA, Buriakova AV. Vestn Otorinolaringol. 1989 Mar-Apr;(2):14-7.

[Article in Russian]

This paper describes beneficial affects of the therapy of neurosensory hypoacusia that complicated such neuroinfectious diseases as meningococcemia, meningococcic meningitis and meningitides of other etiology using traditional drugs (ATP, aloe, B and C vitamins) in combination with the antihypoxic agent gutimine and its analog. Positive effects were recorded in 17 (81%) out of 21 children. It is indicated that the agent shows higher efficacy when used within the first weeks after the onset of the disease.

MeSH Terms:

Substances:

ISSN: 0042-4668
NLM Unique ID: 0416577
Country: ussr
Vernacular Title: Opyt primeneniia antigipoksantov v lechenii ostroi neirosensornoi tugoukhosti pri meningitakh u detei.
Entry Date: 19890707
Date Completed: 19890707
MeSH Date: 1989/03/01 00:01
Date Revised: 20011128
Entrez Date: 1989/03/01
Citation Subset: IM
Publication Status: ppublish
Vestn Otorinolaringol 1989 Mar-Apr;(2):14-7.
PMID: 2728172 UI: 89268134 [PubMed - indexed for MEDLINE]
From PubMed
254

[Studies on chemical protectors against radiation. XXVI. Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation]
Full author name: Sato, Y; Ohta, S; Sakurai, N; Shinoda, M.

Sato Y, Ohta S, Sakurai N, Shinoda M. Yakugaku Zasshi. 1989 Feb;109(2):113-8.

[Article in Japanese]

The protective potency against skin injury on mice induced by X-irradiation was studied by use of 72 extracts of crude drugs. The protective potency was determined according to the degrees on skin injury after irradiation of 1100R, 30 k Vp soft X-ray. As a result of these study, 16 kinds of crude drugs such as Rosae Fructus, Aloe arborescens (Herba), Citri Leiocarpae Exocarpium, Schizonepetae Spica, Evodiae Fructus, Bupleuri Radix, Corni Fructus, Perillae Herba, Anemarrhenae Rhizoma, Menthae Herba, Trapae Fructus, Angelicae Dahuricae Radix, Sinomeni Caulis et Rhizoma, Ephedrae Herba, Acer nikoense (Cortex), Forsythiae Fructus, revealed protective potencies on skin injury.

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19890817
Date Completed: 19890817
MeSH Date: 1989/02/01 00:01
Date Revised: 20001218
Entrez Date: 1989/02/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1989 Feb;109(2):113-8.
PMID: 2746469 UI: 89310978 [PubMed - indexed for MEDLINE]
From PubMed
255

Aloe vera, salicylic acid, and aspirin for burns.
Full author name: Frumkin, A.

Frumkin A. Plast Reconstr Surg. 1989 Jan;83(1):196.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0032-1052
NLM Unique ID: 1306050
Country: United States
Entry Date: 19890125
Date Completed: 19890125
MeSH Date: 1989/01/01 00:01
Date Revised: 20011128
Entrez Date: 1989/01/01
Citation Subset: AIM, IM
Publication Status: ppublish
Plast Reconstr Surg 1989 Jan;83(1):196.
PMID: 2909067 UI: 89071995 [PubMed - indexed for MEDLINE]
From PubMed
256

Aloe vera for burns.
Full author name: Kivett, W F.

Kivett WF. Plast Reconstr Surg. 1989 Jan;83(1):195.

[Article in English]

Publication Types:

MeSH Terms:

ISSN: 0032-1052
NLM Unique ID: 1306050
Country: United States
Entry Date: 19890125
Date Completed: 19890125
MeSH Date: 1989/01/01 00:01
Date Revised: 20011128
Entrez Date: 1989/01/01
Citation Subset: AIM, IM
Publication Status: ppublish
Plast Reconstr Surg 1989 Jan;83(1):195.
PMID: 2909066 UI: 89071993 [PubMed - indexed for MEDLINE]
From PubMed
257

[Chronic benign familial pemphigus]
Full author name: Kovalev, V M; Tkachenko, L A; Krivenko, Z F; Stefanovskaia, L P.

Kovalev VM, Tkachenko LA, Krivenko ZF, Stefanovskaia LP. Vestn Dermatol Venerol. 1989;(8):65-7.

[Article in Russian]

A female patient aged 50 is described, in whom candidiasis of the large folds has been erroneously diagnosed for 10 years; the diagnosis has not been confirmed by bacteriologic analysis, the therapy has been ineffective, the recurrences developed every year. The patient has developed symmetrical erythematous infiltrative areas in the armpits, groin, and in the folds under mammary glands, with solitary bullae up to 0.5-1.0 cm in diameter, with transparent contents, with thin flaccid covers and fragments thereof, as well as small pigmented vegetation. Basing on the histologic findings (suprabasal vesicles above the basal layer, acantholysis in the epidermis, and negligible lymphocytic infiltrate in the derma), Gougerot-Hailey-Hailey's disease has been diagnosed. The familial nature of the disease could not be established. Therapy with diphenhydramine, methyluracil, dimocifon, aloe extract, and aniline dyes, administered for 20 days, has resulted in clinical cure.

MeSH Terms:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Khronicheskaia dobrokachestvennaia semeinaia puzyrchatka.
Entry Date: 19891221
Date Completed: 19891221
MeSH Date: 1989/01/01 00:01
Date Revised: 20001218
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1989;(8):65-7.
PMID: 2816037 UI: 90051784 [PubMed - indexed for MEDLINE]
From PubMed
258

[Primary screening of the immunopharmacologic activity of Filatov tissue therapy preparations]
Full author name: Degtiarenko, T V; Ivanova, A S; Skvortsov, V Iu; Masternak, T V; Larin, A S.

Degtiarenko TV, Ivanova AS, Skvortsov VIu, Masternak TV, Larin AS. Oftalmol Zh. 1989;(1):34-9.

[Article in Russian]

The paper presents results of primary assessment of immunopharmacologic activity of tissue preparations (peloidodistillate, FiBS, torfot, extract of aloe, placental extract) and the study of their influence on basic links of immune response (experimental investigations were carried out with mice-hybrids F1). It is found that the studied bioregulators possess immunomodulating action on primary humoral immune response and don't increase a hypersensitive reaction of a slowed type. The direction of immunotropic action of tissue preparations depends on the state of immunologic reactivity of the body and the kind of a preparation (variety of immunopharmacologic activity of the distillates groups and albumin preparations). It is expedient to work out indications to the usage of tissue preparations after V. P. Filatov to prevent and treat immunodeficient and immunopathologic conditions of the body.

MeSH Terms:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Pervichnyi skrining immunofarmakologicheskoi aktivnosti preparatov tkanevoi terapii po V.P. Filatovu.
Entry Date: 19890718
Date Completed: 19890718
MeSH Date: 1989/01/01 00:01
Date Revised: 20011119
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1989;(1):34-9.
PMID: 2733969 UI: 89282099 [PubMed - indexed for MEDLINE]
From PubMed
259

Aloe vera and gibberellin. Anti-inflammatory activity in diabetes.
Full author name: Davis, R H; Maro, N P.

Davis RH, Maro NP. J Am Podiatr Med Assoc. 1989 Jan;79(1):24-6.

[Article in English]

Aloe vera inhibits inflammation and adjuvant-induced arthritis. The authors' laboratory has shown that A. vera improves wound healing, which suggests that it does not act like an adrenal steroid. Diabetic animals were used in this study because of their poor wound healing and anti-inflammatory capabilities. The anti-inflammatory activity of A. vera and gibberellin was measured in streptozotocin-induced diabetic mice by measuring the inhibition of polymorphonuclear leukocyte infiltration into a site of gelatin-induced inflammation over a dose range of 2 to 100 mg/kg. Both Aloe and gibberellin similarly inhibited inflammation in a dose-response manner. These data tend to suggest that gibberellin or a gibberellin-like substance is an active anti-inflammatory component in A. vera.

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19890710
Date Completed: 19890710
MeSH Date: 1989/01/01 00:01
Date Revised: 20011128
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1989 Jan;79(1):24-6.
PMID: 2724102 UI: 89258381 [PubMed - indexed for MEDLINE]
From PubMed
260

Effect of water extracts of aloe and some herbs in decreasing blood ethanol concentration in rats. II.
Full author name: Sakai, K; Saitoh, Y; Ikawa, C; Nishihata, T.

Sakai K, Saitoh Y, Ikawa C, Nishihata T. Chem Pharm Bull (Tokyo). 1989 Jan;37(1):155-9.

[Article in English]

Oral administration of ethanol to rats at a dose of 3 g/kg decreased alcohol dehydrogenase (ADH) activity and metabolism of lactate to pyruvate in the liver. The effects of water extracts of Aloe and some other herbs on blood ethanol concentration and on ADH activity in liver cytosol were examined. The water extracts of these herbs caused a faster elimination of ethanol from blood of normal rats when administered orally 30 min before oral administration of ethanol. The rapid elimination of ethanol seems to be due to a protection of ADH activity and the supply of nicotinamide dinucleotide, both of which are reduced by high ethanol concentration. The effects of ethanol in decreasing the enzyme activities relating to its own metabolism occur when high concentrations of ethanol pass through the liver, and thus may primarily appear during the absorption of alcohol from the gastrointestinal tract, when portal concentration of ethanol are very high.

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19890706
Date Completed: 19890706
MeSH Date: 1989/01/01 00:01
Date Revised: 20011128
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1989 Jan;37(1):155-9.
PMID: 2720844 UI: 89249527 [PubMed - indexed for MEDLINE]
From PubMed
261

[Purification, glucose-6-phosphate dehydrogenase inhibition, and HPLC analysis of four 1,8-dihydroxyanthrones]
Full author name: Rychener, M; Steiger, W.

Rychener M, Steiger W. Pharm Acta Helv. 1989;64(1):8-15.

[Article in German]

With regard to the examination of their antipsoriatic properties, four 1,8-dihydroxyanthrones were prepared in a purity greater than 99%: Dithranol (1, anthralin) by chromatographic purification, chrysarobin (2) either by work-up from commercial chrysarobin or by an oxidative cleavage (FeCl3) of aloin, followed by a reduction (SnCl2/HCl) of the produced anthraquinone derivative (6), aloe emodin anthrone (3) by the action of aquous sodium tetraborate on aloin and frangula emodin anthrone (4) by the SnCl2/HCl-reduction of frangula emodin (7) isolated from the dry extract of the bark of alder buckthorn. UV/VIS, IR, 1H-NMR and mass spectra confirmed the structures of the four anthrones which all distinctly inhibited G-6-P dehydrogenase (0.05 mmol, desactivation in 6 h). For clinical studies the anthrones were incorporated into white petrolatum with exclusion of oxygen (under Ar). The anthrone content of the preparations was determined by HPLC (LiChrosorb RP-18, 7 microns [280 x 4 mm]; 1.5 ml/min MeOH/water/HOAc [80:20:0.2]) after extraction with CH2Cl2 (tR = 1: 10.4 min, 2: 15.3 min, 3: 4.7 min, 4: 7.7 min).

MeSH Terms:

Substances:

ISSN: 0031-6865
NLM Unique ID: 0401134
Country: Switzerland
Vernacular Title: Reindarstellung, Glucose-6-phosphat-Dehydrogenase-Hemmung und HPLC-Analytik von vier 1,8-Dihydroxyanthronen.
Entry Date: 19890622
Date Completed: 19890622
MeSH Date: 1989/01/01 00:01
Date Revised: 20001218
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Pharm Acta Helv 1989;64(1):8-15.
PMID: 2717648 UI: 89240828 [PubMed - indexed for MEDLINE]
From PubMed
262

[Prospective study of the immunomodulator properties of i.m. administered "ALVA" extract in patients with solid tumors under a course of chemical immunosuppressive therapy]
Full author name: Michel, P; Pignon, T; Ralamboranto, L; Randrianandraina, S; Ratovonarivo, A; Coulanges, P.

Michel P, Pignon T, Ralamboranto L, Randrianandraina S, Ratovonarivo A, Coulanges P. Arch Inst Pasteur Madagascar. 1989;56(1):253-9.

[Article in French]

Institut Pasteur Antannerivo.

MeSH Terms:

Substances:

ISSN: 0020-2495
NLM Unique ID: 7502526
Country: madagascar
Vernacular Title: Etude prospective des proprietes immunomodulatrices de l'extrait "ALVA" utilise en "I.M." chez des patients atteints de tumeurs solides et en cours de therapie immunosuppressive chimique.
Entry Date: 19900524
Date Completed: 19900524
MeSH Date: 1989/01/01 00:01
Date Revised: 20011128
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Inst Pasteur Madagascar 1989;56(1):253-9.
PMID: 2633709 UI: 90225894 [PubMed - indexed for MEDLINE]
From PubMed
263

[A comprehensive assessment of the phagocytic activity of the blood neutrophils in patients with rubromycosis treated with griseofulvin and nizoral]
Full author name: Belukha, U K; Bidrat, M S; Luk'ianova, A S.

Belukha UK, Bidrat MS, Luk'ianova AS. Vestn Dermatol Venerol. 1989;(1):50-2.

[Article in Russian]

The neutrophilic phagocytic activity (absorption and enzymic bactericidal) is intensified in rubromycosis patients treated with nizoral vs. those administered griseofulvin. it is advisable to combine griseofulvin therapy with biogenic stimulants (pyrogenal, aloe, fiBS, vitreous body).

MeSH Terms:

Substances:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Kompleksnaia otsenka fagotsitarnoi aktivnosti neitrofilov krovi u bol'nykh rubrofitiei, lechennykh grizeoful'vinom i nizoralom.
Entry Date: 19890620
Date Completed: 19890620
MeSH Date: 1989/01/01 00:01
Date Revised: 20001218
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1989;(1):50-2.
PMID: 2524142 UI: 89243798 [PubMed - indexed for MEDLINE]
From PubMed
264

[Evaluation of the cationic-lysosomal test in patients with pneumonia against a background of therapy]
Full author name: Domashenko, O N; Sotnik, Iu P.

Domashenko ON, Sotnik IuP. Lab Delo. 1989;(5):15-7.

[Article in Russian]

The authors' findings evidence that measurements of cationic protein levels is a sufficiently informative test in the complex of investigations that help predict the course of acute pneumonia and the therapeutic efficacy of drugs stimulating the nonspecific resistance of the body. Combined therapy with the use of methyluracil and eleutherococcus is more effective for pneumonia patients than the complex including aloe and antibacterial and symptomatic agents alone.

MeSH Terms:

Substances:

ISSN: 0023-6748
NLM Unique ID: 18230140R
Country: ussr
Vernacular Title: Otsenka kationno-lizosomal'nogo testa u bol'nykh pnevmoniei na fone terapii.
Entry Date: 19890825
Date Completed: 19890825
MeSH Date: 1989/01/01 00:01
Date Revised: 20011119
Entrez Date: 1989/01/01
Citation Subset: IM
Publication Status: ppublish
Lab Delo 1989;(5):15-7.
PMID: 2473250 UI: 89312532 [PubMed - indexed for MEDLINE]
From PubMed
265

Metabolism of barbaloin by intestinal bacteria.
Full author name: Hattori, M; Kanda, T; Shu, Y Z; Akao, T; Kobashi, K; Namba, T.

Hattori M, Kanda T, Shu YZ, Akao T, Kobashi K, Namba T. Chem Pharm Bull (Tokyo). 1988 Nov;36(11):4462-6.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19890609
Date Completed: 19890609
MeSH Date: 1988/11/01 00:01
Date Revised: 20011128
Entrez Date: 1988/11/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1988 Nov;36(11):4462-6.
PMID: 3246014 UI: 89230603 [PubMed - indexed for MEDLINE]
From PubMed
266

[Studies of aloe. II. Mechanism of cathartic effect]
Full author name: Ishii, Y; Tanizawa, H; Takino, Y.

Ishii Y, Tanizawa H, Takino Y. Yakugaku Zasshi. 1988 Sep;108(9):904-10.

[Article in Japanese]

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19890614
Date Completed: 19890614
MeSH Date: 1988/09/01 00:01
Date Revised: 20001218
Entrez Date: 1988/09/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1988 Sep;108(9):904-10.
PMID: 3246654 UI: 89236055 [PubMed - indexed for MEDLINE]
From PubMed
267

Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera.
Full author name: Hart, L A; van Enckevort, P H; van Dijk, H; Zaat, R; de Silva, K T; Labadie, R P.

Hart LA, van Enckevort PH, van Dijk H, Zaat R, de Silva KT, Labadie RP. J Ethnopharmacol. 1988 May-Jun;23(1):61-71.

[Article in English]

Department of Chemical Pharmacy, Faculty of Pharmacy, State University of Utrecht, The Netherlands.

An aqueous extract of Aloe vera gel was analyzed guided by modulatory activity with regard to the in vitro activation of human complement and of human polymorphnuclear leucocytes (PMN). Upon ultrafiltration a high (h-Mr) and a low (l-Mr) molecular mass fraction were obtained. Pre-incubation of human pooled serum with the h-Mr fraction resulted in a depletion of classical and alternative pathway complement activity. In contrast, only the l-Mr fraction could inhibit the production of free oxygen radicals by activated PMNs. The latter activity cannot be attributed to non-specific effects like toxicity, interference with stimulant binding or scavenger activity.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Ireland
Entry Date: 19881026
Date Completed: 19881026
MeSH Date: 1988/05/01 00:01
Date Revised: 20011128
Entrez Date: 1988/05/01
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1988 May-Jun;23(1):61-71.
PMID: 2843719 UI: 88333893 [PubMed - indexed for MEDLINE]
From PubMed
268

Aloe vera.
Full author name: Klein, A D; Penneys, N S.

Klein AD, Penneys NS. J Am Acad Dermatol. 1988 Apr;18(4 Pt 1):714-20.

Erratum in:


[Article in English]

Department of Dermatology, University of Miami School of Medicine, FL.

We review the scientific literature regarding the aloe vera plant and its products. Aloe vera is known to contain several pharmacologically active ingredients, including a carboxypeptidase that inactivates bradykinin in vitro, salicylates, and a substance(s) that inhibits thromboxane formation in vivo. Scientific studies exist that support an antibacterial and antifungal effect for substance(s) in aloe vera. Studies and case reports provide support for the use of aloe vera in the treatment of radiation ulcers and stasis ulcers in man and burn and frostbite injuries in animals. The evidence for a potential beneficial effect associated with the use of aloe vera is sufficient to warrant the design and implementation of well-controlled clinical trials.

Publication Types:

MeSH Terms:

Substances:

Number of References: 27
ISSN: 0190-9622
NLM Unique ID: 7907132
Country: United States
Entry Date: 19880630
Date Completed: 19880630
MeSH Date: 1988/04/01 00:01
Date Revised: 20011128
Entrez Date: 1988/04/01
Citation Subset: IM
Publication Status: ppublish
J Am Acad Dermatol 1988 Apr;18(4 Pt 1):714-20.
PMID: 3286692 UI: 88228558 [PubMed - indexed for MEDLINE]
From PubMed
269

Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study.
Full author name: Kaufman, T; Kalderon, N; Ullmann, Y; Berger, J.

Kaufman T, Kalderon N, Ullmann Y, Berger J. J Burn Care Rehabil. 1988 Mar-Apr;9(2):156-9.

[Article in English]

Faculty of Medicine, Technion-Israel Institute of Technology, Israel.

In the present study, Aloe vera gel (AVG) was applied to experimental second-degree burns in guinea pigs, and its effects on epithelialization, wound contraction, newly formed granulation tissue, and regeneration of hair follicles was compared with that effected by 1% silver sulfadiazine cream (AgSD). Epithelialization (%mean +/- SEM) on postburn day 8, 16, and 24 of the AVG-treated wounds was 38.72% +/- 2.71%, 60.34% +/- 3.28%, and 92.46% +/- 2.26%, respectively, while that of the AgSD-treated burns was 53.35% +/- 2.65%, 94.84% +/- 2.65%, and 100%, respectively (P less than significantly higher than that of the AgSD-treated burns during 24 days of the study (P less than granulation tissue was higher in the AVG-treated wounds (P less than .001), while the hair follicles count was significantly lower (P less than concluded that this preparation of Aloe vera gel hindered the healing process of the present burn wound model when compared with 1% silver sulfadiazine cream.

MeSH Terms:

Substances:

ISSN: 0273-8481
NLM Unique ID: 8110188
Country: United States
Entry Date: 19880602
Date Completed: 19880602
MeSH Date: 1988/03/01 00:01
Date Revised: 20001218
Entrez Date: 1988/03/01
Citation Subset: IM, N
Publication Status: ppublish
J Burn Care Rehabil 1988 Mar-Apr;9(2):156-9.
PMID: 3360818 UI: 88198281 [PubMed - indexed for MEDLINE]
From PubMed
270

Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs.
Full author name: Rodriguez-Bigas, M; Cruz, N I; Suarez, A.

Rodriguez-Bigas M, Cruz NI, Suarez A. Plast Reconstr Surg. 1988 Mar;81(3):386-9.

[Article in English]

Surgical Research Laboratories, University of Puerto Rico School of Medicine, San Juan.

An experimental study was designed using Hartley guinea pigs, who received full-thickness burns covering 3 percent of their body surface area by direct contact with a hot plate. A total of 40 animals were equally divided among four modalities of closed burn wound management as follows: group I: silver sulfadiazine (Silvadine); group II: aloe vera gel extract (Carrington Dermal Wound Gel); group III: salicylic acid cream (aspirin); and group IV: plain gauze occlusive dressing only. The dressings were changed daily, and the size and appearance of each burn wound were recorded until complete healing. On the sixth postburn day, quantitative burn wound cultures were made. The average time to complete healing in the control group was 50 days, and the only significant difference was found in the aloe vera-treated animals, which healed on an average of 30 days (p less than 0.02). Wound bacterial counts were effectively decreased by silver sulfadiazine (p = 0.015) and by aloe vera extract (p = 0.015). From our data it appears that aloe gel extracts permit a faster healing of burn wounds.

MeSH Terms:

Substances:

ISSN: 0032-1052
NLM Unique ID: 1306050
Country: United States
Entry Date: 19880321
Date Completed: 19880321
MeSH Date: 1988/03/01 00:01
Date Revised: 20011128
Entrez Date: 1988/03/01
Citation Subset: AIM, IM
Publication Status: ppublish
Plast Reconstr Surg 1988 Mar;81(3):386-9.
PMID: 3340673 UI: 88125468 [PubMed - indexed for MEDLINE]
From PubMed
271

The influence of selected potential oncostatics of plant origin on the protein biosynthesis in vitro.
Full author name: Paszkiewicz-Gadek, A; Chlabicz, J; Galasinski, W.

Paszkiewicz-Gadek A, Chlabicz J, Galasinski W. Pol J Pharmacol Pharm. 1988 Mar-Apr;40(2):183-90.

[Article in English]

Department of General and Organic Chemistry, Medical Academy, Bialystok, Poland.

Five potential oncostatics of plant origin (reserpine, amphotericin B, rutoside, digoxin, dry aloe extract), and cyclic AMP were investigated for their effect on protein synthesis. The solutions of digoxin and dry aloe extract inhibited protein biosynthesis in vitro. The direct inhibiting effect of digoxin on the ribosomes suggests that this drug forms an inactive complex with this organelle. Therefore it can be concluded that ribosome is the target site of digoxin action. Aloin and aloeemodin are responsible for the inhibitory effect of the solution of dry aloe extract. They inhibit markedly [14C]-leucine incorporation into proteins. Aloin and aloeemodin do not influence directly the ribosomes, but they inhibit elongation factors and peptidyltransferase activities in the complete elongation system. Some preliminary experiments have shown that direct interaction between these substances and elongation factor EF-2 should be taken in account. This observation is the subject of further experiments, in which the characteristics of the inhibitory effect of the components isolated from dry aloe extract will be performed.

MeSH Terms:

Substances:

ISSN: 0301-0244
NLM Unique ID: 0366561
Country: Poland
Entry Date: 19890426
Date Completed: 19890426
MeSH Date: 1988/03/01 00:01
Date Revised: 20011128
Entrez Date: 1988/03/01
Citation Subset: IM
Publication Status: ppublish
Pol J Pharmacol Pharm 1988 Mar-Apr;40(2):183-90.
PMID: 3237568 UI: 89184031 [PubMed - indexed for MEDLINE]
From PubMed
272

Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis.
Full author name: Hogan, D J.

Hogan DJ. CMAJ. 1988 Feb 15;138(4):336-8.

[Article in English]

Department of Medicine, University of Saskatchewan, Saskatoon.

MeSH Terms:

Substances:

ISSN: 0820-3946
NLM Unique ID: 9711805
Country: Canada
Entry Date: 19880318
Date Completed: 19880318
MeSH Date: 1988/02/15 00:01
Date Revised: 20011128
Entrez Date: 1988/02/15
Citation Subset: AIM, IM
Publication Status: ppublish
CMAJ 1988 Feb 15;138(4):336-8.
PMID: 2962713 UI: 88109174 [PubMed - indexed for MEDLINE]
From PubMed
273

Aloe vera. A natural approach for treating wounds, edema, and pain in diabetes.
Full author name: Davis, R H; Leitner, M G; Russo, J M.

Davis RH, Leitner MG, Russo JM. J Am Podiatr Med Assoc. 1988 Feb;78(2):60-8.

[Article in English]

MeSH Terms:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19880621
Date Completed: 19880621
MeSH Date: 1988/02/01 00:01
Date Revised: 20011128
Entrez Date: 1988/02/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1988 Feb;78(2):60-8.
PMID: 3367289 UI: 88214684 [PubMed - indexed for MEDLINE]
From PubMed
274

Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn).
Full author name: Womble, D; Helderman, J H.

Womble D, Helderman JH. Int J Immunopharmacol. 1988;10(8):967-74.

[Article in English]

Renal Immunology Laboratory, University of Texas Southwestern Medical Center, Dallas.

Healing powers have been imputed as being a feature of the gel from the aloe vera plant for centuries. The recent isolation of the active ingredient, acemannan, has made testing of this drug important. Since the drug appears to enhance monocyte function in other experiments, these studies were designed to test the capacity of acemannan to enhance immune response to alloantigen and to test whether the potential enhancement is a monocyte driven phenomenon. Acemannan did not enhance lymphocyte response to syngeneic antigens in the mixed lymphocyte culture (MLC) but importantly increased alloantigenic response in a dose-response fashion (2.6 x 10(-7) - 2.6 x 10(-9)M). This effect of acemannan was shown to be a specific response and to concur with concentrations of in vitro acemannan achievable in vivo. A separate series of mixing experiments demonstrated that acemannan incubation with monocytes permitted monocyte driven signals to enhance T-cell response to lectin. It is concluded that acemannan, the active ingredient of the aloe vera plant, is an important immunoenhancer in that it increases lymphocyte response to alloantigen. It is suggested that the mechanism involves enhancement of monocyte release of IL-I under the aegis of alloantigen. This mechanism may explain in part the recently observed capacity of acemannan to abrogate viral infections in animal and man.

MeSH Terms:

Substances:

ISSN: 0192-0561
NLM Unique ID: 7904799
Country: England
Entry Date: 19890306
Date Completed: 19890306
MeSH Date: 1988/01/01 00:01
Date Revised: 20001218
Entrez Date: 1988/01/01
Citation Subset: IM
Publication Status: ppublish
Int J Immunopharmacol 1988;10(8):967-74.
PMID: 2975271 UI: 89108677 [PubMed - indexed for MEDLINE]
From PubMed
275

Effect of amino acids in Aloe extract on phagocytosis by peripheral neutrophil in adult bronchial asthma.
Full author name: Yagi, A; Shida, T; Nishimura, H.

Yagi A, Shida T, Nishimura H. Arerugi. 1987 Dec;36(12):1094-101.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0021-4884
NLM Unique ID: 0241212
Country: Japan
Entry Date: 19880624
Date Completed: 19880624
MeSH Date: 1987/12/01 00:01
Date Revised: 20011128
Entrez Date: 1987/12/01
Citation Subset: IM
Publication Status: ppublish
Arerugi 1987 Dec;36(12):1094-101.
PMID: 3451730 UI: 88240045 [PubMed - indexed for MEDLINE]
From PubMed
276

Topical anti-inflammatory activity of Aloe vera as measured by ear swelling.
Full author name: Davis, R H; Leitner, M G; Russo, J M.

Davis RH, Leitner MG, Russo JM. J Am Podiatr Med Assoc. 1987 Nov;77(11):610-2.

[Article in English]

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19880506
Date Completed: 19880506
MeSH Date: 1987/11/01 00:01
Date Revised: 20011128
Entrez Date: 1987/11/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1987 Nov;77(11):610-2.
PMID: 3443918 UI: 88172087 [PubMed - indexed for MEDLINE]
From PubMed
277

Experimental and clinical observations on frostbite.
Full author name: Heggers, J P; Robson, M C; Manavalen, K; Weingarten, M D; Carethers, J M; Boertman, J A; Smith, D J Jr; Sachs, R J.

Heggers JP, Robson MC, Manavalen K, Weingarten MD, Carethers JM, Boertman JA, Smith DJ Jr, Sachs RJ. Ann Emerg Med. 1987 Sep;16(9):1056-62.

[Article in English]

Experimental ischemia by the classic frostbite rabbit ear model clearly defined the role of thromboxane as a mediator of progressive dermal ischemia in frostbite injuries. The therapeutic groups consisted of the antiprostanoids, methylprednisolone, and aspirin combined with anti-thromboxane agents Aloe vera and methimazole, while the control group received no therapy. Survival was measured by planimetry for all groups. No tissue survival was evident in the frostbite control group. Methimazole treatment allowed 34.3% survival, Aloe vera 28.2% survival, aspirin 22.5% survival, and methylprednisolone 17.5% survival. The data compare the results of a modified frostbite protocol using ibuprofen with therapeutic modalities used by other clinical services. Of 154 patients treated for frostbite from 1982 to 1985, 56 were treated with our frostbite protocol; 98 were treated with other modalities. Of the 56 protocol patients, 18 suffered 1st degree frostbite, 25, 2nd degree frostbite, and 13, 3rd degree frostbite. For all degrees of frostbite, 67.9% healed without tissue loss, 25.0% healed with partial tissue loss, and 7% required amputation (P less than .001). Of the patients not on protocol, 11 suffered 1st degree frostbite, 51, 2nd degree frostbite, and 36, 3rd degree frostbite. Of these, 32.7% healed without tissue loss, 34.6% healed with tissue loss, and 32.7% required amputation. The morbidity of progressive dermal ischemia in frostbite may be decreased by the therapeutic use of inhibitors of the arachidonic acid cascade.

MeSH Terms:

Substances:

ISSN: 0196-0644
NLM Unique ID: 8002646
Country: United States
Entry Date: 19871001
Date Completed: 19871001
MeSH Date: 2001/03/28 10:01
Date Revised: 20010323
Entrez Date: 1987/09/01
Citation Subset: AIM, IM
Publication Status: ppublish
Ann Emerg Med 1987 Sep;16(9):1056-62.
PMID: 3631670 UI: 87324359 [PubMed - indexed for MEDLINE]
From PubMed
278

Dermabrasion-Loo-punch-excision technique for the treatment of acne-induced osteoma cutis.
Full author name: Fulton, J E Jr.

Fulton JE Jr. J Dermatol Surg Oncol. 1987 Jun;13(6):655-9.

[Article in English]

Three patients with chronic osteoma cutis secondary to acne vulgaris were treated with the dermabrasion-Loo-punch-excision technique. Under regional nerve block with lidocaine-bipuvacaine (50:50) a uniform dermabrasion was performed across the entire face, including the hairline and 1 cm below the jawline. This exposed the foci of osteoma cutis. Then the appropriate sized Loo punch (usually the 2.0- or the 2.5-mm punch) was used to excise the bluish-gray miliary lesions. The majority of the foci were removed in one operation. Following excision, the lesions were closed with 7-0 prolene suture. To prevent crust formation postoperatively, Aloe-vera-soaked polyethylene oxide gel dressings (Vigilon) were changed twice daily following an ice water compress. Sutures were removed rapidly in 5 to 7 days to prevent the appearance of suture lines. Although one patient required an additional procedure, the cosmetic results were excellent. Only a few small residual blue "dot" lesions remained in these three cases.

MeSH Terms:

ISSN: 0148-0812
NLM Unique ID: 7707501
Country: United States
Entry Date: 19870708
Date Completed: 19870708
MeSH Date: 2001/03/28 10:01
Date Revised: 20010323
Entrez Date: 1987/06/01
Citation Subset: IM
Publication Status: ppublish
J Dermatol Surg Oncol 1987 Jun;13(6):655-9.
PMID: 2953769 UI: 87223433 [PubMed - indexed for MEDLINE]
From PubMed
279

Lymphocutaneous sporotrichosis.
Full author name: Satta, S.

Satta S. Hawaii Med J. 1987 Apr;46(4):124, 127.

[Article in English]

MeSH Terms:

ISSN: 0017-8594
NLM Unique ID: 2984209R
Country: United States
Entry Date: 19870716
Date Completed: 19870716
MeSH Date: 1987/04/01 00:01
Date Revised: 20011128
Entrez Date: 1987/04/01
Citation Subset: IM
Publication Status: ppublish
Hawaii Med J 1987 Apr;46(4):124, 127.
PMID: 3583717 UI: 87221549 [PubMed - indexed for MEDLINE]
From PubMed
280

Aloe vera and wound healing.
Full author name: Davis, R H; Kabbani, J M; Maro, N P.

Davis RH, Kabbani JM, Maro NP. J Am Podiatr Med Assoc. 1987 Apr;77(4):165-9.

[Article in English]

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19870626
Date Completed: 19870626
MeSH Date: 1987/04/01 00:01
Date Revised: 20011128
Entrez Date: 1987/04/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1987 Apr;77(4):165-9.
PMID: 2438402 UI: 87225713 [PubMed - indexed for MEDLINE]
From PubMed
281

The role of thromboxane in experimental inadvertent intra-arterial drug injections.
Full author name: Zachary, L S; Smith, D J Jr; Heggers, J P; Robson, M C; Boertman, J A; Niu, X T; Schileru, R E; Sacks, R J.

Zachary LS, Smith DJ Jr, Heggers JP, Robson MC, Boertman JA, Niu XT, Schileru RE, Sacks RJ. J Hand Surg [Am]. 1987 Mar;12(2):240-5.

[Article in English]

Inadvertent intra-arterial injection of drugs produces a well-defined clinical syndrome whose pathophysiology remains unclear. This study was designed to determine the role of the inflammatory mediator, thromboxane, in intra-arterial drug injections. The rabbit ear model, as described by Kinmonth and Sheppard, was used. Five of the experimental groups were treated with specific or nonspecific thromboxane blocking agents and two groups served as controls. Immunohistochemical staining of the control ears showed elevated levels of thromboxane within the first 6 hours postinjury. The specific thromboxane blocking agents, methimazole and Aloe vera, showed almost complete blockade of thromboxane production. The percentage of ear survival was significantly greater in the group treated with topical Aloe vera (p less than 0.05) and even greater survival was achieved in the combined Aloe vera/methimazole group (p less than 0.01). On the basis of these results, we have begun treatment of such injuries with specific and nonspecific thromboxane blocking agents.

MeSH Terms:

Substances:

ISSN: 0363-5023
NLM Unique ID: 7609631
Country: United States
Entry Date: 19870518
Date Completed: 19870518
MeSH Date: 2001/03/28 10:01
Date Revised: 20010323
Entrez Date: 1987/03/01
Citation Subset: IM
Publication Status: ppublish
J Hand Surg [Am] 1987 Mar;12(2):240-5.
PMID: 3559078 UI: 87167320 [PubMed - indexed for MEDLINE]
From PubMed
282

Bradykinin-degrading glycoprotein in Aloe arborescens var. natalensis.
Full author name: Yagi, A; Harada, N; Shimomura, K; Nishioka, I.

Yagi A, Harada N, Shimomura K, Nishioka I. Planta Med. 1987 Feb;53(1):19-21.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19870529
Date Completed: 19870529
MeSH Date: 1987/02/01 00:01
Date Revised: 20011128
Entrez Date: 1987/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1987 Feb;53(1):19-21.
PMID: 3575507 UI: 87204669 [PubMed - indexed for MEDLINE]
From PubMed
283

The detection of laxative abuse.
Full author name: Morton, J.

Morton J. Ann Clin Biochem. 1987 Jan;24 ( Pt 1):107-8.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0004-5632
NLM Unique ID: 0324055
Country: England
Entry Date: 19870408
Date Completed: 19870408
MeSH Date: 1987/01/01 00:01
Date Revised: 20011128
Entrez Date: 1987/01/01
Citation Subset: IM
Publication Status: ppublish
Ann Clin Biochem 1987 Jan;24 ( Pt 1):107-8.
PMID: 3827173 UI: 87155129 [PubMed - indexed for MEDLINE]
From PubMed
284

Studies on the activity of individual plants of an antidiabetic plant mixture.
Full author name: Al-Awadi, F M; Gumaa, K A.

Al-Awadi FM, Gumaa KA. Acta Diabetol Lat. 1987 Jan-Mar;24(1):37-41.

[Article in English]

A blood glucose lowering extract of a mixture of five plants in use by Kuwaiti diabetics was studied for the identification of its active component(s). Only the extracts of myrrh and aloe gums effectively increased glucose tolerance in both normal and diabetic rats. The remaining components, gum olibanum, Nigella sativa seeds and gum assafoetida were without effect.

MeSH Terms:

Substances:

ISSN: 0001-5563
NLM Unique ID: 0123567
Country: Italy
Entry Date: 19870916
Date Completed: 19870916
MeSH Date: 1987/01/01 00:01
Date Revised: 20011128
Entrez Date: 1987/01/01
Citation Subset: IM
Publication Status: ppublish
Acta Diabetol Lat 1987 Jan-Mar;24(1):37-41.
PMID: 3618079 UI: 87294875 [PubMed - indexed for MEDLINE]
From PubMed
285

Plant lectin, ATF1011, on the tumor cell surface augments tumor-specific immunity through activation of T cells specific for the lectin.
Full author name: Yoshimoto, R; Kondoh, N; Isawa, M; Hamuro, J.

Yoshimoto R, Kondoh N, Isawa M, Hamuro J. Cancer Immunol Immunother. 1987;25(1):25-30.

[Article in English]

The possibility that a plant lectin as a carrier protein would specifically activate T cells, resulting in the augmentation of antitumor immunity was investigated. ATF1011, a nonmitogenic lectin for T cells purified from Aloe arborescens Mill, bound equally to normal and tumor cells. ATF1011 binding on the MM102 tumor cell surfaces augmented anti-trinitrophenyl (TNP) antibody production of murine splenocytes when the mice were primarily immunized with TNP-conjugated MM102 tumor cells. The alloreactive cytotoxic T cell response was also augmented by allostimulator cells binding ATF1011 on the cell surfaces. These augmented responses may be assumed to be mediated by the activation of helper T cells recognizing ATF1011 as a carrier protein. Killer T cells were induced against ATF1011 antigen in the H-2 restricted manner using syngeneic stimulator cells bearing ATF1011 on the cell surfaces. When this lectin was administered intralesionally into the tumors, induction of cytotoxic effector cells was demonstrated. These results suggest that intralesionally administered ATF1011 binds to the tumor cell membrane and activates T cells specific for this carrier lectin in situ, which results in the augmented induction of systemic antitumor immunity.

MeSH Terms:

Substances:

ISSN: 0340-7004
NLM Unique ID: 8605732
Country: germany, west
Entry Date: 19870820
Date Completed: 19870820
MeSH Date: 1987/01/01 00:01
Date Revised: 20001218
Entrez Date: 1987/01/01
Citation Subset: IM
Publication Status: ppublish
Cancer Immunol Immunother 1987;25(1):25-30.
PMID: 3496156 UI: 87244147 [PubMed - indexed for MEDLINE]
From PubMed
286

[Induction of lymphoblastic transformation by a polysaccharide extract of a native Madagascar plant Aloe vahombe: ALVA]
Full author name: Ralamboranto, L; Rakotovao, L H; Coulanges, P; Corby, G; Janot, C; Le Deaut, J Y.

Ralamboranto L, Rakotovao LH, Coulanges P, Corby G, Janot C, Le Deaut JY. Arch Inst Pasteur Madagascar. 1987;53(1):227-31.

[Article in French]

Universite de Madagascar, E.E.S. Sciences Antananarivo.

MeSH Terms:

Substances:

ISSN: 0020-2495
NLM Unique ID: 7502526
Country: madagascar
Vernacular Title: Induction de la transformation lymphoblastique par un extrait polysaccharidique d'une plante endemique malgache l'Aloe vahombe: "l'ALVA".
Entry Date: 19880628
Date Completed: 19880628
MeSH Date: 1987/01/01 00:01
Date Revised: 20011128
Entrez Date: 1987/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Inst Pasteur Madagascar 1987;53(1):227-31.
PMID: 3451709 UI: 88239878 [PubMed - indexed for MEDLINE]
From PubMed
287

The glucomannan system from Aloe vahombe (liliaceae). III. Comparative studies on the glucomannan components isolated from the leaves.
Full author name: Vilkas, E; Radjabi-Nassab, F.

Vilkas E, Radjabi-Nassab F. Biochimie. 1986 Sep;68(9):1123-7.

[Article in English]

The polysaccharide mixture obtained by hot water extraction of Aloe vahombe leaves is composed of at least four different paritally acetylated glucomannans which differ in molecular weight, glucose to mannose ratios and acetyl contents. Furthermore, one fraction contains a small but significant amount of protein which could not be removed by gel filtration in a hydrogen-bond-breaking medium, by DEAE-Sephadex A-50 anion exchange chromatography, or by Sevag's method.

MeSH Terms:

Substances:

ISSN: 0300-9084
NLM Unique ID: 1264604
Country: France
Entry Date: 19870122
Date Completed: 19870122
MeSH Date: 1986/09/01 00:01
Date Revised: 20011128
Entrez Date: 1986/09/01
Citation Subset: IM
Publication Status: ppublish
Biochimie 1986 Sep;68(9):1123-7.
PMID: 3096390 UI: 87049830 [PubMed - indexed for MEDLINE]
From PubMed
288

Wound care forum: Readers' remedies for pressure sores.
Full author name: Cuzzell, J Z.

Cuzzell JZ. Am J Nurs. 1986 Aug;86(8):923-4.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0002-936X
NLM Unique ID: 0372646
Country: United States
Entry Date: 19860917
Date Completed: 19860917
MeSH Date: 1986/08/01 00:01
Date Revised: 20011128
Entrez Date: 1986/08/01
Citation Subset: AIM, IM, N
Publication Status: ppublish
Am J Nurs 1986 Aug;86(8):923-4.
PMID: 3638127 UI: 86293078 [PubMed - indexed for MEDLINE]
From PubMed
289

The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel.
Full author name: Grindlay, D; Reynolds, T.

Grindlay D, Reynolds T. J Ethnopharmacol. 1986 Jun;16(2-3):117-51.

[Article in English]

The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components.

Publication Types:

MeSH Terms:

Number of References: 154
ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Switzerland
Entry Date: 19861008
Date Completed: 19861008
MeSH Date: 1986/06/01 00:01
Date Revised: 20011128
Entrez Date: 1986/06/01
Citation Subset: IM, Q
Publication Status: ppublish
J Ethnopharmacol 1986 Jun;16(2-3):117-51.
PMID: 3528673 UI: 86309500 [PubMed - indexed for MEDLINE]
From PubMed
290

Aloe vera, fiction or fact.
Full author name: Natow, A J.

Natow AJ. Cutis. 1986 Feb;37(2):106, 108.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0011-4162
NLM Unique ID: 0006440
Country: United States
Entry Date: 19860429
Date Completed: 19860429
MeSH Date: 1986/02/01 00:01
Date Revised: 20011128
Entrez Date: 1986/02/01
Citation Subset: IM
Publication Status: ppublish
Cutis 1986 Feb;37(2):106, 108.
PMID: 3956253 UI: 86163412 [PubMed - indexed for MEDLINE]
From PubMed
291

Antiarthritic activity of anthraquinones found in aloe for podiatric medicine.
Full author name: Davis, R H; Agnew, P S; Shapiro, E.

Davis RH, Agnew PS, Shapiro E. J Am Podiatr Med Assoc. 1986 Feb;76(2):61-6.

[Article in English]

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19860220
Date Completed: 19860220
MeSH Date: 1986/02/01 00:01
Date Revised: 20011128
Entrez Date: 1986/02/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1986 Feb;76(2):61-6.
PMID: 3941379 UI: 86088605 [PubMed - indexed for MEDLINE]
From PubMed
292

[Effect of aloe on the resistance of the optic nerve system of the eye]
Full author name: Dumbrova, N E; Sotnikova, E p; Gorianova, N A.

Dumbrova NE, Sotnikova E, Gorianova NA. Oftalmol Zh. 1986;(8):494-6.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Vliianie aloe na rezistentnost' zritel'no-nervnogo apparata glaza.
Entry Date: 19870417
Date Completed: 19870417
MeSH Date: 1986/01/01 00:01
Date Revised: 20011128
Entrez Date: 1986/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1986;(8):494-6.
PMID: 3822364 UI: 87145550 [PubMed - indexed for MEDLINE]
From PubMed
293

[Antimetastatic properties of aloe juice]
Full author name: Gribel', N V; Pashinskii, V G.

Gribel' NV, Pashinskii VG. Vopr Onkol. 1986;32(12):38-40.

[Article in Russian]

An evaluation of antimetastatic properties of succus Aloes was carried out using three types of experimental tumors of mice and rats. It was found that succus Aloes treatment contributes to reduction of tumor mass, metastatic foci and metastasis frequency at different stages of tumor progress without affecting major tumor growth. Succus Aloes potentiates the antitumor effect of 5-fluorouracil and cyclophosphamide as components of combination chemotherapy.

MeSH Terms:

Substances:

ISSN: 0507-3758
NLM Unique ID: 0413775
Country: ussr
Vernacular Title: Protivometastaticheskie svoistva soka aloe.
Entry Date: 19870217
Date Completed: 19870217
MeSH Date: 1986/01/01 00:01
Date Revised: 20011128
Entrez Date: 1986/01/01
Citation Subset: IM
Publication Status: ppublish
Vopr Onkol 1986;32(12):38-40.
PMID: 3798837 UI: 87095708 [PubMed - indexed for MEDLINE]
From PubMed
294

The antidiabetic activity of aloes: preliminary clinical and experimental observations.
Full author name: Ghannam, N; Kingston, M; Al-Meshaal, I A; Tariq, M; Parman, N S; Woodhouse, N.

Ghannam N, Kingston M, Al-Meshaal IA, Tariq M, Parman NS, Woodhouse N. Horm Res. 1986;24(4):288-94.

[Article in English]

The dried sap of the aloe plant (aloes) is one of several traditional remedies used for diabetes in the Arabian peninsula. Its ability to lower the blood glucose was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. During the ingestion of aloes, half a teaspoonful daily for 4-14 weeks, the fasting serum glucose level fell in every patient from a mean of 273 +/- 25 (SE) to 151 +/- 23 mg/dl (p less than 0.05) with no change in body weight. In normal mice, both glibenclamide (10 mg/kg twice daily) and aloes (500 mg/kg twice daily) induced hypoglycaemia after 5 days, 71 +/- 6.2 and 91 +/- 7.6 mg/dl, respectively, versus 130 +/- 7 mg/dl in control animals (p less than 0.01); only glibenclamide was effective after 3 days. In the diabetic mice, fasting plasma glucose was significantly reduced by glibenclamide and aloes after 3 days. Thereafter only aloes was effective and by day 7 the plasma glucose was 394 +/- 22.0 versus 646 +/- 35.9 mg/dl, in the controls and 726 +/- 30.9 mg/dl in the glibenclamide treated group (p less than 0.01). We conclude that aloes contains a hypoglycaemic agent which lowers the blood glucose by as yet unknown mechanisms.

MeSH Terms:

Substances:

ISSN: 0301-0163
NLM Unique ID: 0366126
Country: Switzerland
Entry Date: 19870122
Date Completed: 19870122
MeSH Date: 1986/01/01 00:01
Date Revised: 20011128
Entrez Date: 1986/01/01
Citation Subset: IM
Publication Status: ppublish
Horm Res 1986;24(4):288-94.
PMID: 3096865 UI: 87055702 [PubMed - indexed for MEDLINE]
From PubMed
295

Comparative effectiveness of topical treatments for hydrofluoric acid burns.
Full author name: Bracken, W M; Cuppage, F; McLaury, R L; Kirwin, C; Klaassen, C D.

Bracken WM, Cuppage F, McLaury RL, Kirwin C, Klaassen CD. J Occup Med. 1985 Oct;27(10):733-9.

[Article in English]

Hydrofluoric acid (HF) burns are characterized by progressive tissue necrosis and severe pain. Numerous topical treatments have been proposed, yet few have been studied experimentally. The present study was designed to examine the comparative efficacy of recommended treatments. Hair on the hind legs of rats was removed and 48 hours later 70% HF was applied. Calcium gluconate, Zephiran (benzalkonium chloride), A + D Ointment, aloe gel, and magnesium ointment were applied topically and burn development was monitored. Calcium gluconate significantly reduced burn size as early as one hour after application. Significant protection continued for seven days after the single application. The other treatments were not effective in decreasing or delaying HF burn development. The results indicated that calcium gluconate ointment was the most effective topical treatment for HF burns.

MeSH Terms:

Substances:

ISSN: 0096-1736
NLM Unique ID: 7502807
Country: United States
Entry Date: 19860110
Date Completed: 19860110
MeSH Date: 1985/10/01 00:01
Date Revised: 20011128
Entrez Date: 1985/10/01
Citation Subset: IM
Publication Status: ppublish
J Occup Med 1985 Oct;27(10):733-9.
PMID: 4067676 UI: 86061946 [PubMed - indexed for MEDLINE]
From PubMed
296

Isolation of a new aloe-emodin dianthrone diglucoside from senna and its potentiating effect on the purgative activity of sennoside A in mice.
Full author name: Nakajima, K; Yamauchi, K; Kuwano, S.

Nakajima K, Yamauchi K, Kuwano S. J Pharm Pharmacol. 1985 Oct;37(10):703-6.

[Article in English]

Two aloe-emodin dianthrone diglucosides (I and II) were isolated from the leaves of Cassia angustifolia Vahl by successive column chromatography with Amberlite XAD-2, silica gel, Polyamide C-200 and Sephadex LH-20. The stereostructures of I and II were elucidated as trans and meso isomers at 10-10', respectively, from the patterns of the ultraviolet absorption spectra and circular dichroism curves. This is the first report of isolation of diglucoside I from senna. Despite the lack of purgative activity, diglucoside I exerts a potentiating effect of about 1.3 times on the purgative activity of sennoside A in mice when even 15% is included in the mixture. The difference between I and a third active glycoside based on aloe-emodin is also discussed.

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 19860213
Date Completed: 19860213
MeSH Date: 1985/10/01 00:01
Date Revised: 20011128
Entrez Date: 1985/10/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 1985 Oct;37(10):703-6.
PMID: 2867138 UI: 86088452 [PubMed - indexed for MEDLINE]
From PubMed
297

Prevention of atheromatous heart disease.
Full author name: Agarwal, O P.

Agarwal OP. Angiology. 1985 Aug;36(8):485-92.

[Article in English]

Five thousand patients of atheromatous heart disease, presented as angina pectoris, were studied over a period of five years. After adding the 'Husk of Isabgol' and 'aloe vera' (an indigenous plant known as ghee-guar-ka-paththa) to the diet, a marked reduction in total serum cholesterol, serum triglycerides, fasting and post prandial blood sugar level in diabetic patients, total lipids and also increase in HDL were noted. Simultaneously the clinical profile of these patients showed reduction in the frequency of anginal attacks and gradually, the drugs, like verapamil, nifedipine, beta-blockers and nitrates, were tapered. The patients, most benefitted, were diabetics (without adding any antidiabetic drug). The exact mechanism of the action of the above two substances is not known, but it appears, that probably they act by their high fibre contents. Both these substances need further evaluation. The most interesting aspect of the study was that no untoward side effect was noted and all the five thousand patients are surviving till date.

MeSH Terms:

Substances:

ISSN: 0003-3197
NLM Unique ID: 0203706
Country: United States
Entry Date: 19850930
Date Completed: 19850930
MeSH Date: 1985/08/01 00:01
Date Revised: 20011128
Entrez Date: 1985/08/01
Citation Subset: IM
Publication Status: ppublish
Angiology 1985 Aug;36(8):485-92.
PMID: 2864002 UI: 85304965 [PubMed - indexed for MEDLINE]
From PubMed
298

[Treatment of children with persistent cough in pharyngitis]
Full author name: Grigor'eva, I F.

Grigor'eva IF. Vestn Otorinolaringol. 1985 Jul-Aug;(4):13-6.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0042-4668
NLM Unique ID: 0416577
Country: ussr
Vernacular Title: Lechenie detei, stradaiushchikh dlitel'nym kashlem pri faringite.
Entry Date: 19851029
Date Completed: 19851029
MeSH Date: 1985/07/01 00:01
Date Revised: 20011128
Entrez Date: 1985/07/01
Citation Subset: IM
Publication Status: ppublish
Vestn Otorinolaringol 1985 Jul-Aug;(4):13-6.
PMID: 4049630 UI: 86020430 [PubMed - indexed for MEDLINE]
From PubMed
299

Effect of Aloe extract on peripheral phagocytosis in adult bronchial asthma.
Full author name: Shida, T; Yagi, A; Nishimura, H; Nishioka, I.

Shida T, Yagi A, Nishimura H, Nishioka I. Planta Med. 1985 Jun;(3):273-5.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19851018
Date Completed: 19851018
MeSH Date: 1985/06/01 00:01
Date Revised: 20011128
Entrez Date: 1985/06/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1985 Jun;(3):273-5.
PMID: 4034752 UI: 85298907 [PubMed - indexed for MEDLINE]
From PubMed
300

Effect of aloe lectin on deoxyribonucleic acid synthesis in baby hamster kidney cells.
Full author name: Yagi, A; Machii, K; Nishimura, H; Shida, T; Nishioka, I.

Yagi A, Machii K, Nishimura H, Shida T, Nishioka I. Experientia. 1985 May 15;41(5):669-71.

[Article in English]

A homogeneous glycoprotein (mol. wt 40,000) containing 34% carbohydrate was isolated from Aloe arborescens var. natalensis. At a concentration of 5 micrograms/ml, this glycoprotein was shown to stimulate deoxyribonucleic acid (DNA) synthesis in baby hamster kidney (BHK) cells and to have the properties of a lectin which reacts with sheep blood cells. The chemical and physical properties of the glycoprotein (aloe lectin) are also discussed.

MeSH Terms:

Substances:

ISSN: 0014-4754
NLM Unique ID: 0376547
Country: Switzerland
Entry Date: 19850703
Date Completed: 19850703
MeSH Date: 1985/05/15 00:01
Date Revised: 20011128
Entrez Date: 1985/05/15
Citation Subset: IM
Publication Status: ppublish
Experientia 1985 May 15;41(5):669-71.
PMID: 3996544 UI: 85204262 [PubMed - indexed for MEDLINE]
From PubMed
301

Liquid chromatographic determination of barbaloin (aloin) in foods.
Full author name: Yamamoto, M; Ishikawa, M; Masui, T; Nakazawa, H; Kabasawa, Y.

Yamamoto M, Ishikawa M, Masui T, Nakazawa H, Kabasawa Y. J Assoc Off Anal Chem. 1985 May-Jun;68(3):493-4.

[Article in English]

A simple and rapid liquid chromatographic method is described for the determination of barbaloin (aloin, 10-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthraceno ne) in foods. Barbaloin is extracted with water from foods containing aloe and the extract is cleaned up on a disposable cartridge by using methanol-water (55 + 45) as eluant. The eluted barbaloin is separated by liquid chromatography on a YMC A-302 column with methanol-water (50 + 50) mobile phase, and detected at 293 nm. Recoveries of barbaloin added to foods at the levels of 0.05 and 0.50 mg/g were 94.4-100%. Assay results for commercial food samples indicated that the present method is applicable to a variety of foods supplemented with aloe.

MeSH Terms:

Substances:

ISSN: 0004-5756
NLM Unique ID: 7505559
Country: United States
Entry Date: 19850904
Date Completed: 19850904
MeSH Date: 1985/05/01 00:01
Date Revised: 20011128
Entrez Date: 1985/05/01
Citation Subset: IM
Publication Status: ppublish
J Assoc Off Anal Chem 1985 May-Jun;68(3):493-4.
PMID: 4019374 UI: 85260998 [PubMed - indexed for MEDLINE]
From PubMed
302

Topical effect of aloe with ribonucleic acid and vitamin C on adjuvant arthritis.
Full author name: Davis, R H; Shapiro, E; Agnew, P S.

Davis RH, Shapiro E, Agnew PS. J Am Podiatr Med Assoc. 1985 May;75(5):229-37.

[Article in English]

MeSH Terms:

Substances:

ISSN: 8750-7315
NLM Unique ID: 8501423
Country: United States
Entry Date: 19850731
Date Completed: 19850731
MeSH Date: 1985/05/01 00:01
Date Revised: 20011128
Entrez Date: 1985/05/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatr Med Assoc 1985 May;75(5):229-37.
PMID: 2409266 UI: 85236976 [PubMed - indexed for MEDLINE]
From PubMed
303

[Evaluation of the effectiveness of long-term dispensary observation and treatment of patients with osteoarthrosis deformans]
Full author name: Burkhanova, P A.

Burkhanova PA. Ter Arkh. 1985;57(8):143-5.

[Article in Russian]

During 1979-1984, 240 outpatients aged 30 to 65 years suffering from primary osteoarthrosis deformans with primary involvement of the knee joints were followed up. One of the dispensary groups consisted of 180 patients with osteoarthrosis deformans without synovitis, the other one of 60 patients with associated osteoarthrosis and synovitis. Prolonged follow up and repeated multiple modality treatment inhibited the progression of the pathological process, reduced the clinical and functional disease manifestations permitting the patients' work fitness to be preserved.

MeSH Terms:

Substances:

ISSN: 0040-3660
NLM Unique ID: 2984818R
Country: ussr
Vernacular Title: Otsenka effektivnosti dlitel'nogo dispansernogo nabliudeniia i lecheniia bol'nykh deformiruiushchim osteoartrozom.
Entry Date: 19860114
Date Completed: 19860114
MeSH Date: 1985/01/01 00:01
Date Revised: 20011128
Entrez Date: 1985/01/01
Citation Subset: IM
Publication Status: ppublish
Ter Arkh 1985;57(8):143-5.
PMID: 4071431 UI: 86071062 [PubMed - indexed for MEDLINE]
From PubMed
304

Fluorophotometry of barbaloin in Aloe.
Full author name: Ishii, Y; Tanizawa, H; Takino, Y.

Ishii Y, Tanizawa H, Takino Y. Chem Pharm Bull (Tokyo). 1984 Dec;32(12):4946-50.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19850708
Date Completed: 19850708
MeSH Date: 1984/12/01 00:01
Date Revised: 20011128
Entrez Date: 1984/12/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1984 Dec;32(12):4946-50.
PMID: 6534543 UI: 85201914 [PubMed - indexed for MEDLINE]
From PubMed
305

[Aloe, a succulent plant with therapeutic action]
Full author name: Lutomski, J.

Lutomski J. Pharm Unserer Zeit. 1984 Nov;13(6):172-6.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0048-3664
NLM Unique ID: 0337763
Country: germany, west
Vernacular Title: Aloe, Topfzierpflanze mit therapeutischer Wirkung.
Entry Date: 19850206
Date Completed: 19850206
MeSH Date: 1984/11/01 00:01
Date Revised: 20011128
Entrez Date: 1984/11/01
Citation Subset: IM
Publication Status: ppublish
Pharm Unserer Zeit 1984 Nov;13(6):172-6.
PMID: 6514764 UI: 85088729 [PubMed - indexed for MEDLINE]
From PubMed
306

Allergic contact dermatitis to compound tincture of benzoin.
Full author name: James, W D; White, S W; Yanklowitz, B.

James WD, White SW, Yanklowitz B. J Am Acad Dermatol. 1984 Nov;11(5 Pt 1):847-50.

[Article in English]

Nineteen cases of allergic contact dermatitis to compound tincture of benzoin are described. Patch testing to individual components revealed positive reactions to all ingredients except aloe. An alternative preparation, Mastisol, was successfully used without primarily inducing allergy. It should be considered for use before benzoin because once allergy to benzoin exists, cross-reactions to Mastisol usually occur. This is probably due to the presence of a common ingredient, styrax gum.

MeSH Terms:

Substances:

ISSN: 0190-9622
NLM Unique ID: 7907132
Country: United States
Entry Date: 19850211
Date Completed: 19850211
MeSH Date: 1984/11/01 00:01
Date Revised: 20011128
Entrez Date: 1984/11/01
Citation Subset: IM
Publication Status: ppublish
J Am Acad Dermatol 1984 Nov;11(5 Pt 1):847-50.
PMID: 6239881 UI: 85080810 [PubMed - indexed for MEDLINE]
From PubMed
307

Tic douloureux: report of successful treatment.
Full author name: Hayes, S M.

Hayes SM. Gen Dent. 1984 Sep-Oct;32(5):441-2.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0363-6771
NLM Unique ID: 7610466
Country: United States
Entry Date: 19841218
Date Completed: 19841218
MeSH Date: 1984/09/01 00:01
Date Revised: 20011128
Entrez Date: 1984/09/01
Citation Subset: D
Publication Status: ppublish
Gen Dent 1984 Sep-Oct;32(5):441-2.
PMID: 6593276 UI: 85028365 [PubMed - indexed for MEDLINE]
From PubMed
308

Treatment for flash burns of the conjunctiva.
Full author name: Lawrence, D.

Lawrence D. N Engl J Med. 1984 Aug 9;311(6):413.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0028-4793
NLM Unique ID: 0255562
Country: United States
Entry Date: 19840823
Date Completed: 19840823
MeSH Date: 1984/08/09 00:01
Date Revised: 20011128
Entrez Date: 1984/08/09
Citation Subset: AIM, IM
Publication Status: ppublish
N Engl J Med 1984 Aug 9;311(6):413.
PMID: 6738664 UI: 84245764 [PubMed - indexed for MEDLINE]
From PubMed
309

Contact dermatitis from aloe arborescens.
Full author name: Nakamura, T; Kotajima, S.

Nakamura T, Kotajima S. Contact Dermatitis. 1984 Jul;11(1):51.

[Article in English]

MeSH Terms:

ISSN: 0105-1873
NLM Unique ID: 7604950
Country: Denmark
Entry Date: 19840917
Date Completed: 19840917
MeSH Date: 1984/07/01 00:01
Date Revised: 20011128
Entrez Date: 1984/07/01
Citation Subset: IM
Publication Status: ppublish
Contact Dermatitis 1984 Jul;11(1):51.
PMID: 6744846 UI: 84260543 [PubMed - indexed for MEDLINE]
From PubMed
310

Further studies of the glucomannan from Aloe vahombe (liliaceae). II. Partial hydrolyses and NMR 13C studies.
Full author name: Radjabi-Nassab, F; Ramiliarison, C; Monneret, C; Vilkas, E.

Radjabi-Nassab F, Ramiliarison C, Monneret C, Vilkas E. Biochimie. 1984 Jul-Aug;66(7-8):563-7.

[Article in English]

The polysaccharide from Aloe vahombe (lilaceae) was submitted to partial hydrolyses by sulfuric, oxalic and phosphoric acid. Some oligosaccharides were isolated and investigated by chemical and 13C NMR spectroscopic methods. Their structure was determined. The results prove unambiguously that in the analyzed material the D-mannose is linked to the D-glucose by beta-1----4 linkages to form a carbohydrate heteropolymer.

MeSH Terms:

Substances:

ISSN: 0300-9084
NLM Unique ID: 1264604
Country: France
Entry Date: 19850426
Date Completed: 19850426
MeSH Date: 1984/07/01 00:01
Date Revised: 20001218
Entrez Date: 1984/07/01
Citation Subset: IM
Publication Status: ppublish
Biochimie 1984 Jul-Aug;66(7-8):563-7.
PMID: 6529590 UI: 85150286 [PubMed - indexed for MEDLINE]
From PubMed
311

[Therapeutic use of aloe in experimental stomach ulcers]
Full author name: Sotnikova, E P.

Sotnikova EP. Vrach Delo. 1984 Jun;(6):71-4.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0049-6804
NLM Unique ID: 0413607
Country: ussr
Vernacular Title: Lechebnoe primenenie aloe pri eksperimental'nykh iazvakh zheludka.
Entry Date: 19841017
Date Completed: 19841017
MeSH Date: 1984/06/01 00:01
Date Revised: 20011128
Entrez Date: 1984/06/01
Citation Subset: IM
Publication Status: ppublish
Vrach Delo 1984 Jun;(6):71-4.
PMID: 6474988 UI: 84302089 [PubMed - indexed for MEDLINE]
From PubMed
312

Ethnopharmacologic study of Chinese rhubarb.
Full author name: Peigen, X; Liyi, H; Liwei, W.

Peigen X, Liyi H, Liwei W. J Ethnopharmacol. 1984 May;10(3):275-93.

[Article in English]

This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity. It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata, e.g. Rheum palmatum, R. palmatum var. tanguticum, R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Switzerland
Entry Date: 19840904
Date Completed: 19840904
MeSH Date: 1984/05/01 00:01
Date Revised: 20011128
Entrez Date: 1984/05/01
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1984 May;10(3):275-93.
PMID: 6748707 UI: 84269150 [PubMed - indexed for MEDLINE]
From PubMed
313

[Use of immunomodulating preparations in the complex treatment of children with different forms of rheumatism]
Full author name: Chalaia, A F.

Chalaia AF. Pediatriia. 1984 May;(5):43-5.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0031-403X
NLM Unique ID: 0405563
Country: ussr
Vernacular Title: Ispol'zovanie immunomoduliruiushchikh preparatov v kompleksnom lechenii detei s razlichnymi formami revmatizma.
Entry Date: 19840824
Date Completed: 19840824
MeSH Date: 1984/05/01 00:01
Date Revised: 20011128
Entrez Date: 1984/05/01
Citation Subset: IM
Publication Status: ppublish
Pediatriia 1984 May;(5):43-5.
PMID: 6611542 UI: 84272105 [PubMed - indexed for MEDLINE]
From PubMed
314

Aloe Vera in dentistry.
Full author name: Sturm, P G; Hayes, S M.

Sturm PG, Hayes SM. J Bergen Cty Dent Soc. 1984 May;50(8):11-4.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0092-9832
NLM Unique ID: 7507180
Country: United States
Entry Date: 19841011
Date Completed: 19841011
MeSH Date: 1984/05/01 00:01
Date Revised: 20011128
Entrez Date: 1984/05/01
Citation Subset: D
Publication Status: ppublish
J Bergen Cty Dent Soc 1984 May;50(8):11-4.
PMID: 6590551 UI: 84289299 [PubMed - indexed for MEDLINE]
From PubMed
315

Adrenal chromaffin cells form functional cholinergic synapses in culture.
Full author name: Ogawa, M; Ishikawa, T; Irimajiri, A.

Ogawa M, Ishikawa T, Irimajiri A. Nature. 1984 Jan 5-11;307(5946):66-8.

[Article in English]

Adrenomedullary cells and autonomic ganglion cells originate from the neural crest. Both cell types synthesize, store and release catecholamines; however, their structural and functional properties are distinctly different. Aloe and Levi-Montalcini have shown in vivo that when the adrenal medulla is exposed to exogenous nerve growth factor (NGF) most cells differentiate into neuronal cells substantially similar to sympathetic neurones. Experiments in vitro have also shown that neonatal as well as adult adrenal chromaffin cells and their neoplastic correlate (PC12 cells) undergo neurone-like morphologic differentiation in response to NGF. From these morphological and biochemical studies alone, however, it remains uncertain whether the functional neuronal transformation is also accompanied. We report here that the adrenal chromaffin cells in culture can differentiate into neuronal cells having functional synapses which were found to be cholinergic in nature. Furthermore, the type of synaptic vesicles in the newly formed synapses was apparently dependent upon K+ levels in the culture medium.

MeSH Terms:

Substances:

ISSN: 0028-0836
NLM Unique ID: 0410462
Country: England
Entry Date: 19840223
Date Completed: 19840223
MeSH Date: 1984/01/05 00:01
Date Revised: 20001218
Entrez Date: 1984/01/05
Citation Subset: IM
Publication Status: ppublish
Nature 1984 Jan 5-11;307(5946):66-8.
PMID: 6690984 UI: 84093594 [PubMed - indexed for MEDLINE]
From PubMed
316

Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae).
Full author name: Yagi, A; Hamada, K; Mihashi, K; Harada, N; Nishioka, I.

Yagi A, Hamada K, Mihashi K, Harada N, Nishioka I. J Pharm Sci. 1984 Jan;73(1):62-5.

[Article in English]

Neutral polysaccharides that inhibit carrageenin-induced edema in rats were isolated from the nondialysate of the pulp of Aloe saponaria by gel filtration. These were shown to be a linear polymer of a 1,4-linked beta-D-mannopyranose (mol. wt. 15,000) containing 18% acetyl groups (As mannan 1), and a 1,4-linked alpha-D-mannopyranose polymer containing a single branch on the principal chain consisting of D-glucose residues linked at C-2 and C-4 (mol. wt. 66,000), with 10% acetyl groups (As mannan 2). As mannan 1 inhibited carrageenin-induced hind paw edema at 50 mg/kg ip in rats; As mannan 2 was not tested for pharmacological activity. A crude preparation of both As mannans was effective when given intraperitoneally, but was ineffective when given orally.

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19840320
Date Completed: 19840320
MeSH Date: 1984/01/01 00:01
Date Revised: 20011128
Entrez Date: 1984/01/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1984 Jan;73(1):62-5.
PMID: 6694085 UI: 84114380 [PubMed - indexed for MEDLINE]
From PubMed
317

[Efficacy of tissue therapy in vascular pathology of the organ of vision]
Full author name: Semenova, G S; Gogina, I F; Abashina, N N.

Semenova GS, Gogina IF, Abashina NN. Oftalmol Zh. 1984;(6):347-50.

[Article in Russian]

MeSH Terms:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Effektivnost' tkanevoi terapii pri sosudistoi patologii organa zreniia.
Entry Date: 19850118
Date Completed: 19850118
MeSH Date: 1984/01/01 00:01
Date Revised: 20011128
Entrez Date: 1984/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1984;(6):347-50.
PMID: 6504478 UI: 85062369 [PubMed - indexed for MEDLINE]
From PubMed
318

[Use of an ointment containing levomycetin, methyluracil and aloe extract in plastic operations with transplantation of free flaps of the mucosa or skin]
Full author name: Krasnikov, P G.

Krasnikov PG. Oftalmol Zh. 1984;(1):14-6.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Primenenie mazi, soderzhashchei levomitsetin, metiluratsil i ekstrakt aloe, pri plasticheskikh operatsiiakh s peresadkoi svobodnykh loskutov slizistoi ili kozhi.
Entry Date: 19840730
Date Completed: 19840730
MeSH Date: 1984/01/01 00:01
Date Revised: 20011128
Entrez Date: 1984/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1984;(1):14-6.
PMID: 6377157 UI: 84246682 [PubMed - indexed for MEDLINE]
From PubMed
319

Effect of Aloe barbedensis & clofibrate on serum lipids in triton-induced hyperlipidaemia in Presbytis monkeys.
Full author name: Dixit, V P; Joshi, S.

Dixit VP, Joshi S. Indian J Med Res. 1983 Sep;78:417-21.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0971-5916
NLM Unique ID: 0374701
Country: India
Entry Date: 19840605
Date Completed: 19840605
MeSH Date: 1983/09/01 00:01
Date Revised: 20011128
Entrez Date: 1983/09/01
Citation Subset: IM
Publication Status: ppublish
Indian J Med Res 1983 Sep;78:417-21.
PMID: 6674162 UI: 84184543 [PubMed - indexed for MEDLINE]
From PubMed
320

Aloe Vera, true and false.
Full author name: Felts, J H.

Felts JH. N C Med J. 1983 Sep;44(9):599.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0029-2559
NLM Unique ID: 2984805R
Country: United States
Entry Date: 19831220
Date Completed: 19831220
MeSH Date: 1983/09/01 00:01
Date Revised: 20011128
Entrez Date: 1983/09/01
Citation Subset: IM
Publication Status: ppublish
N C Med J 1983 Sep;44(9):599.
PMID: 6579379 UI: 84039893 [PubMed - indexed for MEDLINE]
From PubMed
321

[Effect of a plant extract combination preparation on gastrointestinal transit time and bile acid excretion]
Full author name: Matzkies, F; Webs, B.

Matzkies F, Webs B. Fortschr Med. 1983 Jul 28;101(27-28):1304-6.

[Article in German]

The effect of a plant extract containing Rhizoma curcumae, Fructus silybi mariani, Herba chelidonii, Aloe, Radix podophylli paltati, Radix gentianae and Cortex chinae on the evacuation of feces and on the metabolism of bile acids was investigated with 8 healthy women for a period of 14 days. In the preliminary period there was a stoolweight of 105 +/- 16 g/day. Under treatment the weight of stool rose to 422 +/- 104 g/day. Frequency of stools increased from 1.1 +/- 0.2 evacuations/day to 3.3 +/- 1.1 evacuation/day. Transit time decreased from 64 +/- 20 hours to 18 +/- 4 hours. Elimination of bile acid amounted to 549 +/- 397 mumol/day. It increased under treatment to 908 +/- 832 mumol/day. No changes were found in the laboratory blood tests. The concentration of potassium in the blood also remained constant.

MeSH Terms:

Substances:

ISSN: 0015-8178
NLM Unique ID: 2984763R
Country: germany, east
Vernacular Title: Wirkung eines pflanzlichen Kombinationspraparats auf die gastrointestinale Transitzeit und die Gallensauren-Ausscheidung.
Entry Date: 19831123
Date Completed: 19831123
MeSH Date: 1983/07/28 00:01
Date Revised: 20001218
Entrez Date: 1983/07/28
Citation Subset: IM
Publication Status: ppublish
Fortschr Med 1983 Jul 28;101(27-28):1304-6.
PMID: 6618384 UI: 84006300 [PubMed - indexed for MEDLINE]
From PubMed
322

Experience with a screening method for laxative abuse.
Full author name: de Wolff, F A; Edelbroek, P M; de Haas, E J; Vermeij, P.

de Wolff FA, Edelbroek PM, de Haas EJ, Vermeij P. Hum Toxicol. 1983 Apr;2(2):385-9.

[Article in English]

1 Abuse of laxatives may lead to a variety of serious disorders which are usually difficult to recognize because of the heterogenicity of the toxic effects. 2 In order to facilitate the diagnosis of chronic laxative poisoning, a laboratory screening method for the detection of colonic stimulants in urine has been designed and has been applied in practice over a three-year-period. 3 During this period, 157 samples from 81 patients were sent to the laboratory. Fifteen patients (18.5%) were definitely shown to use self-prescribed laxatives. 4 Next to the diphenolic compounds: bisacodyl, phenolphthalein and bisoxatin, the anthraquinone derivative rhein, a metabolite of vegetable laxatives, was found in several cases. In the urine of three patients a substance resembling rhein was found, which was shown to be aloe-emodin. 5 It is concluded that chronic self-poisoning with laxatives is a fairly common disorder than can easily be overlooked. Laboratory screening of the urine of suspected patients is an economic and reliable method for its diagnosis.

MeSH Terms:

Substances:

ISSN: 0144-5952
NLM Unique ID: 8206759
Country: England
Entry Date: 19830811
Date Completed: 19830811
MeSH Date: 1983/04/01 00:01
Date Revised: 20001218
Entrez Date: 1983/04/01
Citation Subset: IM
Publication Status: ppublish
Hum Toxicol 1983 Apr;2(2):385-9.
PMID: 6862485 UI: 83236460 [PubMed - indexed for MEDLINE]
From PubMed
323

[Anorexia nervosa as a manifestation of endogenous depression in puberty]
Full author name: Sorokina, T T; Evsegneev, R A.

Sorokina TT, Evsegneev RA. Zh Nevropatol Psikhiatr Im S S Korsakova. 1983;83(8):1195-8.

[Article in Russian]

Possible interrelation between anorexia nervosa and affective pathology is discussed. The authors present an analysis of clinical observations where the anorexia nervosa syndrome was developing in the presence of endogenous circulatory depression. It is noted that in some cases of latent depression, this syndrome may present the most prominent feature in the clinical picture of the disease, which makes its diagnosis and treatment rather difficult. Differential diagnostic signs permitting the differentiation between "depressive" anorexia nervosa and its other nosologic variants are discussed.

MeSH Terms:

Substances:

ISSN: 0044-4588
NLM Unique ID: 8710066
Country: ussr
Vernacular Title: Nervnaia anoreksiia ka proiavlenie endogennoi depressii v pubertatnom vozraste.
Entry Date: 19831123
Date Completed: 19831123
MeSH Date: 1983/01/01 00:01
Date Revised: 20011128
Entrez Date: 1983/01/01
Citation Subset: IM
Publication Status: ppublish
Zh Nevropatol Psikhiatr Im S S Korsakova 1983;83(8):1195-8.
PMID: 6624346 UI: 84020030 [PubMed - indexed for MEDLINE]
From PubMed
324

Antibradykinin active material in Aloe saponaria.
Full author name: Yagi, A; Harada, N; Yamada, H; Iwadare, S; Nishioka, I.

Yagi A, Harada N, Yamada H, Iwadare S, Nishioka I. J Pharm Sci. 1982 Oct;71(10):1172-4.

[Article in English]

A material having antibradykinin activity on isolated guinea pig ileum was partially purified from the nondialysate of the pulp of Aloe saponaria by repetition of gel chromatography using a hydrophilic polyvinyl gel and dextran gels. From the results of amino acid and carbohydrate analyses, the antibradykinin-active material was estimated to be a glycoprotein. It was found that this material catalyzes the hydrolysis of bradykinin at pH 7.4. The results of peptide analysis using reversed-phase high-performance liquid chromatography coupled with amino acid analysis indicate that this glycoprotein cleaves the Gly4-Phe5 and Pro7-Phe8 bonds of the bradykinin molecule.

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19830119
Date Completed: 19830119
MeSH Date: 1982/10/01 00:01
Date Revised: 20011128
Entrez Date: 1982/10/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1982 Oct;71(10):1172-4.
PMID: 7143219 UI: 83059226 [PubMed - indexed for MEDLINE]
From PubMed
325

Cardiac stimulant action of constituents of Aloe saponaria.
Full author name: Yagi, A; Shibata, S; Nishioka, I; Iwadare, S; Ishida, Y.

Yagi A, Shibata S, Nishioka I, Iwadare S, Ishida Y. J Pharm Sci. 1982 Jul;71(7):739-41.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19821202
Date Completed: 19821202
MeSH Date: 1982/07/01 00:01
Date Revised: 20011128
Entrez Date: 1982/07/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1982 Jul;71(7):739-41.
PMID: 7120054 UI: 83009672 [PubMed - indexed for MEDLINE]
From PubMed
326

The evaluation of natural substances in the treatment of adjuvant arthritis.
Full author name: Hanley, D C; Solomon, W A; Saffran, B; Davis, R H.

Hanley DC, Solomon WA, Saffran B, Davis RH. J Am Podiatry Assoc. 1982 Jun;72(6):275-84.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0003-0538
NLM Unique ID: 7505577
Country: United States
Entry Date: 19820807
Date Completed: 19820807
MeSH Date: 1982/06/01 00:01
Date Revised: 20011128
Entrez Date: 1982/06/01
Citation Subset: IM
Publication Status: ppublish
J Am Podiatry Assoc 1982 Jun;72(6):275-84.
PMID: 7086049 UI: 82214838 [PubMed - indexed for MEDLINE]
From PubMed
327

Contact dermatitis to Aloe arborescens.
Full author name: Shoji, A.

Shoji A. Contact Dermatitis. 1982 May;8(3):164-7.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0105-1873
NLM Unique ID: 7604950
Country: Denmark
Entry Date: 19820917
Date Completed: 19820917
MeSH Date: 1982/05/01 00:01
Date Revised: 20011128
Entrez Date: 1982/05/01
Citation Subset: IM
Publication Status: ppublish
Contact Dermatitis 1982 May;8(3):164-7.
PMID: 7094571 UI: 82234742 [PubMed - indexed for MEDLINE]
From PubMed
328

Pharmacological studies on a plant lectin aloctin A. II. Inhibitory effect of aloctin A on experimental models of inflammation in rats.
Full author name: Saito, H; Ishiguro, T; Imanishi, K; Suzuki, I.

Saito H, Ishiguro T, Imanishi K, Suzuki I. Jpn J Pharmacol. 1982 Feb;32(1):139-42.

[Article in English]

A glycoprotein, Aloctin A, which was isolated from Aloe arborescens Mill, markedly inhibits adjuvant arthritis in rats and carrageenin-induced edema in rats.

MeSH Terms:

Substances:

ISSN: 0021-5198
NLM Unique ID: 2983305R
Country: Japan
Entry Date: 19820826
Date Completed: 19820826
MeSH Date: 1982/02/01 00:01
Date Revised: 20011128
Entrez Date: 1982/02/01
Citation Subset: IM
Publication Status: ppublish
Jpn J Pharmacol 1982 Feb;32(1):139-42.
PMID: 7087254 UI: 82217562 [PubMed - indexed for MEDLINE]
From PubMed
329

[Immunomodulating properties of an extract isolated and partially purified from Aloe vahombe. 3.Study of antitumoral properties and contribution to the chemical nature and active principle]
Full author name: Ralamboranto, L; Rakotovao, L H; Le Deaut, J Y; Chaussoux, D; Salomon, J C; Fournet, B; Montreuil, J; Rakotonirina-Randriambeloma, P J; Dulat, C; Coulanges, P.

Ralamboranto L, Rakotovao LH, Le Deaut JY, Chaussoux D, Salomon JC, Fournet B, Montreuil J, Rakotonirina-Randriambeloma PJ, Dulat C, Coulanges P. Arch Inst Pasteur Madagascar. 1982;50(1):227-56.

[Article in French]

An immuno-modulator fraction (Alva) extracted from an endemic plant, in the south of Madagascar, the Aloe vahombe, significantly protects mice against bacterial, parasitic and fungal infections. Wishing to verify whether the fraction Alva was active in tumour reduction, we studied its effect on the development of experimental fibrosarcoma and melanoma in mice by intravenous and intracutaneous injections and injections directly into the tumour of the immunostimulant fraction. We have observed cures, only in the case of the McC3-1 tumour but it is encouraging to note that under different experimental conditions the rate of growth of tumours in animals which were treated is slower than in those not treated. The Alva fraction is a substance which is hydrosoluble, thermostabile, having a molecular weight exceeding 30 000 and is a polysaccharide. The predominant sugars are glucose and mannose in 3:1 ratio. Preliminary studies of its action seem to indicate that the Alva fraction acts upon non-specific response and could possibly stimulate the phagocyte activity of the peritoneal macrophagus.

MeSH Terms:

Substances:

ISSN: 0020-2495
NLM Unique ID: 7502526
Country: madagascar
Vernacular Title: Etude des proprietes immunodulatrices d'un extrait isole et partiellement purifie a partir de l'Aloe vahombe. 3. Etude des proprietes antitumorales et contribution a l'etude de la nature chimique du principe actif.
Entry Date: 19831028
Date Completed: 19831028
MeSH Date: 1982/01/01 00:01
Date Revised: 20011128
Entrez Date: 1982/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Inst Pasteur Madagascar 1982;50(1):227-56.
PMID: 7186335 UI: 83307688 [PubMed - indexed for MEDLINE]
From PubMed
330

Biotransformation of aloenin, a bitter glucoside constituent of Aloe arborescens, by rats.
Full author name: Hirata, T; Sakano, S; Suga, T.

Hirata T, Sakano S, Suga T. Experientia. 1981 Dec 15;37(12):1252-3.

[Article in English]

Aloenin has been established to be 4-methoxy-6-(2-beta-D-glucopyranosyloxy-4-hydroxy-6-methylphenyl)-2-pyrone ; it shows an inhibitory activity for gastric juice secretion. Rats metabolized it to 4-methoxy-6-(2,4-dihydroxy-6-methylphenyl)-2-pyrone, 2,5-dimethyl-7-hydroxychromone and glucose, which were excreted in the feces and the urine. The distribution of the radioactivity originating from 14C-labeled aloenin was studied. The tracer found in the kidney and the liver reached 60% of the amount administered 24 h after feeding and decreased rapidly in the next 24 h.

MeSH Terms:

Substances:

ISSN: 0014-4754
NLM Unique ID: 0376547
Country: Switzerland
Entry Date: 19820412
Date Completed: 19820412
MeSH Date: 1981/12/15 00:01
Date Revised: 20001218
Entrez Date: 1981/12/15
Citation Subset: IM
Publication Status: ppublish
Experientia 1981 Dec 15;37(12):1252-3.
PMID: 7035211 UI: 82117428 [PubMed - indexed for MEDLINE]
From PubMed
331

Pharmacological studies on a plant lectin, Aloctin A. I. Growth inhibition of mouse methylcholanthrene-induced fibrosarcoma (Meth A) in ascites form by Aloctin A.
Full author name: Imanishi, K; Ishiguro, T; Saito, H; Suzuki, I.

Imanishi K, Ishiguro T, Saito H, Suzuki I. Experientia. 1981 Nov 15;37(11):1186-7.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0014-4754
NLM Unique ID: 0376547
Country: Switzerland
Entry Date: 19820322
Date Completed: 19820322
MeSH Date: 1981/11/15 00:01
Date Revised: 20011128
Entrez Date: 1981/11/15
Citation Subset: IM
Publication Status: ppublish
Experientia 1981 Nov 15;37(11):1186-7.
PMID: 7319006 UI: 82095515 [PubMed - indexed for MEDLINE]
From PubMed
332

Folk remedies as indicators of common illnesses: examples from the United States-Mexico border.
Full author name: Trotter, R T 2nd.

Trotter RT 2nd. J Ethnopharmacol. 1981 Sep;4(2):207-21.

[Article in English]

A sample of 1235 case examples of remedios caseros (home remedies) were analyzed to determine the characteristics of the ethnopharmacological resources currently in use in Mexican American communities along the eastern end of the United States-Mexico border. The data analysis confirms that there is a core group of most frequently used remedies that constitute the bulk of the home treatment of common ailments in that area. The data further indicate that there is a relatively well-defined group of ailments that are considered to be more amenable to ethnopharmacological intervention than to treatment by the conventional medical system. Some of the remedios (both botanical and non-botanical) are presented, and a preliminary model of ailments that receive treatment from home remedies, as opposed to medical treatment, is proposed.

MeSH Terms:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Switzerland
Entry Date: 19820212
Date Completed: 19820212
MeSH Date: 1981/09/01 00:01
Date Revised: 20011128
Entrez Date: 1981/09/01
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1981 Sep;4(2):207-21.
PMID: 7311597 UI: 82079314 [PubMed - indexed for MEDLINE]
From PubMed
333

[Effect of penicillin on the formation of gonococcal L forms]
Full author name: Stepanenko, V I; Maidaniuk, V F; Mamilos, P.

Stepanenko VI, Maidaniuk VF, Mamilos P. Mikrobiol Zh. 1981 Jul-Aug;43(4):513-5.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0201-8462
NLM Unique ID: 7909597
Country: ussr
Vernacular Title: Vliianie penitsillina na obrazovanie L-form gonokokka.
Entry Date: 19811122
Date Completed: 19811122
MeSH Date: 1981/07/01 00:01
Date Revised: 20011128
Entrez Date: 1981/07/01
Citation Subset: IM
Publication Status: ppublish
Mikrobiol Zh 1981 Jul-Aug;43(4):513-5.
PMID: 6792470 UI: 82013055 [PubMed - indexed for MEDLINE]
From PubMed
334

[Late treatment results using various methods in syphilis]
Full author name: Kaganovich, E L; Chalovskii, V A; Koshcheeva, G G; Kopit, K K; Danilova, L S.

Kaganovich EL, Chalovskii VA, Koshcheeva GG, Kopit KK, Danilova LS. Vestn Dermatol Venerol. 1981 May;(5):70-2.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Otdalennye rezul'taty lecheniia bol'nykh sifilisom razlichnymi metodami.
Entry Date: 19811222
Date Completed: 19811222
MeSH Date: 1981/05/01 00:01
Date Revised: 20011128
Entrez Date: 1981/05/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1981 May;(5):70-2.
PMID: 7293466 UI: 82042227 [PubMed - indexed for MEDLINE]
From PubMed
335

[Studies of Aloe. I. Cathartic effects].
Full author name: Ishii, Y; Tanizawa, H; Ikemoto, C; Takino, Y.

Ishii Y, Tanizawa H, Ikemoto C, Takino Y. Yakugaku Zasshi. 1981 Mar;101(3):254-8.

[Article in Japanese]

MeSH Terms:

Substances:

ISSN: 0031-6903
NLM Unique ID: 0413613
Country: Japan
Entry Date: 19820120
Date Completed: 19820120
MeSH Date: 1981/03/01 00:01
Date Revised: 20011128
Entrez Date: 1981/03/01
Citation Subset: IM
Publication Status: ppublish
Yakugaku Zasshi 1981 Mar;101(3):254-8.
PMID: 7299637 UI: 82055224 [PubMed - indexed for MEDLINE]
From PubMed
336

[Resorptive effect of electrotherapy in traumatic cataract]
Full author name: Cherikchi, L E; Gizhitsa, S E.

Cherikchi LE, Gizhitsa SE. Oftalmol Zh. 1981;36(6):344-7.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Rassasyvaiushchie deistvie elektroterapii pri travmaticheskoi katarakte.
Entry Date: 19820225
Date Completed: 19820225
MeSH Date: 1981/01/01 00:01
Date Revised: 20011128
Entrez Date: 1981/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1981;36(6):344-7.
PMID: 7312268 UI: 82081273 [PubMed - indexed for MEDLINE]
From PubMed
337

[Immunostimulating properties of an extract isolated from Aloe vahombe. 2. Protection in mice by fraction F1 against infections by Listeria monocytogenes, Yersinia pestis, Candida albicans and Plasmodium berghei]
Full author name: Brossat, J Y; Ledeaut, J Y; Ralamboranto, L; Rakotovao, L H; Solar, S; Gueguen, A; Coulanges, P.

Brossat JY, Ledeaut JY, Ralamboranto L, Rakotovao LH, Solar S, Gueguen A, Coulanges P. Arch Inst Pasteur Madagascar. 1981;48(1):11-34.

[Article in French]

A partially purified extract of leaves of Aloe vahombe, a plant endemic in the south of Madagascar, administered intravenously to mice, protects them against infection of bacteria (Listeria monocytogenes, Yersinia pestis), parasites (Plasmodium berghei) and fungus (Candida albicans). The protective fraction must be administered two days before inoculation of the pathogenic agent. These results significantly confirm those we obtained in earlier study on mice infection by Klebsiella pneumoniae. Currently we are testing the protective action of the purified extract on the experimental development of sarcomas, and we are in the process of analysing the mode of action of this non specific immunostimulant.

MeSH Terms:

Substances:

ISSN: 0020-2495
NLM Unique ID: 7502526
Country: madagascar
Vernacular Title: Etude des proprietes immunostimulantes d'un extrait isole a partir d'Aloe vahombe.
Entry Date: 19820708
Date Completed: 19820708
MeSH Date: 1981/01/01 00:01
Date Revised: 20011128
Entrez Date: 1981/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Inst Pasteur Madagascar 1981;48(1):11-34.
PMID: 7044327 UI: 82205272 [PubMed - indexed for MEDLINE]
From PubMed
338

Aloe vera--fact or quackery.
Full author name: Spoerke, D G; Ekins, B R.

Spoerke DG, Ekins BR. Vet Hum Toxicol. 1980 Dec;22(6):418-24.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0145-6296
NLM Unique ID: 7704194
Country: United States
Entry Date: 19810528
Date Completed: 19810528
MeSH Date: 1980/12/01 00:01
Date Revised: 20011128
Entrez Date: 1980/12/01
Citation Subset: IM
Publication Status: ppublish
Vet Hum Toxicol 1980 Dec;22(6):418-24.
PMID: 7210473 UI: 81154882 [PubMed - indexed for MEDLINE]
From PubMed
339

[Our treatment experience with secondary recurrent syphilis]
Full author name: Romanenko, G F; Barankina, A M; Cherkezov, R G; Mordziavko, N F; Podol'skaia, T N.

Romanenko GF, Barankina AM, Cherkezov RG, Mordziavko NF, Podol'skaia TN. Vestn Dermatol Venerol. 1980 Sep;(9):66-9.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Nash opyt lecheniia bol'nykh vtorichnym retsidivnym sifilisom.
Entry Date: 19801216
Date Completed: 19801216
MeSH Date: 1980/09/01 00:01
Date Revised: 20011128
Entrez Date: 1980/09/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1980 Sep;(9):66-9.
PMID: 7424164 UI: 81035457 [PubMed - indexed for MEDLINE]
From PubMed
340

Hypersensitivity to aloe.
Full author name: Morrow, D M; Rapaport, M J; Strick, R A.

Morrow DM, Rapaport MJ, Strick RA. Arch Dermatol. 1980 Sep;116(9):1064-5.

[Article in English]

Hypersensitivity, manifested by generalized nummular eczematous and papular dermatitis, and presumably by contact urticaria, developed in a 47-year-old man after four years of using oral and topical aloe. Patch tests for aloe were positive in this patient.

MeSH Terms:

Substances:

ISSN: 0003-987X
NLM Unique ID: 0372433
Country: United States
Entry Date: 19801125
Date Completed: 19801125
MeSH Date: 1980/09/01 00:01
Date Revised: 20011128
Entrez Date: 1980/09/01
Citation Subset: AIM, IM
Publication Status: ppublish
Arch Dermatol 1980 Sep;116(9):1064-5.
PMID: 7416761 UI: 81020159 [PubMed - indexed for MEDLINE]
From PubMed
341

Traditional medicine in health care.
Full author name: Sayed, M D.

Sayed MD. J Ethnopharmacol. 1980 Mar;2(1):19-22.

[Article in English]

The state of research on plants used in traditional medicine and its development in Egypt is indicated by the number of scientific institutions devoted to this problem: Universities, the National Research Centre, the Desert Institute and the Horticulture Department of the Ministry of Agriculture. Moreover, the use of certain medicinal plants has been "industrialised', e.g., Ammi visnaga, Cymbopogon proximus, Nigella sativa and Aloe vera. Other plants are under investigation: Urginea maritima, Phytolacca americana and Euphorbia sp. (known for its claimed antitumour properties), Glycyrrhiza glabra, Cynara scolymus and Solanum laciniatum.

MeSH Terms:

Substances:

ISSN: 0378-8741
NLM Unique ID: 7903310
Country: Switzerland
Entry Date: 19810413
Date Completed: 19810413
MeSH Date: 1980/03/01 00:01
Date Revised: 20001218
Entrez Date: 1980/03/01
Citation Subset: IM
Publication Status: ppublish
J Ethnopharmacol 1980 Mar;2(1):19-22.
PMID: 7464176 UI: 81120989 [PubMed - indexed for MEDLINE]
From PubMed
342

[Immunostimulant properties of an extract isolated and partially purified from Aloe vahombe]
Full author name: Solar, S; Zeller, H; Rasolofonirina, N; Coulanges, P; Ralamboranto, L; Andriatsimahavandy, A A; Rakotovao, L H; Le Deaut, J Y.

Solar S, Zeller H, Rasolofonirina N, Coulanges P, Ralamboranto L, Andriatsimahavandy AA, Rakotovao LH, Le Deaut JY. Arch Inst Pasteur Madagascar. 1980;47(1):9-39.

[Article in French]

When the mice are given a hypodermic infection of unrefined Vahombe extract, the Aloe called Vahombe is a liliaceous plant growing in the South of Madagascar, they are protected against the infection caused by the Klebsiella, a pneumonia vector to man, giving rise to an experimental septicaemia in the mouse. Neither bactericide nor bacteriostatic activity has been detected yet about Aloe extract. The anti-infectious activity is proportional to the dose of extract injected, the protecting power is the greatest when the mice have been treated with Aloe, two or three days previously to the infection due to Klebsiella pneumoniae. We have determined the LD50 (Lethal dose 50) for the check batches (non-treated mice) and for the batches of protected mice. We were able to show that the previous injection developed the resistance to infection, multiplied from thirtyfold to a hundrefold. We have tackled the purification of the substance--made soluble after lyophilisation of the crude extract--by means of filtration with Sephadex G50. It would be the first time, for all we know, that a substance endowed with organism. At present we are proceeding with the purification of the active principle and contemplating trying the protective power upon virus infections as well as upon cancerous or parasitic ones.

MeSH Terms:

Substances:

ISSN: 0020-2495
NLM Unique ID: 7502526
Country: madagascar
Vernacular Title: Mise en evidence et etude des proprietes immunostimulantes d'un extrait isole et partiellement purifie a partir d'Aloe vahombe.
Entry Date: 19810720
Date Completed: 19810720
MeSH Date: 1980/01/01 00:01
Date Revised: 20011128
Entrez Date: 1980/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Inst Pasteur Madagascar 1980;47(1):9-39.
PMID: 7016057 UI: 81206295 [PubMed - indexed for MEDLINE]
From PubMed
343

[Effect of biostymine on various immunological processes]
Full author name: Kucharska, E.

Kucharska E. Ann Acad Med Stetin. 1980;26:369-86.

[Article in Polish]

MeSH Terms:

Substances:

ISSN: 1427-4930
NLM Unique ID: 7506854
Country: Poland
Vernacular Title: Wplyw biostyminy na niektore procesy immunologiczne.
Entry Date: 19831123
Date Completed: 19831123
MeSH Date: 1980/01/01 00:01
Date Revised: 20011128
Entrez Date: 1980/01/01
Citation Subset: IM
Publication Status: ppublish
Ann Acad Med Stetin 1980;26:369-86.
PMID: 6985295 UI: 84021873 [PubMed - indexed for MEDLINE]
From PubMed
344

Therapeutic use of natural anthraquinone for other than laxative actions.
Full author name: Anton, R; Haag-Berrurier, M.

Anton R, Haag-Berrurier M. Pharmacology. 1980;20 Suppl 1:104-12.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19800712
Date Completed: 19800712
MeSH Date: 1980/01/01 00:01
Date Revised: 20011128
Entrez Date: 1980/01/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1980;20 Suppl 1:104-12.
PMID: 6246546 UI: 80190336 [PubMed - indexed for MEDLINE]
From PubMed
345

[Treatment of chronic subatrophic and atrophic rhinitis]
Full author name: Radchenko, A Ia; Danilov, L N.

Radchenko AIa, Danilov LN. Zh Ushn Nos Gorl Bolezn. 1979 May-Jun;(3):64.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0044-4650
NLM Unique ID: 9427210
Country: ussr
Vernacular Title: K voprosu lecheniia bol'nykh khronicheskimi subatroficheskimi i atroficheskimi rinitami.
Entry Date: 19790829
Date Completed: 19790829
MeSH Date: 1979/05/01 00:01
Date Revised: 20011128
Entrez Date: 1979/05/01
Citation Subset: IM
Publication Status: ppublish
Zh Ushn Nos Gorl Bolezn 1979 May-Jun;(3):64.
PMID: 572118 UI: 79205524 [PubMed - indexed for MEDLINE]
From PubMed
346

Properties of a carboxypeptidase from aloe.
Full author name: Fujita, K; Ito, S; Teradaira, R; Beppu, H.

Fujita K, Ito S, Teradaira R, Beppu H. Biochem Pharmacol. 1979 Apr 1;28(7):1261-2.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0006-2952
NLM Unique ID: 0101032
Country: England
Entry Date: 19790725
Date Completed: 19790725
MeSH Date: 1979/04/01 00:01
Date Revised: 20011128
Entrez Date: 1979/04/01
Citation Subset: IM
Publication Status: ppublish
Biochem Pharmacol 1979 Apr 1;28(7):1261-2.
PMID: 36094 UI: 79187308 [PubMed - indexed for MEDLINE]
From PubMed
347

Purification and characterization of two lectins from Aloe arborescens Mill.
Full author name: Suzuki, I; Saito, H; Inoue, S; Migita, S; Takahashi, T.

Suzuki I, Saito H, Inoue S, Migita S, Takahashi T. J Biochem (Tokyo). 1979 Jan;85(1):163-71.

[Article in English]

Two lectins have been isolated from leaves of Aloe arborescens Mill by salt precipitation, pH-dependent fractionation and gel filtration. One lectin (P-2) has a molecular weight of approximately 18,000, consists of two subunits (alphabeta) and contains more than 18% by weight of neutral carbohydrate. The smaller subunit (alpha) has a molecular weight of approximately 7,500 and the larger subunit (beta) a molecular weight of approximately 10,500. The other lectin (S-1) has a molecular weight of approximately 24,000, consists of two subunits (gamma2) with a molecular weight of approximately 12,000 and contains more than 50% by weight of neutral carbohydrate. An interesting feature of the amino acid compositions of these lectins is the high proportion of acidic amino acids, such as aspartic acid and glutamic acid, and the low proportion of methionine and histidine. S-1 has a strong hemagglutinating activity. On the other hand, P-2 has not only hemagglutinating activity but also mitogenic activity on lymphocytes, precipitate-forming reactivity with serum proteins, one of which is alpha2-macroglobulin, and complement C3 activating activity via the alternate pathway.

MeSH Terms:

Substances:

ISSN: 0021-924X
NLM Unique ID: 0376600
Country: Japan
Entry Date: 19790428
Date Completed: 19790428
MeSH Date: 1979/01/01 00:01
Date Revised: 20011128
Entrez Date: 1979/01/01
Citation Subset: IM
Publication Status: ppublish
J Biochem (Tokyo) 1979 Jan;85(1):163-71.
PMID: 104986 UI: 79109516 [PubMed - indexed for MEDLINE]
From PubMed
348

[Complex method of treating chronic inflammatory diseases of the internal femal genitalia of nonspecific etiology]
Full author name: Timchenko, B S; Barkova, M Kh; Gorobchenko, V P.

Timchenko BS, Barkova MKh, Gorobchenko VP. Pediatr Akus Ginekol. 1978 Sep-Oct;(5):43-5.

[Article in Ukrainian]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0031-4048
NLM Unique ID: 2985041R
Country: ussr
Vernacular Title: Kompleksnyi metod likuvannia khronichnykh zapal'nykh zakhvoriuvan' vnutrishnikh statevykh orhaniv zhinok nespetsyfichnoi etiolohii.
Entry Date: 19790115
Date Completed: 19790115
MeSH Date: 1978/09/01 00:01
Date Revised: 20011128
Entrez Date: 1978/09/01
Citation Subset: IM
Publication Status: ppublish
Pediatr Akus Ginekol 1978 Sep-Oct;(5):43-5.
PMID: 362356 UI: 79054235 [PubMed - indexed for MEDLINE]
From PubMed
349

[Drug analysis and pharmakopoea, a critical survey].
Full author name: Wichtl, M.

Wichtl M. Planta Med. 1978 Sep;34(2):113-28.

[Article in German]

Publication Types:

MeSH Terms:

Substances:

Number of References: 54
ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Vernacular Title: Drogenanalytik und Arzneibuch, kritisch betrachtet.
Entry Date: 19781227
Date Completed: 19781227
MeSH Date: 1978/09/01 00:01
Date Revised: 20011128
Entrez Date: 1978/09/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1978 Sep;34(2):113-28.
PMID: 360255 UI: 79034119 [PubMed - indexed for MEDLINE]
From PubMed
350

Clinical trials with Myron and Aloes Compound in cases of bovine infertility.
Full author name: Dange, B N.

Dange BN. Indian Vet J. 1978 Aug;55(8):657-9.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0019-6479
NLM Unique ID: 0374710
Country: India
Entry Date: 19790425
Date Completed: 19790425
MeSH Date: 1978/08/01 00:01
Date Revised: 20011128
Entrez Date: 1978/08/01
Citation Subset: R
Publication Status: ppublish
Indian Vet J 1978 Aug;55(8):657-9.
PMID: 570176 UI: 79108784 [PubMed - indexed for MEDLINE]
From PubMed
351

Effect of leaf extracts of Aloe arborescens Mill subsp. natalensis Berger on growth of Trichophyton mentagrophytes.
Full author name: Fujita, K; Yamada, Y; Azuma, K; Hirozawa, S.

Fujita K, Yamada Y, Azuma K, Hirozawa S. Antimicrob Agents Chemother. 1978 Jul;14(1):132-6.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0066-4804
NLM Unique ID: 0315061
Country: United States
Entry Date: 19781027
Date Completed: 19781027
MeSH Date: 1978/07/01 00:01
Date Revised: 20011128
Entrez Date: 1978/07/01
Citation Subset: IM
Publication Status: ppublish
Antimicrob Agents Chemother 1978 Jul;14(1):132-6.
PMID: 686703 UI: 78255410 [PubMed - indexed for MEDLINE]
From PubMed
352

Specific reaction of aloe extract with serum proteins of various animals.
Full author name: Fujita, K; Suzuki, I; Ochiai, J; Shinpo, K; Inoue, S; Saito, H.

Fujita K, Suzuki I, Ochiai J, Shinpo K, Inoue S, Saito H. Experientia. 1978 Apr 15;34(4):523-4.

[Article in English]

We found that aloe extract contains a lectin-like substance which reacts with serum proteins of various animals. Furthermore, in human serum 2 proteins, alpha2-macroglobulin and alpha1-antitrypsin, were shown to be reactive with aloe extract.

MeSH Terms:

Substances:

ISSN: 0014-4754
NLM Unique ID: 0376547
Country: Switzerland
Entry Date: 19780612
Date Completed: 19780612
MeSH Date: 1978/04/15 00:01
Date Revised: 20011128
Entrez Date: 1978/04/15
Citation Subset: IM
Publication Status: ppublish
Experientia 1978 Apr 15;34(4):523-4.
PMID: 76572 UI: 78148254 [PubMed - indexed for MEDLINE]
From PubMed
353

[Drug information: cathartics. Therapeutic main group: laxatives. 2. 1. Reflex-stimulating laxatives]
Full author name: Lumholtz, I B.

Lumholtz IB. Sygeplejersken. 1978 Mar 22;78(12):19.

[Article in Danish]

MeSH Terms:

Substances:

ISSN: 0106-8350
NLM Unique ID: 0421366
Country: Denmark
Vernacular Title: Laegemiddelinformation: afforingsmidler. Terapeutisk hovedgruppe: laksantia; 2. del. 1. Refleksstimulerende laksantia.
Entry Date: 19780715
Date Completed: 19780715
MeSH Date: 1978/03/22 00:01
Date Revised: 20011128
Entrez Date: 1978/03/22
Citation Subset: N
Publication Status: ppublish
Sygeplejersken 1978 Mar 22;78(12):19.
PMID: 247706 UI: 78181076 [PubMed - indexed for MEDLINE]
From PubMed
354

[New raw material sources for aloe preparations]
Full author name: Abdurakhmanova, G Kh; Nikonova, L P; Nikonov, G K; Davydova, R A.

Abdurakhmanova GKh, Nikonova LP, Nikonov GK, Davydova RA. Farmatsiia. 1978 Mar-Apr;27(2):40-2.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: Novye istochniki syr'ia dlia polucheniia preparatov aloe.
Entry Date: 19780628
Date Completed: 19780628
MeSH Date: 1978/03/01 00:01
Date Revised: 20011128
Entrez Date: 1978/03/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1978 Mar-Apr;27(2):40-2.
PMID: 147773 UI: 78148406 [PubMed - indexed for MEDLINE]
From PubMed
355

[Moderate local hypothermia and its use in certain eye diseases]
Full author name: Chanchikov, G F; Miminoshvili, S Ia.

Chanchikov GF, Miminoshvili SIa. Oftalmol Zh. 1978;(6):438-40.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Umerennaia lokal'naia gipotermiia i ee primenenie pri nekotorykh glaznykh zabolevaniiakh.
Entry Date: 19790124
Date Completed: 19790124
MeSH Date: 1978/01/01 00:01
Date Revised: 20011128
Entrez Date: 1978/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1978;(6):438-40.
PMID: 714351 UI: 79053814 [PubMed - indexed for MEDLINE]
From PubMed
356

[Acute bullous allergic dermatitis due to local application of aloe leaves]
Full author name: Savchak, V I.

Savchak VI. Vestn Dermatol Venerol. 1977 Dec;(12):44-5.

[Article in Russian]

MeSH Terms:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Ostryi bulleznyi allergichekii dermatit ot mestnogo primenenniia list'ev aloe.
Entry Date: 19780426
Date Completed: 19780426
MeSH Date: 1977/12/01 00:01
Date Revised: 20011128
Entrez Date: 1977/12/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1977 Dec;(12):44-5.
PMID: 607684 UI: 78119783 [PubMed - indexed for MEDLINE]
From PubMed
357

Cascarosides A and B.
Full author name: Fairbairn, J W; Evans, F J; Phillipson, J D.

Fairbairn JW, Evans FJ, Phillipson JD. J Pharm Sci. 1977 Sep;66(9):1300-3.

[Article in English]

Electron-impact and field desorption mass spectrometry, together with NMR and circular dichroism spectroscopy, were used to confirm that cascarosides A and B are C-10 isomers of 8-O-(beta-D-glucopyranosyl)barbaloin. Several batches of cascarosides A and B were prepared and oxidatively hydrolyzed to aloe-emodin. The results are discussed in relation to the assay for cascara given in the European Pharmacopoeia, 1971.

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19771125
Date Completed: 19771125
MeSH Date: 1977/09/01 00:01
Date Revised: 20001218
Entrez Date: 1977/09/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1977 Sep;66(9):1300-3.
PMID: 903869 UI: 78007670 [PubMed - indexed for MEDLINE]
From PubMed
358

Biologically active constituents of leaves and roots of Aloe arborescens var. natalensis.
Full author name: Hirata, T; Suga, T.

Hirata T, Suga T. Z Naturforsch [C]. 1977 Sep-Oct;32(9-10):731-4.

[Article in English]

Several biologically active substances, such as aloenin (1), magnesium lactate, aloe-emodin (4), barbaloin (5), and succinic acid, were found to be contained in the leaf juice of Aloe arborescens Mill. var. natalensis Berger, which has widely been used in domestic medicines. Aloenin (1) and magnesium lactate were elucidated to exhibit an inhibitory action on the gastric juice secretion of rats. Various constituents other than the above bioactive substances were found in the leaves and the roots of the plant.

MeSH Terms:

Substances:

ISSN: 0341-0382
NLM Unique ID: 7801143
Country: germany, west
Entry Date: 19780127
Date Completed: 19780127
MeSH Date: 1977/09/01 00:01
Date Revised: 20011128
Entrez Date: 1977/09/01
Citation Subset: IM
Publication Status: ppublish
Z Naturforsch [C] 1977 Sep-Oct;32(9-10):731-4.
PMID: 145111 UI: 78056846 [PubMed - indexed for MEDLINE]
From PubMed
359

Orientation of interphase chromosomes as detected by Giemsa C-bands.
Full author name: Ghosh, S; Roy, S C.

Ghosh S, Roy SC. Chromosoma. 1977 Apr 27;61(1):49-55.

[Article in English]

The orientation of Giemsa C-bands has been studied in mitotic and interphase cells of Allium cepa. A sativum and of Aloe vera. The C-bands in these three species are located at the telomeres, secondary constriction region of the nucleolar chromosomes and the centromeric regions, respectively. Observations in A. cepa and Aloe indicate clearly that the interphase chromosomes are non-random in their orientation and possibly maintain their telophase configuration through the attachment of telomeres and perhaps of kinetochores with the nuclear membrane. Electron micrographs of onion cells also reveal that certain heterochromatic segments are associated with the nuclear membrane.--The nucleolar interstitial C-bands in A. sativum remain free in the nucleoplasm and may come close to each other due to heterochromatic attraction. Such a heterochromatic attraction is also evident between telomeric regions and between centromeres. However, a two by two attachment could not be noticed. A diagrammatic representation of the orientation of interphase chromosomes has been presented.

MeSH Terms:

Substances:

ISSN: 0009-5915
NLM Unique ID: 2985138R
Country: germany, west
Entry Date: 19770922
Date Completed: 19770922
MeSH Date: 1977/04/27 00:01
Date Revised: 20001218
Entrez Date: 1977/04/27
Citation Subset: IM
Publication Status: ppublish
Chromosoma 1977 Apr 27;61(1):49-55.
PMID: 885027 UI: 77224702 [PubMed - indexed for MEDLINE]
From PubMed
360

[A Dragendorff-positive substance from Aloe]
Full author name: Graf, E; Fauss, H.

Graf E, Fauss H. Arch Pharm (Weinheim). 1977 Feb;310(2):171.

[Article in German]

MeSH Terms:

ISSN: 0365-6233
NLM Unique ID: 0330167
Country: germany, west
Vernacular Title: Eine Dragendorff-positive Substanz in Aloe
Entry Date: 19770520
Date Completed: 19770520
MeSH Date: 1977/02/01 00:01
Date Revised: 20011128
Entrez Date: 1977/02/01
Citation Subset: IM
Publication Status: ppublish
Arch Pharm (Weinheim) 1977 Feb;310(2):171.
PMID: 849123 UI: 77156494 [PubMed - indexed for MEDLINE]
From PubMed
361

Aloe mannan, ploysaccharide, from Aloe arborescens var. natalensis.
Full author name: Yagi, A; Makino, K; Nishioka, I; Kuchino, Y.

Yagi A, Makino K, Nishioka I, Kuchino Y. Planta Med. 1977 Feb;31(1):17-20.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19770428
Date Completed: 19770428
MeSH Date: 1977/02/01 00:01
Date Revised: 20011128
Entrez Date: 1977/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1977 Feb;31(1):17-20.
PMID: 840922 UI: 77125958 [PubMed - indexed for MEDLINE]
From PubMed
362

[Use of aloe extracts in the treatment of experimental corneal ulcers]
Full author name: Mortada, A; Hegazy, M A; Hegazy, M R; Helal, M.

Mortada A, Hegazy MA, Hegazy MR, Helal M. Cesk Oftalmol. 1976 Dec;32(6):424-7.

[Article in Czech]

MeSH Terms:

Substances:

ISSN: 0009-059X
NLM Unique ID: 0005023
Country: czechoslovakia
Vernacular Title: Pouziti extraktu aloe pri leceni experimentalnich vredu rohovky
Entry Date: 19770415
Date Completed: 19770415
MeSH Date: 1976/12/01 00:01
Date Revised: 20011128
Entrez Date: 1976/12/01
Citation Subset: IM
Publication Status: ppublish
Cesk Oftalmol 1976 Dec;32(6):424-7.
PMID: 1017041 UI: 77114222 [PubMed - indexed for MEDLINE]
From PubMed
363

[Study of the effect of various drugs on the motor activity of ciliated epithelium under experimental conditions]
Full author name: Markov, G I.

Markov GI. Vestn Otorinolaringol. 1976 Nov-Dec;(6):13-4.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0042-4668
NLM Unique ID: 0416577
Country: ussr
Vernacular Title: Issledovanie vliianie nekotorykh lakarstvennykh sredstv na dvigatel'nuiu aktivnost' mertsatel'nogo epiteliia v eksperimente
Entry Date: 19770428
Date Completed: 19770428
MeSH Date: 1976/11/01 00:01
Date Revised: 20011128
Entrez Date: 1976/11/01
Citation Subset: IM
Publication Status: ppublish
Vestn Otorinolaringol 1976 Nov-Dec;(6):13-4.
PMID: 1035446 UI: 77129299 [PubMed - indexed for MEDLINE]
From PubMed
364

Tumor inhibitors. 114. Aloe emodin: antileukemic principle isolated from Rhamnus frangula L.
Full author name: Kupchan, S M; Karim, A.

Kupchan SM, Karim A. Lloydia. 1976 Jul-Aug;39(4):223-4.

[Article in English]

A systematic fractionation of an ethanol-water (1:1) extract of the seeds of Rhamnus frangula L., guided by assays for tumore-inhibitory activity, led to the isolation of aloe emodin (1). This compound was found to show significant antileukemic activity against the P-388 lymphocytic leukemia in mice. A note-worthy vehicle-dependence of the testing results is reported. In the light of this vehicle-dependence, the re-examination of other anthraquinone derivatives is recommended.

MeSH Terms:

Substances:

ISSN: 0024-5461
NLM Unique ID: 0376626
Country: United States
Entry Date: 19761101
Date Completed: 19761101
MeSH Date: 1976/07/01 00:01
Date Revised: 20011128
Entrez Date: 1976/07/01
Citation Subset: IM
Publication Status: ppublish
Lloydia 1976 Jul-Aug;39(4):223-4.
PMID: 957911 UI: 76266606 [PubMed - indexed for MEDLINE]
From PubMed
365

Bradykinase activity of aloe extract.
Full author name: Fujita, K; Teradaira, R; Nagatsu, T.

Fujita K, Teradaira R, Nagatsu T. Biochem Pharmacol. 1976 Jan 15;25(2):205.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0006-2952
NLM Unique ID: 0101032
Country: United States
Entry Date: 19760525
Date Completed: 19760525
MeSH Date: 1976/01/15 00:01
Date Revised: 20011128
Entrez Date: 1976/01/15
Citation Subset: IM
Publication Status: ppublish
Biochem Pharmacol 1976 Jan 15;25(2):205.
PMID: 1259782 UI: 76160789 [PubMed - indexed for MEDLINE]
From PubMed
366

The anthraquinone laxatives. Biological assay and its relation to chemical structure.
Full author name: Fairbairn, J W.

Fairbairn JW. Pharmacology. 1976;14 Suppl 1:48-61.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

Number of References: 35
ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19761223
Date Completed: 19761223
MeSH Date: 1976/01/01 00:01
Date Revised: 20011128
Entrez Date: 1976/01/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1976;14 Suppl 1:48-61.
PMID: 824655 UI: 77036951 [PubMed - indexed for MEDLINE]
From PubMed
367

Anthraquinone derivatives in vegetable laxatives.
Full author name: van Os, F H.

van Os FH. Pharmacology. 1976;14 Suppl 1:7-17.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

Number of References: 29
ISSN: 0031-7012
NLM Unique ID: 0152016
Country: Switzerland
Entry Date: 19761223
Date Completed: 19761223
MeSH Date: 1976/01/01 00:01
Date Revised: 20011128
Entrez Date: 1976/01/01
Citation Subset: IM
Publication Status: ppublish
Pharmacology 1976;14 Suppl 1:7-17.
PMID: 790407 UI: 77036953 [PubMed - indexed for MEDLINE]
From PubMed
368

Experimental use of aloe vera extract in clinical practice.
Full author name: Northway, R B.

Northway RB. Vet Med Small Anim Clin. 1975 Jan;70(1):89.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0042-4889
NLM Unique ID: 8707901
Country: United States
Entry Date: 19750618
Date Completed: 19750618
MeSH Date: 1975/01/01 00:01
Date Revised: 20011128
Entrez Date: 1975/01/01
Citation Subset: IM
Publication Status: ppublish
Vet Med Small Anim Clin 1975 Jan;70(1):89.
PMID: 1039210 UI: 75141995 [PubMed - indexed for MEDLINE]
From PubMed
369

[Use of aloe in complex treatment of patients with focal pulmonary tuberculosis]
Full author name: Kurilenko, N A.

Kurilenko NA. Vrach Delo. 1974 Aug;0(8):110-1.

[Article in Russian]

MeSH Terms:

ISSN: 0049-6804
NLM Unique ID: 0413607
Country: ussr
Vernacular Title: Primenenie aloe v kompleksnom lechenii bol'nykh ochagovym tuberkulezom legkikh
Entry Date: 19741219
Date Completed: 19741219
MeSH Date: 1974/08/01 00:01
Date Revised: 20011128
Entrez Date: 1974/08/01
Citation Subset: IM
Publication Status: ppublish
Vrach Delo 1974 Aug;0(8):110-1.
PMID: 4411420 UI: 75005824 [PubMed - indexed for MEDLINE]
From PubMed
370

Double-blind comparison of alophen with its components for cathartic effects.
Full author name: Chapman, D D; Pittelli, J J.

Chapman DD, Pittelli JJ. Curr Ther Res Clin Exp. 1974 Aug;16(8):817-20.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

ISSN: 0011-393X
NLM Unique ID: 0372621
Country: United States
Entry Date: 19750521
Date Completed: 19750521
MeSH Date: 1974/08/01 00:01
Date Revised: 20011128
Entrez Date: 1974/08/01
Citation Subset: IM
Publication Status: ppublish
Curr Ther Res Clin Exp 1974 Aug;16(8):817-20.
PMID: 4217249 UI: 75092728 [PubMed - indexed for MEDLINE]
From PubMed
371

Studies on the constituents of Aloe arborescens Mill. var. natalensis Berger. II. The structures of two new aloesin esters.
Full author name: Makino, K; Yagi, A; Nishioka, I.

Makino K, Yagi A, Nishioka I. Chem Pharm Bull (Tokyo). 1974 Jul;22(7):1565-70.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0009-2363
NLM Unique ID: 0377775
Country: Japan
Entry Date: 19750318
Date Completed: 19750318
MeSH Date: 1974/07/01 00:01
Date Revised: 20001218
Entrez Date: 1974/07/01
Citation Subset: IM
Publication Status: ppublish
Chem Pharm Bull (Tokyo) 1974 Jul;22(7):1565-70.
PMID: 4434578 UI: 75056768 [PubMed - indexed for MEDLINE]
From PubMed
372

[Case of an allergic reaction to the administration of aloe juice into the nose]
Full author name: Diba, S A.

Diba SA. Zh Ushn Nos Gorl Bolezn. 1974 Mar-Apr;0(2):108.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0044-4650
NLM Unique ID: 9427210
Country: ussr
Vernacular Title: Sluchai allergicheskoi reaktsii na vvedenie soka aloe v nos
Entry Date: 19750110
Date Completed: 19750110
MeSH Date: 1974/03/01 00:01
Date Revised: 20011128
Entrez Date: 1974/03/01
Citation Subset: IM
Publication Status: ppublish
Zh Ushn Nos Gorl Bolezn 1974 Mar-Apr;0(2):108.
PMID: 4419067 UI: 75022077 [PubMed - indexed for MEDLINE]
From PubMed
373

[Treatment of traumatic hemorrhages into the vitreous body with fibrinolysin in combination with other methods]
Full author name: Logai, I M.

Logai IM. Oftalmol Zh. 1974;29(4):260-5.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Lechenie travmaticheskikh krovoizliianii v steklovidnoe telo fibrinolizinom v komplekse s drugimi metodami
Entry Date: 19750203
Date Completed: 19750203
MeSH Date: 1974/01/01 00:01
Date Revised: 20011128
Entrez Date: 1974/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1974;29(4):260-5.
PMID: 4279385 UI: 75045875 [PubMed - indexed for MEDLINE]
From PubMed
374

[Behcet's syndrome]
Full author name: Kursanov, Iu V; Sheinkman, E V.

Kursanov IuV, Sheinkman EV. Klin Med (Mosk). 1973 Oct;51(10):130-3.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0023-2149
NLM Unique ID: 2985204R
Country: ussr
Vernacular Title: K voprosu o bolezni Bekhcheta.
Entry Date: 19740611
Date Completed: 19740611
MeSH Date: 1973/10/01 00:01
Date Revised: 20011128
Entrez Date: 1973/10/01
Citation Subset: IM
Publication Status: ppublish
Klin Med (Mosk) 1973 Oct;51(10):130-3.
PMID: 4787272 UI: 74141466 [PubMed - indexed for MEDLINE]
From PubMed
375

Lemberger elaborates.
Full author name: Lemberger, M A.

Lemberger MA. J Am Pharm Assoc. 1973 Jun;13(6):277.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0003-0465
NLM Unique ID: 7505576
Country: United States
Entry Date: 19730809
Date Completed: 19730809
MeSH Date: 1973/06/01 00:01
Date Revised: 20011128
Entrez Date: 1973/06/01
Citation Subset: IM
Publication Status: ppublish
J Am Pharm Assoc 1973 Jun;13(6):277.
PMID: 4710074 UI: 73192728 [PubMed - indexed for MEDLINE]
From PubMed
376

Effect of aloe in O-T-C products sought.
Full author name: Hollander, S.

Hollander S. J Am Pharm Assoc. 1973 Jun;13(6):277.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0003-0465
NLM Unique ID: 7505576
Country: United States
Entry Date: 19730809
Date Completed: 19730809
MeSH Date: 1973/06/01 00:01
Date Revised: 20011128
Entrez Date: 1973/06/01
Citation Subset: IM
Publication Status: ppublish
J Am Pharm Assoc 1973 Jun;13(6):277.
PMID: 4710073 UI: 73192727 [PubMed - indexed for MEDLINE]
From PubMed
377

[Comparison of various methods for the spectrophotmetric determination of aloin in aloe DAB 7-DDR].
Full author name: Thieme, H; Diez, V.

Thieme H, Diez V. Pharmazie. 1973 May;28(5):331-5.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0031-7144
NLM Unique ID: 9800766
Country: germany, east
Vernacular Title: Vergleich verschiedener Methoden zur spektrophotometrischen Bestimmung von Aloin in Aloe DAB 7-DD.
Entry Date: 19730904
Date Completed: 19730904
MeSH Date: 1973/05/01 00:01
Date Revised: 20011128
Entrez Date: 1973/05/01
Citation Subset: IM
Publication Status: ppublish
Pharmazie 1973 May;28(5):331-5.
PMID: 4715052 UI: 73208618 [PubMed - indexed for MEDLINE]
From PubMed
378

Use of aloe in treating leg ulcers and dermatoses.
Full author name: Zawahry, M E; Hegazy, M R; Helal, M.

Zawahry ME, Hegazy MR, Helal M. Int J Dermatol. 1973 Jan-Feb;12(1):68-73.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0011-9059
NLM Unique ID: 0243704
Country: United States
Entry Date: 19730524
Date Completed: 19730524
MeSH Date: 1973/01/01 00:01
Date Revised: 20011128
Entrez Date: 1973/01/01
Citation Subset: IM
Publication Status: ppublish
Int J Dermatol 1973 Jan-Feb;12(1):68-73.
PMID: 4266516 UI: 73147673 [PubMed - indexed for MEDLINE]
From PubMed
379

Chromones in aloe species. II. Aloesone.
Full author name: Holdsworth, D K.

Holdsworth DK. Planta Med. 1972 Aug;22(1):54-8.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19730105
Date Completed: 19730105
MeSH Date: 1972/08/01 00:01
Date Revised: 20011128
Entrez Date: 1972/08/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1972 Aug;22(1):54-8.
PMID: 5083248 UI: 73032113 [PubMed - indexed for MEDLINE]
From PubMed
380

Potentiation of wound infection by adhesive adjuncts.
Full author name: Panek, P H; Prusak, M P; Bolt, D; Edlich, R F.

Panek PH, Prusak MP, Bolt D, Edlich RF. Am Surg. 1972 Jun;38(6):343-5.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0003-1348
NLM Unique ID: 0370522
Country: United States
Entry Date: 19720718
Date Completed: 19720718
MeSH Date: 1972/06/01 00:01
Date Revised: 20011128
Entrez Date: 1972/06/01
Citation Subset: IM
Publication Status: ppublish
Am Surg 1972 Jun;38(6):343-5.
PMID: 5025316 UI: 72182076 [PubMed - indexed for MEDLINE]
From PubMed
381

[Treatment of parodontopathies in the Soviet Union in the light of the literature in the years 1960-1969]
Full author name: Zakrzewska, R.

Zakrzewska R. Czas Stomatol. 1971 Jun;24(6):597-602.

[Article in Polish]

MeSH Terms:

Substances:

ISSN: 0011-4553
NLM Unique ID: 2984742R
Country: Poland
Vernacular Title: Leczenie parodontopatii w Zwiazku Radzieckim na podstawie pismiennictwa w latach 1960-1969.
Entry Date: 19710916
Date Completed: 19710916
MeSH Date: 1971/06/01 00:01
Date Revised: 20011128
Entrez Date: 1971/06/01
Citation Subset: D, IM
Publication Status: ppublish
Czas Stomatol 1971 Jun;24(6):597-602.
PMID: 5283734 UI: 71253266 [PubMed - indexed for MEDLINE]
From PubMed
382

Plants used against cancer. A survey.
Full author name: Hartwell, J L.

Hartwell JL. Lloydia. 1971 Jun;34(2):204-55.

[Article in English]

Publication Types:

MeSH Terms:

Substances:

Number of References: 311
ISSN: 0024-5461
NLM Unique ID: 0376626
Country: United States
Entry Date: 19711216
Date Completed: 19711216
MeSH Date: 1971/06/01 00:01
Date Revised: 20011128
Entrez Date: 1971/06/01
Citation Subset: IM
Publication Status: ppublish
Lloydia 1971 Jun;34(2):204-55.
PMID: 4938826 UI: 72015351 [PubMed - indexed for MEDLINE]
From PubMed
383

Chromones in aloe species. I. Aloesin--a C-glucosyl-7-hydroxychromone.
Full author name: Holdsworth, D K.

Holdsworth DK. Planta Med. 1971 Apr;19(4):322-5.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19710624
Date Completed: 19710624
MeSH Date: 1971/04/01 00:01
Date Revised: 20011128
Entrez Date: 1971/04/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1971 Apr;19(4):322-5.
PMID: 5573544 UI: 71183434 [PubMed - indexed for MEDLINE]
From PubMed
384

[German Pharmacopoeia, 7th edition, VII. Delivery]

[No authors listed]. Pharmazie. 1970 Dec;25(12):713-23.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0031-7144
NLM Unique ID: 9800766
Country: germany, east
Vernacular Title: Deutsches Arzneibuch, 7. Ausgabe, VII. Lieferung.
Entry Date: 19710330
Date Completed: 19710330
MeSH Date: 1970/12/01 00:01
Date Revised: 20011128
Entrez Date: 1970/12/01
Citation Subset: IM
Publication Status: ppublish
Pharmazie 1970 Dec;25(12):713-23.
PMID: 5499272 UI: 71107822 [PubMed - indexed for MEDLINE]
From PubMed
385

[Anthraquinones and anthraquinone glycosides. 19. Synthesis of alpha and beta frangulin and frangula-emodin-9-anthron-10-C-glycoside]
Full author name: Muhlemann, H; Lyk, P J.

Muhlemann H, Lyk PJ. Pharm Acta Helv. 1970 Dec;45(12):728-53.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0031-6865
NLM Unique ID: 0401134
Country: Switzerland
Vernacular Title: Anthrachinone und Anthrachinonglykoside. 19. Synthese von alpha-und beta-Frangulin und Frangula-Emodin-9-anthron-10-C-glucosid.
Entry Date: 19710330
Date Completed: 19710330
MeSH Date: 1970/12/01 00:01
Date Revised: 20011128
Entrez Date: 1970/12/01
Citation Subset: IM
Publication Status: ppublish
Pharm Acta Helv 1970 Dec;45(12):728-53.
PMID: 5499269 UI: 71107814 [PubMed - indexed for MEDLINE]
From PubMed
386

[A liver preparation from plants]
Full author name: Kurz, J F.

Kurz JF. Z Allgemeinmed. 1970 Oct 20;46(29):1476-8.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0300-8673
NLM Unique ID: 7700691
Country: germany, west
Vernacular Title: Ein pflanzliches Hepatikum.
Entry Date: 19701204
Date Completed: 19701204
MeSH Date: 1970/10/20 00:01
Date Revised: 20011128
Entrez Date: 1970/10/20
Citation Subset: IM
Publication Status: ppublish
Z Allgemeinmed 1970 Oct 20;46(29):1476-8.
PMID: 5471596 UI: 71009839 [PubMed - indexed for MEDLINE]
From PubMed
387

The assessment of purgative principles in aloes.
Full author name: Mapp, R K; McCarthy, T J.

Mapp RK, McCarthy TJ. Planta Med. 1970 Aug;18(4):361-5.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19701127
Date Completed: 19701127
MeSH Date: 1970/08/01 00:01
Date Revised: 20011128
Entrez Date: 1970/08/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1970 Aug;18(4):361-5.
PMID: 5469396 UI: 71004637 [PubMed - indexed for MEDLINE]
From PubMed
388

[Study of aloe extract in ampuls]
Full author name: Kurilenko, M I.

Kurilenko MI. Farmatsiia. 1970 May-Jun;19(3):66-8.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: K izucheniiu ampulirovannogo ekstrakta aloe.
Entry Date: 19700906
Date Completed: 19700906
MeSH Date: 1970/05/01 00:01
Date Revised: 20011128
Entrez Date: 1970/05/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1970 May-Jun;19(3):66-8.
PMID: 5429701 UI: 70237213 [PubMed - indexed for MEDLINE]
From PubMed
389

Hypokalemic metabolic alkalosis due to Carter's little pills.
Full author name: Ramirez, B; Marieb, N J.

Ramirez B, Marieb NJ. Conn Med. 1970 Mar;34(3):169-70.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0010-6178
NLM Unique ID: 0372745
Country: United States
Entry Date: 19700416
Date Completed: 19700416
MeSH Date: 1970/03/01 00:01
Date Revised: 20011128
Entrez Date: 1970/03/01
Citation Subset: IM
Publication Status: ppublish
Conn Med 1970 Mar;34(3):169-70.
PMID: 5416858 UI: 70129321 [PubMed - indexed for MEDLINE]
From PubMed
390

[The effect of drug therapy on the processes of cerebralcompensation].
Full author name: Barashnev, Iu I.

Barashnev IuI. Zh Nevropatol Psikhiatr Im S S Korsakova. 1970;70(12):1815-9.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0044-4588
NLM Unique ID: 8710066
Country: ussr
Vernacular Title: Vliianie medikamentoznoi terapii na protsessy kompensatsii v mozgu (eksperimental'noe issledovanie)
Entry Date: 19710617
Date Completed: 19710617
MeSH Date: 1970/01/01 00:01
Date Revised: 20011128
Entrez Date: 1970/01/01
Citation Subset: IM
Publication Status: ppublish
Zh Nevropatol Psikhiatr Im S S Korsakova 1970;70(12):1815-9.
PMID: 5537548 UI: 71176862 [PubMed - indexed for MEDLINE]
From PubMed
391

A comparative investigation of methods used to estimate aloin and related compounds in Aloes.
Full author name: McCarthy, T J; Mapp, R K.

McCarthy TJ, Mapp RK. Planta Med. 1970 Jan;18(1):36-43.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19700615
Date Completed: 19700615
MeSH Date: 1970/01/01 00:01
Date Revised: 20011128
Entrez Date: 1970/01/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1970 Jan;18(1):36-43.
PMID: 5441604 UI: 70176233 [PubMed - indexed for MEDLINE]
From PubMed
392

[Anaphylactic shock after injection of aloe]
Full author name: Trakhtenberg, S B.

Trakhtenberg SB. Klin Med (Mosk). 1970 Jan;48(1):140-1.

[Article in Russian]

MeSH Terms:

ISSN: 0023-2149
NLM Unique ID: 2985204R
Country: ussr
Vernacular Title: Anafilakticheskii shok posle in"ektsii aloe.
Entry Date: 19700724
Date Completed: 19700724
MeSH Date: 1970/01/01 00:01
Date Revised: 20011128
Entrez Date: 1970/01/01
Citation Subset: IM
Publication Status: ppublish
Klin Med (Mosk) 1970 Jan;48(1):140-1.
PMID: 5419557 UI: 70203556 [PubMed - indexed for MEDLINE]
From PubMed
393

[Dry preparation of Aloe]
Full author name: Kurilenko, M I.

Kurilenko MI. Farmatsiia. 1969 Nov-Dec;18(6):31-5.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: O sukhom preparate aloe.
Entry Date: 19700519
Date Completed: 19700519
MeSH Date: 1969/11/01 00:01
Date Revised: 20011128
Entrez Date: 1969/11/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1969 Nov-Dec;18(6):31-5.
PMID: 5379668 UI: 70154599 [PubMed - indexed for MEDLINE]
From PubMed
394

Anthraquinone drugs. II. Inadvertent acetylation of aloe-emodin during preparation of aglycones from crude drugs--UV, IR, and NMR spectra of the products.
Full author name: Gyanchandani, N D; Nigam, I C.

Gyanchandani ND, Nigam IC. J Pharm Sci. 1969 Jul;58(7):833-5.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19691025
Date Completed: 19691025
MeSH Date: 1969/07/01 00:01
Date Revised: 20011128
Entrez Date: 1969/07/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1969 Jul;58(7):833-5.
PMID: 5810201 UI: 69287775 [PubMed - indexed for MEDLINE]
From PubMed
395

Anthraquinone drugs. I. Thin-layer chromatographic identification of aloes, cascara, senna, and certain synthetic laxatives in pharmaceutical dosage forms.
Full author name: Gyanchandani, N D; Yamamoto, M; Nigam, I C.

Gyanchandani ND, Yamamoto M, Nigam IC. J Pharm Sci. 1969 Feb;58(2):197-200.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19690604
Date Completed: 19690604
MeSH Date: 1969/02/01 00:01
Date Revised: 20011128
Entrez Date: 1969/02/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1969 Feb;58(2):197-200.
PMID: 5779859 UI: 69164785 [PubMed - indexed for MEDLINE]
From PubMed
396

Distribution of glycosyl compounds in South African Aloe species.
Full author name: McCarthy, T J.

McCarthy TJ. Planta Med. 1969 Feb;17(1):1-7.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19690708
Date Completed: 19690708
MeSH Date: 1969/02/01 00:01
Date Revised: 20011128
Entrez Date: 1969/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1969 Feb;17(1):1-7.
PMID: 5772272 UI: 69193093 [PubMed - indexed for MEDLINE]
From PubMed
397

[Toxic and caustic complications through use of so-called abortifacients]
Full author name: Vago, O.

Vago O. Z Geburtshilfe Perinatol. 1969;170(3):272-7.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0300-967X
NLM Unique ID: 0326205
Country: germany, west
Vernacular Title: Toxische und kaustische Komplikationen durch Gebrauch sogenannter fruchtabtreibender Arzneimittel.
Entry Date: 19690930
Date Completed: 19690930
MeSH Date: 1969/01/01 00:01
Date Revised: 20011128
Entrez Date: 1969/01/01
Citation Subset: IM
Publication Status: ppublish
Z Geburtshilfe Perinatol 1969;170(3):272-7.
PMID: 5802425 UI: 69262326 [PubMed - indexed for MEDLINE]
From PubMed
398

The effects of prednisolone, indomethacin, and Aloe vera gel on tissue culture cells.
Full author name: Brasher, W J; Zimmermann, E R; Collings, C K.

Brasher WJ, Zimmermann ER, Collings CK. Oral Surg Oral Med Oral Pathol. 1969 Jan;27(1):122-8.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0030-4220
NLM Unique ID: 0376406
Country: United States
Entry Date: 19690207
Date Completed: 19690207
MeSH Date: 1969/01/01 00:01
Date Revised: 20011128
Entrez Date: 1969/01/01
Citation Subset: D, IM
Publication Status: ppublish
Oral Surg Oral Med Oral Pathol 1969 Jan;27(1):122-8.
PMID: 5248724 UI: 69068827 [PubMed - indexed for MEDLINE]
From PubMed
399

[Ophthalmic drugs. 38]
Full author name: Metzner, R.

Metzner R. Pharm Prax. 1969;10:218-24.

[Article in German]

Publication Types:

MeSH Terms:

Substances:

Number of References: 102
ISSN: 0048-3656
NLM Unique ID: 0401136
Country: germany, east
Vernacular Title: Ophthalmika. 38.
Entry Date: 19700322
Date Completed: 19700322
MeSH Date: 1969/01/01 00:01
Date Revised: 20011128
Entrez Date: 1969/01/01
Citation Subset: IM
Publication Status: ppublish
Pharm Prax 1969;10:218-24.
PMID: 4905112 UI: 70106512 [PubMed - indexed for MEDLINE]
From PubMed
400

[Remote results of treatment of kraurosis vulvae with biogenic stimulators]
Full author name: Nudol'skaia, O E.

Nudol'skaia OE. Akush Ginekol (Mosk). 1968 Dec;44(12):45-7.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0002-3906
NLM Unique ID: 0370456
Country: ussr
Vernacular Title: Otdalennye rezul'taty lecheniia krauroza vul'vy biogennymi stimuliatorami.
Entry Date: 19700922
Date Completed: 19700922
MeSH Date: 1968/12/01 00:01
Date Revised: 20011128
Entrez Date: 1968/12/01
Citation Subset: IM
Publication Status: ppublish
Akush Ginekol (Mosk) 1968 Dec;44(12):45-7.
PMID: 5743742 UI: 70253576 [PubMed - indexed for MEDLINE]
From PubMed
401

Phytochemical investigation of the flowers of Cassia reticulata Willd. (Leguminosae).
Full author name: Messmer, W M; Farnsworth, N R; Persinos, G J; Wilkes, J D.

Messmer WM, Farnsworth NR, Persinos GJ, Wilkes JD. J Pharm Sci. 1968 Nov;57(11):1996-8.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0022-3549
NLM Unique ID: 2985195R
Country: United States
Entry Date: 19690204
Date Completed: 19690204
MeSH Date: 1968/11/01 00:01
Date Revised: 20011128
Entrez Date: 1968/11/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Sci 1968 Nov;57(11):1996-8.
PMID: 5725937 UI: 69061091 [PubMed - indexed for MEDLINE]
From PubMed
402

[Study on drugs of the anthraquinone series. XIX. The determination of the sennosides C and D]
Full author name: Lemli, J; Cuveele, J.

Lemli J, Cuveele J. Pharm Acta Helv. 1968 Oct;43(10):689-92.

[Article in French]

MeSH Terms:

Substances:

ISSN: 0031-6865
NLM Unique ID: 0401134
Country: Switzerland
Vernacular Title: Recherches sur les drogues a principes anthraquinoniques. XIX. Le dosage des sennosides C et D.
Entry Date: 19681202
Date Completed: 19681202
MeSH Date: 1968/10/01 00:01
Date Revised: 20011128
Entrez Date: 1968/10/01
Citation Subset: IM
Publication Status: ppublish
Pharm Acta Helv 1968 Oct;43(10):689-92.
PMID: 5682587 UI: 69009356 [PubMed - indexed for MEDLINE]
From PubMed
403

[Natural anthraquinones]
Full author name: Romanova, A S.

Romanova AS. Farmatsiia. 1968 Sep-Oct;17(5):71-6.

[Article in Russian]

Publication Types:

MeSH Terms:

Substances:

Number of References: 139
ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: Prirodnye antrakhony.
Entry Date: 19710602
Date Completed: 19710602
MeSH Date: 1968/09/01 00:01
Date Revised: 20011128
Entrez Date: 1968/09/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1968 Sep-Oct;17(5):71-6.
PMID: 4928368 UI: 71161043 [PubMed - indexed for MEDLINE]
From PubMed
404

The metabolism of anthracene derivatives and organic acids in selected Aloe species.
Full author name: McCarthy, T J.

McCarthy TJ. Planta Med. 1968 Aug;16(3):348-56.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19691021
Date Completed: 19691021
MeSH Date: 1968/08/01 00:01
Date Revised: 20011128
Entrez Date: 1968/08/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1968 Aug;16(3):348-56.
PMID: 5734284 UI: 69282164 [PubMed - indexed for MEDLINE]
From PubMed
405

[Aloes-wood, agalloch-wood, eagle-wood]
Full author name: Foucaud, A; Reveillere, H; Mahe, M.

Foucaud A, Reveillere H, Mahe M. Presse Med. 1968 Apr 27;76(21):1028-9.

[Article in French]

Publication Types:

MeSH Terms:

ISSN: 0032-7867
NLM Unique ID: 0312556
Country: France
Vernacular Title: Bois d'aloes, bois d'agalloche, bois d'aigle.
Entry Date: 19680807
Date Completed: 19680807
MeSH Date: 1968/04/27 00:01
Date Revised: 20011128
Entrez Date: 1968/04/27
Citation Subset: IM, Q
Publication Status: ppublish
Presse Med 1968 Apr 27;76(21):1028-9.
PMID: 4872009 UI: 68282827 [PubMed - indexed for MEDLINE]
From PubMed
406

Current status of aloe as a cure-all.
Full author name: Gjerstad, G; Riner, T D.

Gjerstad G, Riner TD. Am J Pharm Sci Support Public Health. 1968 Mar-Apr;140(2):58-64.

[Article in English]

MeSH Terms:

ISSN: 0002-9467
NLM Unique ID: 0416354
Country: United States
Entry Date: 19680807
Date Completed: 19680807
MeSH Date: 1968/03/01 00:01
Date Revised: 20011128
Entrez Date: 1968/03/01
Citation Subset: IM
Publication Status: ppublish
Am J Pharm Sci Support Public Health 1968 Mar-Apr;140(2):58-64.
PMID: 5656044 UI: 68283048 [PubMed - indexed for MEDLINE]
From PubMed
407

[Methods of quantitative determination of aloin]
Full author name: Tareeva, N B; Romanova, A S; Ban'kovskii, A I.

Tareeva NB, Romanova AS, Ban'kovskii AI. Farmatsiia. 1968 Mar-Apr;17(2):81-4.

[Article in Russian]

Publication Types:

MeSH Terms:

Substances:

Number of References: 35
ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: Metody kolichestvennogo opredeleniia aloina.
Entry Date: 19690507
Date Completed: 19690507
MeSH Date: 1968/03/01 00:01
Date Revised: 20011128
Entrez Date: 1968/03/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1968 Mar-Apr;17(2):81-4.
PMID: 4887051 UI: 69140203 [PubMed - indexed for MEDLINE]
From PubMed
408

[Modern pharmaceutical preparations of plant origin]
Full author name: Berezhinskaia, V V; Kondratenko, P T.

Berezhinskaia VV, Kondratenko PT. Farmatsiia. 1968 Mar-Apr;17(2):84-90.

[Article in Russian]

Publication Types:

MeSH Terms:

Substances:

Number of References: 82
ISSN: 0367-3014
NLM Unique ID: 0136541
Country: ussr
Vernacular Title: Sovremennye lekarstvennye preparaty rastitel'nogo proiskhozhdeniia.
Entry Date: 19690507
Date Completed: 19690507
MeSH Date: 1968/03/01 00:01
Date Revised: 20011128
Entrez Date: 1968/03/01
Citation Subset: IM
Publication Status: ppublish
Farmatsiia 1968 Mar-Apr;17(2):84-90.
PMID: 4180293 UI: 69140204 [PubMed - indexed for MEDLINE]
From PubMed
409

[Effect of bitters on cardiac output, heart rate and blood pressure]
Full author name: Glatzel, H.

Glatzel H. Planta Med. 1968 Feb;16(1):82-94.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Vernacular Title: Der Einfluss von Bittermittelen auf Herzuschlagvolumen, Herzschlagfrequenz und Blutdruck.
Entry Date: 19681219
Date Completed: 19681219
MeSH Date: 1968/02/01 00:01
Date Revised: 20011128
Entrez Date: 1968/02/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1968 Feb;16(1):82-94.
PMID: 5693772 UI: 69027252 [PubMed - indexed for MEDLINE]
From PubMed
410

[A complex of medication for maintaining visual function in glaucoma]
Full author name: Dancheva, L D; Barg, Ts M; Cherikchi, L E; Kashintseva, L T; Dmitrieva, M O; Mel'nik, L S; Ivashchenko, K M; Volkotrub, A F.

Dancheva LD, Barg TsM, Cherikchi LE, Kashintseva LT, Dmitrieva MO, Mel'nik LS, Ivashchenko KM, Volkotrub AF. Oftalmol Zh. 1968;23(7):504-10.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Kompleks lechebnykh sredstv dlia sokhraneniia zritel'nykh funktsii pri glaukome.
Entry Date: 19691016
Date Completed: 19691016
MeSH Date: 1968/01/01 00:01
Date Revised: 20011128
Entrez Date: 1968/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1968;23(7):504-10.
PMID: 5733820 UI: 69276613 [PubMed - indexed for MEDLINE]
From PubMed
411

[Blood circulation effectiveness of natural spices]
Full author name: Glatzel, H.

Glatzel H. Med Klin. 1967 Dec 22;62(51):1987-9.

[Article in German]

MeSH Terms:

ISSN: 0025-8458
NLM Unique ID: 0376637
Country: germany, west
Vernacular Title: Kreislaufwirksamkeit naturlicher Gewurze.
Entry Date: 19681003
Date Completed: 19681003
MeSH Date: 2000/03/22 09:00
Date Revised: 20011128
Entrez Date: 1967/12/22
Citation Subset: IM
Publication Status: ppublish
Med Klin 1967 Dec 22;62(51):1987-9.
PMID: 5595352 UI: 68363074 [PubMed - indexed for MEDLINE]
From PubMed
412

Investigations of antibacterial activity in the aloe.
Full author name: Bruce, W G.

Bruce WG. S Afr Med J. 1967 Oct 7;41(38):984.

[Article in English]

MeSH Terms:

ISSN: 0038-2469
NLM Unique ID: 0404520
Country: South Africa
Entry Date: 19680121
Date Completed: 19680121
MeSH Date: 1967/10/07 00:01
Date Revised: 20011128
Entrez Date: 1967/10/07
Citation Subset: IM
Publication Status: ppublish
S Afr Med J 1967 Oct 7;41(38):984.
PMID: 4964813 UI: 68055027 [PubMed - indexed for MEDLINE]
From PubMed
413

Recommended methods for the evaluation of drugs. Prepared by the Joint Committee of the Pharmaceutical Society and the Society for Analytical Chemistry on recommended methods for the evaluation of drugs. The chemical assay of aloes.

[No authors listed]. Analyst. 1967 Sep;92(98):593-6.

[Article in English]

MeSH Terms:

ISSN: 0003-2654
NLM Unique ID: 0372652
Country: England
Entry Date: 19680215
Date Completed: 19680215
MeSH Date: 1967/09/01 00:01
Date Revised: 20011128
Entrez Date: 1967/09/01
Citation Subset: IM
Publication Status: ppublish
Analyst 1967 Sep;92(98):593-6.
PMID: 6074677 UI: 68094706 [PubMed - indexed for MEDLINE]
From PubMed
414

The distribution of aloesin in some South African Aloe species.
Full author name: McCarthy, T J; Haynes, L J.

McCarthy TJ, Haynes LJ. Planta Med. 1967 Aug;15(3):342-4.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0032-0943
NLM Unique ID: 0066751
Country: germany, west
Entry Date: 19691021
Date Completed: 19691021
MeSH Date: 1967/08/01 00:01
Date Revised: 20011128
Entrez Date: 1967/08/01
Citation Subset: IM
Publication Status: ppublish
Planta Med 1967 Aug;15(3):342-4.
PMID: 5618645 UI: 69282152 [PubMed - indexed for MEDLINE]
From PubMed
415

Morphology and anatomy in Aloinae. I. Gasteria verrucosa (Mill.) Haworth.
Full author name: Wellendorf, M.

Wellendorf M. Dan Tidsskr Farm. 1967 Aug;41(8):139-54.

[Article in English]

MeSH Terms:

ISSN: 0011-6513
NLM Unique ID: 0373174
Country: Denmark
Entry Date: 19680928
Date Completed: 19680928
MeSH Date: 1967/08/01 00:01
Date Revised: 20011128
Entrez Date: 1967/08/01
Citation Subset: IM
Publication Status: ppublish
Dan Tidsskr Farm 1967 Aug;41(8):139-54.
PMID: 5594485 UI: 68358996 [PubMed - indexed for MEDLINE]
From PubMed
416

[Experimental treatment of fractures with adaptogens]
Full author name: Kadyrov, M A; Shakirov, D Sh.

Kadyrov MA, Shakirov DSh. Eksp Khir Anesteziol. 1967 Mar-Apr;12(2):50-2.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0013-3329
NLM Unique ID: 0373214
Country: ussr
Vernacular Title: Lechenie perelomov adaptogenami v eksperimente.
Entry Date: 19691023
Date Completed: 19691023
MeSH Date: 1967/03/01 00:01
Date Revised: 20011128
Entrez Date: 1967/03/01
Citation Subset: IM
Publication Status: ppublish
Eksp Khir Anesteziol 1967 Mar-Apr;12(2):50-2.
PMID: 5618925 UI: 69285519 [PubMed - indexed for MEDLINE]
From PubMed
417

[The effects of tissue therapy and vitamin therapy on unconditioned vascular reflexes and intraocular pressure in glaucomatous patients]
Full author name: Bakurskaia, V Ia.

Bakurskaia VIa. Oftalmol Zh. 1967;22(1):8-11.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0030-0675
NLM Unique ID: 0401105
Country: ussr
Vernacular Title: Vliianie tkanevoi terapii, vitaminoterapii na bezuslovnye sosudistye refleksy i vnutriglanznoe davlenie u glaukomnykh bol'nykh.
Entry Date: 19700202
Date Completed: 19700202
MeSH Date: 1967/01/01 00:01
Date Revised: 20011128
Entrez Date: 1967/01/01
Citation Subset: IM
Publication Status: ppublish
Oftalmol Zh 1967;22(1):8-11.
PMID: 5620784 UI: 70063477 [PubMed - indexed for MEDLINE]
From PubMed
418

[Research on drugs with anthraquinone bases. XIV. Isolation of a new heteroside from Senna leaves: diglucoside of aloe emodin dianthrone]
Full author name: Lemli, J; Cuveele, J.

Lemli J, Cuveele J. Pharm Acta Helv. 1967 Jan;42(1):37-40.

[Article in French]

MeSH Terms:

Substances:

ISSN: 0031-6865
NLM Unique ID: 0401134
Country: Switzerland
Vernacular Title: Recherches sur les drogues a principes anthraquinoniques. XIV. Isolement d'un nouvel heteroside a partir des feuilles de sene: l'aloe-emodine-dianthrone diglucoside.
Entry Date: 19671114
Date Completed: 19671114
MeSH Date: 1967/01/01 00:01
Date Revised: 20011128
Entrez Date: 1967/01/01
Citation Subset: IM
Publication Status: ppublish
Pharm Acta Helv 1967 Jan;42(1):37-40.
PMID: 5232805 UI: 67255417 [PubMed - indexed for MEDLINE]
From PubMed
419

[Results of conservative treatment of patients with endarteriosis and atherosclerosis of vessels of the extremities in out-and inpatient conditions]
Full author name: Zaitsev, G P; Poriadin, V T; Rozenfel'd, E S.

Zaitsev GP, Poriadin VT, Rozenfel'd ES. Klin Khir. 1966 Nov;11:8-14.

[Article in Russian]

MeSH Terms:

ISSN: 0023-2130
NLM Unique ID: 0376360
Country: ussr
Vernacular Title: Rezul'taty konservativnogo lecheniia bol'nykh endarteriozom i aterosklerozom sosudov konechnostei v usloviiakh stastionara i pokikliniki.
Entry Date: 19690411
Date Completed: 19690411
MeSH Date: 1966/11/01 00:01
Date Revised: 20011128
Entrez Date: 1966/11/01
Citation Subset: IM
Publication Status: ppublish
Klin Khir 1966 Nov;11:8-14.
PMID: 6003135 UI: 69118763 [PubMed - indexed for MEDLINE]
From PubMed
420

[Quantitative microdetermination of aloin by thin layer chromatography]
Full author name: Longo, R; Fumagalli, U.

Longo R, Fumagalli U. Boll Chim Farm. 1966 Oct;105(10):767-9.

[Article in Italian]

MeSH Terms:

Substances:

ISSN: 0006-6648
NLM Unique ID: 0372534
Country: Italy
Vernacular Title: Microdeterminazione quantitativa dell'aloina per cromatografia su strato sottile.
Entry Date: 19681106
Date Completed: 19681106
MeSH Date: 1966/10/01 00:01
Date Revised: 20011128
Entrez Date: 1966/10/01
Citation Subset: IM
Publication Status: ppublish
Boll Chim Farm 1966 Oct;105(10):767-9.
PMID: 6001040 UI: 68409991 [PubMed - indexed for MEDLINE]
From PubMed
421

[Studies on anti-bacterial and anti-fungal activities of Cape aloe]
Full author name: Soeda, M; Otomo, M; Ome, M; Kawashima, K.

Soeda M, Otomo M, Ome M, Kawashima K. Nippon Saikingaku Zasshi. 1966 Oct;21(10):609-14.

[Article in Japanese]

MeSH Terms:

Substances:

ISSN: 0021-4930
NLM Unique ID: 2984804R
Country: Japan
Entry Date: 19671120
Date Completed: 19671120
MeSH Date: 1966/10/01 00:01
Date Revised: 20011128
Entrez Date: 1966/10/01
Citation Subset: IM
Publication Status: ppublish
Nippon Saikingaku Zasshi 1966 Oct;21(10):609-14.
PMID: 4963249 UI: 67263380 [PubMed - indexed for MEDLINE]
From PubMed
422

[On the preparation and testing of aloe extract, with a suggestion for DAB 7]
Full author name: Bogs, U; Zessin, G.

Bogs U, Zessin G. Pharmazie. 1966 Sep;21(9):547-50.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0031-7144
NLM Unique ID: 9800766
Country: germany, east
Vernacular Title: Zur Herstellung und Prufung von Extractum Aloes. Zugleich ein Vorschlag fur das DAB 7.
Entry Date: 19690217
Date Completed: 19690217
MeSH Date: 1966/09/01 00:01
Date Revised: 20011128
Entrez Date: 1966/09/01
Citation Subset: IM
Publication Status: ppublish
Pharmazie 1966 Sep;21(9):547-50.
PMID: 6002471 UI: 69079547 [PubMed - indexed for MEDLINE]
From PubMed
423

[Studies of the effect of tissue preparations on the function of some biological catalysts]
Full author name: Savits'kii, V I.

Savits'kii VI. Fiziol Zh. 1966 Jul-Aug;12(4):510-7.

[Article in Ukrainian]

MeSH Terms:

Substances:

ISSN: 0015-3311
NLM Unique ID: 7806823
Country: ussr
Vernacular Title: Doslidzhennia vplyvu tkanynnykh preparativ na funktsiiu deiakykh biokatalizatoriv.
Entry Date: 19690803
Date Completed: 19690803
MeSH Date: 1966/07/01 00:01
Date Revised: 20011128
Entrez Date: 1966/07/01
Citation Subset: IM
Publication Status: ppublish
Fiziol Zh 1966 Jul-Aug;12(4):510-7.
PMID: 6004551 UI: 69209708 [PubMed - indexed for MEDLINE]
From PubMed
424

[The treatment of periodontosis by injections of aloe extract and their influence on the phosphorus-calcium metabolism]
Full author name: Noskov, A D.

Noskov AD. Stomatologiia (Mosk). 1966 Jul-Aug;45(4):13-5.

[Article in Russian]

MeSH Terms:

Substances:

ISSN: 0039-1735
NLM Unique ID: 0412072
Country: ussr
Vernacular Title: Lechenie parodontoza in"ektsiiami ekstrakta aloe i ikh vliianie na fosforno-kal'tsievyi obmen.
Entry Date: 19661002
Date Completed: 19661002
MeSH Date: 1966/07/01 00:01
Date Revised: 20011128
Entrez Date: 1966/07/01
Citation Subset: D, IM
Publication Status: ppublish
Stomatologiia (Mosk) 1966 Jul-Aug;45(4):13-5.
PMID: 5220965 UI: 66158238 [PubMed - indexed for MEDLINE]
From PubMed
425

Aloe-emodin glycosides of senna leaf.
Full author name: Fairbairn, J W; Shrestha, A B.

Fairbairn JW, Shrestha AB. J Pharm Pharmacol. 1966 Jul;18(7):467-70.

[Article in English]

MeSH Terms:

Substances:

ISSN: 0022-3573
NLM Unique ID: 0376363
Country: England
Entry Date: 19670804
Date Completed: 19670804
MeSH Date: 1966/07/01 00:01
Date Revised: 20011128
Entrez Date: 1966/07/01
Citation Subset: IM
Publication Status: ppublish
J Pharm Pharmacol 1966 Jul;18(7):467-70.
PMID: 4381729 UI: 67166688 [PubMed - indexed for MEDLINE]
From PubMed
426

[3. On methods of constituent determination of aloe. On photometric aloin determination by the method of B. Janiak and H. Bohmert]
Full author name: Bohme, H; Kreutzig, L.

Bohme H, Kreutzig L. Arzneimittelforschung. 1966 Feb;16(2):212-4.

[Article in German]

MeSH Terms:

Substances:

ISSN: 0004-4172
NLM Unique ID: 0372660
Country: germany, west
Vernacular Title: 3. Uber Methoden zur Wertbestimmung von Aloe. Zur photometrischen Aloin-Bestimmung nach B. Janiak und H. Bohmert.
Entry Date: 19680112
Date Completed: 19680112
MeSH Date: 1966/02/01 00:01
Date Revised: 20011128
Entrez Date: 1966/02/01
Citation Subset: IM
Publication Status: ppublish
Arzneimittelforschung 1966 Feb;16(2):212-4.
PMID: 6014017 UI: 68044038 [PubMed - indexed for MEDLINE]
From PubMed
427

[Changes in aminotransferase activity under the effect of biogenic stimulators]
Full author name: Savitskii, V I.

Savitskii VI. Ukr Biokhim Zh. 1966;38(4):392-7.

[Article in Ukrainian]

MeSH Terms:

Substances:

ISSN: 0041-610X
NLM Unique ID: 0414153
Country: ussr
Vernacular Title: Zminy aktyvnosti aminotransferaz pid vplyvom biohennykh stymuliatoriv.
Entry Date: 19680913
Date Completed: 19680913
MeSH Date: 1966/01/01 00:01
Date Revised: 20011128
Entrez Date: 1966/01/01
Citation Subset: IM
Publication Status: ppublish
Ukr Biokhim Zh 1966;38(4):392-7.
PMID: 5999372 UI: 68351822 [PubMed - indexed for MEDLINE]
From PubMed
428

[Aloe--a valuable medicinal plant]
Full author name: Nikolaev, A B.

Nikolaev AB. Feldsher Akush. 1966;31(4):51-3.

[Article in Russian]

MeSH Terms:

ISSN: 0014-9772
NLM Unique ID: 16930040R
Country: ussr
Vernacular Title: Aloe--tsennoe lekarstvennoe rastenie.
Entry Date: 19660601
Date Completed: 19660601
MeSH Date: 1966/01/01 00:01
Date Revised: 20011128
Entrez Date: 1966/01/01
Citation Subset: N
Publication Status: ppublish
Feldsher Akush 1966;31(4):51-3.
PMID: 5176350 UI: 66103382 [PubMed - indexed for MEDLINE]
From PubMed
429

[Experience with the use of an ointment containing biostimulating Aloe juice]
Full author name: Skripkin, Iu K; Sharanova, G Ia.

Skripkin IuK, Sharanova GIa. Vestn Dermatol Venerol. 1965 Jun;39(6):74-5.

[Article in Russian]

MeSH Terms:

ISSN: 0042-4609
NLM Unique ID: 0414246
Country: ussr
Vernacular Title: Opyt primeneniia krema s biostimulirovannym sokom aloe.
Entry Date: 19660418
Date Completed: 19660418
MeSH Date: 1965/06/01 00:01
Date Revised: 20011128
Entrez Date: 1965/06/01
Citation Subset: IM
Publication Status: ppublish
Vestn Dermatol Venerol 1965 Jun;39(6):74-5.
PMID: 5859158 UI: 66080957 [PubMed - indexed for MEDLINE]
From PubMed
430

[On the quantitative determination of aloin by means of paper and thin-layer chromatography. 1. On methods for the valuation of aloe]
Full author name: Bohme, H; Kreutzig, L.

Bohme H, Kreutzig L. Mitt Dtsch Pharm Ges Pharm Ges DDR. 1964 Nov;34(11):681-9.

[Article in German]

MeSH Terms:

ISSN: 0012-0561
NLM Unique ID: 0326216
Country: germany, west
Vernacular Title: Uber die quantitative Ermittlung von Aloin mittels Papier- und Dunnschichtchromatographie. 1. Uber Methoden zur Wertbestimmung von Aloe.
Entry Date: 19651120
Date Completed: 19651120
MeSH Date: 1964/11/01 00:01
Date Revised: 20011128
Entrez Date: 1964/11/01
Citation Subset: IM
Publication Status: ppublish
Mitt Dtsch Pharm Ges Pharm Ges DDR 1964 Nov;34(11):681-9.
PMID: 5896924 UI: 66004745 [PubMed - indexed for MEDLINE]
From PubMed
431

Contribution to the paper chromatographic examination of Aloe drugs. 2. Aloe.

AWE W, AUTERHOFF H, WACHSMUTHMELM CL. Arzneimitt. Forsch. 1958 Apr;8(4):243-5.

[Article in German]

Keywords:

Secondary Source ID:

Vernacular Title: Beitrage zur papierchromatographischen Untersuchung von Aloe-Dr
Entry Month: 195812
UI: 58078309
From OldMedline
432

[On the occurrence of aloin in Aloe vera in addition to comparative studies with the fresh juice of Capealoe (Aloe ferox) and the dried extract prepared from it]

AWE W, KUEMMELL HJ. Arch Pharm (Berlin) 1962 Nov;295/67:819-22.

[Article in German]

Keywords:

Entry Month: 196312
UI: 62157461
From OldMedline
433

[Comparative evaluation of the effect of emulsions from juices of Aloe arborescens and Aloe striatula in preventing radiation injuries]

MORDVINOVA NP, ROSTOTSKII BK. Med Radiol (Moskva) 1961 Nov;6:16-20.

[Article in Russian]

Keywords:

Entry Month: 196212
UI: 62077328
From OldMedline
434

Possibility of the use of thermo-analytic micro-analysis in pharmacognosy. I. Characteristic behavior of a microfragment of Aloe.

CHIARLO B. Minerva farm., Tor. 1958 Dec;7(12):230-1.

[Article in Italian]

Keywords:

Secondary Source ID:

Vernacular Title: Possibilita di impiego dei microsaggi termoanalitici in farmaco
Entry Month: 195912
UI: 59051862
From OldMedline
435

Carotenoid pigments of the flowers of Aloe saponaria Haut.

GRANGAUD R, NICOL M. C. rend. Soc. biol. 1958;152(8-9):1237-41.

[Article in French]

Keywords:

Secondary Source ID:

Vernacular Title: Sur les pigments carotenoides des fleurs d'Aloe saponaria Haut.
Entry Month: 195912
UI: 59048767
From OldMedline
436

Spirals and chromomeres in the early prophase of the miosis of Aloe eru Berger.

EBERLE P. Chromosoma, Berl. 1957;8(6):573-84.

[Article in German]

Keywords:

Secondary Source ID:

Vernacular Title: Spiralen und Chromomeren in der fruhen Prophase der Meiosis von
Entry Month: 195812
UI: 58066633
From OldMedline
437

The use of Aloe Vera in the treatment of thermal and irradiation burns in laboratory animals and humans.

ASHLEY FL, O'LOUGHLIN BJ, PETERSON R, FERNANDEZ L, STEIN H, SCHWARTZ AN. Plastic & Reconstr. Surg. 1957 Nov;20(5):383-96.

[Article in English]

Keywords:

Secondary Source ID:

Entry Month: 195812
UI: 58047893
From OldMedline
438

Quantitative determination of aloin in Aloe capensis. I. Determination by paper chromatography with planimetric evaluation of spot surfaces.

KRAUS L. Pharmazie 1957 Oct;12(10):693-5.

[Article in German]

Keywords:

Secondary Source ID:

Vernacular Title: Die quantitative Bestimmung des Aloins in Aloe capensis. I. Bes
Entry Month: 195812
UI: 58036942
From OldMedline
439

Antibacterial properties of aloes (Aloe).

MORDARSKI M. Arch. immun. ter. dosw. 1956;4:349-59.

[Article in Polish]

Keywords:

Secondary Source ID:

Vernacular Title: Antybakteryjne wllasnosci aloesow (Aloe).
Entry Month: 195812
UI: 58031455
From OldMedline
440

MICRO-DETERMINATION OF ALOIN IN SOME SOUTH AFRICAN ALOE SPECIES.

MCCARTHY TJ, PRICE CH. PHARM WEEKBL 1965 JUN 18;100:761-3.

[Article in English]

Keywords:

ISSN: 0031-6911
Journal Title Code: P2X
Country: Netherlands
Entry Month: 196511
UI: 65138067
From OldMedline
441

AN INVESTIGATION OF SOME SOUTH AFRICAN ALOE SPECIES AS POTENTIAL SOURCES OF HOMONATALOIN.

MCCARTHY TJ, PRICE CH. PHARM WEEKBL 1965 JUL 30;100:912-6.

[Article in English]

Keywords:

ISSN: 0031-6911
Journal Title Code: P2X
Country: Netherlands
Entry Month: 196511
UI: 65132542
From OldMedline
442

CHEMOTAXONOMY OF ASPHODELIODEAE (LILIACEAE) KRAUSE 1930. VI. ALOIN AND HOMONATALOIN IN ALOE SPECIES.

RHEEDEVANOUDTSHOORN MC, GERRITSMA KW. NATURWISSENSCHAFTEN 1965 APR;52:186.

[Article in English]

Keywords:

ISSN: 0028-1042
Journal Title Code: NSW
Country: Germany
Entry Month: 196509
UI: 65113101
From OldMedline
443

[STUDIES IN THE FIELD OF ANTHRAQUINONES. V. REIDIN A AND ALOE-EMODIN DIANTHRONE IN SENNAE FOLIUM]

LEMLI J, DEQUEKER R, CUVEELE J. PHARM WEEKBL 1964 MAY 29;99:589-92.

[Article in Dutch]

Keywords:

ISSN: 0031-6911
Journal Title Code: P2X
Country: Netherlands
Vernacular Title: ONDERZOEKINGEN OP HET GEBIED VAN DE ANTRACHINONDROGERIJEN. V. R
Entry Month: 196508
UI: 65101034
From OldMedline
444

[STUDIES ON THE EFFECT OF CAPE ALOE FOR IRRADIATION LEUCOPENIA]

SOEDA M, FUKIWARA M, OTOMO M. NIPPON IGAKU HOSHASEN GAKKAI ZASSHI 1964 DEC;24:1109-12.

[Article in Japanese]

Keywords:

ISSN: 0048-0428
Journal Title Code: O3G
Country: Japan
Entry Month: 196507
UI: 65082913
From OldMedline
445

CHEMETAXONOMY OF ASPHODELEAE AND ALOINEAE (LILIACEAE). IV. A CONTRIBUTION TO THE PRESENCE OF HYDROXYANTHRAQUINONES IN THE GENUS ALOE (1, 2, 3).

RHEEDEVAN OUDTSHOORN, GERRITSMA KW. PHARM WEEKBL 1964 DEC 18;99:1425-30.

[Article in English]

Keywords:

ISSN: 0031-6911
Journal Title Code: P2X
Country: Netherlands
Entry Month: 196505
UI: 65062375
From OldMedline
446

BACTERIOSTATIC PROPERTY OF ALOE VERA.

LORENZETTI LJ, SALISBURY R, BEAL JL, BALDWIN JN. J PHARM SCI 1964 OCT;53:1287.

[Article in English]

Keywords:

ISSN: 0022-3549
Journal Title Code: JO7
Country: United States
Entry Month: 196505
UI: 65057321
From OldMedline
447

[ALOE EXTRACT ELECTROPHORESIS AND KERATOPLASTY IN CATARACT FOLLOWING PHLYCTENULAR KERATITIS]

RAINCHIK VIU. OFTALMOL ZH 1964;19:447-50.

[Article in Russian]

Keywords:

ISSN: 0030-0675
Journal Title Code: OG8
Country: Ukraine
Vernacular Title: ELEKTROFOREZ 'EKSTRAKTA ALO'E I KERATOPLASTIKA PRI BEL'MAKH POS
Entry Month: 196504
UI: 65050178
From OldMedline
448

[A CASE OF OPTIC NEURITIS CAUSED BY THERMAL BURNS OF THE FACE, TRUNK AND UPPER AND LOWER EXTREMITIES]

PAVLIUCHENKO PI. OFTALMOL ZH 1964;19:153.

[Article in Russian]

Keywords:

ISSN: 0030-0675
Journal Title Code: OG8
Country: Ukraine
Vernacular Title: SLUCHA I NEVRITA ZRITEL'NYKH NERVOV V REZUL'TATE TERMICHESKOGO
Entry Month: 196411
UI: 64134592
From OldMedline
449

[TREATMENT OF SOME DISEASES OF THE ANTERIOR SECTION OF THE EYE WITH RADIOACTIVE THALLIUM-204]

DENISIUK SD. OFTALMOL ZH 1964;19:126-30.

[Article in Russian]

Keywords:

ISSN: 0030-0675
Journal Title Code: OG8
Country: Ukraine
Vernacular Title: LECHENIE RADIOAKTIVNYM TALIEM-204 NEKOTORYKH ZABOLEVANI I PERED
Entry Month: 196411
UI: 64134581
From OldMedline
450

[ALOINOSIDE B, A NEW GLYCOSIDE FROM ALOE]

HOERHAMMER L, WAGNER H, BITTNER G. Z NATURFORSCH [B] 1964 MAR;19:222-6.

[Article in German]

Keywords:

ISSN: 0044-3174
Journal Title Code: XYU
Country: germany, west
Vernacular Title: ALOINOSID B, EIN NEUES GLYKOSID AUS ALOE.
Entry Month: 196411
UI: 64132758
From OldMedline
451

HISTOLOGIC AND HISTOCHEMICAL STUDIES ON THE MECHANISM OF ACTION OF BIOSTYMIN IN THE ANIMAL BODY.

FORTAK W, KARASEK M, KOLASZY'NSKI J. ARCH IMMUNOL THER EXP (WARSZ) 1964;12:96-105.

[Article in English]

Keywords:

ISSN: 0004-069X
Journal Title Code: 79O
Country: Poland
Entry Month: 196409
UI: 64110067
From OldMedline
452

HISTOLOGIC AND HISTOCHEMICAL STUDIES ON THE INFLUENCE OF BIOSTYMIN ON REGENERATION OF HEPATIC PARENCHYMA IN WHITE RATS.

FORTAK W. ARCH IMMUNOL THER EXP (WARSZ) 1964;12:80-95.

[Article in English]

Keywords:

ISSN: 0004-069X
Journal Title Code: 79O
Country: Poland
Entry Month: 196409
UI: 64110065
From OldMedline
453

[STUDIES IN THE FIELD OF THE ANTHRAQUINONE DRUGS. V. REIDIN A AND ALOE-EMODIN DIANTHRONE IN SENNA LEAVES]

LEMLI J, DEQUEKER R, CUVEELE J. PHARM WEEKBL 1964 MAY 29;99:589-92.

[Article in Dutch]

Keywords:

ISSN: 0031-6911
Journal Title Code: P2X
Country: Netherlands
Vernacular Title: ONDERZOEKINGEN OP HET GEBIED VAN DE ANTRACHINONDROGERIJEN. V. R
Entry Month: 196409
UI: 64109403
From OldMedline
454

[CLINICAL EXPERIMENTS ON SUPPOSITORIES WITH A BASE OF ANTHRAQUINONE GLYCOSIDES FROM RHUBARB (SODIUM DERIVATIVES) AND FROM ALOE (SILVER DERIVATIVES) IN HEMORRHOIDAL DISEASE]

MILSTEIN J. CLINIQUE (PARIS) 1963 NOV;58:677-82.

[Article in French]

Keywords:

ISSN: 0009-935X
Journal Title Code: DM3
Country: France
Vernacular Title: EXP'ERIMENTATION CLINIQUE DE SUPPOSITOIRES 'A BASE DE GLUCOSIDE
Entry Month: 196405
UI: 64055938
From OldMedline
455

[ON POSTINFLUENZA CEREBRAL ANGIODYSTONIA]

SURAT VS. KLIN MED (MOSK) 1963 SEP;41:53-8.

[Article in Russian]

Keywords:

ISSN: 0023-2149
Journal Title Code: KW2
Country: Russia
Vernacular Title: O POSTGRIPPOZNO I TSEREBRAL'NO I ANGIODISTONII.
Entry Month: 196404
UI: 64048510
From OldMedline
456

[EFFECT OF BIOSTYMIN ON THE CYTOCHEMISTRY OF NERVE CELLS OF THE SYMPATHETIC SYSTEM AND ON THE ADRENAL MEDULLA OF WHITE RATS]

FORTAK W, KARASEK M, KOLASZY'NSKI J. ENDOKRYNOL POL 1963 MAR-APR;14:161-71.

[Article in Polish]

Keywords:

ISSN: 0423-104X
Journal Title Code: EHN
Country: Poland
Vernacular Title: WPLYW BIOSTYMINY NA CYTOCHEMI E KOM'OREK NERWOWYCH UKLADU WSP'O
Entry Month: 196402
UI: 64017127
From OldMedline
457

[Biostimin in the treatment of bronchial asthma]

KOKOCHA B, ROMANSKI B. Pol Tyg Lek 1962 Aug 20;17:1340-3.

[Article in Polish]

Keywords:

Entry Month: 196312
UI: 62226327
From OldMedline
458

Aloe vera gel in peptic ulcer therapy: preliminary report.

BLITZ JJ, SMITH JW, GERARD JR. J Amer Osteopath Ass 1963 Apr;62:731-5.

[Article in English]

Keywords:

Entry Month: 196312
UI: 62163443
From OldMedline
459

The quantitative conversion of barbaloin to aloe-emodin and its application to the evaluation of aloes.

FAIRBAIRN JW, SIMIC S. J Pharm Pharmacol 1963 May;15:325-8.

[Article in English]

Keywords:

Entry Month: 196312
UI: 62154467
From OldMedline
460

[Comparative studies on South African species of Aloe]

HORHAMMER L, WAGNER H, BITTNER G. Arzneimittelforschung 1963 Jul;13:537-41.

[Article in German]

Keywords:

Entry Month: 196312
UI: 62153497
From OldMedline
461

[Microanalytical determination of aloin]

GERRITSMA KW, RHEEDE VAN OUDTSHOORN MC. Pharm Weekbl 1962 Oct 12;97:765-76.

[Article in Dutch]

Keywords:

Entry Month: 196312
UI: 62152307
From OldMedline
462

[Effect of different doses of tissue preparations on the regulation of intraocular pressure in patients with glaucoma]

KASHINTSEVA LT. Oftal Zh 1962;17:93-100.

[Article in Russian]

Keywords:

Entry Month: 196212
UI: 62055545
From OldMedline
463

[A method for the quantitative determination of aloin]

JANIAK B, BOEHMERT H. Arzneimittelforschung 1962 Apr;12:431-5.

[Article in German]

Keywords:

Entry Month: 196212
UI: 62052513
From OldMedline
464

[Indications for electrophoresis with aloe extract and diathermy in the treatment of postoperative and posttraumatic complications]

CHERIKCHI LE. Oftal Zh 1962;17:87-93.

[Article in Russian]

Keywords:

Entry Month: 196212
UI: 62019998
From OldMedline
465

[Syrup of aloe with iron in the treatment of hypochromic anemia in infants]

KISLIAK NS, POZNIAK IS. Pediatriia 1961 Jul;40:41-3.

[Article in Russian]

Keywords:

Entry Month: 196112
UI: 60076210
From OldMedline
466

[Kraurosis of the vulva and its treatment with biogenic stimulators]

NUDOL'SKAIA OE. Sovet Med 1960 Dec;24:86-93.

[Article in Russian]

Keywords:

Entry Month: 196112
UI: 60049500
From OldMedline
467

[The aloes. II. Chromatographic study of the anthracene derivatives in various fresh aloes]

DURAND M, PARIS R. Ann Pharm Franc 1960 Dec;18:846-52.

[Article in French]

Keywords:

Entry Month: 196112
UI: 60044765
From OldMedline

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