Quecksilberdampf aus Amalgam


13.1.2001


The chemistry and physiological action of mercury as used in amalgam fillings 

by ES Talbot 

From OHIO STATE J DENT SCI, 2(1):1-12 (Jan. 1, 1882) 

Read before the Illinois State Dental Society, held at Rock Island, May 10,
1881 

The name Mercury was given by the ancients in honor of Mercurius, the
messenger of the gods, whose volatile character mercury is supposed to typify.
It is seldom found in the native state, but is usually combined. The most
important as well as the most abundant combination is the sulphide of mercury,
or cinnabar. It is found united with silver, forming an amalgam. The largest and
richest mines are found in California. The process of obtaining pure mercury
from the sulphide is very simple. The ore is mixed with one-half its weight of
lime, and then distilled in iron retorts. The mercury is extracted and the lime
remains in the retort. 

It is a heavy fluid metal, odorless, tasteless, of a whitish color, and when free
from other metals it does not tarnish, and its globules roll freely over white
paper without leaving a streak or losing their form. It is liquid at ordinary
temperatures. It boils at 662 degrees F., and solidifies at -40 degrees F. into a
malleable mass of octahedral crystals. It is volatile at all temperatures,
evaporation being much accelerated by the application of heat. The symbol is
Hg, atomic weight 200. Mercury combines with other elements and radicals in
two proportions. Those compounds in which the LESSER acidulous radicals
are united are termed mercurous. The higher mercuric -- thus, calomel (HgCl)
is mercurous chloride; while corrosive sublimate (HgCl2) is mercuric chloride. 

Mercury combines with chlorine, iodine, bromine, lead, oxygen, phosphorous,
sulphur, arsenic, bismuth, etc., forming compounds, some of which are used
medicinally. The metal itself, rubbed up in confection of roses, licorice or suet
until globules are not visible to the unaided eye, is used in medicine. 

Amalgams were introduced into this country as fillings for decayed teeth in
1833. Since that time unlimited discussion has arisen among the general
practitioners of medicine as well as the dentists, in regard to the practicability of
utilizing this material in dentistry. The first amalgams were composed of pure
silver and mercury, manufactured by M. Taveau. Later, Dr. Evans combined
pure tin with a small quantity of cadmium, and Dr. Townsend formed an
amalgam with four parts of silver to five parts of tin. 

Following these compositions came numerous others made from gold, silver,
platinum, and tin, until to-day we have more than a hundred varieties in the
market, varying slightly in metals and proportions, that each manufacturer may
rightly claim an original preparation. These different metals are melted in a
crucible in their proper proportions by weight, and poured into ingots. 

These are filed or cut into minute particles, ready for use. When the cavity in
the tooth is prepared, a sufficient quantity of filings is rubbed up with mercury
into a paste, the surplus mercury squeezed out, and the filling is inserted into the
tooth. 

From its first application as a filling the better class of dental practitioners
waged war against it on general principles; not alone on account of the
deleterious effects of the mercury in its composition, but because of its unsightly
appearance and demoralizing effects upon the dental profession. The manner in
which it was introduced into the country called forth the censure of all having a
regard for professional etiquette: "Two adventurers, without skill or any claim
to the title of dentist, suddenly appeared in New York and began dental
practice amid such a shower of advertisements, a profusion of display, and a
metaphorical flourish of trumpets, as caused our staid and dignified dental
ancestry to bound with surprise and indignation". [vide History of American
Dentistry] 

From that time onward the use of amalgam has increased, until now tons are
consumed yearly in filling teeth. Dr. Harris, in his opening address to the first
class of the Baltimore College of Dental Surgery, in 1840, says: "It is one of the
most objectionable articles for filling teeth that can be employed, and yet from
the wonderful virtues ascribed to this pernicious compound by those who used
it, thousands were induced to try its efficacy". 

At the meetings of the dental societies this subject was spiritedly discussed with
strong arguments against its use. The first official act in the matter was the
appointment in 1841 of a committee by the American Society of Dental
Surgeons to report on the use of lithodeon -- mineral paste, and all other
substances of which mercury is an ingredient, for stopping teeth. They reported
in substance that the use of all such articles was hurtful to the teeth and every
part of the mouth, and that there was no tooth in which caries in it could be
arrested and the organ rendered serviceable by being filled, in which gold could
not be employed. This report was unanimously adopted. [vide American
Journal of Dental Science] 

At a meeting of the same society July 20, 1843, the use of amalgams was
declared to be malpractice, and a committee appointed to further investigate
the subject. They referred the matter to the Medical Society of the county of
Onondaga, New York. The report of the medical committee was to the effect
that no care in the combination or the use of the paste will prevent its
occasional bad effects. 

In 1845, the Mississippi Valley Association of Dental Surgeons resolved that
the use of Amalgam fillings was unprofessional and injurious, and would not be
countenanced by its members. Theca tions of the various societies had very
little effect; amalgam forced its way into the offices of the majority of dentists in
the country. Many excellent practitioners were expelled, and others resigned
from the societies to which they belonged. 

In 1850, a resolution was passed unanimously by the American Society of
dental Surgeons to rescind the pledge made by the same society previously.
Thus ended the so-called amalgam war. It will be observed that no scientific
researches were made to ascertain whether deleterious effects were produced
by mercury; the chief object of the disturbance was, apparently, to rid the
profession of charlatans and their obnoxious materials. 

These discussions, which have caused so much bitterness and enmity among
the members of societies, have latterly aroused a feeling of enquiry into the
scientific analysis of this filling for teeth, resulting in the discovery of a quality in
its composition ccapable of producing salivation, and all other symptoms of
poisoning. Many able practitioners of dentistry have experimented with all the
different acids with no satisfactory results. When we consider that nitric acid
dissolves mercury at 60 degrees F.; concentrated sulphuric acid dissolves
mercury only when heated; hydro-chloric acid does not affect it at all -- how
can we expect the weaker acids of the mouth, diluted by saliva, to cause a
chemical change? 

If past experiments have proved unsatisfactory, it does not discourage me in
the attempt to discover, if possible, by experiment and by the careful study of
the subject of mercury in its every particular, some clue to this perplexing
question. Having satisfied myself that the poisonous effects are not produced
by the chemical changes in the mouth, I have entirely ignored this theory, and
have looked about for a more simple and direct cause. In commenting upon
mercurial poisoning, the idea has been advanced that the vaporization of
mercury takes place only during the hardening process, and, that being
consummated so quickly, no deleterious effects can occur. 

In the construction of an amalgam two changes take place, the first being the
mechanical, or mixing together of the ingredients, the second the chemical, or
hardening of the composition. My first experiment was to place metallic
mercury in a four ounce glass-stoppered bottle, and submit it to the gold test,
by suspending a piece of gold foil in the centre of the bottle, taking care that it
did not come in contact with the sides, and cementing the stopper. I placed it
under different temperatures, of from 20 to 130 degrees F. In about thirty-six
hours the surface of the gold became coated with mercury, giving it a gray
color. This proved the evaporation of the metal. 

I then mixed a quantity of the Chicago Refining Co.'s amalgam, according to
their formula, three parts of mercury to eight parts of filings, and subjected it to
the same test. The reagent was not sufficiently delicate to produce any
perceptible change. Wishing to bring the highest chemical skill to bear upon the
experiments, I consulted Prof. Haines, of Rush Medical College, who kindly
assisted me. At his suggestion, I procured two delicate reagents, the
ammonio-nitrate of silver, and the chloride of platinum. In preparing the
ammonio-nitrate of silver, I allowed thirty grains of nitrate of silver to the ounce
of water, and put a small quantity of the solution in the test tube. This was
heated, and aqua ammonia added until a precipitate formed. Increasing the
aqua ammonia until the precipitate cleared up, I took a quill and, with this
liquid, wrote upon white paper. After putting the substance to be tested in the
bottle, the strip of paper was placed across the mouth of the bottle, and the
stopper cemented. 

Should a vapor arise, the liquid would become black. Leaving the bottle for ten
minutes, I examined it again, and found the writing in plain black coloring. The
chloride of platinum produced the same results, but required more time to
accomplish it. The rapidity with which the evaporation of mercury takes place
depends upon the amount of heat and the surface exposed, and not upon the
quantity of mercury contained in the fillings. 

Thus a jar containing one quart of water would evaporate the same quantity as
a jar of like surface containing a gallon, the latter taking four times longer to
empty. 

In the following experiments, I attached a thermometer to a water bath, and
heated to the temperature of the body, 98 degrees to 100 degrees F., to
maintain an even temperature. I conducted these experiments in the dark, as
the rays of light decompose the ammonio-nitrate of silver. The strips of paper
containing the reagent were placed in the mouths of all the bottles, including an
empty bottle, which was used in each experiment, to prove there was no
mistake. 

Experiment No. 2 -- Three bottles were prepared. In the first was placed an
amalgam filling made from Chicago Refining Company's amalgam, according to
their formula. In the second was placed an amalgam filling of like size,
containing five grains more of mercury. In the third bottle there was nothing.
After a lapse of ten minutes I examined the bottles and found the writing on the
paper across the mouth of bottles Nos. 1 and 2 was black, while there was no
discoloration of paper in the third bottle. 

Experiment No. 3 -- A repetition of No. 2, with the exception of the reagent
chloride of platinum being substituted for the ammonio-nitrate of silver. The
results were the same in both. The time required for the latter being ten hours,
while but ten minutes were required for the ammonio-nitrate of silver. In
conducting the remainder of the experiments the ammonio-nitrate of silver was
employed, it being the more delicate reagent, consequently producing a more
marked impression, and also consuming less time than chloride of platinum. 

Experiment No. 4 -- Two bottles were prepared. In the first bottle were
placed scraps of amalgam six months old. In the second there was nothing. In
ten minutes the writing on the paper was black in the first bottle, and uncolored
in the second. 

Experiment No. 5 -- Bottle No. 1 contained amalgam fillings which had
remained in the teeth from two to ten years. Bottle No. 2 was empty. The
results in both being the same as in Experiment No. 4. 

Experiment No. 6 -- In bottle No. 1 I put an amalgam filling which had been in
the mouth sixteen years. In bottle No. 2 there was nothing. At the end of
twenty-four hours I found the paper discolored in the first, and not in the
second. 

Experiment No. 7 -- To demonstrate that nothing in the composition of the
fresh filings could cause the discoloration I allowed some filings to remain
sealed in the bottle for twenty-four hours. At the end of that time discovered no
signs of color on the paper. 

Experiment No. 8 -- I procured four preparations of mercurious vivus. 

No. 1 contained 1/10 gr. mercury to 1 gr. of sugar of milk. 

No. 2 " 1/100 " " " " 

No. 3 " 1/1000 gr. " " " " 

No. 4 " 1/1000000 " " " " 

A small quantity of each of these preparations was placed in bottles marked 1,
2, 3, 4. In No. 5 there was nothing save the reagent. The effect was alike in
each of the four bottles containing the mixture. Those having the greatest
quantity of mercury caused the deepest color to the paper and required less
time. As before, No. 5 was unaffected. 

In order to determine the difference, if any, in weight after evaporation, I
obtained strong glasstubes one-half inch in length, and one-fourth inch in
diameter, and packed them carefully with amalgam fillings. Allowing
twenty-four hours for hardening, I weighed them, and at the end of three
months I again weighed them, finding in some no change at all, and in others an
increase in weight. This is accounted for by the fact that oxydation and
accumulation of moisture on the amalgam equaled in some and exceeded in
others the loss of weight by evaporation. 

I am in possession of numberless cases of poisoning from mercury in amalgam
fillings. I will mention but one, and report one case from my practice. 

The Dental Register, January, 1872, has the following case of poisoning from
mercury in a tooth filling: "John T. Smith died from salivation, caused from
having a tooth filled with amalgam. Dr. Sprague attended the case, and
afterwards called Drs. Davis and Buffin, all of whom agreed that he was
suffering from the effects of mercury present in the amalgam used in filling one
of his teeth. The filling had salivated the unfortunate man, and, as the inside of
his mouth, throat, and windpipe swelled, respiration was hindered, and finally
ceased altogether. 

Dr. Davis made the post-mortem examination in the presence of the coroner
and jury of inquest, opening the chest, taking out the lungs, and extracting the
filled tooth. No signs of diseases were found, except that caused by the
mercury, and it was made clear to the jury by the Doctor that this caused his
death. The jury returned a verdict that the deceased came to his death by
suffocation, caused by inflammation of the glands and infiltration of the tissues
of the neck, producing closing of the traechea by pressure thereon; 'and we
further believe that the above causes were brought about by the action of
mercury, used in filling the second 

A case in practice: A lady from one of the towns in Illinois came to Chicago for
treatment, having been troubled with dyspepsia and nervous debility for two
years. While under the physician's care she complained constantly of a peculiar
feeling and taste in her mouth. The doctor suspected the trouble might arise
from a rubber plate which she had worn for four years, and advised her to
consult me. Upon examination, I found a full upper plate, composed of rubber,
and on the lower jaw the molars were gone, except the second and third upon
the left side. In the crown of the wisdom tooth was a large amalgam filling, and
also one in the crown and posterior approximal surface extending to the free
margin of the gum in the second molar. 

These had been inserted about two years previous. I noticed that the gums and
the mucous lining of the mouth and salivary glands were quite tender. There
was a strong metallic taste in the mouth, and a metallic odor to the breath. She
had a peculiar paralyzed sensation in the left side of the tongue, which she had
experienced for two years. She also informed me that the saliva flowed so
freely that at night her clothing and pillow were saturated, and estimated the
loss of saliva each night to equal one pint. I suggested the removal of the
amalgam fillings and rubber plate, and substitution of gold. She assented to the
proposition, and as early as possible I undertook the operations. 

Upon removing the amalgam fillings and applying the rubber dam, the saliva
flowed in streams, completely saturating several towels. After refilling the teeth,
and inserting a gold plate, the unpleasant sensation in the tongue and metallic
taste disappeared. At the end of two weeks the glands were greatly improved,
and the soreness under the tongue (of which she had complained at her first
visit) was healed. 

It is the accepted opinion of physicians generally, that mercury uncombined has
no constitutional effect. Dr. Atkinson said before the meeting of the American
Dental Association in Boston, August, 1880: "You must combine the molecules
of mercury with some other agent before they can have any affinity for the body
at all. One who is familiar with the old method of making looking-glasses, with
tin foil and mercury, knows that the workman would be literally saturated with
it, so that he could not be capable of handling a gold or silver watch without its
becoming amalgamated, and all this, too, without his health being compromised
by the mercury so long as it remains in a metallic state". 

The correctness of this theory may be questioned, as it has been proven that
these workmen have been affected by the vapor of mercury, when not
protected by a veil over the mouth and nose. 

Dr. Bartholow, in his work on Therapeutics, p. 177, says: "As used in the
mechanical arts, by gilders and others, the fumes of mercury cause wasting,
ptyalism, necrosis of bones, trembling, impaired intellect, and, in women,
abortion". "Walter Pope mentions a workman who for six months had not
handled mercury; yet he rendered a piece of copper as white as silver by
rubbing it between his fingers". Parish says that long trituration of calomel
increases its power to salivate. This is also applicable to all preparations of
mercury used with an excipient, medicinally. 

The homeopaths divide and subdivide particles, according to the required
preparations, some of the radical members of the school claiming best results
from the highest potencies, while the more conservative practitioners prefer a
middle ground. They rub up pure mercury with sugar of milk into six different
grades, the first containing one-tenth gr. of mercury to one gr. sugar of milk; the
second, one one-hundredth gr. of mercury to one gr. sugar of milk, etc., as
before mentioned in this paper. These are the finest forms in which mercury is
prescribed, and yet the severest cases of salivation and constitutional symptoms
have been produced by these agents, on account of their being so readily taken
up by the blood. 

Is it not a reasonable supposition that, if poisonous symptoms are produced in
proportion with the subdivision of the particles of mercury, that the system will
be more severely affected by the vapor of mercury, which is finer than any
mechanical subdivision can be? Dr. Somers recalls an instance of a lady patient
becoming completely salivated, the gums and mucous lining of the mouth
inflamed and teeth loosened, by taking a second bath, in which forty grains of
the black oxide of mercury were used. He thinks she could not have absorbed
one-twentieth of the amount in the form of vapor. 

As a forcible illustration, I quote the experience of the sailors on board the
man-of-war "Triumph", which, in April, 1810, took from the wreck of a
Spanish ship thirty tons of quicksilver, contained in bags of fifty pounds each. 

In the course of a fortnight some of the bags decayed and burst, the
quick-silver mixing with the bilge water, the emanations from which coated all
the metal about the ship. Nearly all of the crew were salivated. 

In order to ascertain the effect of the vapor of mercury, I have employed it in a
series of experiments upon plants and animals. 

Experiment No. 1 -- While conducting my experiments in the laboratory I was
frequently visited by a family of roaches, who appeared to take an interest in
my operations. Suddenly they all disappeared, and it immediately suggested
itself to my mind that their sudden departure argued favorably in the question of
utilizing them in my experiments. I took four two-ounce bottles and put in No.
1 pure mercury; No. 2, amalgam scraps six months old; No. 3, fillings from
two to ten years old; No. 4, fillings sixteen years old. After placing a roach in
each bottle, I tied a piece of cloth over the mouth in order that the air might
circulate. Evidently the bugs were not fond of mercury, for they clung to the
tops of the bottles as long as life lasted. Roach in No. 1, containing pure
mercury, died in three days; roach in No. 2 was next to follow; roach in No. 3
lived a few days longer; and in No. 4 outlived them all by several days. 

Experiment No. 2 -- I prepared three bottles. The No. 1 contained ten grains
of pure mercury; No. 2 contained an amalgam filling three months old; No. 3
was an empty bottle. In each of the bottles I put two roaches. In two days one
in the bottle containing pure mercury died; the remaining one in the same bottle
lived nine days from the time it was put in. In the bottle containing the amalgam
filling one roach died in four days, while the other one died in eleven days;
while those in the empty bottle lived fifteen and sixteen days. 

Experiment No. 3 -- On February 9th I placed an amalgam filling at the base of
a sensitive plant. On examination, about the fourth day, I discovered that the
extremities of the leaves had changed color and were dry and brittle, like the
leaves in early Autumn; gradually the whole leaf was affected, and at the end of
ten days the plant was dead, notwithstanding the care and nourishment it
received. 

Experiment No. 4 -- In a four-quart glass jar I put about four ounces of
mercury, and made a platform of wire gauze, fastening it two inches from the
bottom of the jar. I placed a Guinea pig in the jar, and covered the top with
gauze. Twice each day I removed him for exercise and nourishment. He thrived
well for ten days, but at the end of that time he commenced to droop, and
refused food and water. He became emaciated and trembling; the body and
limbs were cold. He lingered along for two weeks and died. 

Experiment No. 5 -- I administered six grains of mercurius vivus, first
trituration, to a dog with his supper, and repeated the dose next morning with
his breakfast. The blood and liver were examined under the microscope in the
evening and found to contain globules of mercury. 

It is the opinion of many eminent scientists that mercury inhaled into the lungs
produces a greater effect than when taken into the stomach. Among this
number Prof. Stille in his Therapeutics, Vol. 2, page 789, says: "Of the several
modes by which mercury is made to enter the body, inhalation most speedily
produces the specific influence of the medicine". Claude Bernard, late
Professor in "Le College de France", makes the statement in one of his
lectures. This is readily understood when we consider that the drug taken into
the lungs in the form of vapor is distributed over a large surface and brought in
direct contact with oxygenated blood, and thus carried to all parts of the body. 

Mercury taken into the system in small quantities, long continued, manifests
itself in a variety of ways. One of the first symptoms noticeable is an increased
flow of the secretions of the body -- salivation being the most striking -- the
glands becoming inflamed and the mucous membrane tender. The gums tumefy
and change in color to a dark rose tint; the tongue is swollen; the patient not
only experiences an unpleasant metallic taste, but the breath becomes
impregnated also. Sometimes extensive ulcers attack the throat, gums and
cheeks; oedema of the glottis, with difficulty in breathing and swallowing. 

The digestive apparatus is involved, with loss of appetite, nausea and vomiting,
and frequently pain and tenderness of the stomach; the bowels loose, and often
bloody stools. The fatty constituents are removed, and the patient becomes
emaciated; no part of the body is more affected by mercury than the nervous
system; the body trembles; sometimes one limb, and again both limbs contract.
A sense of coldness and occasional chills are experienced; often neuralgic pains
are felt, particularly around the motor nerves; mental debility and loss of
memory. These are some of the many symptoms caused by the inhalation of the
vapor of mercury. 

RESUME 

There are in the market many varieties of amalgams. Evaporation does not
depend upon quality or age, but all amalgams will send off the vapor of
mercury. This has been proved conclusively by its destruction of animal and
vegetable life, and by chemical tests. Evaporation is facilitated by an increase of
surface, consequently a greater amount of vapor would arise from several small
fillings than from one large filling. 

The facility with which mercury is taken into the lungs by continued inhalations
and the rapidity with which it enters the blood, requires less mercury to
produce systemic effects than when taken into the stomach. In order to
produce systemic effects from metallic mercury, it must be rubbed up with an
excipient,to reduce the particles to a size capable of entering the capillary
system, or it must be taken into the lungs in the form of vapor. 

 


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