Copyright © 2001
Aribert Deckers
and
Copyright © 2001
Antares Real-Estate

Todesrate 1:50

2.7.2001

Mit einer nicht zu überbietenden Dreistigkeit behaupten Kriminelle immer und immer wieder in WWW-Foren und auf Veranstaltungen und auf zum Teil in hoher Auflage gedruckten Flugblättern, Impfen sei nicht nötig, Impfen sei schädlich - und überhaupt, zum Beispiel, es seien ja (Zitat aus einem WWW-Forum):

Tatsache ist: FSME (Frühsommer-Meningitis/Encephalitis) hat bei Ungeimpften eine grauenhafte Todesrate: zwischen 1:100 bis herunter zu 1:50.

Das heißt: Fast jeder 50. Ungeimpfte stirbt an den Folgen der FSME-Infektion!

Tatsache ist: Von den Überlebenden hat die Hälfte lebenslang bleibende Schäden.

Und dennoch gibt es Kriminelle, die behaupten, es gäbe in Europa kein einziges ungeimpftes Kind mit Spätfolgen einer FSME...

Die Menschen, die den Kriminellen glauben und sich an deren Weisungen halten, gefährden sich und vor allem das Leben ihrer Kinder. Das Erschreckende: den Tätern geschieht nichts!

Sie hinterlassen Kranke, vielleicht sogar Leichen. Doch niemand macht ihnen den Prozess. Die deutsche Justiz dreht Däumchen und die deutsche Politik beschäftigt sich lieber mit so weltbewegenden Dingen wie dem "Ehrenamt in der Schule".

So läuft das Gesindel, das Leichen hinterläßt, weiterhin frei herum...

Tun Sie etwas dagegen!

- - -

Eine Suche in der Web-Site der "U.S. National Library of Medicine" liefert fast 3000 Fundstellen zum Suchbegriff "tick-borne encephalitis".

Die Suchergebnisse (aus Platzgründen nur als ZIP-Files):

LYMETBE1.ZIP 354.78 KBytes : #    1 - #  500 * Auszug zu TBE aus PubMed, Stand 29.6.2001 
LYMETBE2.ZIP 279.88 KBytes : #  501 - # 1000 * Auszug zu TBE aus PubMed, Stand 29.6.2001  
LYMETBE3.ZIP 242.19 KBytes : # 1001 - # 1500 * Auszug zu TBE aus PubMed, Stand 29.6.2001
LYMETBE4.ZIP 190.27 KBytes : # 1501 - # 2000 * Auszug zu TBE aus PubMed, Stand 29.6.2001  
LYMETBE5.ZIP 118.55 KBytes : # 2001 - # 2500 * Auszug zu TBE aus PubMed, Stand 29.6.2001  
LYMETBE6.ZIP  55.95 KBytes : # 2500 - # 2895 * Auszug zu TBE aus PubMed, Stand 29.6.2001

Bitte beachten Sie, daß FSME bzw "Frühsommer-Meningitis/Encephalitis" deutsche Ausdrücke sind. Auf Englisch heißt es "TBE" = "tick-borne-encephalitis". Mit dem Suchbegriff "FSME" haben Sie in internationalen Suchmaschinen fast keinerlei Erfolg!

Zu "tick-borne encephalitis death" findet die Suchmaschine 45 Fundstellen, die ich im Anhang aufliste.

Leider gibt es zur Zeit keinen geeigneten Impfstoff für Kleinkinder und Säuglinge. Deshalb müssen Sie besondere Vorsichtsregeln beachten:

Über das Impfen im allgemeinen und im speziellen können Sie sich hier informieren:

http://www.aap.org/new/idphotos.htm
http://www.immunize.org
http://www.cdc.gov/nip/publications/6mishome.htm

Mehr über Statistik bei Krankheiten und bei Medikamenten erfahren Sie hier: Über den Sumpf

Aribert Deckers


Journal Citations:

Item 1 displayed (out of 45 found).

Cost-benefit ratio of tick-borne encephalitis vaccination of French troops based in Kosovo
[Cost-benefit ratio of tick-borne encephalitis vaccination of French troops based in Kosovo]

Desjeux G,  Lemardeley P,  Colin C,  Pascal B,  Labarere J.

Rev Epidemiol Sante Publique. 2001 Jun;49(3):249-257.

[Article in English]


Hopital d'Instruction des Armees Desgenettes. Service de Medecine des Collectivites, BP 25, 69998 Lyon-Armees.

Background: French military troops based in Kosovo are exposed to Tick-Borne Encephalitis (TBE) biorisk. An efficacious vaccine is available to prevent this disease, burdened by high morbidity and mortality. The epidemiologic features of TBE in Kosovo are unprecise. To help the French Department of Defense to make a decision about immunization against TBE, we performed a cost-benefit analysis. Methods: By a Bayes'analysis decision, we have estimated the net benefits for a three-injection vaccine program versus absence of vaccination, for all French military troops based in Kosovo. Time expectancy was 4 years. Through the review of several medical reports, we have estimated the useful parameters for this study: morbidity incidence rate, mortality rate, sequelae rate, efficacy vaccine and side effects. We have chosen as initial hypothesis a sero-conversion rate of 1,080 per 100,000 men-by-year. Human life was valorized in francs, by calculating the allowance paid by Department of Defense to the family in case of death or for sequelae. Results: Net benefits arised to 2.17 millions of francs. The vaccine program cost was 25.0 millions of francs. 140 cases of encephalitis viruses were saved by vaccination. Nevertheless a sensibility analysis has shown that results are well reliable with TBE incidence rate. Conclusion: The break even point being close to the incidence rate of the initial assumption, the decision to vaccine all French military troops depends at the same time on a better knowledge of the incidence of the disease in Kosovo, but also of the number of potentially avoided cases of tick-borne encephalitis and of the programs of vaccination concerning this disease of the other countries forming the United Nations Organization forces.

ISSN: 0398-7620
Journal Title Code: RST
Vernacular Title: Etude cout-benefice de la vaccination contre l'encephalite a tique chez les militaires francais au Kosovo.
Entry Date: 20010627
MeSH Date: 2001/06/28 10:00
Entrez Date: 2001/06/28 10:00
http://www.e2med.com/display_pdf.asp?Journal=resp&Volume=49&Issue=3&Page=249&Population=
Publication Status: ppublish
Rev Epidemiol Sante Publique 2001 Jun;49(3):249-257.
PMID: 11427828 UI: 0 [PubMed - as supplied by publisher]
From PubMed

Item 2 displayed (out of 45 found).

Distribution and characterization of tick-borne encephalitis viruses from Siberia and far-eastern Asia.

Hayasaka D,  Ivanov L,  Leonova GN,  Goto A,  Yoshii K,  Mizutani T,  Kariwa H,  Takashima I.

J Gen Virol. 2001 Jun;82(Pt 6):1319-28.

[Article in English]


Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

In this study, tick-borne encephalitis (TBE) viruses from Siberia and far-eastern Asia were characterized in order to determine virus subtype distribution. TBE viruses were isolated from ticks (Ixodes persulcatus) collected in the far-eastern (Khabarovsk and Vladivostok) and Siberian (Irkutsk) regions of Russia in 1999. Phylogenetic analysis showed that isolates formed distinct clusters of far-eastern and Siberian subtypes. There was also a minor difference in antigenicity between the Irkutsk isolates and other TBE virus strains, as demonstrated by the reactivity of monoclonal antibodies. Amino acid alignments of the E gene showed that the Irkutsk isolates had a single amino acid change at position 234 (Q or H); this amino acid position is considered to be a 'signature' of Siberian subtype TBE viruses. Strains isolated in Irkutsk also exhibited equivalent or somewhat higher virulence in mice compared with far-eastern TBE virus isolates. All viruses isolated in this study (i.e. far-east Asian and Siberian isolates) have 3' non-coding regions (NCRs) of almost the same length, which contrasts with the various sizes of 3'NCRs of other TBE viruses strains reported previously. The data presented in this study show that the 3'NCR is uniform among TBE viruses isolated from Siberia and far-eastern Asia and that the 3'NCR is essential for TBE virus growth in tick and/or rodent host cells.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 0022-1317
Journal Title Code: I9B
NLM Unique ID: 0077340
Country: England
Entry Date: 20010522
Date Completed: 20010628
MeSH Date: 2001/06/29 10:01
Entrez Date: 2001/05/23 10:00
Citation Subset: IM
http://vir.sgmjournals.org/cgi/pmidlookup?view=full&pmid=11369875
Full text URL: http://vir.sgmjournals.org/cgi/content/full/82/6/1319
Publication Status: ppublish
J Gen Virol 2001 Jun;82(Pt 6):1319-28.
PMID: 11369875 UI: 21262215 [PubMed - indexed for MEDLINE]
From PubMed

Item 3 displayed (out of 45 found).

Infectious cDNA clone of attenuated Langat tick-borne flavivirus (strain E5) and a 3' deletion mutant constructed from it exhibit decreased neuroinvasiveness in immunodeficient mice.

Pletnev AG.

Virology. 2001 Apr 10;282(2):288-300.

[Article in English]


Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA. apletnev@niaid.nih.gov

Forty-five years ago a naturally attenuated tick-borne flavivirus, Langat (LGT) strain TP21, was recovered from ticks in Malaysia. Subsequently, it was tested as a live attenuated vaccine for virulent tick-borne encephalitis viruses. In a large clinical trial its attenuation was confirmed but there was evidence of a low level of residual virulence. Thirty-five years ago further attenuation of LGT TP21 was achieved by multiple passages in eggs to yield mutant E5. To study the genetic determinants of the further attenuation exhibited by E5 and to allow us to manipulate the genome of this virus for the purpose of developing a satisfactory live attenuated tick-borne flavivirus vaccine, we recovered infectious E5 virus from a full-length cDNA clone. The recombinant E5 virus (clone 651) recovered from a full-length infectious cDNA clone was more attenuated in immunodeficient mice than that of its biologically derived E5 parent. Increase in attenuation was associated with three amino acid substitutions, two located in the structural protein E and one in nonstructural protein NS4B. Subsequently an even greater degree of attenuation was achieved by creating a viable 320 nucleotide deletion in the 3'-noncoding region of infectious full-length E5 cDNA. This deletion mutant was not cytopathic in simian Vero cells and it replicated to lower titer than its E5-651 parent. In addition, the E5 3' deletion mutant was less neuroinvasive in SCID mice than its E5-651 parent. Significantly, the deletion mutant proved to be 119,750 times less neuroinvasive in SCID mice than its progenitor, LGT strain TP21. Despite its high level of attenuation, the E5 3' deletion mutant remained highly immunogenic and intraperitoneal (ip) inoculation of 10 PFU induced complete protection in Swiss mice against subsequent challenge with 2000 ip LD50 of the wild-type LGT TP21.

MeSH Terms:

Substances:

ISSN: 0042-6822
Journal Title Code: XEA
NLM Unique ID: 0110674
Country: United States
Entry Date: 20010406
Date Completed: 20010510
MeSH Date: 2001/05/22 10:01
Entrez Date: 2001/04/06 10:00
Citation Subset: IM
http://www.idealibrary.com/links/citation/0042-6822/282/288
Publication Status: ppublish
Virology 2001 Apr 10;282(2):288-300.
PMID: 11289811 UI: 21186343 [PubMed - indexed for MEDLINE]
From PubMed

Item 4 displayed (out of 45 found).

Trends in flavivirus infections in Japan.

Kurane I,  Takasaki T,  Yamada K.

Emerg Infect Dis. 2000 Nov-Dec;6(6):569-71.

[Article in English]


National Institute of Infectious Diseases, Tokyo, Japan.

Although Japanese encephalitis has declined as an important cause of illness and death in Japan, infection with other flaviviruses has become a public health concern. Recently, reports of imported dengue cases, as well as isolations of tick-borne encephalitis virus, have increased.

MeSH Terms:

ISSN: 1080-6040
Journal Title Code: COD
NLM Unique ID: 9508155
Country: United States
Entry Date: 20010103
Date Completed: 20010103
MeSH Date: 2001/02/28 10:01
Entrez Date: 2000/11/15 11:00
Citation Subset: IM
http://www.cdc.gov/ncidod/eid/vol6no6/kurata.htm
Full text URL: http://www.cdc.gov/ncidod/eid/vol6no6/kurata.htm
Publication Status: ppublish
Emerg Infect Dis 2000 Nov-Dec;6(6):569-71.
PMID: 11076713 UI: 20530921 [PubMed - indexed for MEDLINE]
From PubMed

Item 5 displayed (out of 45 found).

[Tick-borne meningoencephalitis in Thurgau Canton: a clinical and epidiomological analysis].
[Tick-borne meningoencephalitis in Thurgau Canton: a clinical and epidiomological analysis]

Schwanda M,  Oertli S,  Frauchiger B,  Krause M.

Schweiz Med Wochenschr. 2000 Oct 14;130(41):1447-55.

[Article in German]


Medizinische Klinik, Kantonsspital Munsterlingen.

BACKGROUND: Tick-borne meningo-encephalitis (TBE) is caused by a flavivirus species that is transmitted from rodents to humans by Ixodes ticks. The clinical picture of central nervous system involvement varies from febrile headache to lethal encephalitis. To date no specific treatment exists, although protective active immunisation is available. METHODS: We present the clinical and epidemiological data from 73 patients with TBE who acquired the infection in Canton Thurgau in the years 1996-1999. RESULTS: Canton Thurgau is a state in eastern Switzerland with a population of 230,000. Within the last five years the reported cases of TBE have increased more than threefold. The area where infectious tick bites were registered has expanded from the western to the eastern part and now encompasses the entire state. The risk of infection is clearly related to frequent activities in wooded areas, though outdoor activities not in forests also carry a considerable risk. In > 80% of the cases a postviral neurasthenic syndrome develops involving absence from work for two months on average. In the elderly and patients who present with encephalitic symptoms, a worse outcome with persistent neurological symptoms or even death has been observed. CONCLUSION: The increasing incidence of TBE, the expansion of infectious ticks to the east and high morbidity justify active immunisation against TBE on a broad scale in Canton Thurgau.

MeSH Terms:

ISSN: 0036-7672
Journal Title Code: UEI
NLM Unique ID: 0404401
Country: Switzerland
Vernacular Title: Die Fruhsommer-Meningoenzephalitis im Kanton Thurgau: eine klinisch-epidemiologische Analyse.
Entry Date: 20001121
Date Completed: 20001207
MeSH Date: 2001/02/28 10:01
Entrez Date: 2000/11/15 11:00
Citation Subset: IM
Publication Status: ppublish
Schweiz Med Wochenschr 2000 Oct 14;130(41):1447-55.
PMID: 11075408 UI: 20526544 [PubMed - indexed for MEDLINE]
From PubMed

Item 6 displayed (out of 45 found).

[Epidemiology and progress of early summer meningoencephalitis in Baden-Wurttemberg between 1994 and 1999. A prospective study of 731 patients].
[Epidemiology and progress of early summer meningoencephalitis in Baden-Wurttemberg between 1994 and 1999. A prospective study of 731 patients]

Kaiser R.

Dtsch Med Wochenschr. 2000 Sep 29;125(39):1147-53.

[Article in German]


Neurologische Klinik und Poliklinik, Universitat Freiburg.

BACKGROUND AND OBJECTIVE: Tick-borne encephalitis (TBE) may develop into a serious disease leading to invalidism in a considerable proportion of patients. Detailed clinical and epidemiological data about the risks of TBE in Baden-Wurttemberg have been missing. A prospective study was started in 1994 to investigate the areas of risk in this part of Germany and to describe the clinical course and prognosis of TBE. PATIENTS AND METHODS: Doctors at all departments of Internal Medicine, Neurology and Paediatrics, at diagnostic laboratories and the departments of public health were asked to participate in this study. Data were recorded by means of a questionnaire. RESULTS: Between 1994 and 1999, 771 patients with TBE were recorded. Detailed clinical and epidemiological data were available for 731 patients. In 88% of the patients infection took place during leisure time activity, two thirds of infections occurring between June and August. The median incubation period was 8 days with a range of 4-28 days. 71% of the patients reported a prodromal stage with flu-like symptoms. TBE manifested as isolated meningitis in 47%, as meningoencephalitis in 42% and as meningoencephalomyelitis in 11%. With increasing age the number with a serious course of disease also increased. The most frequent symptoms were impairment of consciousness, ataxia and pareses of the limbs. In the children, the course of disease and prognosis was much better than in adults. Of 230 patients who were re-examined between 1 and 5 years after the acute illness 23% suffered from persisting moderate or severe symptoms. The death rate was about 1.4%. CONCLUSION: In Baden-Wurttemberg, tick bites are associated with a high risk of tick-borne encephalitis and severe neurological complications. Therefore, active immunization is recommended for all persons exposing themselves to ticks. Persisting complications after TBE are by far more common than serious complications after active immunization.

MeSH Terms:

ISSN: 0012-0472
Journal Title Code: ECL
NLM Unique ID: 0006723
Country: Germany
Vernacular Title: Epidemiologie und Verlauf der Fruhsommer-Meningoenzephalitis in Baden-Wurttemberg zwischen 1994 und 1999. Eine prospektive Studie an 731 Patienten.
Entry Date: 20001114
Date Completed: 20001121
MeSH Date: 2001/02/28 10:01
Entrez Date: 2000/11/15 11:00
Citation Subset: IM
Publication Status: ppublish
Dtsch Med Wochenschr 2000 Sep 29;125(39):1147-53.
PMID: 11075241 UI: 20526377 [PubMed - indexed for MEDLINE]
From PubMed

Item 7 displayed (out of 45 found).

[The situation of tick-borne encephalitis morbidity in the Maritime Territory].
[The situation of tick-borne encephalitis morbidity in the Maritime Territory]

Borisova ON,  Gorkovenko LE.

Med Parazitol (Mosk). 2000 Jul-Sep;(3):18-21.

[Article in Russian]

No Abstract Available.

MeSH Terms:

ISSN: 0025-8326
Journal Title Code: M72
NLM Unique ID: 0376635
Country: Russia
Vernacular Title: Situatsiia po zabolevaemosti kleshchevym entsefalitom v Primorskom krae.
Entry Date: 20001027
Date Completed: 20001027
MeSH Date: 2001/02/28 10:01
Entrez Date: 2000/09/12 11:00
Citation Subset: IM
Publication Status: ppublish
Med Parazitol (Mosk) 2000 Jul-Sep;(3):18-21.
PMID: 10981406 UI: 20436713 [PubMed - indexed for MEDLINE]
From PubMed

Item 8 displayed (out of 45 found).

[7 questions about early summer meningoencephalitis. When is there a risk for residual damage]?
[7 questions about early summer meningoencephalitis. When is there a risk for residual damage?]

Brandner M.

MMW Fortschr Med. 2000 Jul 27;142(30):14.

[Article in German]

No Abstract Available.

Universitatsklinikum Essen, Institut fur Virologie.

Publication Types:

MeSH Terms:

ISSN: 1438-3276
Journal Title Code: DHP
NLM Unique ID: 100893959
Country: Germany
Vernacular Title: Sieben Fragen zur FSME. Wann drohen Restschaden?
Entry Date: 20001107
Date Completed: 20001107
MeSH Date: 2001/02/28 10:01
Entrez Date: 2000/08/24 11:00
Citation Subset: IM
Publication Status: ppublish
MMW Fortschr Med 2000 Jul 27;142(30):14.
PMID: 10955013 UI: 20411777 [PubMed - indexed for MEDLINE]
From PubMed

Item 9 displayed (out of 45 found).

Poliomyelitic-like illness in central European encephalitis.

Schellinger PD,  Schmutzhard E,  Fiebach JB,  Pfausler B,  Maier H,  Schwab S.

Neurology. 2000 Jul 25;55(2):299-302.

[Article in English]


Department of Neurology, University of Heidelberg, Germany. Peter_Schellinger@med.uni-heidelberg.de

Central European encephalitis (CEE) may be accompanied by myeloradiculitic symptoms in up to 5% of patients. The authors report six patients with a myelitic form of CEE mimicking acute poliomyelitis with bulbar and arm predominance and a poor prognosis. Three patients died. Of the survivors, only one can perform most activities of daily living, but still needs assisted ventilation at night. Autopsy in one patient showed severe cervicothoracic inflammation with changes almost exclusively in anterior horn cells and roots, as typically seen in poliomyelitis.

MeSH Terms:

ISSN: 0028-3878
Journal Title Code: NZ0
NLM Unique ID: 0401060
Country: United States
Entry Date: 20000815
Date Completed: 20000815
MeSH Date: 2000/08/19 11:00
Date Revised: 20001218
Entrez Date: 2000/07/26 11:00
Citation Subset: AIM,  IM
http://www.neurology.org/cgi/pmidlookup?view=full&pmid=10908911
Publication Status: ppublish
Neurology 2000 Jul 25;55(2):299-302.
PMID: 10908911 UI: 20371025 [PubMed - indexed for MEDLINE]
From PubMed

Item 10 displayed (out of 45 found).

Tick-borne encephalitis.

Dumpis U,  Crook D,  Oksi J.

Clin Infect Dis. 1999 Apr;28(4):882-90.

Comment in: 


[Article in English]


Nuffield Department of Medicine, University of Oxford, United Kingdom.

Tick-borne encephalitis (TBE) is a zoonotic arbovirus infection endemic to Russia and Eastern and Central Europe. Despite being a common and serious life-threatening disease for which a mass vaccination program was implemented in Austria, there is only limited reference to this disease in the English-language literature. TBE is transmitted to humans usually by the bite of a tick (either Ixodes persulcatus or Ixodes ricinus); occasionally, cases occur following consumption of infected unpasteurized milk. Transmission is seasonal and occurs in spring and summer, particularly in rural areas favored by the vector. TBE is a serious cause of acute central nervous system disease, which may result in death or long-term neurological sequelae. Effective vaccines are available in a few countries. The risk for travelers of acquiring TBE is increasing with the recent rise in tourism to areas of endemicity during spring and summer.

Publication Types:

MeSH Terms:

Number of References: 98
ISSN: 1058-4838
Journal Title Code: A4J
NLM Unique ID: 9203213
Country: United States
Entry Date: 20000623
Date Completed: 20000623
MeSH Date: 2000/07/06 11:00
Date Revised: 20001218
Entrez Date: 2000/05/29 09:00
Citation Subset: IM
Publication Status: ppublish
Clin Infect Dis 1999 Apr;28(4):882-90.
PMID: 10825054 UI: 20283201 [PubMed - indexed for MEDLINE]
From PubMed

Item 11 displayed (out of 45 found).

Morphological features of cell death in various types of acute tick-borne encephalitis.

Kamalov NI,  Novozhilova AP,  Kreichman GS,  Sokolova ED.

Neurosci Behav Physiol. 1999 Jul-Aug;29(4):449-53.

[Article in English]

No Abstract Available.

Electron Microscopy and Histochemistry Laboratory, Military Medical Academy, St. Petersburg.

MeSH Terms:

ISSN: 0097-0549
Journal Title Code: NZO
NLM Unique ID: 0330471
Country: United States
Entry Date: 20000111
Date Completed: 20000111
MeSH Date: 1999/12/03 09:00
Date Revised: 20001218
Entrez Date: 1999/12/03 09:00
Citation Subset: IM
Publication Status: ppublish
Neurosci Behav Physiol 1999 Jul-Aug;29(4):449-53.
PMID: 10582230 UI: 20048943 [PubMed - indexed for MEDLINE]
From PubMed

Item 12 displayed (out of 45 found).

[The morphological characteristics of cell death in different forms of acute tick-borne encephalitis].
[The morphological characteristics of cell death in different forms of acute tick-borne encephalitis]

Kamalov NI,  Novozhilova AP,  Kreichman GS,  Sokolova ED.

Morfologiia. 1998;114(4):54-8.

[Article in Russian]


Laboratory of Electron Microscopy and Histochemistry, Military Medical Academy, St. Petersburg.

The study was aimed to identify different types of cell death in monkey brain in flavivirus experimental encephalitis. 10 brain areas most vulnerable ("indicator") of the disease in its different forms (symptomless, intermediate and severe) were examined in animals infected intracerebrally with viruses of tick-borne encephalitis. Cells of ectodermal and mesenchymal origin displayed apoptosis that was most pronounced in intermediate form of the severity of the disease. Apoptosis was not characteristic for the symptomless form of tick-borne encephalitis. Two types of apoptosis morphological manifestations in nerve cells were described.

MeSH Terms:

ISSN: 1026-3543
Journal Title Code: BW7
NLM Unique ID: 9317610
Country: Russia
Vernacular Title: Morfologicheskie osobennosti kletochnoi gibeli pri razlichnykh formakh ostrogo kleshchevogo entsefalita.
Entry Date: 19981230
Date Completed: 19981230
MeSH Date: 1998/11/25 03:02
Date Revised: 20001218
Entrez Date: 1998/11/25 03:02
Citation Subset: IM
Publication Status: ppublish
Morfologiia 1998;114(4):54-8.
PMID: 9826821 UI: 99044057 [PubMed - indexed for MEDLINE]
From PubMed

Item 13 displayed (out of 45 found).

[Apoptosis as a mechanism for the cytopathic action of tick-borne encephalitis virus].
[Apoptosis as a mechanism for the cytopathic action of tick-borne encephalitis virus]

Isaeva MP,  Leonova GN,  Kozhemiako VB,  Borisevich VG,  Maistrovskaia OS,  Rasskazov VA.

Vopr Virusol. 1998 Jul-Aug;43(4):182-6.

[Article in Russian]


The ability of tick-borne encephalitis (TBE) virus to cause programmed cell death (apoptosis) in viral infection of newborn mice and of two cell cultures is studied. The time course of virus antigen accumulation detected by enzyme immunoassay and of endonuclease fragmentation of nuclear DNA detected by agarose gel electrophoresis is compared. All three TBE strains differing by the source of isolation and biological characteristics can cause oligonucleosomal fragmentation of DNA of brain cells of two-day white mice and of SPEV cells in acute infection. In VERO-E6 cells the same three strains caused a latent infection; accumulation of virus antigen was not associated with endonuclease fragmentation of DNA or any other signs of cytopathic destruction. These data indicate that TBE virus can cause programmed cell death both in vitro and in vivo, which is apparently one mechanism of the cytopathic effect of the virus.

MeSH Terms:

Substances:

ISSN: 0507-4088
Journal Title Code: XL8
NLM Unique ID: 0417337
Country: Russia
Vernacular Title: Apoptoz kak mehanizm tsitopaticheskogo deistviia virusa kleshchevogo entsefalita.
Entry Date: 19981221
Date Completed: 19981221
MeSH Date: 1998/10/29 03:03
Date Revised: 20001218
Entrez Date: 1998/10/29 03:03
Citation Subset: IM
Publication Status: ppublish
Vopr Virusol 1998 Jul-Aug;43(4):182-6.
PMID: 9791885 UI: 99008097 [PubMed - indexed for MEDLINE]
From PubMed

Item 14 displayed (out of 45 found).

Human ehrlichioses: newly recognized infections transmitted by ticks.

Dumler JS,  Bakken JS.

Annu Rev Med. 1998;49:201-13.

[Article in English]


Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

Human ehrlichioses are tick-borne infections caused by bacteria in the genus Ehrlichia. Human monocytic ehrlichiosis is caused by Ehrlichia chaffeensis and human granulocytic ehrlichiosis is caused by an agent similar to Ehrlichia equi. E. chaffeensis infects mononuclear phagocytes and is transmitted by Lone Star ticks (Amblyomma americanum) found in the south central and eastern United States. The agent of human granulocytic ehrlichiosis infects mostly neutrophils, it transmitted by Ixodes species ticks, and occurs mostly in the upper midwest and northeast United States. Despite the undifferentiated presentation of both ehrlichioses with fever, headache, myalgias, leukopenia, thrombocytopenia, and elevated liver enzyme activities, the diagnostic methods are distinct. Occasional severe complications include meningoencephalitis, adult respiratory distress syndrome, shock, and opportunistic infections. Immunocompromised patients are at high risk for death. An adverse outcome is associated with delayed diagnosis and therapy; thus, empirical treatment is advocated. Treatment with doxycycline usually results in prompt defervescence and cure.

Publication Types:

MeSH Terms:

Substances:

Number of References: 56
ISSN: 0066-4219
Journal Title Code: 6DR
NLM Unique ID: 2985151R
Country: United States
Entry Date: 19980430
Date Completed: 19980430
MeSH Date: 1998/03/24 03:01
Date Revised: 20001218
Entrez Date: 1998/03/24 03:01
Citation Subset: IM
http://med.annualreviews.org/cgi/pmidlookup?view=full&pmid=9509259
Publication Status: ppublish
Annu Rev Med 1998;49:201-13.
PMID: 9509259 UI: 98169997 [PubMed - indexed for MEDLINE]
From PubMed

Item 15 displayed (out of 45 found).

Expression of a biologically active antiviral antibody using a sindbis virus vector system.

Liang XH,  Jiang HH,  Levine B.

Mol Immunol. 1997 Aug-Sep;34(12-13):907-17.

[Article in English]


Department of Medicine, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

Monoclonal antibodies to the Sindbis virus E2 envelope glycoprotein protect mice against lethal encephalitis and mediate viral clearance from neurons. To facilitate structure-function analyses of anti-E2 mAbs, we developed an expression system that can be used for the construction of genetically engineered anti-E2 mAbs. We constructed recombinant Sindbis/immunoglobulin gene chimeric viruses that express heavy and light chains of an anti-E2 monoclonal antibody, R6. We used a PCR-based strategy to clone the entire rearranged heavy and light chain genes from R6 hybridoma cell cDNA into a double subgenomic Sindbis virus vector. The recombinant viruses, SIN/R6L and SIN/R6H, were generated by transfecting BHK-21 cells with in vitro transcribed RNA from Sindbis virus/R6 light chain and Sindbis virus/R6 heavy chain cDNA clones, respectively. Twelve hours after co-infection of BHK cells with SIN/R6L and SIN/R6H, the tissue culture supernatant contained up to 1.4 mg/ml of recombinant R6 IgG. The heavy and light chains of recombinant R6 were associated as judged by co-purification on protein A/G sepharose and co-electrophoresis of non-reduced proteins. The ELISA reactivity to Sindbis virus antigen was similar for recombinant R6 and R6 purified from ascites fluid. Furthermore, the in vivo biologic activity of recombinant R6 was similar to that of R6 purified from ascites; recombinant R6 treatment completely protected Balb/cJ mice from paralysis and death due to infection with neuroadapted Sindbis virus and also resulted in the clearance of infectious virus from the brains of immunodeficient scid mice persistently infected with wild-type Sindbis virus. Thus, the co-infection of BHK cells with SIN/R6L and SIN/R6H leads to the expression, assembly, and secretion of a biologically active recombinant antiviral antibody. Our results suggest that the Sindbis virus vector system is a simple and powerful tool for the production of functional, genetically engineered antibodies.

MeSH Terms:

Substances:

Grant Support:

ISSN: 0161-5890
Journal Title Code: NG1
NLM Unique ID: 7905289
Country: England
Entry Date: 19980306
Date Completed: 19980306
MeSH Date: 1998/02/17 08:06
Date Revised: 20001218
Entrez Date: 1998/02/17 08:06
Citation Subset: IM
Publication Status: ppublish
Mol Immunol 1997 Aug-Sep;34(12-13):907-17.
PMID: 9464526 UI: 98124173 [PubMed - indexed for MEDLINE]
From PubMed

Item 16 displayed (out of 45 found).

[The clinico-epidemiological characteristics of tick-borne encephalitis in Perm Province].
[The clinico-epidemiological characteristics of tick-borne encephalitis in Perm Province]

Ustinova OI,  Volechova GM,  Deviatkov MI,  Gusmanova AI.

Zh Mikrobiol Epidemiol Immunobiol. 1997 May-Jun;(3):33-6.

[Article in Russian]


The epidemiological features and clinical manifestations of tick-borne encephalitis on the territory of Perm Province in 1953-1993 are characterized. In spite of antiepidemic measures a high morbidity level is preserved at the focus of infection with the prevalence of clinical forms accompanied by brain lesions and a tendency to the growth of mortality.

MeSH Terms:

ISSN: 0372-9311
Journal Title Code: Y9O
NLM Unique ID: 0415217
Country: Russia
Vernacular Title: Kliniko-epidemiologicheskie osobennosti kleshchevogo entsefalita v Permskoi oblasti.
Entry Date: 19970925
Date Completed: 19970925
MeSH Date: 1997/09/26
Date Revised: 20001218
Entrez Date: 1997/09/26
Citation Subset: IM
Publication Status: ppublish
Zh Mikrobiol Epidemiol Immunobiol 1997 May-Jun;(3):33-6.
PMID: 9304324 UI: 97398014 [PubMed - indexed for MEDLINE]
From PubMed

Item 17 displayed (out of 45 found).

[Effect of low-intensity radiation on the course of experimental tick-borne encephalitis].
[Effect of low-intensity radiation on the course of experimental tick-borne encephalitis]

Leonova GN,  Maistrovskaia OS,  Krylova NV.

Vopr Virusol. 1997 May-Jun;42(3):129-33.

[Article in Russian]


Effects of low-intensive laser exposure in the 630 to 890 nm waveband on the course of experimental tick-borne encephalitis were studied in vitro and in vivo. Virus-static effect of the exposure was revealed: titers of the exposed virus dropped, infective activity decreased, and interferon production was inhibited. The exposure had no apparent effect on the virus which penetrated into the cells. In addition to its manifest prophylactic effect, low-intensive laser exposure is capable of activating the infectious process during the acute period of tick-borne encephalitis by causing more frequent and sooner death of animals. Effects of interferon inducers during the acute period of viral infections are discussed.

MeSH Terms:

Substances:

ISSN: 0507-4088
Journal Title Code: XL8
NLM Unique ID: 0417337
Country: Russia
Vernacular Title: Vliianie nizkointensivnykh izluchenii na techenie eksperimental'nogo kleshchevogo entsefalita.
Entry Date: 19970915
Date Completed: 19970915
MeSH Date: 1997/09/20
Date Revised: 20001218
Entrez Date: 1997/09/20
Citation Subset: IM
Publication Status: ppublish
Vopr Virusol 1997 May-Jun;42(3):129-33.
PMID: 9297344 UI: 97342080 [PubMed - indexed for MEDLINE]
From PubMed

Item 18 displayed (out of 45 found).

Isolation of a flavivirus related to the tick-borne encephalitis complex from human cases in Saudi Arabia.

Zaki AM.

Trans R Soc Trop Med Hyg. 1997 Mar-Apr;91(2):179-81.

[Article in English]


Dr Suliman Fakeeh Hospital, Jeddah, Saudi Arabia.

A flavivirus related to the tick-borne encephalitis complex was isolated from the blood of 6 male butchers, aged 24-39 years, in Jeddah, Saudi Arabia in November and December 1995. Two of the patients died and the other 4 recovered completely. Four more patients, 3 males and 1 female, were diagnosed serologically by immunoglobulin M capture enzyme-linked immunosorbent assay and seroconversion in acute and convalescent blood samples examined by indirect immunofluorescent test using Vero cells infected with the isolated virus. The virus identity was confirmed at the Centers for Disease Control and Prevention, Fort Collins, Colorado, USA, by the polymerase chain reaction; it was closely related to Kayasanur Forest disease virus. All infected patients had similar clinical and laboratory symptoms and signs, including fever, headache, generalized body aches, arthralgia, anorexia, vomiting, leucopenia, thrombocytopenia, elevated liver enzymes (serum glutamic oxalacetic and serum glutamic pyruvic transaminases), elevated creatinine phosphokinase, and elevated blood urea. One patient developed symptoms of encephalitis, but survived without any sequel. Skin rash developed in 2 patients, morbilliform on the hands, feet, and lower abdomen of one patient and purpuric associated with melaena in the second patient. Eight of the 10 confirmed patients were working with sheep, and the disease may be a zoonotic viral infection.

MeSH Terms:

ISSN: 0035-9203
Journal Title Code: WBU
NLM Unique ID: 7506129
Country: England
Entry Date: 19970710
Date Completed: 19970710
MeSH Date: 1997/03/01
Date Revised: 20001218
Entrez Date: 1997/03/01
Citation Subset: IM
Publication Status: ppublish
Trans R Soc Trop Med Hyg 1997 Mar-Apr;91(2):179-81.
PMID: 9196762 UI: 97340263 [PubMed - indexed for MEDLINE]
From PubMed

Item 19 displayed (out of 45 found).

[Pseudotumorous form of chronic tick-borne encephalitis].
[Pseudotumorous form of chronic tick-borne encephalitis]

Meierova RA.

Klin Med (Mosk). 1997;75(6):31-4.

[Article in Russian]

No Abstract Available.

Irkutsk City Clinic Hospital.

MeSH Terms:

Substances:

ISSN: 0023-2149
Journal Title Code: KW2
NLM Unique ID: 2985204R
Country: Russia
Vernacular Title: O psevdotumoroznoi forme khronicheskogo kleshchevogo entsefalita.
Entry Date: 19970827
Date Completed: 19970827
MeSH Date: 1997/01/01
Date Revised: 20001218
Entrez Date: 1997/01/01
Citation Subset: IM
Publication Status: ppublish
Klin Med (Mosk) 1997;75(6):31-4.
PMID: 9273396 UI: 97388022 [PubMed - indexed for MEDLINE]
From PubMed

Item 20 displayed (out of 45 found).

Tick-borne encephalitis: possibly a fatal disease in its acute stage. PCR amplification of TBE RNA from postmortem brain tissue.

Tomazic J,  Poljak M,  Popovic P,  Maticic M,  Beovic B,  Avsic-Zupanc T,  Lotric S,  Jereb M,  Pikelj F,  Gale N.

Infection. 1997 Jan-Feb;25(1):41-3.

[Article in English]


Dept. of Infectious Diseases, University Medical Centre Ljubljana, Slovenia.

Tick-borne encephalitis has occurred regularly in Europe since it was first diagnosed in 1931 by Schneider. The mortality rate of patients with this disease is 1-2%. Death usually occurs in the acute stage of illness. A case report of a 28-year-old patient from Slovenia, who died shortly after the onset of tick-borne encephalitis, is described. The clinical course of disease, results of serological tests, neuropathological findings and polymerase chain reaction amplification of parts of viral genome from postmortem brain tissues are presented.

MeSH Terms:

Substances:

ISSN: 0300-8126
Journal Title Code: GO8
NLM Unique ID: 0365307
Country: Germany
Entry Date: 19970708
Date Completed: 19970708
MeSH Date: 1997/01/01
Date Revised: 20001218
Entrez Date: 1997/01/01
Citation Subset: IM
Publication Status: ppublish
Infection 1997 Jan-Feb;25(1):41-3.
PMID: 9039538 UI: 97191592 [PubMed - indexed for MEDLINE]
From PubMed

Item 21 displayed (out of 45 found).

[Development of early-summer meningoencephalitis (FSME) in the Thurgau region 1990-1995--a new endemic area?]

Baumberger P,  Krech T,  Frauchiger B.

Schweiz Med Wochenschr. 1996 Nov 30;126(48):2072-7.

[Article in German]


Medizinische Klinik, Kantonsspital, Frauenfeld.

Tick-borne encephalitis (TBE) is a viral infection transmitted by bites of infected ticks. The clinical course is mostly mild, but death occurs in 1-2% of TBE infections and nearly half of patients with meningitis/meningoencephalitis show residual disease, above all chronic headache. TBE-infected ticks occur only in endemic areas. A knowledge of the endemic areas is very important for immunoprophylaxis of TBE. In recent years between 26 and 97 cases of TBE have occurred in Switzerland. The largest endemic areas are in Canton Schaffhausen, the northern part of Canton Zurich and the north-west of Canton Thurgau. Another endemic area is known in the region of Thun in Canton Berne. Another possible endemic area is known in the Zurich Oberland around Elgg, only 7 km from Aadorf in Thurgau. Up to now, Diessenhofen in the north-west of Thurgau was the only known possible endemic area. In 1994 and 1995 we observed an accumulation of TBE infections in western Thurgau. The question was whether there are other endemic areas in Thurgau. In this retrospective analysis we studied the TBE cases in Thurgau between 1990 and 1995 with data derived from the cantonal health authorities reports. Clinical data were taken from case histories of the two cantonal hospitals in Frauenfeld and Munsterlingen, completed by data from family doctors and patients. Between 1990 and 1995 30 TBE infections (1990; 1, 1991: 4, 1992: 3, 1993: 1, 1994: 4 certain, 3 uncertain, 1995: 14) were observed. TBE infections appeared between May and October (maximum in May). 14 patients remembered a bite by a tick several weeks before onset of the illness. 7 bites occurred in the area of Frauenfeld/Aadorf. Only one bite occurred in Diessenhofen. 2 patients were infected in well-known endemic areas in Canton Zurich, a vicinal region in the west of Thurgau. In 1995 the incidence of TBE in Thurgau was 5.4/100000 population. In 9 of the 14 patients recalling a bite by a tick (64.4%), the bites occurred near their domicile. No bite was seen east of a line between Steckborn and Weinfelden. The incidence of TBE in Thurgau in 1995 was clearly higher than the average in Switzerland in recent years (0.46/100000), and higher than in the well-known endemic areas in the vicinity (Schaffhausen 3.95, Zurich 1.31). Based on our data, the region Frauenfeld/Aadorf must be declared a new endemic area for TBE. Probably the well-known endemic area in the Zurich Oberland in the vicinity of Elgg has spread eastward. Persons who are often in the forests of this region should be advised to be vaccinated.

MeSH Terms:

ISSN: 0036-7672
Journal Title Code: UEI
NLM Unique ID: 0404401
Country: Switzerland
Vernacular Title: Entwicklung der Fruhsommer-Meningoenzephalitis (FSME) in der Region Thurgau 1990-1995--ein neues Endemiegebiet?
Entry Date: 19970116
Date Completed: 19970116
MeSH Date: 1996/11/30
Date Revised: 20001218
Entrez Date: 1996/11/30
Citation Subset: IM
Publication Status: ppublish
Schweiz Med Wochenschr 1996 Nov 30;126(48):2072-7.
PMID: 8992627 UI: 97121939 [PubMed - indexed for MEDLINE]
From PubMed

Item 22 displayed (out of 45 found).

MRI abnormalities in tick-borne encephalitis.

Lorenzl S,  Pfister HW,  Padovan C,  Yousry T.

Lancet. 1996 Mar 9;347(9002):698-9.

[Article in English]


Publication Types:

MeSH Terms:

ISSN: 0140-6736
Journal Title Code: L0S
NLM Unique ID: 2985213R
Country: England
Entry Date: 19960417
Date Completed: 19960417
MeSH Date: 1996/03/09
Date Revised: 20001218
Entrez Date: 1996/03/09
Citation Subset: AIM,  IM
Publication Status: ppublish
Lancet 1996 Mar 9;347(9002):698-9.
PMID: 8596421 UI: 96175942 [PubMed - indexed for MEDLINE]
From PubMed

Item 23 displayed (out of 45 found).

[Ultrastructural pathology of the lymph nodes in tick-borne encephalitis]

Erman BA,  Tulakina LG,  Konev VP,  Poleshchuk TI.

Arkh Patol. 1996 Mar-Apr;58(2):37-41.

[Article in Russian]


Lymph nodes of humans and experimental animals with tick-borne encephalitis (TBE) were studied using electron microscopy. TBE virus reproduction occurred in macrophages, reticular and plasma cells. Severe organelle destruction was found in the above cells and lymphocytes. The results suggest that macrophage, reticular and plasmatic cell death is due to the virus reproduction, while lymphocyte death is due to the toxic effect. It is evident that the outcome is determined by pathological process in lymphoid organs.

MeSH Terms:

ISSN: 0004-1955
Journal Title Code: 8OE
NLM Unique ID: 0370604
Country: Russia
Vernacular Title: Ul'trastrukturnaia patologiia limfaticheskikh uzlov pri kleshchevom entsefalite.
Entry Date: 19960911
Date Completed: 19960911
MeSH Date: 1996/03/01
Date Revised: 20001218
Entrez Date: 1996/03/01
Citation Subset: IM
Publication Status: ppublish
Arkh Patol 1996 Mar-Apr;58(2):37-41.
PMID: 8712939 UI: 96284683 [PubMed - indexed for MEDLINE]
From PubMed

Item 24 displayed (out of 45 found).

Arboviral disease--United States, 1994.

[No authors listed].

MMWR Morb Mortal Wkly Rep. 1995 Sep 8;44(35):641-4.

[Article in English]


Arboviruses are mosquitoborne and tickborne agents that persist in nature in complex cycles involving birds and mammals, including humans. Characteristics of arboviral infection include fever, headache, encephalitis, and sometimes death. In 1994, health departments in 20 states reported 100 presumptive or confirmed human cases of arboviral disease to CDC. Of these, 76 were California (CAL) serogroup encephalitis; 20, St. Louis encephalitis (SLE); two, western equine encephalomyelitis (WEE); one, eastern equine encephalomyelitis (EEE); and one, Powassan encephalitis (POW). This report summarizes information about arboviral disease in the United States during 1994.

MeSH Terms:

ISSN: 0149-2195
Journal Title Code: NE8
NLM Unique ID: 7802429
Country: United States
Entry Date: 19950921
Date Completed: 19950921
MeSH Date: 1995/09/08
Date Revised: 20001218
Entrez Date: 1995/09/08
Citation Subset: IM
Publication Status: ppublish
MMWR Morb Mortal Wkly Rep 1995 Sep 8;44(35):641-4.
PMID: 7643850 UI: 95371599 [PubMed - indexed for MEDLINE]
From PubMed

Item 25 displayed (out of 45 found).

[The reaction of taiga ticks to an attractant. 1. The experimental contact of nymphs with attractant-acaricidal granules]

Naumov RL,  Vitlin LM.

Med Parazitol (Mosk). 1995 Jul-Sep;(3):49-50.

[Article in Russian]


Four experimental variants used the following: 1) granules only from a filler (control); 2) those from a filler and an attractant; 3) and 4) those from a filler, an attractant, and a toxicant (permethrin or lambda cigalothrin, respectively). Each experiment used 20 nymphs of the first laboratory generation. 90 and 25% were in contact with attractive and control granules, respectively. Out of the nymphs in experiments 3 and 4 granules, 94 and 100% died. The contacts of 4 sec or more duration led to death. The experimental findings suggest that the designing and application of attractive acaricidal granules in the foci of tick-borne encephalitis and Lyme's disease are promising.

MeSH Terms:

Substances:

ISSN: 0025-8326
Journal Title Code: M72
NLM Unique ID: 0376635
Country: Russia
Vernacular Title: Reaktsiia taezhnykh kleshchei na attraktant. Soobshchenie 1. Kontakt nimf s attraktivno-akaritsidnymi granulami v eksperimente.
Entry Date: 19951208
Date Completed: 19951208
MeSH Date: 1995/07/01
Date Revised: 20001218
Entrez Date: 1995/07/01
Citation Subset: IM
Publication Status: ppublish
Med Parazitol (Mosk) 1995 Jul-Sep;(3):49-50.
PMID: 7476685 UI: 96010933 [PubMed - indexed for MEDLINE]
From PubMed

Item 26 displayed (out of 45 found).

Change in phenotype of tick-borne encephalitis virus following passage in Ixodes ricinus ticks and associated amino acid substitution in the envelope protein.

Labuda M,  Jiang WR,  Kaluzova M,  Kozuch O,  Nuttall PA,  Weismann P,  Eleckova E,  Zuffova E,  Gould EA.

Virus Res. 1994 Mar;31(3):305-15.

[Article in English]


Institute of Virology, Slovak Academy of Sciences, Bratislava.

Serial passage of an uncloned tick-borne encephalitis virus (strain 4387 isolated from the liver and lungs of a bank vole) in Ixodes ricinus ticks, was accompanied by gradual reduction in virulence of the virus, as indicated by transmission of virus by infected ticks feeding on laboratory mice. After the 7th serial passage in ticks (strain 4387/7), 95% of mice survived the bite of infected ticks. The surviving infected mice showed either no or only low viraemia although virus could be isolated from the brains of some mice 14 and 30 days after commencement of tick feeding, implying that the tick passaged virus might have established a persistent infection in the mice. Tests for haemagglutinating capacity were positive with TBE strain 4387 but strain 4387/7 exhibited no haemagglutinating activity over a wide pH range, suggesting that phenotypic changes, resulting from selection, had affected the site on the viral envelope protein that binds red blood cell receptors. Sequencing of the envelope protein gene of the virulent TBE strain 4387 showed 3 amino acid codon differences from western European TBE virus strain Neudorfl, which is also virulent for mice. The attenuated virus 4387/7, had an amino acid substitution that was different from 4387 and Neudorfl TBE virus (amino acid 84, E to K) and a second substitution different from 4387 but identical to Neudorfl virus (amino acid 319, I to T). Thus, the phenotypic change from virulence to attenuation was associated with a single amino acid codon change in the viral envelope gene of TBE virus. It is recognised, however, that amino acid substitutions in other parts of the viral genome have not been ruled out.

MeSH Terms:

Substances:

Secondary Source ID:

ISSN: 0168-1702
Journal Title Code: X98
NLM Unique ID: 8410979
Country: Netherlands
Entry Date: 19940621
Date Completed: 19940621
MeSH Date: 1994/03/01
Date Revised: 20001218
Entrez Date: 1994/03/01
Citation Subset: IM
Publication Status: ppublish
Virus Res 1994 Mar;31(3):305-15.
PMID: 8191785 UI: 94249282 [PubMed - indexed for MEDLINE]
From PubMed

Item 27 displayed (out of 45 found).

[The clinical picture and pathogenesis of polyradiculoneuropathy in tick-borne encephalitis]

Dekonenko EP,  Umanskii KG,  Frolova MP,  Skudra MP.

Zh Nevropatol Psikhiatr Im S S Korsakova. 1994;94(4):27-30.

[Article in Russian]


Based on examination of tick-borne encephalitis patients with ascending polyradiculoneuropathy the authors describe the character of the disease, its clinical picture and the results of laboratory studies, etc. Differential diagnosis is made between the indicated syndrome associated with tick-borne encephalitis and sporadic polyradiculoneuropathies. A detailed description is given for the first time of the clinical and pathomorphological picture of that gravest form of tick-borne encephalitis. As regards the character of the clinical and pathomorphological alterations, the ascending polyradiculoneuropathy associated with tick-borne encephalitis is meningoencephalomyelitis with the radicular syndrome which often determines the disease gravity and prognosis.

MeSH Terms:

ISSN: 0044-4588
Journal Title Code: Y9Y
NLM Unique ID: 8710066
Country: Russia
Vernacular Title: Klinika i patogenez poliradikulonevropatii pri kleshchevom entsefalite.
Entry Date: 19950310
Date Completed: 19950310
MeSH Date: 1994/01/01
Date Revised: 20001218
Entrez Date: 1994/01/01
Citation Subset: IM
Publication Status: ppublish
Zh Nevropatol Psikhiatr Im S S Korsakova 1994;94(4):27-30.
PMID: 7856370 UI: 95159731 [PubMed - indexed for MEDLINE]
From PubMed

Item 28 displayed (out of 45 found).

[Tick-borne encephalitis in Alsace]

Collard M,  Gut JP,  Christmann D,  Hirsch E,  Nastorg G,  Sellal F,  Haller X.

Rev Neurol (Paris). 1993;149(3):198-201.

[Article in French]


Clinique Neurologique, CHU Strasbourg.

Central European tick-borne encephalitis is mainly found in Central European countries and Austria where hundreds of cases are reported each year. Apart from 2 cases diagnosed in Alsace in 1968 and 1970 respectively, this disease was hitherto unknown in France. We report 8 new cases observed in Alsace between 1985 and 1990. Clinical presentation in these 10 patients was a pure meningitis syndrome in 4 cases and meningo-encephalitis in 6 cases, very severe in 3 of them. All patients recovered rapidly, and only 3 have slight sequelae. In a seroprevalence survey conducted in 1989 among 619 professional foresters of Eastern France, 8% were found to be seropositive, which suggests that the disease is often unrecognized. A study of the large series published in Austria and in other Central European countries has shown that the prognosis of tick-borne encephalitis is not always as favourable as it was in the Alsatian cases: severe sequelae or death occur in 1 to 2% of the patients. The need for a better detection of the disease and for vaccination of the subjects at risk must be emphasized.

MeSH Terms:

ISSN: 0035-3787
Journal Title Code: SU9
NLM Unique ID: 2984779R
Country: France
Vernacular Title: L'encephalite a tiques en Alsace.
Entry Date: 19931206
Date Completed: 19931206
MeSH Date: 1993/01/01
Date Revised: 20001218
Entrez Date: 1993/01/01
Citation Subset: IM
Publication Status: ppublish
Rev Neurol (Paris) 1993;149(3):198-201.
PMID: 8235212 UI: 94053235 [PubMed - indexed for MEDLINE]
From PubMed

Item 29 displayed (out of 45 found).

Infection of Macaca radiata with viruses of the tick-borne encephalitis group.

Kenyon RH,  Rippy MK,  McKee KT Jr,  Zack PM,  Peters CJ.

Microb Pathog. 1992 Nov;13(5):399-409.

[Article in English]


Disease Assessment Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702-5011.

Our studies confirmed the susceptibility of Macaca radiata (bonnet macaques) to Kyasanur Forest disease (KFD) and enabled us to demonstrate KFD virus-specific gastrointestinal and lymphoid lesions. Significant histopathological changes occurred in the small and large intestine, spleen and lymph nodes; and viral antigens were found in these same organs by immunohistochemistry. Viral antigen-positive cells were always associated with histological evidence of necrosis, which suggests that cell death occurred directly from viral replication or secondarily from attack by immune mechanisms. In contrast, M. radiata infected with Omsk virus did not show any signs of clinical disease, and no virus could be isolated from tissues or blood at the end of the experiment. However, M. radiata infected with Russian spring-summer encephalitis (RSSE) developed clinical signs in the central nervous system; and, in one monkey, RSSE virus was isolated from the brain, and viral antigen was localized in neurons. Our data indicate that M. radiata is an excellent model to study human disease caused by KFD virus and could serve as a model for human disease caused by other, related strains of this group of viruses.

MeSH Terms:

Substances:

ISSN: 0882-4010
Journal Title Code: MIC
NLM Unique ID: 8606191
Country: England
Entry Date: 19930505
Date Completed: 19930505
MeSH Date: 2001/03/28 10:01
Date Revised: 20010323
Entrez Date: 1992/11/01
Citation Subset: IM
Publication Status: ppublish
Microb Pathog 1992 Nov;13(5):399-409.
PMID: 1297916 UI: 93218542 [PubMed - indexed for MEDLINE]
From PubMed

Item 30 displayed (out of 45 found).

Dual infection of Ixodes ricinus ticks with two viruses of the tick-borne encephalitis complex.

Weismann P,  Labuda M,  Kozuch O.

Acta Virol. 1990 Aug;34(4):353-7.

[Article in English]


Institute of Virology, Slovak Academy of Sciences, Bratislava, Czechoslavakia.

Ixodes ricinus female ticks were inoculated with Skalica (SK) virus (non-pathogenic for adult albino mice by subcutaneous route) and 14 days later they were challenged with strain 198 of Tick-borne Encephalitis (TBE) virus (highly pathogenic for adult albino mice by subcutaneous route). After additional 14 days of incubation, 42.9 to 65.0% of the adult (10-12 g) albino mice infested with these double infected ticks developed antibodies to TBE without signs of sickness (transmission of SK virus), while paralysis or death was registered in 35.0 to 57.1% of infested mice (transmission of strain 198) depending on the concentration of strain 198 used for inoculation of ticks. However, a low degree of interference to superinfection with strain 198 was observed, when the dissected tick salivary glands were examined by subcutaneous inoculation of adult albino mice (more than 90% of examined salivary glands contained strain 198 virus).

MeSH Terms:

ISSN: 0001-723X
Journal Title Code: 286
NLM Unique ID: 0370401
Country: czechoslovakia
Entry Date: 19910408
Date Completed: 19910408
MeSH Date: 1990/08/01
Date Revised: 20001218
Entrez Date: 1990/08/01
Citation Subset: IM
Publication Status: ppublish
Acta Virol 1990 Aug;34(4):353-7.
PMID: 1981446 UI: 91157689 [PubMed - indexed for MEDLINE]
From PubMed

Item 31 displayed (out of 45 found).

Replication of Langat virus in immunocompetent cells of mice subjected to immobilization stress.

Ozherelkov SV,  Khozinsky VV,  Semenov BF.

Acta Virol. 1990 May;34(3):291-4.

[Article in English]


Institute of Poliomyelitis and Viral Encephalitides, Academy of Medical Sciences, U.S.S.R., Moscow.

Immobilization stress (hypokinesis) in Balb/c mice may aggravate asymptomatic infection with Langat virus (strain TP-21) as evidenced by 4-fold increased lethality in comparison with control animals. The virus levels in the spleen and brain of stressed and infected mice and the in vitro yield of the virus in immunocompetent cells derived from stressed mice were significantly higher than in controls. Enhanced virus replication in latter cells may contribute to increased accumulation of the infectious agent in lymphatic tissues, which would facilitate virus invasion into CNS followed with acute disease and death of animals.

MeSH Terms:

ISSN: 0001-723X
Journal Title Code: 286
NLM Unique ID: 0370401
Country: czechoslovakia
Entry Date: 19910226
Date Completed: 19910226
MeSH Date: 1990/05/01
Date Revised: 20001218
Entrez Date: 1990/05/01
Citation Subset: IM
Publication Status: ppublish
Acta Virol 1990 May;34(3):291-4.
PMID: 1980400 UI: 91112507 [PubMed - indexed for MEDLINE]
From PubMed

Item 32 displayed (out of 45 found).

[Isolation of tick-borne encephalitis viruses from the cervical spinal cord in meningoencephalitis]

Gresikova M,  Sekeyova M,  Peci J,  Slacikova M.

Bratisl Lek Listy. 1989 Apr;90(4):271-3.

[Article in Slovak]


In 1988 the organs of a male were examined post mortem for the presence of viruses in isolation experiments on white suckling mice. The virus isolated from the cervical spinal cord was identified as the virus of tick-borne encephalitis. Although death from tick-borne encephalitis is rather rare in Slovakia, the disease requires great attention with special focus on preventive measures.

MeSH Terms:

ISSN: 0006-9248
Journal Title Code: B5N
NLM Unique ID: 0065324
Country: czechoslovakia
Vernacular Title: Izolacia virusu kliest'ovej encefalitidy z krcnej miechy pri meningoencefalitide.
Entry Date: 19890928
Date Completed: 19890928
MeSH Date: 1989/04/01
Date Revised: 20001218
Entrez Date: 1989/04/01
Citation Subset: IM
Publication Status: ppublish
Bratisl Lek Listy 1989 Apr;90(4):271-3.
PMID: 2765957 UI: 89353586 [PubMed - indexed for MEDLINE]
From PubMed

Item 33 displayed (out of 45 found).

[Changes in the organs of the immune system of Syrian hamsters infected by the tick-borne encephalitis virus with various degrees of virulence]

Karmysheva VI,  Pogodina VV.

Vopr Virusol. 1987 May-Jun;32(3):342-7.

[Article in Russian]


On the model of Syrian hamsters inoculated intracerebrally with 9 tick-borne encephalitis (TBE) virus strains varying in virulence, the specific involvement of the organs of the immune system (spleen and lymph nodes) was established and morphological features of the process described. The most severe destructive changes of these organs were found in the hamsters inoculated with highly virulent strains which appeared to be one of the factors leading to 100% death of the animals. In hamsters inoculated with strains of low virulence, the destructive changes in immunogenesis organs were less marked, but active migration and proliferative processes developed in them. The above-described differences in the involvement of the immune system organs should be taken into consideration in the interpretation of TBE pathogenesis and evaluation of the degree of virulence of the virus strains.

MeSH Terms:

Substances:

ISSN: 0507-4088
Journal Title Code: XL8
NLM Unique ID: 0417337
Country: ussr
Vernacular Title: Izmeneniia v organakh immunnoi sistemy siriiskikh khomiachkov, zarazhennykh virusom kleshchevogo entsefalita raznoi stepeni virulentnosti.
Entry Date: 19871201
Date Completed: 19871201
MeSH Date: 1987/05/01
Date Revised: 20001218
Entrez Date: 1987/05/01
Citation Subset: IM
Publication Status: ppublish
Vopr Virusol 1987 May-Jun;32(3):342-7.
PMID: 3314145 UI: 88044665 [PubMed - indexed for MEDLINE]
From PubMed

Item 34 displayed (out of 45 found).

Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus. Brief report.

Phillpotts RJ,  Stephenson JR,  Porterfield JS.

Arch Virol. 1987;93(3-4):295-301.

[Article in English]


Adult Balb/c mice were passively immunized with monoclonal antibodies (100 micrograms/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD50 of TBE virus (Neudorfl isolate). None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge.

MeSH Terms:

Substances:

ISSN: 0304-8608
Journal Title Code: 8L7
NLM Unique ID: 7506870
Country: Austria
Entry Date: 19870423
Date Completed: 19870423
MeSH Date: 1987/01/01
Date Revised: 20001218
Entrez Date: 1987/01/01
Citation Subset: IM
Publication Status: ppublish
Arch Virol 1987;93(3-4):295-301.
PMID: 3827600 UI: 87155995 [PubMed - indexed for MEDLINE]
From PubMed

Item 35 displayed (out of 45 found).

[Study of immunological mechanisms of action of temperature and emotional stress factors in experimental flavivirus infections]

Ozherelkov SV,  Khozinskii VV,  Semenov BF.

Zh Mikrobiol Epidemiol Immunobiol. 1986 Dec;(12):95-9.

[Article in Russian]


The influence of two stress factors, sharp changes in temperature and hypokinesia, on the course of experimental tick-borne encephalitis and Langat virus infections in mice has been studied. The data obtained in this study indicate that both factors produce defects in T- and B-cell-mediated immunity, accompanied by the activation of asymptomatic infection and the decrease of the mean survival time in acute infection. These two stress factors, differing in their intensity and nature (physical and emotional), have been shown to produce the same effect on the course of acute and asymptomatic flavivirus infections. In the former case the mean survival time of the animals decreases, and in the latter case clinically manifest infection develops. Under the conditions of hypokinesia (or changes in temperature), the death rate among the animals infected with langat virus has been found to increase 3- to 4-fold in comparison with the controls, the mortality level in the groups subjected to different stress factors being the same.

MeSH Terms:

ISSN: 0372-9311
Journal Title Code: Y9O
NLM Unique ID: 0415217
Country: ussr
Vernacular Title: Issledovanie immunologicheskikh mekhanizmov deistviia temperaturnykh i emotsional'nykh stress-faktorov pri eksperimental'nykh flavivirusnykh infektsiiakh
Entry Date: 19870330
Date Completed: 19870330
MeSH Date: 1986/12/01
Date Revised: 20001218
Entrez Date: 1986/12/01
Citation Subset: IM
Publication Status: ppublish
Zh Mikrobiol Epidemiol Immunobiol 1986 Dec;(12):95-9.
PMID: 3030031 UI: 87151957 [PubMed - indexed for MEDLINE]
From PubMed

Item 36 displayed (out of 45 found).

H-2 restricted regulation by soluble autoantigens of the tick-borne encephalitis virus-induced autoreactive T-effector and T-suppressor lymphocytes in mice.

Khozinsky VV,  Semenov BF.

Acta Virol. 1986 Jan;30(1):35-44.

[Article in English]


Soluble autoantigens (mouse red blood cells lysed by sonication) blocked in vitro the antigen-recognizing receptors of tick-borne encephalitis (TBE) virus-induced autoreactive T-lymphocytes (ARTL), effectors of the local graft-versus-host reaction (GVHR) in a syngeneic system and prevented the development of GVHR in vivo. Antigen-recognizing receptors were also found on T-suppressors (Ts) that became activated during experimental tick-borne encephalitis in mice and inhibited the activity of ARTL. The interaction between these receptors and autoantigens in vitro resulted in a loss of the ability of Ts to inhibit in vivo the ARTL-mediated GVHR. A similar result was obtained with ARTL and Ts activated in mice infected with Langat, dengue type 2 (D2) and yellow fever (strain 17D) viruses. The block of the antigen-recognizing receptors of T-cells was reversible, and not associated with lymphokine production or effector death. The block of the antigen-recognizing receptors in vitro and the loss of the corresponding T-cell function in vivo occurred provided that the donors of soluble erythrocyte antigens (SEA) and of the lymphocytes had at least one common major histocompatibility complex (MHC) haplotype. Injection SEA from donors whose H-2 complex haplotypes were identical to those of TBE-infected recipients prevented in the latter the formation of ARTL or Ts. The autoantigens inhibiting the ARTL and Ts activities seemed to be products of the MHC genes. The role of soluble H-2 autoantigens in preventing virus-induced autoimmune reaction and maintaining a state of natural immunological tolerance is discussed.

MeSH Terms:

Substances:

ISSN: 0001-723X
Journal Title Code: 286
NLM Unique ID: 0370401
Country: czechoslovakia
Entry Date: 19860612
Date Completed: 19860612
MeSH Date: 1986/01/01
Date Revised: 20001218
Entrez Date: 1986/01/01
Citation Subset: IM
Publication Status: ppublish
Acta Virol 1986 Jan;30(1):35-44.
PMID: 2871731 UI: 86211725 [PubMed - indexed for MEDLINE]
From PubMed

Item 37 displayed (out of 45 found).

[Role of virus-induced autoreactive T-lymphocytes, T-suppressors and the serum factor regulating their activity in the pathogenesis of experimental infection caused by the Langat virus in mice]

Khozinskii VV,  Semenov BF.

Zh Mikrobiol Epidemiol Immunobiol. 1985 Aug;(8):66-73.

[Article in Russian]


The precursors of autoreactive T-lymphocytes (PARTL) have been detected in the spleen of mice infected with Langat virus. When introduced into syngeneic recipients, PARTL differentiate in their lymph nodes into autoreactive T-lymphocytes (ARTL) causing a fatal autoimmune disease in the syngeneic recipients in vivo and capable of destroying syngeneic cell cultures in vitro. In the thymus of mice infected with Langat virus T-suppressors (TS) inhibiting the differentiation of PARTL into ARTL have been detected. The serum of intact mice has been shown to contain the serum blocking factor (SBF) which suppresses the differentiation of PARTL and the activity of TS from donors having common H-2 haplotypes of the gene complex with serum donors. In the course of viral infection the decrease of SBF activity and, simultaneously, the activation of PARTL and TS occur. The activation of PARTL and TS in infected mice may be suppressed by the injection of the serum of intact donors identical in H-2 haplotypes. The injection of ARTL induced by Langat virus into syngeneic recipients infected with this virus provokes the transformation of asymptomatic infection into acute infection, while TS and SBF blocking the differentiation of PARTL protect the animals from death.

MeSH Terms:

Substances:

ISSN: 0372-9311
Journal Title Code: Y9O
NLM Unique ID: 0415217
Country: ussr
Vernacular Title: Rol' virusindutsirovannykh autoreaktivnykh T-limfotsitov, T-supressorov i syvorotochnogo faktora, reguliruiushchego ikh aktivnost' v patogeneze eksperimental'noi infektsii, vyzvannoi virusom Langat u myshei.
Entry Date: 19851210
Date Completed: 19851210
MeSH Date: 1985/08/01
Date Revised: 20001218
Entrez Date: 1985/08/01
Citation Subset: IM
Publication Status: ppublish
Zh Mikrobiol Epidemiol Immunobiol 1985 Aug;(8):66-73.
PMID: 2998127 UI: 86046711 [PubMed - indexed for MEDLINE]
From PubMed

Item 38 displayed (out of 45 found).

Variability of Powassan virus cultured in tissue explants and organism of Hyalomma anatolicum ticks.

Khozinskaya GA,  Chunikhin SP,  Khozinsky VV,  Stefutkina LF.

Acta Virol. 1985 Jul;29(4):305-11.

[Article in English]


The variability of Powassan virus was studied during successive passages in Hyalomma anatolicum ticks or prolonged reproduction in their tissue explants. It had been shown that in the course of tick passages and during reproduction in the explants, pathogenicity of the virus in respect to causing acute disease in mice after peripheral inoculation was decreased, while virus ability to cause death after intracerebral (i.c.) inoculation remained unchanged. In mice infected with the original strain P-40 of Powassan virus damaging effect of the immune response prevailed, while in mice infected with the strains passaged for a long time in ticks (strain P-40Hat) or in tick tissue explants (strain P-40Haex), the protective effect of the immune response was prominent.

MeSH Terms:

ISSN: 0001-723X
Journal Title Code: 286
NLM Unique ID: 0370401
Country: czechoslovakia
Entry Date: 19851105
Date Completed: 19851105
MeSH Date: 1985/07/01
Date Revised: 20001218
Entrez Date: 1985/07/01
Citation Subset: IM
Publication Status: ppublish
Acta Virol 1985 Jul;29(4):305-11.
PMID: 2864833 UI: 86022533 [PubMed - indexed for MEDLINE]
From PubMed

Item 39 displayed (out of 45 found).

Risks and benefits of vaccinations.

Wiedermann G,  Ambrosch F,  Kollaritsch H,  Kundi M.

Infect Control. 1984 Sep;5(9):438-44.

[Article in English]


Any medical intervention is expected to prevent sickness and complications of a disease rather than to induce them. This is true for therapy as well as prophylaxis. Special formulas have been developed to calculate the risks and benefits of vaccinations simply but with sufficient accuracy. The risk ratio (Q) tells how many times the risk of contracting certain complications or even death from a disease is greater in unvaccinated than in vaccinated individuals. The risk difference (D) directly expresses the number of complications or deaths that may be prevented by a certain vaccination. It is even possible to evaluate the epidemiologic trend of a disease and to calculate or estimate the point of time when the risks of disease and vaccination are just balanced, ie, when a vaccination has lost its beneficial effect. Vaccinations against measles, poliomyelitis and tick borne encephalitis in Austria are highly beneficial. BCG vaccination is still beneficial on a low level in Austria as far as protection against tuberculosis is concerned. This effect will persist for the rest of this century. The benefit of pertussis vaccination depends on the local epidemiologic situation. It has expired for non-risk groups in Austria since 1976 but continues to persist in the US.

MeSH Terms:

ISSN: 0195-9417
Journal Title Code: GTM
NLM Unique ID: 8008357
Country: United States
Entry Date: 19841210
Date Completed: 19841210
MeSH Date: 1984/09/01
Date Revised: 20001218
Entrez Date: 1984/09/01
Citation Subset: IM,  N
Publication Status: ppublish
Infect Control 1984 Sep;5(9):438-44.
PMID: 6567619 UI: 85029688 [PubMed - indexed for MEDLINE]
From PubMed

Item 40 displayed (out of 45 found).

[Effect of virazole on the antiviral activity of poly(G) X poly(C) and other polyribonucleotide interferonogens]

Vil'ner LM,  Lashkevich VA.

Antibiotiki. 1984 Jun;29(6):450-3.

[Article in Russian]


The effect of virazole on the antiviral activity of poly (G) X poly (C), poly (G, A) X X poly (C) and poly(G, I) X poly (C) was studied in cell cultures and on mice. It was shown that virazole in concentrations not sufficient for significant inhibition of the development of vesicular stomatitis virus or Sindbis virus in chick embryo cell cultures markedly increased the antiviral effect and allowed decreasing the minimum effective doses of the synthetic polyribonucleotide complexes with respect to the above viruses. Combined administration of poly (G) X poly (C) and virazole to mice 1-2 or 24 hours after infection with tick-borne encephalitis virus provided a much more pronounced decrease in the death rate of the animals than the use of the interferonogen alone. Virazole per se was little active and had no significant effect on the intensity of interferonogenesis promoted by the use of poly (G) X poly (C). A possibility of successful therapy of viral infections with polyribonucleotide interferonogens in combination with virazole or other chemotherapeutic drugs with broad antiviral spectrum is discussed.

MeSH Terms:

Substances:

ISSN: 0003-5637
Journal Title Code: 6GC
NLM Unique ID: 0375020
Country: ussr
Vernacular Title: Vliianie virazola na protivovirusnuiu aktivnost' poli(G) X poli(Ts) i drugikh poliribonukleotidnykh interferonogenov.
Entry Date: 19841003
Date Completed: 19841003
MeSH Date: 1984/06/01
Date Revised: 20001218
Entrez Date: 1984/06/01
Citation Subset: IM
Publication Status: ppublish
Antibiotiki 1984 Jun;29(6):450-3.
PMID: 6089650 UI: 84305783 [PubMed - indexed for MEDLINE]
From PubMed

Item 41 displayed (out of 45 found).

[Effect of amphotericin B on the interferonogenic activity of poly(G) . poly(C) and poly(G,I) . poly(C) in mice and their resistance to infection by the tick-borne encephalitis virus]

Vil'ner LM.

Antibiotiki. 1982 Nov;27(11):827-30.

[Article in Russian]


It was shown that amphotericin B, a polyenic macrolide markedly potentiated in mice the interferonogenic activity of the two-strand synthetic polyribonucleotide complexes, Poly (G) . Poly (C) and Poly (G, I) . Poly (C). At the same time amphotericin B used in high or low doses lowered or somewhat increased respectively the protective effect of Poly (G) . Poly (C) and Poly (G, I) . Poly (C) which was not adequate to the antibiotic effect on their interferonogenic activity. It was found that amphotericin B stimulated in the mice the infection caused by the forest spring encephalitis virus, accelerated the period of its manifestation and increased the death rate. This effect correlated with the concentration of amphotericin B and the dose of the virus. The relationship between the differential effect of amphotericin B on the interferonogenic and antiviral activity of polyribonucleotide interferonogenes and the stimulation of the viral infection by them is discussed.

MeSH Terms:

Substances:

ISSN: 0003-5637
Journal Title Code: 6GC
NLM Unique ID: 0375020
Country: ussr
Vernacular Title: Vliianie amfoteritsina B na interferonogennuiu aktivnost' poli(G) poli(Ts), poli(G,I) poli(Ts) v organizme myshei i ikh rezistentnost' k zarazheniiu virusom kleshchevogo entsefalita.
Entry Date: 19830225
Date Completed: 19830225
MeSH Date: 1982/11/01
Date Revised: 20001218
Entrez Date: 1982/11/01
Citation Subset: IM
Publication Status: ppublish
Antibiotiki 1982 Nov;27(11):827-30.
PMID: 7181466 UI: 83099179 [PubMed - indexed for MEDLINE]
From PubMed

Item 42 displayed (out of 45 found).

[Effect of different polyribonucleotide interferonogens on acute and latent viral infections in mice]

Vil'ner LM,  Kogan EM,  Timkovskii AL,  Tiufanov AV,  Finogenova EV.

Vopr Virusol. 1980 Jan-Feb;(1):67-71.

[Article in Russian]


Poly(G) . poly(C) and poly(I) . poly(C) complexes administered soon after the viral challenge induced a high survival rate in mice with experimental tick-borne encephalitis. The protective effect was still noted when the treatment was given 24 hours after the infection. If the therapy was conducted at the end of the incubation period, at the peak of the virus reproduction in the mouse brain, poly(I) . poly(C) intensified the infection development and increased the animal death rate, while poly(G) . poly(C) had no such effect. Poly(I) . poly(C) injected 12 hours after the peak of the virus-induced interferonogenesis led to death of 80% animals inoculated with non-pathogenous Newcastle disease virus. The action of various samples of poly(I) . poly(C) was diverse. Poly(G) . poly(C) failed to effect the outcome of latent viral infection. The death of infected mice induced by polyribonucleotide complexes was not connected with their anti-viral interferonogenous activity, but correlated with the level of their toxicity for the intact animals. The results of the study have confirmed the risk of using poly(I) . poly(C) for the therapy of viral infections, especially during their clinical manifestation, and proved the safety of application of poly(G) . poly(C) and of some other polyribonucleotide interferonogens.

MeSH Terms:

Substances:

ISSN: 0507-4088
Journal Title Code: XL8
NLM Unique ID: 0417337
Country: ussr
Vernacular Title: Vliianie razlichnykh poliribonukleotidnykh interferonogenov na ostruiu i latentnuiu virusnuiu infektsiiu myshei.
Entry Date: 19801125
Date Completed: 19801125
MeSH Date: 1980/01/01
Date Revised: 20001218
Entrez Date: 1980/01/01
Citation Subset: IM
Publication Status: ppublish
Vopr Virusol 1980 Jan-Feb;(1):67-71.
PMID: 7415152 UI: 81017051 [PubMed - indexed for MEDLINE]
From PubMed

Item 43 displayed (out of 45 found).

[Study of the antiviral activity of a poly I : poly-C complex with poly-L-lysine in monkeys]

Burgasova MP.

Antibiotiki. 1977 May;22(5):458-60.

[Article in Russian]


Antiviral activity of poly-I-poly-C complex with poly-L-lysine was studied on macaco rhesus. The complex bifilamentous polyribonucleotide induced active production of serum interferon and provided pronounced protection of the monkeys infected intracutaneously with the variolovaccine virus (10 LD50 for the monkeys in intracutaneous infection). The effectiveness of the protective effect depended on the scheme and route of the drug administration. The highest prophylactic and therapeutic effect was provided by local administration of the complex in a dose of I mg per I kg of the body weight, the incubation period being increased 2--3 times and the period of the skin affections being decreased approximately 2 times. The results of the studies on the effect of poly-I-poly-C complex with poly-L-lysine were evident of definite prophylactic activity of the drug against experimental vernal encephalitis in the monkeys. The animals not treated with the inductor died on the 16th or 17th day after infection because of the paralysis of the trunc and extremities muscles. The clinical evidences of the disease in the animals treated with the drug were not uniform: from complete health to death.

MeSH Terms:

Substances:

ISSN: 0003-5637
Journal Title Code: 6GC
NLM Unique ID: 0375020
Country: ussr
Vernacular Title: Izuchenie protivovirusnoi aktivnosti kompleksa poli-I : poli-Ts s poli-L-lizinom u obez'ian
Entry Date: 19770812
Date Completed: 19770812
MeSH Date: 1977/05/01
Date Revised: 20001218
Entrez Date: 1977/05/01
Citation Subset: IM
Publication Status: ppublish
Antibiotiki 1977 May;22(5):458-60.
PMID: 406827 UI: 77220270 [PubMed - indexed for MEDLINE]
From PubMed

Item 44 displayed (out of 45 found).

Encephalic necrosis and inflammatory reaction in fetuses and newborns.

Dambska M.

Pol Med J. 1968;7(2):404-34.

[Article in English]


Publication Types:

MeSH Terms:

Number of References: 84
ISSN: 0032-2938
Journal Title Code: PB1
NLM Unique ID: 0376721
Country: Poland
Entry Date: 19680814
Date Completed: 19680814
MeSH Date: 1968/01/01
Date Revised: 20001218
Entrez Date: 1968/01/01
Citation Subset: IM
Publication Status: ppublish
Pol Med J 1968;7(2):404-34.
PMID: 4872572 UI: 68311611 [PubMed - indexed for MEDLINE]
From PubMed

Item 45 displayed (out of 45 found).

Pathogenicity of tick-borne encephalitis virus for the chicken embryo. I. Influence of chicken embryo age and incubation temperature on the lethal activity of the virus.

Slonim D,  Roslerova V.

Acta Virol. 1965 Nov;9(6):473-80.

[Article in English]


MeSH Terms:

ISSN: 0001-723X
Journal Title Code: 286
NLM Unique ID: 0370401
Country: czechoslovakia
Entry Date: 19660526
Date Completed: 19660526
MeSH Date: 1965/11/01
Date Revised: 20001218
Entrez Date: 1965/11/01
Citation Subset: IM
Publication Status: ppublish
Acta Virol 1965 Nov;9(6):473-80.
PMID: 4379429 UI: 66100499 [PubMed - indexed for MEDLINE]
From PubMed

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